Jason Boehme, MD

Education
Fellowship, - Pediatric Critical Care, University of California, San Francisco
Residency, - School of Medicine, University of California, San Francisco

  1. Mendonca D, Zinter MS, Devarajan SR, Boehme J, Suter B, Maletic-Savatic M, Muscal E, Pehlivan D. Recurrent Sterile Polyserositis Reveals an Underrecognized Autoinflammatory Phenotype in MECP2 Duplication Syndrome. Clinical genetics 2026. PMID: 42661474


  2. Tsoi SM, Keller RL, Sacks LD, Sebastian V, Datar SA, Smith MA, Boehme J, Fineman JR, Amin EK. Extracorporeal Life Support (ECLS) for Pulmonary Vein Stenosis Interventions. Pediatric cardiology 2026. PMID: 42622639


  3. Hyde J, Smith MA, Swami N, Hwang JH, Chao Y, Boehme J, Raff GW, Nilsson CN, Gong W, Deutsch GH, Johnson EG, Wang T, Black SM, Datar SA, Maltepe E, Fineman JR. Pulmonary Vascular Endothelial Dysfunction Is Induced by Nonpulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model. Comprehensive Physiology 2025. PMID: 41214305


  4. Hyde J, Smith MA, Swami N, Hwang JH, Chao Y, Boehme J, Raff GW, Nilsson CN, Gong W, Deutsch GH, Johnson EG, Wang T, Black SM, Datar SA, Maltepe E, Fineman JR. Pulmonary Vascular Endothelial Dysfunction is Induced by Non-Pulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model. bioRxiv : the preprint server for biology 2025. PMID: 41280121


  5. Smith MA, Guardado ES, Boehme J, Datar SA, Maltepe E, Swami N, Raff GW, Bodansky A, Chelladurai P, Moreno J, Prince AR, Powers N, Huang GN, de Jesus Perez V, Fineman JR. Microvascular preservation & cardiomyocyte hyperplasia underlie adaptive right ventricle development in congenital heart disease-pulmonary arterial hypertension. American journal of physiology. Heart and circulatory physiology 2025. PMID: 40924618


  6. Boehme JT, Datar SA, Sun X, Gong W, Lu Q, Soto J, Smith MA, Garcia-Flores AE, Raff GW, Wang T, Maltepe E, Black SM, Fineman JR. Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation. Scientific Reports 2025. PMID: 40348934


  7. Smith MA, Chiacchia S, Boehme J, Datar SA, Morell E, Keller RL, Romer A, Colglazier E, Parker C, Becerra J, Fineman JR. MicroRNA Profiling to Inform Disease Classification, Severity, and Treatment Response in Pediatric Pulmonary Hypertension. American journal of physiology. Heart and circulatory physiology 2024. PMID: 39589759


  8. Sun X, Moreno Caceres S, Yegambaram M, Lu Q, Pokharel MD, Boehme JT, Datar SA, Aggarwal S, Wang T, Fineman JR, Black SM. The mitochondrial redistribution of ENOS is regulated by AKT1 and dimer status. Nitric oxide : biology and chemistry 2024. PMID: 39332480


  9. Maltepe E, Smith M, Boehme J, Datar SA, Hutchings RS, Vento CA, Manzoor H, Loucks A, Winger JA, Fineman JR. OMX: A Novel Oxygen Delivery Biotherapeutic Improves Outcomes in an Ovine Model of Controlled Hemorrhagic Shock. Shock (Augusta, Ga.) 2024. PMID: 38662597


  10. Boehme JT, Sun X, Lu Q, Barton J, Wu X, Gong W, Raff GW, Datar SA, Wang T, Fineman JR, Black SM. Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation. Nitric oxide : biology and chemistry 2023. PMID: 38061411


  11. Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA. HIF-1a promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow. Scientific Reports 2021. PMID: 33446832


  12. Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR. Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease. Pulmonary circulation 2020. PMID: 32489641


  13. Johnson Kameny R, Datar SA, Boehme JB, Morris C, Zhu T, Goudy BD, Johnson EG, Galambos C, Raff GW, Sun X, Wang T, Chiacchia SR, Lu Q, Black SM, Maltepe E, Fineman JR. Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling. American journal of respiratory cell and molecular biology 2019. PMID: 30620615


  14. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS biology 2019. PMID: 30677022


  15. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS biology 2018. PMID: 30335746


  16. Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR. Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease. American journal of physiology. Heart and circulatory physiology 2018. PMID: 29906222


  17. Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA. KLF2-mediated disruption of PPAR-? signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. American journal of physiology. Heart and circulatory physiology 2018. PMID: 29631374


  18. Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E. Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. American journal of physiology. Heart and circulatory physiology 2016. PMID: 27591215


  19. Boehme J, Maltepe E. Spare hypoxia, spoil the child? The Journal of clinical investigation 2015. PMID: 25689257