Associate Professor
Assistant Clinical Professor of Pediatrics
+1 415 502-2604
+1 415 476-3466

Biography

William Bernal, MD, MPH, is a board certified pediatric rheumatologist who joined the faculty at UCSF in 2013. Previously, he was an attending physician in pediatric rheumatology at The Children’s Hospital of Philadelphia (CHOP), where he had completed his fellowship. At CHOP, Dr. Bernal worked in the Center for Amplified Musculoskeletal Pain Syndrome at CHOP for two years. There, he was a member of a multidisciplinary team that treats pediatric patients with pain amplification syndromes, such as amplified musculoskeletal pain syndrome, juvenile fibromyalgia and complex regional pain syndrome. Dr. Bernal is continuing this work at UCSF as part of the Integrative Pediatric Pain and Palliative Care Program (IP3), where he and other providers see pediatric patients with chronic pain.

Publications

Salehi S, Tavabie OD, Verma S, McPhail MJ, Farzaneh F, Bernal W, Menon K, Agarwal K, Aluvihare VR. Serum miRNA signatures in recovery from acute and chronic liver injury and selection for liver transplantation. Liver Transpl. 2020 Apr 16.
Jayalakshmi VT, Bernal W. Update on the management of acute liver failure. Curr Opin Crit Care. 2020 Apr; 26(2):163-170.
Moreau R, Clària J, Aguilar F, Fenaille F, Lozano JJ, Junot C, Colsch B, Caraceni P, Trebicka J, Pavesi M, Alessandria C, Nevens F, Saliba F, Welzel TM, Albillos A, Gustot T, Fernández J, Moreno C, Baldassarre M, Zaccherini G, Piano S, Montagnese S, Vargas V, Genescà J, Solà E, Bernal W, Butin N, Hautbergue T, Cholet S, Castelli F, Jansen C, Steib C, Campion D, Mookerjee R, Rodríguez-Gandía M, Soriano G, Durand F, Benten D, Bañares R, Stauber RE, Gronbaek H, Coenraad MJ, Ginès P, Gerbes A, Jalan R, Bernardi M, Arroyo V, Angeli P. Correction to 'Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF' [J Hepatol 2020 (72) 688-701]. J Hepatol. 2020 Mar 17.
Artzner T, Michard B, Weiss E, Barbier L, Noorah Z, Merle JC, Paugam-Burtz C, Francoz C, Durand F, Soubrane O, Pirani T, Theocharidou E, O'Grady J, Bernal W, Heaton N, Salamé E, Bucur P, Barraud H, Lefebvre F, Serfaty L, Besch C, Bachellier P, Schneider F, Levesque E, Faitot F. Liver transplantation for critically ill cirrhotic patients: stratifying utility based on pre-transplantation factors. Am J Transplant. 2020 Mar 17.
Wallace D, Cowling TE, Walker K, Suddle A, Rowe I, Callaghan C, Gimson A, Bernal W, Heaton N, van der Meulen J. Short- and long-term mortality after liver transplantation in patients with and without hepatocellular carcinoma in the UK. Br J Surg. 2020 Mar 03.
Wan J, Roberts LN, Hendrix W, Konings J, Ow TW, Rabinowich L, Barbouti O, de Laat B, Arya R, Patel VC, Roest M, Lisman T, Bernal W. Whole blood thrombin generation profiles of patients with cirrhosis explored with a near patient assay. J Thromb Haemost. 2020 Apr; 18(4):834-843.
Wallace D, Cowling T, McPhail MJ, Brown SE, Aluvihare V, Suddle A, Auzinger G, Heneghan MA, Rowe IA, Walker K, Heaton N, van der Meulen J, Bernal W. Assessing the time-dependent impact of performance status on outcomes after liver transplantation. Hepatology. 2020 Jan 22.
Lim TY, McPhail MJ, Shah A, Mahgoub S, Nayagam J, Cramp M, Bernal W, Menon K, Jassem W, Joshi D, Heneghan MA, Agarwal K, Heaton ND, Suddle A, O'Grady JG, Aluvihare VR. Sequential Cohort Analysis After Liver Transplantation Shows de Novo Extended Release Tacrolimus Is Safe, Efficacious, and Minimizes Renal Dysfunction. Transplant Direct. 2020 Feb; 6(2):e528.
Tavabie OD, Colwill M, Adamson R, McPhail MJW, Bernal W, Jassem W, Prachialias A, Heneghan M, Aluvihare VR, Agarwal K. A 'real-world' analysis of risk factors for post liver transplant delirium and the effect on length of stay. Eur J Gastroenterol Hepatol. 2020 Jan 09.
Slack AJ, Bernal W. Response to: Is high volume Haemofiltration really necessary to remove Ammonia? Liver Int. 2020 Mar; 40(3):728.
