Ngoc Ly
Professor
Division Chief
Cystic Fibrosis Center Co-Director
+1 415 476-4979
+1 415 476-9278

Biography

My research has focused on the influences of heredity, as well as prenatal and infant environmental exposures ( including environmental, microbial, and nutritional influences) on immune responses and clinical symptoms of allergy and asthma. I have been actively involved and collaborated with investigators on 4 large prospective birth cohort studies and a cross-sectional study relating to environmental and immunological determinants of allergy and asthma.

Clinically, I oversee and direct care for a large number of asthmatic children in the Pediatric Pulmonary Asthma Program at UCSF that I established in 2009. The Asthma Program consists of an asthma care team that includes a nurse practitioner and respiratory therapist certified in asthma education to facilitate asthma education and management for children less than 18 years of age.

My other clinical interests include bronchopulmonary dysplasia (BPD), congenital lung abnormalities, interstitial lung diseases, chronic respiratory failure/insufficiency and neuromuscular respiratory diseases, including assistive therapies such as oxygen, mechanical ventilation, airway clearance devices, or an artificial airway.

Education and Training

Respiratory and Environmental Epidemiology, 2006 Channing Laboratory, Brigham & Women's Hospital and Harvard School of Medicine
MPH, 2004 Public Health, Harvard School of Public Health
Pediatric Pulmonary Fellowship, 2004 Pediatrics, Massachusetts General Hospital and Harvard Medical School
Pediatric Residency, 2001 Pediatrics, Medical College of Virginia
M.D., 1998 School of Medicine, University of Rochester

