Assistant Professor
+1 415 242-6027

Education and Training

M.D., Faculty of Medicine, Hacettepe University
Residency, Pediatrics, Hacettepe University
Ph.D., Pharmacology, Hacettepe University
Fellowship, Pediatric nephrology, University of California, San Francisco

Publications

Cil O, Perwad F. a-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases. Pediatrics. 2020 Apr 03.
Lee S, Cil O, Haggie PM, Verkman AS. 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation. J Med Chem. 2019 Sep 12; 62(17):8330-8337.
Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS. Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A. FASEB J. 2019 Oct; 33(10):11247-11257.
Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS. Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea. FASEB J. 2019 10; 33(10):10924-10934.
Duan T, Cil O, Thiagarajah JR, Verkman AS. Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. JCI Insight. 2019 02 21; 4(4).
Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS. SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. JCI Insight. 2018 07 26; 3(14).
Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman AS. Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1. J Med Chem. 2018 04 12; 61(7):3209-3217.
Cil O, Perwad F. Monogenic Causes of Proteinuria in Children. Front Med (Lausanne). 2018; 5:55.
Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman AS, Anderson MO. Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A). J Med Chem. 2017 06 08; 60(11):4626-4635.
Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ. High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators. J Med Chem. 2017 03 23; 60(6):2401-2410.
Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins. FASEB J. 2017 02; 31(2):751-760.
Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS. Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation. Transl Res. 2017 04; 182:14-26.e4.
Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS. Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide. J Am Soc Nephrol. 2016 Dec; 27(12):3706-3714.
Onur Cil, Puay-Wah Phuan, Sujin Lee, Joseph-Anthony T. Tan, Peter Haggie, Marc H. Levin, Liang Sun, Jay Thiagarajah, Tonghui Ma, Alan S. Verkman. Su1580 A Small-Molecule CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation. Gastroenterology. 2016 Apr 1; 150(4):s532.
Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS. CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):317-327.
Serdaroglu E, Takci S, Kotarsky H, Çil O, Utine E, Yigit S, Fellman V. A Turkish BCS1L mutation causes GRACILE-like disorder. Turk J Pediatr. 2016; 58(6):658-661.
Besbas N, Kalyoncu M, Cil O, Ozgul RK, Bakkaloglu A, Ozaltin F. MCP1 2518 A/G polymorphism affects progression of childhood focal segmental glomerulosclerosis. Ren Fail. 2015; 37(9):1435-9.
Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, Ertunc M, Verkman AS. Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. Kidney Int. 2015 Aug; 88(2):311-20.
Cil O, Besbas N, Duzova A, Topaloglu R, Peco-Antic A, Korkmaz E, Ozaltin F. Genetic abnormalities and prognosis in patients with congenital and infantile nephrotic syndrome. Pediatr Nephrol. 2015 Aug; 30(8):1279-87.
O Cil, C Esteva-Font, ST Tas, S Lee, M Ertunc, AS Verkman. O-071 Salt-sparing Diuretic Action Of A Urea Analogue Inhibitor Of Urea Transporters Ut-a And Ut-b In Rats. Archives of Disease in Childhood. 2014 Oct 1; 99(Suppl 2):a50.
Esteva-Font C, Cil O, Phuan PW, Su T, Lee S, Anderson MO, Verkman AS. Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors. FASEB J. 2014 Sep; 28(9):3878-90.
Verkman AS, Esteva-Font C, Cil O, Anderson MO, Li F, Li M, Lei T, Ren H, Yang B. Small-molecule inhibitors of urea transporters. Subcell Biochem. 2014; 73:165-77.
Unal S, Gumruk F, Yigit S, Tuncer M, Tavil B, Cil O, Takci S, Urata M, Hotta T, Kang D, Cetin M. A novel mutation in protein C gene (PROC) causing severe phenotype in neonatal period. Pediatr Blood Cancer. 2014 Apr; 61(4):763-4.
Celebi N, Cil H, Cil O, Canbay O, Onur R, Aypar U. Protective effect of coenzyme Q10 in paclitaxel-induced peripheral neuropathy in rats. Neurosciences (Riyadh). 2013 Apr; 18(2):133-7.
Ozaltin F, Besbas N, Iskit AB, Cil O, Akcoren Z, Kale G, Bakkaloglu A. Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis. Ren Fail. 2013; 35(3):380-5.
E Serdaroglu, S Takci, H Kotarsky, O Cil, E Utine, S Yigit, V Fellman. 1036 Gracile Syndrome in a Turkish Newborn Infant Caused by a Homozygous Mutation (P99L) in Complex Iii Assembly Factor BCS1L. Archives of Disease in Childhood. 2012 Oct 1; 97(Suppl 2):a297.
O Cil, M Ertunc, R Onur. 1415 The Diuretic Effect of Urea Analog Dimethylthiourea in Rats. Archives of Disease in Childhood. 2012 Oct 1; 97(Suppl 2):a403.
Cil O, Ertunc M, Onur R. The diuretic effect of urea analog dimethylthiourea in female Wistar rats. Hum Exp Toxicol. 2012 Oct; 31(10):1050-5.
Cil O, Ertunc M, Gucer KS, Ozaltin F, Iskit AB, Onur R. Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical. Ren Fail. 2012; 34(2):211-20.
Barua M, Cil O, Paterson AD, Wang K, He N, Dicks E, Parfrey P, Pei Y. Family history of renal disease severity predicts the mutated gene in ADPKD. J Am Soc Nephrol. 2009 Aug; 20(8):1833-8.
Wang K, Zhao X, Chan S, Cil O, He N, Song X, Paterson AD, Pei Y. Evidence for pathogenicity of atypical splice mutations in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 2009 Feb; 4(2):442-9.