Moreau R, Clària J, Aguilar F, Fenaille F, Lozano JJ, Junot C, Colsch B, Caraceni P, Trebicka J, Pavesi M, Alessandria C, Nevens F, Saliba F, Welzel TM, Albillos A, Gustot T, Fernández J, Moreno C, Baldassarre M, Zaccherini G, Piano S, Montagnese S, Vargas V, Genescà J, Solà E, Bernal W, Butin N, Hautbergue T, Cholet S, Castelli F, Jansen C, Steib C, Campion D, Mookerjee R, Rodríguez-Gandía M, Soriano G, Durand F, Benten D, Bañares R, Stauber RE, Gronbaek H, Coenraad MJ, Ginès P, Gerbes A, Jalan R, Bernardi M, Arroyo V, Angeli P. Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF. J Hepatol. 2020 Apr; 72(4):688-701.
Bernal W, Caldwell SH, Lisman T. Nails in the coffin of fresh frozen plasma to prevent or treat bleeding in cirrhosis? J Hepatol. 2020 Jan; 72(1):12-13.
Blasi A, Patel VC, Adelmeijer J, Azarian S, Hernandez Tejero M, Calvo A, Fernández J, Bernal W, Lisman T. Mixed Fibrinolytic Phenotypes in Decompensated Cirrhosis and Acute-on-Chronic Liver Failure with Hypofibrinolysis in Those With Complications and Poor Survival. Hepatology. 2020 Apr; 71(4):1381-1390.
Blasi A, Patel VC, Adelmeijer J, Azarian S, Aziz F, Fernández J, Bernal W, Lisman T. Plasma levels of circulating DNA are associated with outcome, but not with activation of coagulation in decompensated cirrhosis and ACLF. JHEP Rep. 2019 Sep; 1(3):179-187.
Lai JC, Sonnenday CJ, Tapper EB, Duarte-Rojo A, Dunn MA, Bernal W, Carey EJ, Dasarathy S, Kamath BM, Kappus MR, Montano-Loza AJ, Nagai S, Tandon P. Frailty in liver transplantation: An expert opinion statement from the American Society of Transplantation Liver and Intestinal Community of Practice. Am J Transplant. 2019 07; 19(7):1896-1906.
Tavabie OD, Bernal W. How to manage: acute liver failure. Frontline Gastroenterol. 2020 Jan; 11(1):70-74.
Kim JD, Cho EJ, Ahn C, Park SK, Choi JY, Lee HC, Kim DY, Choi MS, Wang HJ, Kim IH, Yeon JE, Seo YS, Tak WY, Kim MY, Lee HJ, Kim YS, Jun DW, Sohn JH, Kwon SY, Park SH, Heo J, Jeong SH, Lee JH, Nakayama N, Mochida S, Ido A, Tsubouchi H, Takikawa H, Acharya SK, Bernal W, O'Grady J, Kim YJ. A Model to Predict 1-Month Risk of Transplant or Death in Hepatitis A-Related Acute Liver Failure. Hepatology. 2019 Aug; 70(2):621-629.
Plauth M, Bernal W, Dasarathy S, Merli M, Plank LD, Schütz T, Bischoff SC. ESPEN guideline on clinical nutrition in liver disease. Clin Nutr. 2019 04; 38(2):485-521.
Hepgul N, Sleeman KE, Firth AM, Johnston A, Teo JTH, Bernal W, Dobson RJB, Higginson IJ. In response to Ballantyne and Schaefer's 'Consent and the ethical duty to participate in health data research'. J Med Ethics. 2019 05; 45(5):351-352.
McPhail MJW, Harrison D, Rowan K, Bernal W. The authors reply. Crit Care Med. 2018 10; 46(10):e1018.
Lisman T, Kleiss S, Patel VC, Fisher C, Adelmeijer J, Bos S, Singanayagam A, Stoy SH, Shawcross DL, Bernal W. In vitro efficacy of pro- and anticoagulant strategies in compensated and acutely ill patients with cirrhosis. Liver Int. 2018 11; 38(11):1988-1996.
McPhail MJW, Parrott F, Wendon JA, Harrison DA, Rowan KA, Bernal W. Incidence and Outcomes for Patients With Cirrhosis Admitted to the United Kingdom Critical Care Units. Crit Care Med. 2018 05; 46(5):705-712.
Zabron A, Quaglia A, Fatourou E, Peddu P, Lewis D, Heneghan M, Willars C, Auzinger G, Heaton N, Wendon J, Kane P, Karani J, Bernal W. Clinical and prognostic associations of liver volume determined by computed tomography in acute liver failure. Liver Int. 2018 09; 38(9):1592-1601.
Støy S, Patel VC, Sturgeon JP, Manakkat Vijay GK, Lisman T, Bernal W, Shawcross DL. Platelet-leucocyte aggregation is augmented in cirrhosis and further increased by platelet transfusion. Aliment Pharmacol Ther. 2018 05; 47(10):1375-1386.