Publications

Smith MA, McGarry ME, Ly NP, Zinter MS. Outcomes of Children With Cystic Fibrosis Admitted to PICUs. Pediatr Crit Care Med. 2020 Apr 17.
Ngoc P. Ly. Severe Asthma: Clinical Studies and Clinical Trials in Children. . 2020 Jan 1; 271-285.
Ross KR, Gupta R, DeBoer MD, Zein J, Phillips BR, Mauger DT, Li C, Myers RE, Phipatanakul W, Fitzpatrick AM, Ly NP, Bacharier LB, Jackson DJ, Celedón JC, Larkin A, Israel E, Levy B, Fahy JV, Castro M, Bleecker ER, Meyers D, Moore WC, Wenzel SE, Jarjour NN, Erzurum SC, Teague WG, Gaston B. Severe asthma during childhood and adolescence: A longitudinal study. J Allergy Clin Immunol. 2020 Jan; 145(1):140-146.e9.
Fitzpatrick AM, Szefler SJ, Mauger DT, Phillips BR, Denlinger LC, Moore WC, Sorkness RL, Wenzel SE, Gergen PJ, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Israel E, Levy BD, Meyers DA, Teague WG, Bacharier LB, Ly NP, Phipatanakul W, Ross KR, Zein J, Jarjour NN. Development and initial validation of the Asthma Severity Scoring System (ASSESS). J Allergy Clin Immunol. 2020 Jan; 145(1):127-139.
Coverstone AM, Bacharier LB, Wilson BS, Fitzpatrick AM, Teague WG, Phipatanakul W, Wenzel SE, Gaston BM, Bleecker ER, Moore WC, Ramratnam S, Jarjour NN, Ly NP, Fahy JV, Mauger DT, Schechtman KB, Yin-DeClue H, Boomer JS, Castro M. Clinical significance of the bronchodilator response in children with severe asthma. Pediatr Pulmonol. 2019 11; 54(11):1694-1703.
McGarry ME, Neuhaus JM, Nielson DW, Ly NP. Regional variations in longitudinal pulmonary function: A comparison of Hispanic and non-Hispanic subjects with cystic fibrosis in the United States. Pediatr Pulmonol. 2019 09; 54(9):1382-1390.
Zinter MS, Dvorak CC, Mayday MY, Iwanaga K, Ly NP, McGarry ME, Church GD, Faricy LE, Rowan CM, Hume JR, Steiner ME, Crawford ED, Langelier C, Kalantar K, Chow ED, Miller S, Shimano K, Melton A, Yanik GA, Sapru A, DeRisi JL. Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children. Clin Infect Dis. 2019 05 17; 68(11):1847-1855.
Guilbert TW, Bacharier LB, Mauger DT, Phipatanakul W, Szefler SJ, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CD, Cabana MD, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF, Ly N, Meade K, Morgan W, Moy J, Olin JT, Peters SP, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Teague WG, Thyne S, Martinez FD. Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children. J Allergy Clin Immunol. 2019 May; 143(5):1934-1937.e4.
Fitzpatrick AM, Gillespie SE, Mauger DT, Phillips BR, Bleecker ER, Israel E, Meyers DA, Moore WC, Sorkness RL, Wenzel SE, Bacharier LB, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Jarjour NN, Larkin A, Levy BD, Ly NP, Ortega VE, Peters SP, Phipatanakul W, Ramratnam S, Teague WG. Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 2019 Jun; 143(6):2052-2061.
DeBoer MD, Phillips BR, Mauger DT, Zein J, Erzurum SC, Fitzpatrick AM, Gaston BM, Myers R, Ross KR, Chmiel J, Lee MJ, Fahy JV, Peters M, Ly NP, Wenzel SE, Fajt ML, Holguin F, Moore WC, Peters SP, Meyers D, Bleecker ER, Castro M, Coverstone AM, Bacharier LB, Jarjour NN, Sorkness RL, Ramratnam S, Irani AM, Israel E, Levy B, Phipatanakul W, Gaffin JM, Gerald Teague W. Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma. BMC Pulm Med. 2018 Apr 10; 18(1):58.
Matt S Zinter, Christopher C Dvorak, Madeline Y Mayday, Kensho Iwanaga, Ngoc P Ly, Meghan E McGarry, Gwynne D Church, Lauren E Faricy, Courtney M Rowan, Janet R Hume, Marie E Steiner, Emily D Crawford, Charles Langelier, Katrina Kalantar, Eric D Chow, Steve Miller, Kristin Shimano, Alexis Melton, Greg A Yanik, Anil Sapru, Joseph L DeRisi. Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children. bioRxiv. 2018 Mar 29; 291864.
