Michelle Hsiang
Assistant Professor
+1 415 476-0301
+1 415 476-1343

Biography

Dr. Michelle Hsiang’s career is focused on improving the health of children through clinical care and the study of malaria, an infectious disease that is one of the leading causes of morbidity and mortality in resource-limited settings. Her research is in the evaluation of diagnostic and drug-based strategies for malaria elimination. Specifically, she is interested in helping national malaria programs find and treat patients who are without symptoms, but are infected and serve as reservoirs for persistent transmission. She currently has field sites in Swaziland, Namibia, Thailand, and Indonesia. She is Associate Director, Operational Research for the UCSF Global Health Group’s Malaria Elimination Initiative. She is funded by grants from National Institutes of Health, the Horchow Family Fund for Endowed Scholars in Pediatrics at the University of Texas Southwestern, the Bill and Melinda Gates Foundation, and the Novartis Foundation.

Dr. Hsiang completed her undergraduate training at Stanford University. She received her MD at Baylor College of Medicine, and completed a residency in Pediatrics and fellowship in Pediatric Infectious Diseases at the University of California, San Francisco. She joined the faculty at UCSF in 2012.

Education and Training

Fellow, 06/2012 Pediatric Infectious Diseases, University of California, San Francisco
Resident, 06/2008 Pediatrics, University of California, San Francisco
M.D., 05/2005 Medicine, Baylor College of Medicine
B.A., 06/2000 Human Biology, Stanford University

