Associate Professor

Biography

My current research focuses on the interactions between human Cytomegalovirus (CMV) and specific hematopoietic and oral mucosal cell types. CMV is the source of serious disease in immunocompromised individuals including newborns, transplant recipients and AIDS patients. Our ultimate goal is to understand virus transmission, develop effective anti-CMV vaccines, and design new therapies to target CMV lytic and latent infections.

Education and Training

Research Associate, 2/2005 Molecular Virology, Stanford University
Postdoctoral Fellow, 9/2004 Molecular Virology, Stanford University
Ph.D, 10/2000 Immunology, University of Torino
B.Sc., 07/1995 Biological Sciences, University of Torino

Publications

Vo M, Aguiar A, McVoy MA, Hertel L. Cytomegalovirus Strain TB40/E Restrictions and Adaptations to Growth in ARPE-19 Epithelial Cells. Microorganisms. 2020 Apr 24; 8(4).
Al Qaffas A, Camiolo S, Nichols J, Davison AJ, Ourahmane A, Cui X, Schleiss MR, Hertel L, Dittmer DP, McVoy MA. Genome Sequence of Human Cytomegalovirus Ig-KG-H2, a Variant of Strain KG Propagated in the Presence of Neutralizing Antibodies. Microbiol Resour Announc. 2020 Apr 23; 9(17).
Qi Y, He L, Cui X, Hertel L, Freed DC, Fu TM, Kauvar LM, McVoy MA, Ruan Q. Comparative neutralizing potencies of antibodies suggest conservation as well as mechanistic differences in human cytomegalovirus entry into epithelial and endothelial cells. Virol J. 2020 Apr 08; 17(1):50.
Galinato M, Shimoda K, Aguiar A, Hennig F, Boffelli D, McVoy MA, Hertel L. Single-Cell Transcriptome Analysis of CD34+ Stem Cell-Derived Myeloid Cells Infected With Human Cytomegalovirus. Front Microbiol. 2019; 10:577.
Ourahmane A, Cui X, He L, Catron M, Dittmer DP, Al Qaffasaa A, Schleiss MR, Hertel L, McVoy MA. Inclusion of Antibodies to Cell Culture Media Preserves the Integrity of Genes Encoding RL13 and the Pentameric Complex Components During Fibroblast Passage of Human Cytomegalovirus. Viruses. 2019 03 05; 11(3).
Coronel R, Jesus DM, Dalle Ore L, Mymryk JS, Hertel L. Activation of Langerhans-Type Dendritic Cells Alters Human Cytomegalovirus Infection and Reactivation in a Stimulus-Dependent Manner. Front Microbiol. 2016; 7:1445.
Coronel R, Takayama S, Juwono T, Hertel L. Dynamics of Human Cytomegalovirus Infection in CD34+ Hematopoietic Cells and Derived Langerhans-Type Dendritic Cells. J Virol. 2015 May; 89(10):5615-32.
Hertel L. Human cytomegalovirus tropism for mucosal myeloid dendritic cells. Rev Med Virol. 2014 Nov; 24(6):379-95.
Lauron EJ, Yu D, Fehr AR, Hertel L. Human cytomegalovirus infection of langerhans-type dendritic cells does not require the presence of the gH/gL/UL128-131A complex and is blocked after nuclear deposition of viral genomes in immature cells. J Virol. 2014 Jan; 88(1):403-16.
Hertel L. Herpesviruses and intermediate filaments: close encounters with the third type. Viruses. 2011 07; 3(7):1015-40.
Lee AW, Wang N, Hornell TM, Harding JJ, Deshpande C, Hertel L, Lacaille V, Pashine A, Macaubas C, Mocarski ES, Mellins ED. Human cytomegalovirus decreases constitutive transcription of MHC class II genes in mature Langerhans cells by reducing CIITA transcript levels. Mol Immunol. 2011 May; 48(9-10):1160-7.
Miller MS, Furlong WE, Pennell L, Geadah M, Hertel L. RASCAL is a new human cytomegalovirus-encoded protein that localizes to the nuclear lamina and in cytoplasmic vesicles at late times postinfection. J Virol. 2010 Jul; 84(13):6483-96.
Miller MS, Hertel L. Onset of human cytomegalovirus replication in fibroblasts requires the presence of an intact vimentin cytoskeleton. J Virol. 2009 Jul; 83(14):7015-28.
Mandic L, Miller MS, Coulter C, Munshaw B, Hertel L. Human cytomegalovirus US9 protein contains an N-terminal signal sequence and a C-terminal mitochondrial localization domain, and does not alter cellular sensitivity to apoptosis. J Gen Virol. 2009 May; 90(Pt 5):1172-1182.
