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Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype.
Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development.
Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.
The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation.
Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development.
CHAMP, a novel cardiac-specific helicase regulated by MEF2C.
HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.
The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness.