Professor
+1 510 333-3487 ext. 2289
+1 510 601-3957

Biography

Ann Petru, MD is a Pediatric Infectious Diseases physician who has been working at Children’s Hospital Oakland since completing her residency there. She was involved in many clinical trials in the 1980s and 1990s, then started to focus more on HIV and AIDS as that epidemic started to affect children. In addition to HIV and AIDS, she has focused on common and challenging problems in the field, including use of antibiotics in children, common “Staph” and “Strep” infections, bacterial and other forms of meningitis, Epstein-Barr virus infection (EBV), and coccidioidomycosis (the fungus that causes Valley Fever). However, her primary focus has been the treatment support of children living with HIV/AIDS and preventing transmission of HIV from mothers to their babies.

Dr. Petru provided care for the first pediatric HIV/AIDS case in the Bay Area in 1983. In 1986, she started the Pediatric HIV/AIDS Program, which has treated more than 800 HIV-infected and HIV-exposed infants, children and adolescents. Many of her patients were among the first to participate in clinical trials that provided AZT treatment for children, then followed by many other drugs as they were becoming available for adults and where data in children was lacking. These groundbreaking studies allowed her and her staff to evaluate many drug combinations for HIV management, immunizations in children with HIV, and the long-term effects on children receiving drugs for HIV disease. Because drug therapies have been so successful, children are living much longer and their treatment has become far simpler and better tolerated. Aggressive identification of HIV infection before and during pregnancy and improved therapies have dramatically reduced transmission of HIV from mothers to their children over the last 20 years. However, many families in the Bay Area and other areas in northern California are adopting children with HIV infection from other countries, so her clinic continues to see a slow but steady influx of new patients.

Education and Training

Residency, Pediatrics, Children's Hospital & Research Center
MD, , University of California