Connolly B, Maddocks M, MacBean V, Bernal W, Hart N, Hopkins P, Rafferty GF. Nonvolitional assessment of tibialis anterior force and architecture during critical illness. Muscle Nerve. 2018 06; 57(6):964-972.
Bernal W. Biomarkers for risk assessment in paracetamol hepatotoxicity. Lancet Gastroenterol Hepatol. 2018 02; 3(2):76-77.
Bernal W. Improving outcomes for transplantation of critically ill patients with cirrhosis? Clin Liver Dis (Hoboken). 2017 Jul; 10(1):25-28.
Bernal W. Reversing frailty through early postoperative nutrition and mobility? Clin Liver Dis (Hoboken). 2017 Jul; 10(1):4-8.
Lisman T, Bernal W. Management of Hemostatic Disorders in Patients With Advanced Liver Disease Admitted to an Intensive Care Unit. Transfus Med Rev. 2017 10; 31(4):245-251.
Spencer CH, Rouster-Stevens K, Gewanter H, Syverson G, Modica R, Schmidt K, Emery H, Wallace C, Grevich S, Nanda K, Zhao YD, Shenoi S, Tarvin S, Hong S, Lindsley C, Weiss JE, Passo M, Ede K, Brown A, Ardalan K, Bernal W, Stoll ML, Lang B, Carrasco R, Agaiar C, Feller L, Bukulmez H, Vehe R, Kim H, Schmeling H, Gerstbacher D, Hoeltzel M, Eberhard B, Sundel R, Kim S, Huber AM, Patwardhan A. Biologic therapies for refractory juvenile dermatomyositis: five years of experience of the Childhood Arthritis and Rheumatology Research Alliance in North America. Pediatr Rheumatol Online J. 2017 Jun 13; 15(1):50.
Bernal W. El hígado en la enfermedad sistémica: sepsis y enfermedad crítica. Clin Liver Dis (Hoboken). 2016 Nov; 8(Suppl 1):S6-S9.
Bateman RM, Sharpe MD, Jagger JE, Ellis CG, Solé-Violán J, López-Rodríguez M, Herrera-Ramos E, Ruíz-Hernández J, Borderías L, Horcajada J, González-Quevedo N, Rajas O, Briones M, Rodríguez de Castro F, Rodríguez Gallego C, Esen F, Orhun G, Ergin Ozcan P, Senturk E, Ugur Yilmaz C, Orhan N, Arican N, Kaya M, Kucukerden M, Giris M, Akcan U, Bilgic Gazioglu S, Tuzun E, Riff R, Naamani O, Douvdevani A, Takegawa R, Yoshida H, Hirose T, Yamamoto N, Hagiya H, Ojima M, Akeda Y, Tasaki O, Tomono K, Shimazu T, Ono S, Kubo T, Suda S, Ueno T, Ikeda T, Hirose T, Ogura H, Takahashi H, Ojima M, Kang J, Nakamura Y, Kojima T, Shimazu T, Ikeda T, Suda S, Izutani Y, Ueno T, Ono S, Taniguchi T, O M, Dinter C, Lotz J, Eilers B, Wissmann C, Lott R, Meili MM, Schuetz PS, Hawa H, Sharshir M, Aburageila M, Salahuddin N, Chantziara V, Georgiou S, Tsimogianni A, Alexandropoulos P, Vassi A, Lagiou F, Valta M, Micha G, Chinou E, Michaloudis G, Kodaira A, Ikeda T, Ono S, Ueno T, Suda S, Izutani Y, Imaizumi H, De la Torre-Prados MV, Garcia-De la Torre A, Enguix-Armada A, Puerto-Morlan A, Perez-Valero V, Garcia-Alcantara A, Bolton N, Dudziak J, Bonney S, Tridente A, Nee P, Nicolaes G, Wiewel M, Schultz M, Wildhagen K, Horn J, Schrijver R, Van der Poll T, Reutelingsperger C, Pillai S, Davies G, Mills G, Aubrey R, Morris K, Williams P, Evans P, Gayat EG, Struck J, Cariou A, Deye N, Guidet B, Jabert S, Launay J, Legrand M, Léone M, Resche-Rigon M, Vicaut E, Vieillard-Baron A, Mebazaa A, Arnold R, Capan M, Linder A, Akesson P, Popescu M, Tomescu D, Sprung CL, Calderon Morales R, Munteanu G, Orenbuch-Harroch E, Levin P, Kasdan H, Reiter A, Volker T, Himmel Y, Cohen Y, Meissonnier J, Girard L, Rebeaud F, Herrmann I, Delwarde B, Peronnet E, Cerrato E, Venet F, Lepape A, Rimmelé T, Monneret G, Textoris J, Beloborodova N, Moroz V, Osipov A, Bedova A, Sarshor