Beth Apsel Winger, MD, PhD

Dr. Winger’s research is focused on advancing precision medicine to improve therapeutics and outcomes for patients with cancer and other blood diseases. Her research has two main focuses: 1) understanding mutations in kinases so that we can expand the use of targeted therapies and match the right drug to the right patient, and 2) developing precision dosing strategies to give every patient the right amount of drug for their body.

  1. Brooks J, Ismaeil S, Hughes MS, Apsel-Winger B, Lu Y, Huang L, Higham C, Nelson K, Long S, Gupta A, Lalefar NR, Anderson E, Pulsipher MA, Pai SY, Keizer RJ, Dvorak CC, Long-Boyle J. Prospective Evaluation of Thiotepa Pharmacokinetics in Children and Young Adults Undergoing Allogeneic or Autologous Hematopoietic Cell Transplantation. Journal of clinical pharmacology 2026. PMID: 42760872


  2. Pithadia DJ, Heskel MJ, Shotayev A, Davda S, Durand R, Cooke D, Czechowicz J, Lesh M, Cornett P, Shimano KA, Mathes EF, Frieden IJ, Apsel Winger B. Alpelisib, a PI3Kα inhibitor, effectively treats vascular anomalies with diverse genotypes and phenotypes. Blood vessels, thrombosis & hemostasis 2025. PMID: 41623364


  3. Apsel Winger B, Polli JW, Long-Boyle J, Weber A, Brooks J, Parikh J, Damian V. Prediction of neutrophil nadir and recovery following paediatric haematopoietic cell transplantation with busulfan conditioning. British journal of clinical pharmacology 2025. PMID: 41017130


  4. Rangarajan A, Sviezhentseva I, Gunderson E, Pikman Y, Jacobson MP, Apsel Winger B. A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancer. Frontiers in oncology 2025. PMID: 40831936


  5. Winger BA, Ajayi A, Vichinsky E. Diagnosis and Treatment of Alpha Thalassemia Major. Hemoglobin 2025. PMID: 40038042


  6. Dvorak CC, Temple WC, Cisneros GS, Chu J, Winestone LE, Higham CS, Shimano KA, Kharbanda S, Avagyan S, Pauerstein P, Huang JN, Cheng G, Waters E, Winger BA, Cowan MJ, Long-Boyle JR. Younger Children with Non-Malignant Disease Have Increased Incidence of Mixed Myeloid Chimerism After Allogeneic Hematopoietic Cell Transplantation with Busulfan-Based Conditioning. Transplantation and cellular therapy 2025. PMID: 39938805


  7. Marinoff AE, Thrall A, Aaronson K, Braun BS, Castellanos M, Chu J, Hermiston M, Huang BJ, Levinson A, Southworth E, Winger BA, Olshen A, Stieglitz E. Thrombopoietin Receptor Agonists for Thrombocytopenia in Pediatric Hematologic Malignancies. Pediatric blood & cancer 2025. PMID: 39780402


  8. Apsel Winger B, Dowd CF, Shimano KA, Devine WP, Mathes E, Frieden I, Schaefer C, Kothari A. Effective Use of ALK Inhibitors in EML4::ALK-Positive Lymphatic Malformations. Pediatric blood & cancer 2024. PMID: 39529238


  9. Paolino J, Dimitrov B, Apsel Winger B, Sandoval-Perez A, Rangarajan AV, Ocasio-Martinez N, Tsai HK, Li Y, Robichaud AL, Khalid D, Hatton C, Gillani R, Polonen P, Dilig A, Gotti G, Kavanagh J, Adhav AA, Gow S, Tsai J, Li Y, Ebert BL, Van Allen EM, Bledsoe J, Kim AS, Tasian SK, Cooper SL, Cooper TM, Hijiya N, Sulis ML, Shukla NN, Magee JA, Mullighan CG, Burke MJ, Luskin MR, Mar BG, Jacobson MP, Harris MH, Stegmaier K, Place AE, Pikman Y. Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research 2023. PMID: 37725576


  10. Apsel Winger B, Devine WP, Hsiao EC, Zapala M, Van Ziffle J, Gupta N, Frieden IJ, Shimano KA. EML4::ALK fusions in complex lymphatic malformations. Pediatric blood & cancer 2023. PMID: 37377128


  11. Sandoval-P?rez A, Winger BA, Jacobson MP. Correction to "Assessing the Activation of Tyrosine Kinase KIT through Free Energy Calculations". Journal of chemical theory and computation 2022. PMID: 36493348


  12. Sandoval-P?rez A, Winger BA, Jacobson MP. Assessing the Activation of Tyrosine Kinase KIT through Free Energy Calculations. Journal of chemical theory and computation 2022. PMID: 36166736


  13. Huang L, Winger BA, Cheah V, Gingrich D, Marzan F, Lu Y, Cooper JC, Aweeka F, Long-Boyle J. Quantification of N, N' N"-triethylenethiophosphoramide, N, N"-triethylenephosphoramide, cyclophosphamide, and 4-hydroxy-cyclophosphamide in microvolume human plasma to support neonatal and pediatric drug studies. Journal of chromatography open 2022. PMID: 35875822