Publications

Takayanagi A, Petru A. Twelve-year-old With Chronic Chest and Abdominal Pain. Pediatr Infect Dis J. 2017 05; 36(5):533.
Rainwater-Lovett K, Ziemniak C, Watson D, Luzuriaga K, Siberry G, Petru A, Chen Y, Uprety P, McManus M, Ho YC, Lamers SL, Persaud D. Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection. PLoS One. 2017; 12(2):e0170548.
Labeaud AD, Wentworth B, Gildengorin G, Tam K, Guardia-Labar L, Petru A. Comparison of moderate and severe hospitalized Pediatric 2009 H1N1 influenza cases. Pediatr Infect Dis J. 2013 Feb; 32(2):e90-3.
Islam S, Cooney T, Singh A, Petru AM, LaBeaud AD. Photo quiz. Painful arthritis and extremity rash in an 8-year-old boy. Clin Infect Dis. 2012 May; 54(10):1473, 1514-5.
Patel NC, Hertel PM, Estes MK, de la Morena M, Petru AM, Noroski LM, Revell PA, Hanson IC, Paul ME, Rosenblatt HM, Abramson SL. Vaccine-acquired rotavirus in infants with severe combined immunodeficiency. N Engl J Med. 2010 Jan 28; 362(4):314-9.
Yeh J, Culbertson C, Petru AM. Purulent pericardial effusion in a 14-year-old girl. Pediatr Infect Dis J. 2009 Dec; 28(12):1140, 1147-8.
Louie JK, Roy-Burman A, Guardia-Labar L, Boston EJ, Kiang D, Padilla T, Yagi S, Messenger S, Petru AM, Glaser CA, Schnurr DP. Rhinovirus associated with severe lower respiratory tract infections in children. Pediatr Infect Dis J. 2009 Apr; 28(4):337-9.
Butensky James E, Harmatz P, Lee M, Kennedy C, Petru A, Wara D, Miaskowski C. Altered iron metabolism in children with human immunodeficiency virus disease. Pediatr Hematol Oncol. 2009 Mar; 26(2):69-84.
Louie JK, Kajon AE, Holodniy M, Guardia-LaBar L, Lee B, Petru AM, Hacker JK, Schnurr DP. Severe pneumonia due to adenovirus serotype 14: a new respiratory threat? Clin Infect Dis. 2008 Feb 01; 46(3):421-5.
Chang K, Petru AM, Lee BP. A seven-month-old infant with acute onset of neurologic deterioration. Pediatr Infect Dis J. 2007 Nov; 26(11):1072-3, 1078-9.
Cohan D, Feakins C, Wara D, Petru A, McNicholl I, Schillinger D, Lu J, Kuritzkes D, Deeks SG. Perinatal transmission of multidrug-resistant HIV-1 despite viral suppression on an enfuvirtide-based treatment regimen. AIDS. 2005 Jun 10; 19(9):989-90.
Berk DR, Falkovitz-Halpern MS, Hill DW, Albin C, Arrieta A, Bork JM, Cohan D, Nilson B, Petru A, Ruiz J, Weintrub PS, Wenman W, Maldonado YA. Temporal trends in early clinical manifestations of perinatal HIV infection in a population-based cohort. JAMA. 2005 May 11; 293(18):2221-31.
Nachman S, Kim S, King J, Abrams EJ, Margolis D, Petru A, Shearer W, Smith E, Moye J, Blanchard S, Hawkins E, Bouquin P, Vink P, Benson M, Estep S, Malinoski F. Safety and immunogenicity of a heptavalent pneumococcal conjugate vaccine in infants with human immunodeficiency virus type 1 infection. Pediatrics. 2003 Jul; 112(1 Pt 1):66-73.
Lester P, Chesney M, Cooke M, Weiss R, Whalley P, Perez B, Glidden D, Petru A, Dorenbaum A, Wara D. When the time comes to talk about HIV: factors associated with diagnostic disclosure and emotional distress in HIV-infected children. . 2002 Nov 01; 31(3):309-17.
Frenkel LM, Capparelli EV, Dankner WM, Xu J, Smith IL, Ballow A, Culnane M, Read JS, Thompson M, Mohan KM, Shaver A, Robinson CA, Stempien MJ, Burchett SK, Melvin AJ, Borkowsky W, Petru A, Kovacs A, Yogev R, Goldsmith J, McFarland EJ, Spector SA. Oral ganciclovir in children: pharmacokinetics, safety, tolerance, and antiviral effects. The Pediatric AIDS Clinical Trials Group. J Infect Dis. 2000 Dec; 182(6):1616-24.
Ramos-Gomez FJ, Petru A, Hilton JF, Canchola AJ, Wara D, Greenspan JS. Oral manifestations and dental status in paediatric HIV infection. Int J Paediatr Dent. 2000 Mar; 10(1):3-11.
Stiehm ER, Fletcher CV, Mofenson LM, Palumbo PE, Kang M, Fenton T, Sapan CV, Meyer WA, Shearer WT, Hawkins E, Fowler MG, Bouquin P, Purdue L, Sloand EM, Nemo GJ, Wara D, Bryson YJ, Starr SE, Petru A, Burchett S. Use of human immunodeficiency virus (HIV) human hyperimmune immunoglobulin in HIV type 1-infected children (Pediatric AIDS clinical trials group protocol 273). J Infect Dis. 2000 Feb; 181(2):548-54.
Chen Y, Winchester R, Korber B, Gagliano J, Bryson Y, Hutto C, Martin N, McSherry G, Petru A, Wara D, Ammann A. Influence of HLA alleles on the rate of progression of vertically transmitted HIV infection in children: association of several HLA-DR13 alleles with long-term survivorship and the potential association of HLA-A*2301 with rapid progression to AIDS. Long-Term Survivor Study. Hum Immunol. 1997 Jul; 55(2):154-62.
Nielsen K, McSherry G, Petru A, Frederick T, Wara D, Bryson Y, Martin N, Hutto C, Ammann AJ, Grubman S, Oleske J, Scott GB. A descriptive survey of pediatric human immunodeficiency virus-infected long-term survivors. Pediatrics. 1997 Apr; 99(4):E4.
Azimi PH, Willert J, Petru A. Severe esophagitis in a newborn infant. Pediatr Infect Dis J. 1996 Apr; 15(4):385.
Rabin RL, Roederer M, Maldonado Y, Petru A, Herzenberg LA, Herzenberg LA. Altered representation of naive and memory CD8 T cell subsets in HIV-infected children. J Clin Invest. 1995 May; 95(5):2054-60.
Gallo D, Petru A, Yeh ET, Hanson CV. No evidence of perinatal transmission of HTLV-II. J Acquir Immune Defic Syndr (1988). 1993 Oct; 6(10):1168-70.
Petru A, Dunphy MG, Azimi P, Janner D, Gallo D, Hanson C, Sohmer P, Stanley M. Reliability of polymerase chain reaction in the detection of human immunodeficiency virus infection in children. Pediatr Infect Dis J. 1992 Jan; 11(1):30-3.
Johnson DC, Petru A, Azimi PH. Foreign body pulmonary granulomas in an abuser of nasally inhaled drugs. Pediatrics. 1991 Jul; 88(1):159-61.
Petru A. Multisystem disease in an eight-year-old boy. Pediatr Infect Dis J. 1991 Jul; 10(7):550, 553-4.
Janner D, Petru AM, Belchis D, Azimi PH. Fatal adenovirus infection in a child with acquired immunodeficiency syndrome. Pediatr Infect Dis J. 1990 Jun; 9(6):434-6.
Kulhanjian J, Dunphy MG, Hamstra S, Levernier K, Rankin M, Petru A, Azimi P. Randomized comparative study of ampicillin/sulbactam vs. ceftriaxone for treatment of soft tissue and skeletal infections in children. Pediatr Infect Dis J. 1989 Sep; 8(9):605-10.
Petru AM, Azimi PH, Cummins SK, Sjoerdsma A. African sleeping sickness in the United States. Successful treatment with eflornithine. Am J Dis Child. 1988 Feb; 142(2):224-8.
Azimi PH, Levernier K, Lefrak LM, Petru AM, Barrett T, Schenck H, Sandhu AS, Duritz G, Valesco M. Malassezia furfur: a cause of occlusion of percutaneous central venous catheters in infants in the intensive care nursery. Pediatr Infect Dis J. 1988 Feb; 7(2):100-3.
Azimi PH, Chase PA, Petru AM. Mycoplasmas: their role in pediatric disease. Curr Probl Pediatr. 1984 Aug; 14(8):1-46.
Petru A, Azimi PH. Esophagitis associated with Candida infection in a neonate. Clin Pediatr (Phila). 1984 Mar; 23(3):179-81.