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CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.
Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma.
Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects.
Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation.
De novo formation of the biliary system by TGFß-mediated hepatocyte transdifferentiation.
Discovery of stimulation-responsive immune enhancers with CRISPR activation.
Divergent clonal selection dominates medulloblastoma at recurrence.
Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.
Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness.