Peter Oishi
Associate Professor
+1 415 476-1043
+1 415 514-0235

Biography

Dr. Oishi specializes in the care of critically ill pediatric patients. He is the Medical Director of the Pediatric Intensive Care Unit and the UCSF Benioff Children's Hospital Transport Program and Access Center. In addition, Dr. Oishi is the Medical Director of the Pediatric Respiratory Extracorporeal Life Support program. His research has been focused on pulmonary vascular disease, particularly that related to congenital heart defects.

Publications

Zinter MS, Barrows BD, Ursell PC, Kowalek K, Kalantar K, Cambronero N, DeRisi JL, Oishi P, Dvorak CC. Extracorporeal life support survival in a pediatric hematopoietic cellular transplant recipient with presumed GvHD-related fulminant myocarditis. Bone Marrow Transplant. 2017 09; 52(9):1330-1333.
Oishi P, Fineman JR. Pulmonary Hypertension. Pediatr Crit Care Med. 2016 Aug; 17(8 Suppl 1):S140-5.
Nair AB, Oishi P. Venovenous Extracorporeal Life Support in Single-Ventricle Patients with Acute Respiratory Distress Syndrome. Front Pediatr. 2016; 4:66.
Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR. Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. Am J Physiol Heart Circ Physiol. 2016 Jul 01; 311(1):H137-45.
Karamlou T, Oishi P. Glucose metabolism after pediatric cardiac surgery: Too many sweets will ruin your appetite. J Thorac Cardiovasc Surg. 2015 Sep; 150(3):505-6.
Kameny RJ, He Y, Morris C, Sun C, Johengen M, Gong W, Raff GW, Datar SA, Oishi PE, Fineman JR. Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype. Am J Physiol Heart Circ Physiol. 2015 Jul 01; 309(1):H157-65.
Johnson RC, Datar SA, Oishi PE, Bennett S, Maki J, Sun C, Johengen M, He Y, Raff GW, Redington AN, Fineman JR. Adaptive right ventricular performance in response to acutely increased afterload in a lamb model of congenital heart disease: evidence for enhanced Anrep effect. Am J Physiol Heart Circ Physiol. 2014 Apr 15; 306(8):H1222-30.
Datar SA, Oishi PE, Gong W, Bennett SH, Sun CE, Johengen M, Maki J, Johnson RC, Raff GW, Fineman JR. Altered reactivity and nitric oxide signaling in the isolated thoracic duct from an ovine model of congenital heart disease with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2014 Apr 01; 306(7):H954-62.
Shue EH, Schecter SC, Gong W, Etemadi M, Johengen M, Iqbal C, Derderian SC, Oishi P, Fineman JR, Miniati D. Antenatal maternally-administered phosphodiesterase type 5 inhibitors normalize eNOS expression in the fetal lamb model of congenital diaphragmatic hernia. J Pediatr Surg. 2014 Jan; 49(1):39-45; discussion 45.
Radman M, Keller RL, Oishi P, Datar SA, Wellnitz K, Azakie A, Hanley F, Char D, Hsu JH, Amrinovin R, Adatia I, Fineman JR. Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan). J Thorac Cardiovasc Surg. 2014 Jul; 148(1):212-9.
Oishi PE, Klein OD, Keller RL. Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an effort to formulate a departmental policy. J Pediatr. 2013 Sep; 163(3):616-7.e1.
Bernstein HS, Samad T, Cholsiripunlert S, Khalifian S, Gong W, Ritner C, Aurigui J, Ling V, Wilschut KJ, Bennett S, Hoffman J, Oishi P. Stem cell antigen-1 in skeletal muscle function. PLoS Curr. 2013 Aug 15; 5.
Amirnovin R, Oishi P, Fineman JR, Keller RL. Reply to the editor. J Thorac Cardiovasc Surg. 2013 May; 145(5):1416.
Sharma S, Aramburo A, Rafikov R, Sun X, Kumar S, Oishi PE, Datar SA, Raff G, Xoinis K, Kalkan G, Fratz S, Fineman JR, Black SM. L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow. Pediatr Res. 2013 Jul; 74(1):39-47.