Jackson DJ, Bacharier LB, Mauger DT, Boehmer S, Beigelman A, Chmiel JF, Fitzpatrick AM, Gaffin JM, Morgan WJ, Peters SP, Phipatanakul W, Sheehan WJ, Cabana MD, Holguin F, Martinez FD, Pongracic JA, Baxi SN, Benson M, Blake K, Covar R, Gentile DA, Israel E, Krishnan JA, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Long D, Ly N, Marbin J, Moy JN, Myers RE, Olin JT, Raissy HH, Robison RG, Ross K, Sorkness CA, Lemanske RF. Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations. N Engl J Med. 2018 Mar 08; 378(10):891-901.
McGarry ME, Neuhaus JM, Nielson DW, Burchard E, Ly NP. Pulmonary function disparities exist and persist in Hispanic patients with cystic fibrosis: A longitudinal analysis. Pediatr Pulmonol. 2017 Dec; 52(12):1550-1557.
Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN. Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. J Allergy Clin Immunol Pract. 2018 Mar - Apr; 6(2):545-554.e4.
Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E. Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma. Am J Respir Crit Care Med. 2017 06 01; 195(11):1439-1448.
LM DelRosso, T MDuba, K Iwanaga, E Gibb, J Dy, G Church, N Ly. 0888 AUTO-ADJUSTING CPAP: AN OPTION FOR TREATMENT OF OBSTRUCTIVE SLEEP APNEA IN OBESE CHILDREN. Sleep. 2017 Apr 28; 40(suppl_1):a330-a330.
DelRosso LM, Palacay P, Ly NP. A 6-Month-Old Infant With Different Capnography Values in Polysomnography. Chest. 2017 Feb; 151(2):e45-e48.
Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN. Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med. 2017 02 01; 195(3):302-313.
McGarry ME, Illek B, Ly NP, Zlock L, Olshansky S, Moreno C, Finkbeiner WE, Nielson DW. In vivo and in vitro ivacaftor response in cystic fibrosis patients with residual CFTR function: N-of-1 studies. Pediatr Pulmonol. 2017 04; 52(4):472-479.
DelRosso LM, Hoque R, Mitchell C, Ly NP. Severe Postictal Hypoxemia-Associated Seizure in a 12-Year-Old Child. J Clin Sleep Med. 2016 12 15; 12(12):1691-1693.
Fitzpatrick AM, Jackson DJ, Mauger DT, Boehmer SJ, Phipatanakul W, Sheehan WJ, Moy JN, Paul IM, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan W, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Szefler SJ. Individualized therapy for persistent asthma in young children. J Allergy Clin Immunol. 2016 12; 138(6):1608-1618.e12.
Sheehan WJ, Mauger DT, Paul IM, Moy JN, Boehmer SJ, Szefler SJ, Fitzpatrick AM, Jackson DJ, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan WJ, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Wechsler ME, Phipatanakul W. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. N Engl J Med. 2016 Aug 18; 375(7):619-30.
DelRosso LM, Hoque R, Contreras MB, Ly NP. A 16-Year-Old Boy with Refractory Epilepsy and Sleep-Disordered Breathing. J Clin Sleep Med. 2016 07 15; 12(7):1062-4.
Bacharier LB, Guilbert TW, Mauger DT, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CD, Cabana M, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF, Ly N, Meade K, Morgan W, Moy J, Olin T, Peters SP, Phipatanakul W, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Szefler SJ, Teague WG, Thyne S, Martinez FD. Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial. JAMA. 2015 Nov 17; 314(19):2034-2044.
Elizabeth R. Gibb, Shannon M. Thyne, Daniel N. Kaplan, Ngoc P. Ly. Asthma, FEF25–75, and Hospitalizations in Children. Pediatric Allergy Immunology and Pulmonology. 2013 Sep 1; 26(3):115-121.
Gibb E, Blount R, Lewis N, Nielson D, Church G, Jones K, Ly N. Management of plastic bronchitis with topical tissue-type plasminogen activator. Pediatrics. 2012 Aug; 130(2):e446-50.
Lange NE, Celedón JC, Forno E, Ly NP, Onderdonk A, Bry L, Delaney ML, DuBois AM, Gold DR, Weiss ST, Litonjua AA. Maternal intestinal flora and wheeze in early childhood. Clin Exp Allergy. 2012 Jun; 42(6):901-8.
McLoughlin RM, Calatroni A, Visness CM, Wallace PK, Cruikshank WW, Tuzova M, Ly NP, Ruiz-Perez B, Kattan M, Bloomberg GR, Lederman H, Gern JE, Gold DR. Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohort. Clin Exp Allergy. 2012 Mar; 42(3):392-404.
Ngoc P. Ly, Augusto Litonjua, Diane R. Gold, Juan C. Celedón. Reply. Journal of Allergy and Clinical Immunology. 2011 Nov 1; 128(5):1134.
