Kristin Shimano
Associate Professor
+1 415 476-3831
+1 415 502-4372

Education and Training

M.D., 2003 School of Medicine, Harvard University
Residency, School of Medicine - Pediatrics, University of California, San Francisco

Publications

Friend BD, Bailey-Olson M, Melton A, Shimano KA, Kharbanda S, Higham C, Winestone LE, Huang J, Stieglitz E, Dvorak CC. The impact of total body irradiation-based regimens on outcomes in children and young adults with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2020 Feb; 67(2):e28079.
Kristin A. Shimano, Rachael F. Grace, Carolyn M. Bennett, Robert J Klaassen, Cindy Neunert, Ellis J. Neufeld, Clement Ma, Wendy B. London, Jenny M. Despotovic. A Phase 3 Study of Eltrombopag Vs. Standard First-Line Management for Newly Diagnosed Immune Thrombocytopenia in Children. Blood. 2019 Nov 13; 134(Supplement_1):2369-2369.
Cristina F Contreras, Janel R Long-Boyle, Kristin A. Shimano, Jasmeen Dara, James N Huang, Sandhya Kharbanda, Alexis Melton, Christine Higham, Morton J Cowan, Christopher C. Dvorak. Reduced Toxicity Conditioning for Non-Malignant Hematopoietic Cell Transplants. Blood. 2019 Nov 13; 134(Supplement_1):4481-4481.
Aleksandra S. Dain, Michelle L. Hermiston, Kristin A. Shimano, Sandhya Kharbanda, Alexis Melton, Jasmeen Dara, James N Huang, Christopher C. Dvorak. Role of Disease Mechanism in Hematopoietic Cell Transplantation Outcomes for Hemophagocytic Lymphohistiocytosis. Blood. 2019 Nov 13; 134(Supplement_1):3343-3343.
Neely JA, Dvorak CC, Pantell MS, Melton A, Huang JN, Shimano KA. Autoimmune Cytopenias in Pediatric Hematopoietic Cell Transplant Patients. Front Pediatr. 2019; 7:171.
Grace RF, Shimano KA, Bhat R, Neunert C, Bussel JB, Klaassen RJ, Lambert MP, Rothman JA, Breakey VR, Hege K, Bennett CM, Rose MJ, Haley KM, Buchanan GR, Geddis A, Lorenzana A, Jeng M, Pastore YD, Crary SE, Neier M, Neufeld EJ, Neu N, Forbes PW, Despotovic JM. Second-line treatments in children with immune thrombocytopenia: Effect on platelet count and patient-centered outcomes. Am J Hematol. 2019 07; 94(7):741-750.
Dvorak CC, Higham C, Shimano KA. Transplant-Associated Thrombotic Microangiopathy in Pediatric Hematopoietic Cell Transplant Recipients: A Practical Approach to Diagnosis and Management. Front Pediatr. 2019; 7:133.
Dvorak CC, Long-Boyle J, Dara J, Melton A, Shimano KA, Huang JN, Puck JM, Dorsey MJ, Facchino J, Chang CK, Cowan MJ. Low Exposure Busulfan Conditioning to Achieve Sufficient Multilineage Chimerism in Patients with Severe Combined Immunodeficiency. Biol Blood Marrow Transplant. 2019 07; 25(7):1355-1362.
Brian D. Friend, Mara Bailey-Olson, Christine Higham, Jasmeen Dara, Alexis Melton, Kristin A. Shimano, James Huang, Sandhya Kharbanda, Christopher C. Dvorak. The Impact of Total Body Irradiation-Based Regimens on Outcomes in Children and Young Adults with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation. 2019 Mar 1; 25(3):s197-s198.
Kristin Shimano. Anemia and Neutropenia. . 2019 Jan 1; 443-448.
Schuetz C, Hoenig M, Moshous D, Weinstock C, Castelle M, Bendavid M, Shimano K, Tolbert V, Schulz AS, Dvorak CC. Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation. Blood Adv. 2018 10 09; 2(19):2550-2553.
Grace RF, Despotovic JM, Bennett CM, Bussel JB, Neier M, Neunert C, Crary SE, Pastore YD, Klaassen RJ, Rothman JA, Hege K, Breakey VR, Rose MJ, Shimano KA, Buchanan GR, Geddis A, Haley KM, Lorenzana A, Thompson A, Jeng M, Neufeld EJ, Brown T, Forbes PW, Lambert MP. Physician decision making in selection of second-line treatments in immune thrombocytopenia in children. Am J Hematol. 2018 07; 93(7):882-888.