  14. Li S, Dvorak CC, Lu Y, Chan D, Gobburu JVS, Long-Boyle J, Winger BA. Population Pharmacokinetics of Melphalan for Pediatric Patients Undergoing Hematopoietic Cell Transplantation. 2022. PMID: 35048362


  15. Apsel Winger B, Long SE, Brooks J, Gupta AO, Dvorak CC, Long-Boyle JR. A Guidance for Concomitant Drug Reconciliation Prior to Allogeneic Hematopoietic Cell Transplantation in Children and Young Adults. Frontiers in pediatrics 2021. PMID: 34350148


  16. Pikman Y, Tasian SK, Sulis ML, Stevenson K, Blonquist TM, Apsel Winger B, Cooper TM, Pauly M, Maloney KW, Burke MJ, Brown PA, Gossai N, McNeer JL, Shukla NN, Cole PD, Kahn JM, Chen J, Barth MJ, Magee JA, Gennarini L, Adhav AA, Clinton CM, Ocasio-Martinez N, Gotti G, Li Y, Lin S, Imamovic A, Tognon CE, Patel T, Faust HL, Contreras CF, Cremer A, Cortopassi WA, Garrido Ruiz D, Jacobson MP, Dharia NV, Su A, Robichaud AL, Saur Conway A, Tarlock K, Stieglitz E, Place AE, Puissant A, Hunger SP, Kim AS, Lindeman NI, Gore L, Janeway KA, Silverman LB, Tyner JW, Harris MH, Loh ML, Stegmaier K. Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium. Cancer discovery 2021. PMID: 33563661


  17. Apsel Winger B, Shukla P, Kharbanda S, Keizer RJ, Goswami S, Cowan MJ, Dvorak CC, Long-Boyle J. The Relationship Between Busulfan Exposure and Achievement of Sustained Donor Myeloid Chimerism in Patients with Non-Malignant Disorders. Transplantation and cellular therapy 2020. PMID: 33781528


  18. Shukla P, Goswami S, Keizer RJ, Winger BA, Kharbanda S, Dvorak CC, Long-Boyle J. Assessment of a Model-Informed Precision Dosing Platform Use in Routine Clinical Care for Personalized Busulfan Therapy in the Pediatric Hematopoietic Cell Transplantation (HCT) Population. Frontiers in pharmacology 2020. PMID: 32714184


  19. Wang H, Long-Boyle J, Winger BA, Nicolaides T, Mueller S, Prados M, Ivaturi V. Population Pharmacokinetics of Vemurafenib in Children With Recurrent/Refractory BRAF Gene V600E-Mutant Astrocytomas. Journal of clinical pharmacology 2020. PMID: 32476174


  20. Apsel Winger B, Cortopassi WA, Garrido Ruiz D, Ding L, Jang K, Leyte-Vidal A, Zhang N, Esteve-Puig R, Jacobson MP, Shah NP. ATP-Competitive Inhibitors Midostaurin and Avapritinib Have Distinct Resistance Profiles in Exon 17-Mutant KIT. Cancer research 2019. PMID: 31270078


  21. Winger BA, Foy E, Sud SR, MacKenzie JD, Pua HH, Lau AH, Heyman MB, Laszik Z, Tureen J. Mycobacterium bovis Enterocolitis in an Immunocompromised Host. Journal of pediatric gastroenterology and nutrition 2016. PMID: 26020480


  22. Apsel Winger B, Shah NP. PPAR?: Welcoming the New Kid on the CML Stem Cell Block. Cancer cell 2015. PMID: 26461088


  23. Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS biology 2009. PMID: 19209957


  24. Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, Hoffman R, Williams RL, Shokat KM, Knight ZA. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nature chemical biology 2008. PMID: 18849971


  25. Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat KM. Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha. Cancer cell 2008. PMID: 18691552


  26. Mackey ZB, Baca AM, Mallari JP, Apsel B, Shelat A, Hansell EJ, Chiang PK, Wolff B, Guy KR, Williams J, McKerrow JH. Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei. Chemical biology & drug design 2006. PMID: 16784460


  27. Pillinger MH, Dinsell V, Apsel B, Tolani SN, Marjanovic N, Chan ES, Gomez P, Clancy R, Chang LF, Abramson SB. Regulation of metalloproteinases and NF-kappaB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNA. British journal of pharmacology 2004. PMID: 15210577


  28. Pillinger MH, Rosenthal PB, Tolani SN, Apsel B, Dinsell V, Greenberg J, Chan ES, Gomez PF, Abramson SB. Cyclooxygenase-2-derived E prostaglandins down-regulate matrix metalloproteinase-1 expression in fibroblast-like synoviocytes via inhibition of extracellular signal-regulated kinase activation. Journal of immunology (Baltimore, Md. : 1950) 2003. PMID: 14634122