Publications

Hsiang MS, Ntuku H, Roberts KW, Dufour MK, Whittemore B, Tambo M, McCreesh P, Medzihradsky OF, Prach LM, Siloka G, Siame N, Gueye CS, Schrubbe L, Wu L, Scott V, Tessema S, Greenhouse B, Erlank E, Koekemoer LL, Sturrock HJW, Mwilima A, Katokele S, Uusiku P, Bennett A, Smith JL, Kleinschmidt I, Mumbengegwi D, Gosling R. Effectiveness of reactive focal mass drug administration and reactive focal vector control to reduce malaria transmission in the low malaria-endemic setting of Namibia: a cluster-randomised controlled, open-label, two-by-two factorial design trial. Lancet. 2020 04 25; 395(10233):1361-1373.
Hsiang MS, Ntshalintshali N, Kang Dufour MS, Dlamini N, Nhlabathi N, Vilakati S, Malambe C, Zulu Z, Maphalala G, Novotny J, Murphy M, Schwartz A, Sturrock H, Gosling R, Dorsey G, Kunene S, Greenhouse B. Active Case Finding for Malaria: A 3-Year National Evaluation of Optimal Approaches to Detect Infections and Hotspots Through Reactive Case Detection in the Low-transmission Setting of Eswatini. Clin Infect Dis. 2020 Mar 17; 70(7):1316-1325.
Baltzell KA, Maglior A, Bangu K, Mngadi N, Prach LM, Whittemore B, Ntshalintshali N, Saini M, Dlamini N, Kunene S, Hsiang MS. "We were afraid of the lion that has roared next to us"; community response to reactive focal mass drug administration for malaria in Eswatini (formerly Swaziland). Malar J. 2019 Jul 15; 18(1):238.
Zahlanie Y, Almatrafi M, Filkins L, Hsiang MS. Possible canine source of Streptococcus equi subspecies zooepidemicus causing meningitis in an infant. IDCases. 2019; 17:e00568.
Jacobson JO, Smith JL, Cueto C, Chisenga M, Roberts K, Hsiang M, Gosling R, Mumbengegwi D, Bennett A. Assessing malaria risk at night-time venues in a low-transmission setting: a time-location sampling study in Zambezi, Namibia. Malar J. 2019 May 22; 18(1):179.
Tessema S, Wesolowski A, Chen A, Murphy M, Wilheim J, Mupiri AR, Ruktanonchai NW, Alegana VA, Tatem AJ, Tambo M, Didier B, Cohen JM, Bennett A, Sturrock HJ, Gosling R, Hsiang MS, Smith DL, Mumbengegwi DR, Smith JL, Greenhouse B. Using parasite genetic and human mobility data to infer local and cross-border malaria connectivity in Southern Africa. Elife. 2019 04 02; 8.
McCreesh P, Mumbengegwi D, Roberts K, Tambo M, Smith J, Whittemore B, Kelly G, Moe C, Murphy M, Chisenga M, Greenhouse B, Ntuku H, Kleinschmidt I, Sturrock H, Uusiku P, Gosling R, Bennett A, Hsiang MS. Subpatent malaria in a low transmission African setting: a cross-sectional study using rapid diagnostic testing (RDT) and loop-mediated isothermal amplification (LAMP) from Zambezi region, Namibia. Malar J. 2018 Dec 19; 17(1):480.
Coutrier FN, Tirta YK, Cotter C, Zarlinda I, González IJ, Schwartz A, Maneh C, Marfurt J, Murphy M, Herdiana H, Anstey NM, Greenhouse B, Hsiang MS, Noviyanti R. Laboratory challenges of Plasmodium species identification in Aceh Province, Indonesia, a malaria elimination setting with newly discovered P. knowlesi. PLoS Negl Trop Dis. 2018 11; 12(11):e0006924.
Zelman BW, Baral R, Zarlinda I, Coutrier FN, Sanders KC, Cotter C, Herdiana H, Greenhouse B, Shretta R, Gosling RD, Hsiang MS. Costs and cost-effectiveness of malaria reactive case detection using loop-mediated isothermal amplification compared to microscopy in the low transmission setting of Aceh Province, Indonesia. Malar J. 2018 Jun 01; 17(1):220.
Mumbengegwi DR, Sturrock H, Hsiang M, Roberts K, Kleinschmidt I, Nghipumbwa M, Uusiku P, Smith J, Bennet A, Kizito W, Takarinda K, Ade S, Gosling R. Is there a correlation between malaria incidence and IRS coverage in western Zambezi region, Namibia? Public Health Action. 2018 Apr 25; 8(Suppl 1):S44-S49.