Ly NP, Litonjua A, Gold DR, Celedón JC. Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity? J Allergy Clin Immunol. 2011 May; 127(5):1087-94; quiz 1095-6.
Wu BH, Cabana MD, Hilton JF, Ly NP. Race and asthma control in the pediatric population of Hawaii. Pediatr Pulmonol. 2011 May; 46(5):442-51.
Ly NP, Ruiz-Perez B, McLoughlin RM, Visness CM, Wallace PK, Cruikshank WW, Tzianabos AO, O'Connor GT, Gold DR, Gern JE. Characterization of regulatory T cells in urban newborns. Clin Mol Allergy. 2009 Jul 08; 7:8.
R.M. McLoughlin, N.P. Ly, C.M. Visness, P.K. Wallace, W.W. Cruikshank, B. Ruiz-Perez, J.E. Gern, D.R. Gold. Title: Relation Of Early Life Regulatory T-cell Function And Phenotype Development To Wheeze And Allergy: The Urban Environment And Childhood Asthma. Journal of Allergy and Clinical Immunology. 2009 Feb 1; 123(2):s123.
Hunninghake GM, Soto-Quirós ME, Lasky-Su J, Avila L, Ly NP, Liang C, Klanderman BJ, Raby BA, Gold DR, Weiss ST, Celedón JC. Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations. J Allergy Clin Immunol. 2008 Jul; 122(1):93-8, 98.e1-5.
Ly NP, Soto-Quirós ME, Avila L, Hunninghake GM, Raby BA, Laskey D, Sylvia JS, Celedón JC. Paternal asthma, mold exposure, and increased airway responsiveness among children with asthma in Costa Rica. Chest. 2008 Jan; 133(1):107-14.
Ly NP, Celedón JC. Family history, environmental exposures in early life, and childhood asthma. J Allergy Clin Immunol. 2007 Aug; 120(2):271-2.
Hunninghake GM, Soto-Quirós ME, Avila L, Su J, Murphy A, Demeo DL, Ly NP, Liang C, Sylvia JS, Klanderman BJ, Lange C, Raby BA, Silverman EK, Celedón JC. Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood. J Allergy Clin Immunol. 2007 Jul; 120(1):84-90.
Hunninghake GM, Soto-Quiros ME, Avila L, Ly NP, Liang C, Sylvia JS, Klanderman BJ, Silverman EK, Celedón JC. Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica. J Allergy Clin Immunol. 2007 Mar; 119(3):654-61.
Ly NP, Rifas-Shiman SL, Litonjua AA, Tzianabos AO, Schaub B, Ruiz-Pérez B, Tantisira KG, Finn PW, Gillman MW, Weiss ST, Gold DR. Cord blood cytokines and acute lower respiratory illnesses in the first year of life. Pediatrics. 2007 Jan; 119(1):e171-8.
Litonjua AA, Rifas-Shiman SL, Ly NP, Tantisira KG, Rich-Edwards JW, Camargo CA, Weiss ST, Gillman MW, Gold DR. Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age. Am J Clin Nutr. 2006 Oct; 84(4):903-11.
Ly NP, Ruiz-Pérez B, Onderdonk AB, Tzianabos AO, Litonjua AA, Liang C, Laskey D, Delaney ML, DuBois AM, Levy H, Gold DR, Ryan LM, Weiss ST, Celedón JC. Mode of delivery and cord blood cytokines: a birth cohort study. Clin Mol Allergy. 2006 Sep 26; 4:13.
Ly NP, Gold DR, Weiss ST, Celedón JC. Recurrent wheeze in early childhood and asthma among children at risk for atopy. Pediatrics. 2006 Jun; 117(6):e1132-8.
Gold DR, Willwerth BM, Tantisira KG, Finn PW, Schaub B, Perkins DL, Tzianabos A, Ly NP, Schroeter C, Gibbons F, Campos H, Oken E, Gillman MW, Palmer LJ, Ryan LM, Weiss ST. Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gamma. J Allergy Clin Immunol. 2006 Apr; 117(4):931-8.
Ly NP, Komatsuzaki K, Fraser IP, Tseng AA, Prodhan P, Moore KJ, Kinane TB. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14729-34.
Ly NP, Li Y, Sredl DL, Perkins DL, Finn PW, Weiss ST, Gold DR. Elevated allergen-induced IL-13 secretion predicts IgE elevation in children ages 2-5 years. J Clin Immunol. 2005 Jul; 25(4):314-20.
Dahl M, Hersh CP, Ly NP, Berkey CS, Silverman EK, Nordestgaard BG. The protease inhibitor PI*S allele and COPD: a meta-analysis. Eur Respir J. 2005 Jul; 26(1):67-76.
Hersh CP, Dahl M, Ly NP, Berkey CS, Nordestgaard BG, Silverman EK. Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes: a meta-analysis. Thorax. 2004 Oct; 59(10):843-9.
Contreras JP, Ly NP, Gold DR, He H, Wand M, Weiss ST, Perkins DL, Platts-Mills TA, Finn PW. Allergen-induced cytokine production, atopic disease, IgE, and wheeze in children. J Allergy Clin Immunol. 2003 Dec; 112(6):1072-7.