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Redirection of sphingolipid metabolism drives cytoskeletal defects in SPLIS and reveals ROCK inhibition as therapy.
CD38 expression by neonatal human naive CD4+ T cells shapes their distinct metabolic and tolerogenic properties.
TP53/TAU axis regulates microtubule bundling to control alveolar stem cell mediated regeneration.
Pharmacologic inhibition of IRE1α-dependent decay protects alveolar epithelial identity and prevents pulmonary fibrosis in mice.
Clonal expansion of alveolar fibroblast progeny drives pulmonary fibrosis in mouse models.
Neutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury.
CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target.
Unveiling the proteome-wide autoreactome enables enhanced evaluation of emerging CAR T cell therapies in autoimmunity.
Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 or 16:02 individuals.
PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma.