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COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies.
Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.
Common variants at five new loci associated with early-onset inflammatory bowel disease.
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects.
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Germline KRAS mutations cause Noonan syndrome.
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.