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Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies.
Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.
Common variants at five new loci associated with early-onset inflammatory bowel disease.
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects.
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Germline KRAS mutations cause Noonan syndrome.
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.
Gains of glycosylation comprise an unexpectedly large group of pathogenic mutations.