Associate Professor
+1 415 514-0610
+1 415 476-8214


Brian Feldman, MD, PhD
Walter L. Miller Distinguished Professor
University of California, San Francisco
Department of Pediatrics
Division of Pediatric Endocrinology

A major focus of the Feldman Laboratory is to elucidate previously unrecognized paracrine and endocrine signaling pathways that regulate stem cell fate and differentiation decisions. We are particularly interested in identifying novel pathways that modulate body composition and metabolism. We apply molecular, cellular and in vivo approaches to define these physiological signals as well as examine how perturbations in these pathways can lead to diseases such as diabetes.

Education and Training

, Pediatrics, Harvard University
MD, PhD, Medicine, Stanford University
, Pediatric Endocrinology, UCSF


Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Blecha JE, VanBrocklin HF, Seo Y, Sayeed M, Feldman BJ, Aggarwal R, Behr SC, Shao H, Wilson DM, Villanueva-Meyer JE, Gestwicki JE, Evans MJ. A novel radioligand reveals tissue specific pharmacological modulation of glucocorticoid receptor expression with positron emission tomography. ACS Chem Biol. 2020 Apr 07.
Carter KL, Treurnicht A, Davis KL, Kumar RB, Feldman BJ. A novel platform for isotype-specific testing of autoantibodies. PLoS One. 2019; 14(2):e0211596.
Jung Y, Feldman BJ. A context-specific circadian clock in adipocyte precursor cells modulates adipogenesis. Adipocyte. 2018; 7(4):273-276.
Aggarwal A, Costa MJ, Rivero-Gutiérrez B, Ji L, Morgan SL, Feldman BJ. The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15. Cell Rep. 2017 Nov 28; 21(9):2367-2375.
Du H, Shih CH, Wosczyna MN, Mueller AA, Cho J, Aggarwal A, Rando TA, Feldman BJ. Macrophage-released ADAMTS1 promotes muscle stem cell activation. Nat Commun. 2017 09 22; 8(1):669.
Wong JC, Feldman BJ. Adamts1 responds to systemic cues and gates adipogenesis. Adipocyte. 2017 Oct 02; 6(4):293-297.
Aggarwal A, Feldman D, Feldman BJ. Identification of tumor-autonomous and indirect effects of vitamin D action that inhibit breast cancer growth and tumor progression. J Steroid Biochem Mol Biol. 2018 03; 177:155-158.
Chen PI, Cao A, Miyagawa K, Tojais NF, Hennigs JK, Li CG, Sweeney NM, Inglis AS, Wang L, Li D, Ye M, Feldman BJ, Rabinovitch M. Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension. JCI Insight. 2017 01 26; 2(2):e90427.
Wong JC, Krueger KC, Costa MJ, Aggarwal A, Du H, McLaughlin TL, Feldman BJ. A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo. Sci Signal. 2016 10 25; 9(451):ra103.
Williams JD, Aggarwal A, Swami S, Krishnan AV, Ji L, Albertelli MA, Feldman BJ. Tumor Autonomous Effects of Vitamin D Deficiency Promote Breast Cancer Metastasis. Endocrinology. 2016 Apr; 157(4):1341-7.
Swami S, Krishnan AV, Williams J, Aggarwal A, Albertelli MA, Horst RL, Feldman BJ, Feldman D. Vitamin D mitigates the adverse effects of obesity on breast cancer in mice. Endocr Relat Cancer. 2016 Apr; 23(4):251-64.
Ji L, Gupta M, Feldman BJ. Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3. Endocrinology. 2016 Jan; 157(1):91-7.
Banerjee RR, Marina N, Katznelson L, Feldman BJ. Mifepristone Treatment of Cushing's Syndrome in a Pediatric Patient. Pediatrics. 2015 Nov; 136(5):e1377-81.
Jeong Y, Swami S, Krishnan AV, Williams JD, Martin S, Horst RL, Albertelli MA, Feldman BJ, Feldman D, Diehn M. Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D. Mol Cancer Ther. 2015 Aug; 14(8):1951-61.
Diebold I, Hennigs JK, Miyagawa K, Li CG, Nickel NP, Kaschwich M, Cao A, Wang L, Reddy S, Chen PI, Nakahira K, Alcazar MA, Hopper RK, Ji L, Feldman BJ, Rabinovitch M. BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension. Cell Metab. 2015 Apr 07; 21(4):596-608.
Ota A, Kovary KM, Wu OH, Ahrends R, Shen WJ, Costa MJ, Feldman BJ, Kraemer FB, Teruel MN. Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice. J Lipid Res. 2015 May; 56(5):1068-78.
Chao CS, McKnight KD, Cox KL, Chang AL, Kim SK, Feldman BJ. Novel GATA6 mutations in patients with pancreatic agenesis and congenital heart malformations. PLoS One. 2015; 10(2):e0118449.
