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GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma.
ADAM8 signaling drives neutrophil migration and ARDS severity.
αVβ8 integrin targeting to prevent posterior capsular opacification (PCO).
The effects of low-dose IL-2 on Treg adoptive cell therapy in patients with Type 1 diabetes.
SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine.
MYH9 facilitates autoregulation of adipose tissue depot development.
Repurposing calcium-sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas.
KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.
Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis.
Immunomodulatory activity of humanized anti-IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes.