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In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors.
Bicistronic CAR T-cells Against CD70 & Active Integrin β2 Overcome Antigen Heterogeneity and Preserve Safety in Acute Myeloid Leukemia.
MitoScribe single-cell molecular recorder logs graded signaling dynamics into mitochondrial DNA.
Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease.
Postnatal Abrogation of VEGFR2 Blocks Terminal Cap2 Differentiation by Preventing the Developmental Progression from a Capillary Intermediate Cell State.
Integrated single-nuclei and spatial transcriptomic profiling of human sacrococcygeal teratomas reveals heterogeneity in cellular composition and X-chromosome inactivation.
Synthesis errors in oligonucleotides are propagated into the genome by homology-directed repair.
CD38 expression by neonatal human naïve CD4 + T cells shapes their distinct metabolic state and tolerogenic potential.
Multi-selective RAS(ON) Inhibition Targets Oncogenic RAS Mutations and Overcomes RAS/MAPK-Mediated Resistance to FLT3 and BCL2 Inhibitors in Acute Myeloid Leukemia.
Commensal myeloid crosstalk in neonatal skin regulates cutaneous type 17 inflammation.