Kumar RB, Gupta M, Feldman BJ. The development of next-generation screening and diagnostic platforms will change diabetes care. Expert Rev Mol Diagn. 2015 Mar; 15(3):291-4.
Krueger KC, Costa MJ, Du H, Feldman BJ. Characterization of Cre recombinase activity for in vivo targeting of adipocyte precursor cells. Stem Cell Reports. 2014 Dec 09; 3(6):1147-58.
Zhang B, Kumar RB, Dai H, Feldman BJ. A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes. Nat Med. 2014 Aug; 20(8):948-53.
Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014 May; 14(5):342-57.
Krueger KC, Feldman BJ. Adipose circadian clocks: coordination of metabolic rhythms by clock genes, steroid hormones, and PPARs. Horm Mol Biol Clin Investig. 2013 Aug; 14(1):15-24.
Malloy PJ, Feldman BJ. Cell-autonomous regulation of brown fat identity gene UCP1 by unliganded vitamin D receptor. Mol Endocrinol. 2013 Oct; 27(10):1632-42.
Armstrong SP, Seeber RM, Ayoub MA, Feldman BJ, Pfleger KD. Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V). PLoS One. 2013; 8(6):e65885.
Kocan M, Dalrymple MB, Seeber RM, Feldman BJ, Pfleger KD. Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and ß-Arrestins. Front Endocrinol (Lausanne). 2010; 1:12.
Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, Ptacek LJ, Yamamoto KR, Feldman BJ. Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate. J Biol Chem. 2011 Mar 18; 286(11):9063-70.
So AY, Bernal TU, Pillsbury ML, Yamamoto KR, Feldman BJ. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17582-7.
Feldman BJ. Glucocorticoids influence on mesenchymal stem cells and implications for metabolic disease. Pediatr Res. 2009 Feb; 65(2):249-51.
Kocan M, See HB, Sampaio NG, Eidne KA, Feldman BJ, Pfleger KD. Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis. Mol Endocrinol. 2009 Apr; 23(4):559-71.
So AY, Cooper SB, Feldman BJ, Manuchehri M, Yamamoto KR. Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5745-9.
Feldman BJ. Is your metabolism determined by (cell) fate? Pediatr Res. 2007 Jun; 61(6):636-9.
Bremer AA, Feldman BJ, Iezza G, Clark OH, Rosenthal SM. Report of a hürthle cell neoplasm in a peripubertal girl. Thyroid. 2007 Feb; 17(2):175-8.
Fortescue EB, Shin AY, Greenes DS, Mannix RC, Agarwal S, Feldman BJ, Shah MI, Rifai N, Landzberg MJ, Newburger JW, Almond CS. Cardiac troponin increases among runners in the Boston Marathon. Ann Emerg Med. 2007 Feb; 49(2):137-43, 143.e1.
Rosenthal SM, Feldman BJ, Vargas GA, Gitelman SE. Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction. Pediatr Endocrinol Rev. 2006 Dec; 4 Suppl 1:66-70.
Feldman BJ, Streeper RS, Farese RV, Yamamoto KR. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15675-80.
Gitelman SE, Feldman BJ, Rosenthal SM. Nephrogenic syndrome of inappropriate antidiuresis: a novel disorder in water balance in pediatric patients. Am J Med. 2006 Jul; 119(7 Suppl 1):S54-8.
Huang EA, Feldman BJ, Schwartz ID, Geller DH, Rosenthal SM, Gitelman SE. Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children. J Pediatr. 2006 Jan; 148(1):128-31.
Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL, Gitelman SE. Nephrogenic syndrome of inappropriate antidiuresis. N Engl J Med. 2005 May 05; 352(18):1884-90.
Feldman BJ, Rosenthal D. Carbohydrate-deficient glycoprotein syndrome-associated pericardial effusion treated with corticosteroids and salicylic acid. Pediatr Cardiol. 2002 Jul-Aug; 23(4):469-71.
Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer. 2001 Oct; 1(1):34-45.
Feldman BJ, Hampton T, Cleary ML. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. Blood. 2000 Sep 01; 96(5):1906-13.
Feldman BJ, Reid TR, Cleary ML. Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice. Oncogene. 1997 Nov 27; 15(22):2735-42.
LeBrun DP, Matthews BP, Feldman BJ, Cleary ML. The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains. Oncogene. 1997 Oct 23; 15(17):2059-67.
Fox ME, Feldman BJ, Chu G. A novel role for DNA photolyase: binding to DNA damaged by drugs is associated with enhanced cytotoxicity in Saccharomyces cerevisiae. Mol Cell Biol. 1994 Dec; 14(12):8071-7.