Jagannathan P, Osborne CM, Royce C, Manion MM, Tilton JC, Li L, Fischer S, Hallahan CW, Metcalf JA, McLaughlin M, Pipeling M, McDyer JF, Manley TJ, Meier JL, Altman JD, Hertel L, Davey RT, Connors M, Migueles SA. Comparisons of CD8+ T cells specific for human immunodeficiency virus, hepatitis C virus, and cytomegalovirus reveal differences in frequency, immunodominance, phenotype, and interleukin-2 responsiveness. J Virol. 2009 Mar; 83(6):2728-42.
Hertel L, Chou S, Mocarski ES. Viral and cell cycle-regulated kinases in cytomegalovirus-induced pseudomitosis and replication. PLoS Pathog. 2007 Jan; 3(1):e6.
Lee AW, Hertel L, Louie RK, Burster T, Lacaille V, Pashine A, Abate DA, Mocarski ES, Mellins ED. Human cytomegalovirus alters localization of MHC class II and dendrite morphology in mature Langerhans cells. J Immunol. 2006 Sep 15; 177(6):3960-71.
Yao W, Hertel L, Wahl LM. Dynamics of recurrent viral infection. Proc Biol Sci. 2006 Sep 07; 273(1598):2193-9.
Hertel L, Mocarski ES. Global analysis of host cell gene expression late during cytomegalovirus infection reveals extensive dysregulation of cell cycle gene expression and induction of Pseudomitosis independent of US28 function. J Virol. 2004 Nov; 78(21):11988-2011.
Hertel L, Lacaille VG, Strobl H, Mellins ED, Mocarski ES. Susceptibility of immature and mature Langerhans cell-type dendritic cells to infection and immunomodulation by human cytomegalovirus. J Virol. 2003 Jul; 77(13):7563-74.
Rolle S, De Andrea M, Gioia D, Lembo D, Hertel L, Landolfo S, Gariglio M. The interferon-inducible 204 gene is transcriptionally activated by mouse cytomegalovirus and is required for its replication. Virology. 2001 Aug 01; 286(2):249-55.
Hertel L, Rolle S, De Andrea M, Azzimonti B, Osello R, Gribaudo G, Gariglio M, Landolfo S. The retinoblastoma protein is an essential mediator that links the interferon-inducible 204 gene to cell-cycle regulation. Oncogene. 2000 Jul 27; 19(32):3598-608.
Hertel L, De Andrea M, Azzimonti B, Rolle A, Gariglio M, Landolfo S. The interferon-inducible 204 gene, a member of the Ifi 200 family, is not involved in the antiviral state induction by IFN-alpha, but is required by the mouse cytomegalovirus for its replication. Virology. 1999 Sep 15; 262(1):1-8.
Azzimonti B, Hertel L, Aluffi P, Pia F, Monga G, Zocchi M, Landolfo S, Gariglio M. Demonstration of multiple HPV types in laryngeal premalignant lesions using polymerase chain reaction and immunohistochemistry. J Med Virol. 1999 Sep; 59(1):110-6.
Hertel L, De Andrea M, Bellomo G, Santoro P, Landolfo S, Gariglio M. The HMG protein T160 colocalizes with DNA replication foci and is down-regulated during cell differentiation. Exp Cell Res. 1999 Aug 01; 250(2):313-28.
Gribaudo G, Riera L, Hertel L, Landolfo S. In vitro and in vivo expression analysis of the interferon-inducible 203 gene. J Interferon Cytokine Res. 1999 Feb; 19(2):129-36.
Lembo D, Gribaudo G, Cavallo R, Riera L, Angeretti A, Hertel L, Landolfo S. Human cytomegalovirus stimulates cellular dihydrofolate reductase activity in quiescent cells. Intervirology. 1999; 42(1):30-6.
Lembo D, Cavallo R, Cornaglia M, Mondo A, Hertel L, Angeretti A, Landolfo S. Overexpression of cellular dihydrofolate reductase abolishes the anticytomegaloviral activity of methotrexate. Arch Virol. 1999; 144(7):1397-403.
Hertel L, Foresta P, Barbiero G, Ying GG, Bonelli G, Baccino FM, Landolfo S, Gariglio M. Decreased expression of the high-mobility group protein T160 by antisense RNA impairs the growth of mouse fibroblasts. Biochimie. 1997 Dec; 79(12):717-23.
Gariglio M, Ying GG, Hertel L, Gaboli M, Clerc RG, Landolfo S. The high-mobility group protein T160 binds to both linear and cruciform DNA and mediates DNA bending as determined by ring closure. Exp Cell Res. 1997 Nov 01; 236(2):472-81.
Gariglio M, Foresta P, Sacchi C, Lembo M, Hertel L, Landolfo S. Suppression of high mobility group protein T160 expression impairs mouse cytomegalovirus replication. J Gen Virol. 1997 Mar; 78 ( Pt 3):665-70.
Lembo D, Angeretti A, Benefazio S, Hertel L, Gariglio M, Novelli F, Landolfo S. Constitutive expression of the interferon-inducible protein p202 in NIH 3T3 cells affects cell cycle progression. J Biol Regul Homeost Agents. 1995 Apr-Jun; 9(2):42-6.