Radman M, Mack R, Barnoya J, Castañeda A, Rosales M, Azakie A, Mehta N, Keller R, Datar S, Oishi P, Fineman J. The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR). J Thorac Cardiovasc Surg. 2014 Jan; 147(1):442-50.
Kumar S, Oishi PE, Rafikov R, Aggarwal S, Hou Y, Datar SA, Sharma S, Azakie A, Fineman JR, Black SM. Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow. J Cell Biochem. 2013 Feb; 114(2):435-447.
Sharma S, Barton J, Rafikov R, Aggarwal S, Kuo HC, Oishi PE, Datar SA, Fineman JR, Black SM. Chronic inhibition of PPAR-? signaling induces endothelial dysfunction in the juvenile lamb. Pulm Pharmacol Ther. 2013 Apr; 26(2):271-80.
Oishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman JR. Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow. Pediatr Res. 2013 Jan; 73(1):54-61.
Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman JR. Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis. Pediatr Cardiol. 2013 Feb; 34(2):291-5.
Sharma S, Sun X, Rafikov R, Kumar S, Hou Y, Oishi PE, Datar SA, Raff G, Fineman JR, Black SM. PPAR-? regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow. PLoS One. 2012; 7(9):e41555.
Amirnovin R, Keller RL, Herrera C, Hsu JH, Datar S, Karl TR, Adatia I, Oishi P, Fineman JR. B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion. J Thorac Cardiovasc Surg. 2013 May; 145(5):1279-87.
Radman MR, Goldhoff P, Jones KD, Azakie A, Datar S, Adatia I, Oishi PE, Fineman JR. Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease? Pediatr Cardiol. 2013 Jun; 34(5):1254-7.
Oishi PE, Keller RL. When persistent pulmonary hypertension of the newborn persists. Pediatr Crit Care Med. 2012 Mar; 13(2):224-5.
Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman JR. Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15; 302(6):L530-40.
Aggarwal S, Gross CM, Kumar S, Datar S, Oishi P, Kalkan G, Schreiber C, Fratz S, Fineman JR, Black SM. Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. J Cell Physiol. 2011 Dec; 226(12):3104-13.
Oishi P, Datar SA, Fineman JR. Advances in the management of pediatric pulmonary hypertension. Respir Care. 2011 Sep; 56(9):1314-39; discussion 1339-40.
Fratz S, Fineman JR, Görlach A, Sharma S, Oishi P, Schreiber C, Kietzmann T, Adatia I, Hess J, Black SM. Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease. Circulation. 2011 Mar 01; 123(8):916-23.
Oishi PE, Cholsiripunlert S, Gong W, Baker AJ, Bernstein HS. Myo-mechanical analysis of isolated skeletal muscle. J Vis Exp. 2011 Feb 22; (48).
Tian J, Fratz S, Hou Y, Lu Q, Görlach A, Hess J, Schreiber C, Datar SA, Oishi P, Nechtman J, Podolsky R, She JX, Fineman JR, Black SM. Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease. Physiol Genomics. 2011 Jan 01; 43(2):87-98.
Hsu JH, Oishi P, Wiseman DA, Hou Y, Chikovani O, Datar S, Sajti E, Johengen MJ, Harmon C, Black SM, Fineman JR. Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide. Am J Physiol Lung Cell Mol Physiol. 2010 Jun; 298(6):L880-7.
Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H. Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury. Pediatr Pulmonol. 2009 Nov; 44(11):1118-24.
Tian J, Smith A, Nechtman J, Podolsky R, Aggarwal S, Snead C, Kumar S, Elgaish M, Oishi P, Göerlach A, Fratz S, Hess J, Catravas JD, Verin AD, Fineman JR, She JX, Black SM. Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension. Physiol Genomics. 2009 Dec 30; 40(1):48-60.
Sharma S, Kumar S, Sud N, Wiseman DA, Tian J, Rehmani I, Datar S, Oishi P, Fratz S, Venema RC, Fineman JR, Black SM. Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow. Vascul Pharmacol. 2009 Nov-Dec; 51(5-6):359-64.
Oishi PE, Wiseman DA, Sharma S, Kumar S, Hou Y, Datar SA, Azakie A, Johengen MJ, Harmon C, Fratz S, Fineman JR, Black SM. Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2008 Nov; 295(5):L756-66.