Matt S Zinter, Christopher C Dvorak, Madeline Y Mayday, Kensho Iwanaga, Ngoc P Ly, Meghan E McGarry, Gwynne D Church, Lauren E Faricy, Courtney M Rowan, Janet R Hume, Marie E Steiner, Emily D Crawford, Charles Langelier, Katrina Kalantar, Eric D Chow, Steve Miller, Kristin Shimano, Alexis Melton, Greg A Yanik, Anil Sapru, Joseph L DeRisi. Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children. bioRxiv. 2018 Mar 29; 291864.
Czechowicz JA, Long-Boyle JR, Rosbe KW, Mathes EF, Frieden IJ, Shimano KA. Sirolimus for management of complex vascular anomalies - A proposed dosing regimen for very young infants. Int J Pediatr Otorhinolaryngol. 2018 Feb; 105:48-51.
Delgado-Martin C, Meyer LK, Huang BJ, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey DT, Hermiston ML. JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias. Leukemia. 2017 12; 31(12):2568-2576.
Rachael F Grace, Robert J. Klaassen, Jennifer A Rothman, Kerry Hege, Ellis J Neufeld, Carolyn M. Bennett, Michele Lambert, Vicky R. Breakey, James B. Bussel, George R. Buchanan, Melissa J. Rose, Amy Geddis, Kristin Shimano, Kristina M. Haley, Adonis Lorenzana, Cindy Neunert, Alexis A. Thompson, Yves D. Pastore, Michael Jeng, Shelley E. Crary, Michelle Neier, Travis Brown, Peter Forbes, Jenny M. Despotovic. Clinical Characteristics and Quality of Life of Children with ITP Starting Second Line Treatments: Data from the ITP Consortium of North America ICON1 Study. Blood. 2016 Dec 2; 128(22):249-249.
Breakey R. Vicky, Rachael F Grace, Carolyn M. Bennett, Jenny M. Despotovic, Jennifer A Rothman, Yves D. Pastore, Ellis J Neufeld, Robert J. Klaassen, Michele Lambert, James B. Bussel, George R. Buchanan, Melissa J. Rose, Amy E. Geddis, Kristin Shimano, Kerry Hege, Kristina M. Haley, Adonis Lorenzana, Alexis A. Thompson, Michael Jeng, Shelley E. Crary, Michelle Neier, Travis Brown, Peter Forbes, Cindy Neunert. Comparison of Bleeding Tools in a Cohort of Pediatric Patients with ITP: Data from the Pediatric ITP Consortium of North America ICON1 Study. Blood. 2016 Dec 2; 128(22):4752-4752.
Vanessa P. Tolbert, Robert Goldsby, James Huang, Kristin Shimano, Alexis Melton, Jennifer Willert, Biljana N. Horn, Christopher C. Dvorak, Justin T. Wahlstrom. Daratumumab Is Effective in the Treatment of Refractory Post-Transplant Autoimmune Hemolytic Anemia: A Pediatric Case Report. Blood. 2016 Dec 2; 128(22):4819-4819.
Cristina Delgado-Martin, Kristin Shimano, Matthew S Zinter, Justin T. Wahlstrom, Geoffrey A. Smith, Jack Taunton, Stuart S. Winter, Justine E. Roderick, Michelle Kelliher, Terzah M. Horton, Brent L. Wood, David T Teachey, Michelle L. Hermiston. JAK/STAT Pathway Inhibition Reverts IL7-Induced Glucocorticoid Resistance in a Subset of Human T-Cell Acute Lymphoblastic Leukemia. Blood. 2016 Dec 2; 128(22):3963-3963.
Michele P. Lambert, Rachael F Grace, Cindy Neunert, Jenny M. Despotovic, Rukhmi Bhat, Yves D. Pastore, George R. Buchanan, Robert J. Klaassen, Carolyn M. Bennett, Jennifer A Rothman, Vicky R. Breakey, James B. Bussel, Melissa J. Rose, Amy Geddis, Kristin Shimano, Kerry Hege, Kristina M. Haley, Adonis Lorenzana, Michael Jeng, Shelley E. Crary, Michelle Neier, Travis Brown, Peter Forbes, Ellis J Neufeld. Physician Factors Determining Treatment Decisions in Selecting Second Line Agents for Pediatric ITP. Blood. 2016 Dec 2; 128(22):1008-1008.
Neunert C, Despotovic J, Haley K, Lambert MP, Nottage K, Shimano K, Bennett C, Klaassen R, Stine K, Thompson A, Pastore Y, Brown T, Forbes PW, Grace RF. Thrombopoietin Receptor Agonist Use in Children: Data From the Pediatric ITP Consortium of North America ICON2 Study. Pediatr Blood Cancer. 2016 08; 63(8):1407-13.
Jessica Neely, Christopher C. Dvorak, Matthew Pantell Pantell, Kristin A. Shimano. Autoimmune Cytopenias in Pediatric Hematopoietic Cell Transplant (HCT) Patients. Biology of Blood and Marrow Transplantation. 2016 Mar 1; 22(3):s255.
Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 2012 Jan 11; 481(7380):157-63.