Medzihradsky OF, Kleinschmidt I, Mumbengegwi D, Roberts KW, McCreesh P, Dufour MK, Uusiku P, Katokele S, Bennett A, Smith J, Sturrock H, Prach LM, Ntuku H, Tambo M, Didier B, Greenhouse B, Gani Z, Aerts A, Gosling R, Hsiang MS. Study protocol for a cluster randomised controlled factorial design trial to assess the effectiveness and feasibility of reactive focal mass drug administration and vector control to reduce malaria transmission in the low endemic setting of Namibia. BMJ Open. 2018 01 27; 8(1):e019294.
Hsiang MS, Ranadive N, Chitundu S, Ntshalintshali N, Greenhouse B. Reply to Rossi et al. Clin Infect Dis. 2017 10 30; 65(10):1770-1771.
Ranadive N, Kunene S, Darteh S, Ntshalintshali N, Nhlabathi N, Dlamini N, Chitundu S, Saini M, Murphy M, Soble A, Schwartz A, Greenhouse B, Hsiang MS. Limitations of Rapid Diagnostic Testing in Patients with Suspected Malaria: A Diagnostic Accuracy Evaluation from Swaziland, a Low-Endemicity Country Aiming for Malaria Elimination. Clin Infect Dis. 2017 05 01; 64(9):1221-1227.
Dlamini N, Hsiang MS, Ntshalintshali N, Pindolia D, Allen R, Nhlabathi N, Novotny J, Kang Dufour MS, Midekisa A, Gosling R, LeMenach A, Cohen J, Dorsey G, Greenhouse B, Kunene S. Low-Quality Housing Is Associated With Increased Risk of Malaria Infection: A National Population-Based Study From the Low Transmission Setting of Swaziland. Open Forum Infect Dis. 2017; 4(2):ofx071.
Herdiana H, Cotter C, Coutrier FN, Zarlinda I, Zelman BW, Tirta YK, Greenhouse B, Gosling RD, Baker P, Whittaker M, Hsiang MS. Malaria risk factor assessment using active and passive surveillance data from Aceh Besar, Indonesia, a low endemic, malaria elimination setting with Plasmodium knowlesi, Plasmodium vivax, and Plasmodium falciparum. Malar J. 2016 09 13; 15:468.
N. Mkhonta, R. Allen, D. Pindolia, N. Ntshalintshali, J. Novotny, M. Kang Dufour, R. Gosling, A. LeMenach, J. Cohen, A. Midekisa, B. Greenhouse, M.S. Hsiang, S. Kunene. Housing quality as a potential risk factor for locally acquired malaria infection in Swaziland. Annals of Global Health. 2016 Aug 20; 82(3):400.
Reiner RC, Le Menach A, Kunene S, Ntshalintshali N, Hsiang MS, Perkins TA, Greenhouse B, Tatem AJ, Cohen JM, Smith DL. Mapping residual transmission for malaria elimination. Elife. 2015 Dec 29; 4.
Christina Hermos, Rita Shiau, Michelle Hsiang, Henry Chambers, Erica Pan. Epidemiology of community-associated methicillin-resistant Staphylococcus aureus in San Francisco children. Journal of Pediatric Infectious Diseases. 2015 Jul 28; 4(3):247-259.
Hsiang MS, Gosling RD. Striding Toward Malaria Elimination in China. Am J Trop Med Hyg. 2015 Aug; 93(2):203-204.
Hsiang MS, Greenhouse B, Rosenthal PJ. Reply to Goyal et al. J Infect Dis. 2015 May 15; 211(10):1687.
Sturrock HJ, Cohen JM, Keil P, Tatem AJ, Le Menach A, Ntshalintshali NE, Hsiang MS, Gosling RD. Fine-scale malaria risk mapping from routine aggregated case data. Malar J. 2014 Nov 03; 13:421.
Hsiang MS, Greenhouse B, Rosenthal PJ. Point of care testing for malaria using LAMP, loop mediated isothermal amplification. J Infect Dis. 2014 Oct 15; 210(8):1167-9.
Liu Y, Hsiang MS, Zhou H, Wang W, Cao Y, Gosling RD, Cao J, Gao Q. Malaria in overseas labourers returning to China: an analysis of imported malaria in Jiangsu Province, 2001-2011. Malar J. 2014 Jan 25; 13:29.
Stieglitz E, Hsiang MS, Simko JP, Hirose S, Goldsby RE. Pulmonary coccidiomycosis masquerading as refractory metastatic Ewing sarcoma. J Pediatr Hematol Oncol. 2014 Jan; 36(1):e57-60.
Gosling RD, Hsiang MS. Malaria and severe anemia: thinking beyond Plasmodium falciparum. PLoS Med. 2013 Dec; 10(12):e1001576.
Hsiang MS, Hwang J, Tao AR, Liu Y, Bennett A, Shanks GD, Cao J, Kachur SP, Feachem RG, Gosling RD, Gao Q. Mass drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China. Malar J. 2013 Nov 01; 12:383.
Smith Gueye C, Sanders KC, Galappaththy GN, Rundi C, Tobgay T, Sovannaroth S, Gao Q, Surya A, Thakur GD, Baquilod M, Lee WJ, Bobogare A, Deniyage SL, Satimai W, Taleo G, Hung NM, Cotter C, Hsiang MS, Vestergaard LS, Gosling RD. Active case detection for malaria elimination: a survey among Asia Pacific countries. Malar J. 2013 Oct 09; 12:358.