Hsu JH, Oishi PE, Keller RL, Chikovani O, Karl TR, Azakie A, Adatia I, Fineman JR. Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection. J Thorac Cardiovasc Surg. 2008 Apr; 135(4):746-53.
Sharma S, Sud N, Wiseman DA, Carter AL, Kumar S, Hou Y, Rau T, Wilham J, Harmon C, Oishi P, Fineman JR, Black SM. Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2008 Jan; 294(1):L46-56.
Oishi P, Sharma S, Grobe A, Azakie A, Harmon C, Johengen MJ, Hsu JH, Fratz S, Black SM, Fineman JR. Alterations in cGMP, soluble guanylate cyclase, phosphodiesterase 5, and B-type natriuretic peptide induced by chronic increased pulmonary blood flow in lambs. Pediatr Pulmonol. 2007 Nov; 42(11):1057-71.
Chikovani O, Hsu JH, Keller R, Karl TR, Azakie A, Adatia I, Oishi P, Fineman JR. B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery. J Thorac Cardiovasc Surg. 2007 Nov; 134(5):1179-87.
Hsu JH, Keller RL, Chikovani O, Cheng H, Hollander SA, Karl TR, Azakie A, Adatia I, Oishi P, Fineman JR. B-type natriuretic peptide levels predict outcome after neonatal cardiac surgery. J Thorac Cardiovasc Surg. 2007 Oct; 134(4):939-45.
Sharma S, Grobe AC, Wiseman DA, Kumar S, Englaish M, Najwer I, Benavidez E, Oishi P, Azakie A, Fineman JR, Black SM. Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L960-71.
Lakshminrusimha S, Wiseman D, Black SM, Russell JA, Gugino SF, Oishi P, Steinhorn RH, Fineman JR. The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1491-7.
Oishi PE, Fineman JR. BNP for pediatrics--not quite ready for primetime. Pediatr Crit Care Med. 2006 Jul; 7(4):388-9.
Grobe AC, Wells SM, Benavidez E, Oishi P, Azakie A, Fineman JR, Black SM. Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1069-77.
Shih CY, Sapru A, Oishi P, Azakie A, Karl TR, Harmon C, Asija R, Adatia I, Fineman JR. Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker. J Thorac Cardiovasc Surg. 2006 Mar; 131(3):632-8.
Oishi P, Azakie A, Harmon C, Fitzgerald RK, Grobe A, Xu J, Hendricks-Munoz K, Black SM, Fineman JR. Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1922-32.
Oishi P, Grobe A, Benavidez E, Ovadia B, Harmon C, Ross GA, Hendricks-Munoz K, Xu J, Black SM, Fineman JR. Inhaled nitric oxide induced NOS inhibition and rebound pulmonary hypertension: a role for superoxide and peroxynitrite in the intact lamb. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L359-66.
Fitzgerald RK, Oishi P, Ovadia B, Ross GA, Reinhartz O, Johengen MJ, Fineman JR. Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension. Pediatr Crit Care Med. 2004 Nov; 5(6):571-7.
Ross GA, Oishi P, Azakie A, Fratz S, Fitzgerald RK, Johengen MJ, Harmon C, Hendricks-Munoz K, Xu J, Black SM, Fineman JR. Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension. Am J Physiol Lung Cell Mol Physiol. 2005 Jan; 288(1):L27-35.
Fratz S, Meyrick B, Ovadia B, Johengen MJ, Reinhartz O, Azakie A, Ross G, Fitzgerald R, Oishi P, Hess J, Black SM, Fineman JR. Chronic endothelin A receptor blockade in lambs with increased pulmonary blood flow and pressure. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L592-7.
Thelitz S, Oishi P, Sanchez LS, Bekker JM, Ovadia B, Johengen MJ, Black SM, Fineman JR. Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs. Pediatr Crit Care Med. 2004 May; 5(3):234-9.
Oishi P, Fineman JR. Pharmacologic therapy for persistent pulmonary hypertension of the newborn: as "poly" as the disease itself. Pediatr Crit Care Med. 2004 Jan; 5(1):94-6.