Y, Pautova A, Sergeev A, Chernevskaya E, Odermatt J, Bolliger R, Hersberger L, Ottiger M, Christ-Crain M, Mueller B, Schuetz P, Sharma NK, Tashima AK, Brunialti MK, Machado FR, Assuncao M, Rigato O, Salomao R, Cajander SC, Rasmussen G, Tina E, Söderquist B, Källman J, Strålin K, Lange AL, Sundén-Cullberg JS, Magnuson AM, Hultgren OH, Davies G, Pillai S, Mills G, Aubrey R, Morris K, Williams P, Evans P, Pillai S, Davies G, Mills G, Aubrey R, Morris K, Williams P, Evans P, Pillai S, Davies G, Mills G, Aubrey R, Morris K, Williams P, Evans P, Van der Geest P, Mohseni M, Linssen J, De Jonge R, Duran S, Groeneveld J, Miller R, Lopansri BK, McHugh LC, Seldon A, Burke JP, Johnston J, Reece-Anthony R, Bond A, Molokhia A, Mcgrath C, Nsutebu E, Bank Pedersen P, Pilsgaard Henriksen D, Mikkelsen S, Touborg Lassen A, Tincu R, Cobilinschi C, Tomescu D, Ghiorghiu Z, Macovei R, Wiewel MA, Harmon MB, Van Vught LA, Scicluna BP, Hoogendijk AJ, Horn J, Zwinderman AH, Cremer OL, Bonten MJ, Schultz MJ, Van der Poll T, Juffermans NP, Wiersinga WJ, Eren G, Tekdos Y, Dogan M, Acicbe O, Kaya E, Hergunsel O, Alsolamy S, Ghamdi G, Alswaidan L, Alharbi S, Alenezi F, Arabi Y, Heaton J, Boyce A, Nolan L, Johnston J, Dukoff-Gordon A, Dean A, Molokhia A, Mann Ben Yehudah T, Fleischmann C, Thomas-Rueddel D, Haas C, Dennler U, Reinhart K, Suntornlohanakul O, Khwannimit B, Breckenridge F, Puxty A, Szturz P, Folwarzcny P, Svancara J, Kula R, Sevcik P, Caneva L, Casazza A, Bellazzi E, Marra S, Pagani L, Vetere M, Vanzino R, Ciprandi D, Preda R, Boschi R, Carnevale L, Lopez V, Aguilar Arzapalo M, Barradas L, Escalante A, Gongora J, Cetina M, Adamik B, Jakubczyk D, Kübler A, Radford A, Lee T, Singer J, Boyd J, Fineberg D, Williams M, Russell J, Scarlatescu E, Tomescu D, Droc G, Arama S, Müller M, Straat M, Zeerleder SS, Juffermans NP, Fuchs CF, Scheer CS, Wauschkuhn SW, Vollmer MV, Meissner KM, Kuhn SK, Hahnenkamp KH, Rehberg SR, Gründling MG, Yamamoto N, Ojima M, Hamaguchi S, Hirose T, Akeda Y, Takegawa R, Tasaki O, Shimazu T, Tomono K, Gómez-Sánchez E, Heredia-Rodríguez M, Álvarez-Fuente E, Lorenzo-López M, Gómez-Pesquera E, Aragón-Camino M, et al. Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15-18 March 2016. Crit Care. 2016; 20:347.
Bernal W, Wang Y, Maggs J, Willars C, Sizer E, Auzinger G, Murphy N, Harding D, Elsharkawy A, Simpson K, Larsen FS, Heaton N, O'Grady J, Williams R, Wendon J. Development and validation of a dynamic outcome prediction model for paracetamol-induced acute liver failure: a cohort study. Lancet Gastroenterol Hepatol. 2016 11; 1(3):217-225.
Bernal W. The liver in systemic disease: Sepsis and critical illness. Clin Liver Dis (Hoboken). 2016 Apr; 7(4):88-91.
Canna SW, Costa-Reis P, Bernal WE, Chu N, Sullivan KE, Paessler ME, Behrens EM. Brief report: alternative activation of laser-captured murine hemophagocytes. Arthritis Rheumatol. 2014 Jun; 66(6):1666-71.
Nayak RR, Bernal WE, Lee JW, Kearns MJ, Cheung VG. Stress-induced changes in gene interactions in human cells. Nucleic Acids Res. 2014 Feb; 42(3):1757-71.
Mizesko MC, Banerjee PP, Monaco-Shawver L, Mace EM, Bernal WE, Sawalle-Belohradsky J, Belohradsky BH, Heinz V, Freeman AF, Sullivan KE, Holland SM, Torgerson TR, Al-Herz W, Chou J, Hanson IC, Albert MH, Geha RS, Renner ED, Orange JS. Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2013 Mar; 131(3):840-8.