Sturrock HJ, Hsiang MS, Cohen JM, Smith DL, Greenhouse B, Bousema T, Gosling RD. Targeting asymptomatic malaria infections: active surveillance in control and elimination. PLoS Med. 2013; 10(6):e1001467.
Sturrock HJ, Novotny JM, Kunene S, Dlamini S, Zulu Z, Cohen JM, Hsiang MS, Greenhouse B, Gosling RD. Reactive case detection for malaria elimination: real-life experience from an ongoing program in Swaziland. PLoS One. 2013; 8(5):e63830.
Cotter C, Sturrock HJ, Hsiang MS, Liu J, Phillips AA, Hwang J, Gueye CS, Fullman N, Gosling RD, Feachem RG. The changing epidemiology of malaria elimination: new strategies for new challenges. Lancet. 2013 Sep 07; 382(9895):900-11.
Baltzell KA, Shakely D, Hsiang M, Kemere J, Ali AS, Björkman A, Mårtensson A, Omar R, Elfving K, Msellem M, Aydin-Schmidt B, Rosenthal PJ, Greenhouse B. Prevalence of PCR detectable malaria infection among febrile patients with a negative Plasmodium falciparum specific rapid diagnostic test in Zanzibar. Am J Trop Med Hyg. 2013 Feb; 88(2):289-91.
Eziefula AC, Gosling R, Hwang J, Hsiang MS, Bousema T, von Seidlein L, Drakeley C. Rationale for short course primaquine in Africa to interrupt malaria transmission. Malar J. 2012 Oct 30; 11:360.
Hsiang MS, Shiau R, Nadle J, Chan L, Lee B, Chambers HF, Pan E. Epidemiologic Similarities in Pediatric Community-Associated Methicillin-Resistant and Methicillin-Sensitive Staphylococcus aureus in the San Francisco Bay Area. J Pediatric Infect Dis Soc. 2012 Sep; 1(3):200-11.
Hsiang MS, Hwang J, Kunene S, Drakeley C, Kandula D, Novotny J, Parizo J, Jensen T, Tong M, Kemere J, Dlamini S, Moonen B, Angov E, Dutta S, Ockenhouse C, Dorsey G, Greenhouse B. Surveillance for malaria elimination in Swaziland: a national cross-sectional study using pooled PCR and serology. PLoS One. 2012; 7(1):e29550.
Hsiang MS, Shiau R, Nadle J, Chan L, Lee B, Chambers HF, Pan E.. Journal of Pediatric Infectious Diseases Society. Few Factors Distinguish Pediatric Community-Associated Methicillin-Resistant from Methicillin-Sensitive Staphylococcus aureus Infections: a Case Comparison Study in San Francisco Bay Area. 2012; 1(30):200-211.
Andersen F, Douglas NM, Bustos D, Galappaththy G, Qi G, Hsiang MS, Kusriastuti R, Mendis K, Taleo G, Whittaker M, Price RN, von Seidlein L. Trends in malaria research in 11 Asian Pacific countries: an analysis of peer-reviewed publications over two decades. Malar J. 2011 May 18; 10:131.
Sabot O, Cohen JM, Hsiang MS, Kahn JG, Basu S, Tang L, Zheng B, Gao Q, Zou L, Tatarsky A, Aboobakar S, Usas J, Barrett S, Cohen JL, Jamison DT, Feachem RG. Costs and financial feasibility of malaria elimination. Lancet. 2010 Nov 06; 376(9752):1604-15.
Hsiang MS, Lin M, Dokomajilar C, Kemere J, Pilcher CD, Dorsey G, Greenhouse B. PCR-based pooling of dried blood spots for detection of malaria parasites: optimization and application to a cohort of Ugandan children. J Clin Microbiol. 2010 Oct; 48(10):3539-43.
Carlton EJ, Hsiang M, Zhang Y, Johnson S, Hubbard A, Spear RC. The impact of Schistosoma japonicum infection and treatment on ultrasound-detectable morbidity: a five-year cohort study in Southwest China. PLoS Negl Trop Dis. 2010 May 18; 4(5):e685.
Hsiang MS, Abeyasinghe R, Whittaker M, Feachem RG. Malaria elimination in Asia-Pacific: an under-told story. Lancet. 2010 May 08; 375(9726):1586-7.
Hsiang MS, Carlton EJ, Zhang Y, Zhong B, Dongchuan Q, Cohen PA, Stewart CC, Spear RC. Use of ultrasonography to evaluate Schistosoma japonicum-related morbidity in children, Sichuan Province, China, 2000-2007. Am J Trop Med Hyg. 2010 Jan; 82(1):103-11.
Hermos C, Shiau R, Hsiang M, Chambers HF, Pan E. High Prevalence of Risk Factors among Pediatric Patients with Community-Associated Methicillin Resistant Staphylococcus aureus in San Francisco. Journal of Pediatric Infectious Diseases. 2009; 3(4).