Assistant Professor
+1 415 476-5960

Biography

My research involves understanding innate immune activation during sepsis that leads to subsequent endothelial dysfunction.

Education and Training

, 06/2018 Pediatric Critical Care Medicine, University of California San Francisco
, 06/2014 Pediatrics, Kaiser Permanente Northern California
MD, 05/2011 Medicine, Albany Medical College
BA, 05/2005 Molecular and Cell Biology, University of California Berkeley

Publications

Joffre J, Lloyd E, Wong E, Chung-Yeh C, Nguyen N, Xu F, Legrand M, Hellman J. Catecholaminergic Vasopressors Reduce Toll-Like Receptor Agonist-Induced Microvascular Endothelial Cell Permeability But Not Cytokine Production. Crit Care Med. 2021 Jan 22.
Wong E, Xu F, Joffre J, Nguyen N, Wilhelmsen K, Hellman J. ERK1/2 has Divergent Roles in LPS-Induced Microvascular Endothelial Cell Cytokine Production and Permeability. Shock. 2020 Aug 20.
Joffre J, Yeh CC, Wong E, Thete M, Xu F, Zlatanova I, Lloyd E, Kobzik L, Legrand M, Hellman J. Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury. J Immunol. 2020 Jun 15; 204(12):3339-3350.
Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K. N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. J Immunol. 2017 08 15; 199(4):1465-1475.