Whole-genome sequencing rule-out of suspected hospital-onset Rhizopus outbreaks.

Infection control and hospital epidemiology

2023

https://researcherprofiles.org/profile/401744226

37308466

Chu VT, Nafees S, Waltari E, McNeil N, Caughell C, Sanchez-Guerrero E, Wang L, Stanley K, Cunningham G, Wong J, Phelps M, Tato CM, Miller S, DeRisi JL, Yokoe DS, Ramirez-Avila L, Langelier CR

Abstract

Two independent temporal-spatial clusters of hospital-onset infections were evaluated using whole-genome sequencing (WGS). Phylogenetic analysis confirmed that isolates within each cluster were unrelated despite epidemiological suspicion of outbreaks. The ITS1 region alone was insufficient for accurate analysis. WGS has utility for rapid rule-out of suspected nosocomial outbreaks.

Journal Issue

Volume 44 of Issue 12