Fernando Gonzalez
Associate Professor
+1 415 476-8804
+1 415 502-5821

Biography

My research is focused on determining how the full-term brain responds to acute injury during the neonatal period, and strategies to enhance neuroplasticity and long-term functional outcomes. My specific research goals are to: (1) clearly define the neuronal subpopulations that are vulnerable to ischemia and critical for neurodevelopment, (2) determine the mechanisms of injury and endogenous repair in the immature brain, and (3) define therapeutic strategies to enhance long-term function. Specifically, I am interested in how the immature brain differs from the adult brain in its response to stroke, and how reparative mechanisms can be enhanced with delayed therapy. Throughout my training, I have had broad exposure to various aspects of central nervous system (CNS) development and repair, including: evaluation and inhibition of pain through direct CNS treatment; the effects of local injury on wound healing and phagocytosis; direct evaluation of behavioral, cognitive, and nociceptive function after injury; pathophysiologic mechanisms of early brain injury; and the effects of exogenous therapy on early brain injury. Of these experiences, the ones I found most compelling were those that linked rigorous basic science at the bench to investigation of human disease. For example, my research on the short-term effects of exogenous erythropoietin treatment on neurogenesis after early rodent stroke prompted a study to determine beneficial treatment strategies that improve long-term functional outcomes. This project showed that prolonged erythropoietin treatment is most effective for long-term behavioral improvement, a finding that informed clinical studies in humans to treat neonatal brain injury. My current research is focused on cell type-specific changes in the peri-infarct cortex, including alterations in cell fate, function, and circuit formation. This will have a significant impact in improving knowledge and identifying novel therapies to treat early injury. It is my clear desire to apply this type of translational approach to the field of neonatal brain injury, thereby unifying my interest in neuroscience and brain development with a goal of improving the care of the newborn.

Education and Training

, 2007 Neonatal-Perinatal Medicine, UCSF
, 2004 Pediatrics, Harbor-UCLA Medical Center
M.D., 2001 School of Medicine, Brown University
Sc.B., 1997 Neuroscience, Brown University

Publications

Wu YW, Goodman AM, Chang T, Mulkey SB, Gonzalez FF, Mayock DE, Juul SE, Mathur AM, Van Meurs K, McKinstry RC, Redline RW. Placental pathology and neonatal brain MRI in a randomized trial of erythropoietin for hypoxic-ischemic encephalopathy. Pediatr Res. 2019 Jul 01.
Soul JS, Pressler R, Allen M, Boylan G, Rabe H, Portman R, Hardy P, Zohar S, Romero K, Tseng B, Bhatt-Mehta V, Hahn C, Denne S, Auvin S, Vinks A, Lantos J, Marlow N, Davis JM. Recommendations for the design of therapeutic trials for neonatal seizures. Pediatr Res. 2019 Jun; 85(7):943-954.
Cornet MC, Pasupuleti A, Fang A, Gonzalez F, Shimotake T, Ferriero DM, Glass HC, Cilio MR. Predictive value of early EEG for seizures in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. Pediatr Res. 2018 09; 84(3):399-402.
Juul SE, Comstock BA, Heagerty PJ, Mayock DE, Goodman AM, Hauge S, Gonzalez F, Wu YW. High-Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL): A Randomized Controlled Trial - Background, Aims, and Study Protocol. Neonatology. 2018; 113(4):331-338.
Larpthaveesarp A, Gonzalez FF. Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats. J Vis Exp. 2017 04 21; (122).
Wu YW, Mathur AM, Chang T, McKinstry RC, Mulkey SB, Mayock DE, Van Meurs KP, Rogers EE, Gonzalez FF, Comstock BA, Juul SE, Msall ME, Bonifacio SL, Glass HC, Massaro AN, Dong L, Tan KW, Heagerty PJ, Ballard RA. High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics. 2016 06; 137(6).
Larpthaveesarp A, Georgevits M, Ferriero DM, Gonzalez FF. Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke. Neurobiol Dis. 2016 09; 93:57-63.
Larpthaveesarp A, Ferriero DM, Gonzalez FF. Growth factors for the treatment of ischemic brain injury (growth factor treatment). Brain Sci. 2015 Apr 30; 5(2):165-77.
Wu YW, Gonzalez FF. Erythropoietin: a novel therapy for hypoxic-ischaemic encephalopathy? Dev Med Child Neurol. 2015 Apr; 57 Suppl 3:34-9.
van Velthoven CT, Gonzalez F, Vexler ZS, Ferriero DM. Stem cells for neonatal stroke- the future is here. Front Cell Neurosci. 2014; 8:207.
Gonzalez FF, Larpthaveesarp A, McQuillen P, Derugin N, Wendland M, Spadafora R, Ferriero DM. Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke. Stroke. 2013 Mar; 44(3):753-8.
Xiong T, Gonzalez F, Mu DZ. An overview of risk factors for poor neurodevelopmental outcome associated with prematurity. World J Pediatr. 2012 Nov; 8(4):293-300.
Fang AY, Gonzalez FF, Sheldon RA, Ferriero DM. Effects of combination therapy using hypothermia and erythropoietin in a rat model of neonatal hypoxia-ischemia. Pediatr Res. 2013 Jan; 73(1):12-7.
Wu YW, Bauer LA, Ballard RA, Ferriero DM, Glidden DV, Mayock DE, Chang T, Durand DJ, Song D, Bonifacio SL, Gonzalez FF, Glass HC, Juul SE. Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics. Pediatrics. 2012 Oct; 130(4):683-91.
Gonzalez FF, Fang A, Ferriero DM. Is erythropoietin the answer? Pediatr Res. 2011 Jan; 69(1):2-3.
Wang H, Tang J, Xiong Y, Li X, Gonzalez F, Mu D. Neonatal community-acquired pneumonia: pathogens and treatment. J Paediatr Child Health. 2010 Nov; 46(11):668-72.
Spadafora R, Gonzalez FF, Derugin N, Wendland M, Ferriero D, McQuillen P. Altered fate of subventricular zone progenitor cells and reduced neurogenesis following neonatal stroke. Dev Neurosci. 2010 Jul; 32(2):101-13.
Gonzalez FF, Ferriero DM. Neuroprotection in the newborn infant. Clin Perinatol. 2009 Dec; 36(4):859-80, vii.
Gonzalez FF, Abel R, Almli CR, Mu D, Wendland M, Ferriero DM. Erythropoietin sustains cognitive function and brain volume after neonatal stroke. Dev Neurosci. 2009; 31(5):403-11.
Gonzalez FF, Ferriero DM. Therapeutics for neonatal brain injury. Pharmacol Ther. 2008 Oct; 120(1):43-53.
Gonzalez FF, McQuillen P, Mu D, Chang Y, Wendland M, Vexler Z, Ferriero DM. Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke. Dev Neurosci. 2007; 29(4-5):321-30.
Gonzalez FF, Miller SP. Does perinatal asphyxia impair cognitive function without cerebral palsy? Arch Dis Child Fetal Neonatal Ed. 2006 Nov; 91(6):F454-9.
Guo TZ, Reid K, Davies MF, Nacif-Coelho C, Rabin BC, Gonzalez F, Maze M. Chronic desipramine treatment desensitizes the rat to anesthetic and antinociceptive effects of the alpha2-adrenergic agonist dexmedetomidine. Anesthesiology. 1998 Jun; 88(6):1634-42.