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Pediatric sarcomas: challenges and opportunities.
Honeybadger, a micropeptide encoded by an alternative PVT1 transcript, is a critical negative regulator of RAS-MAPK signaling in MYC-driven tumors.
Firefox, a protein encoded by circular PVT1, is essential for MYC-driven oncogenesis.
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis.
Modeling congenital heart disease: lessons from mice, hPSC-based models, and organoids.
Glioblastoma cellular cross-talk converges on NF-?B to attenuate EGFR inhibitor sensitivity.
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.
Pleiotropic role for MYCN in medulloblastoma.