Alice Chan, MD, PhD

I'm a pediatric immunologist and rheumatologist dedicated to improving our understanding of immune regulation to advance care for patients with immune system disorders. My clinical practice is focused on diagnosing and managing patients with complex or unknown immune system disorders. My research area is focused on studying genes that regulate the immune system. We utilize CRISPR/Cas9 to generate mouse models harboring human mutations to help elucidate the molecular mechanism driving disease.
Education
2019 - Diversity, Equity, and Inclusion Champion Training, University of California
Fellowship, 2016 - Allergy/Immunology, University of California, San Francisco
Fellowship, 2016 - Pediatric Rheumatology, University of California, San Francisco
Residency, 2011 - Pediatrics, University of California, San Francisco
MD, PhD, 2008 - , University of Texas Southwestern Medical School

  1. Alexander JL, Dávila Saldaña BJ, Brazauskas R, Dammalapati SG, Griffith LM, Shah AJ, Shimano KA, Ochs HD, Bleesing JJ, Ebens CL, Kapadia M, Bauchat A, Kapoor N, Oved JH, Eissa H, Lust H, Keller MD, Haines H, Chandrakasan S, Talano JA, Rayes A, Madden L, Shereck E, Miller HK, Satter LF, Martinez C, Rozmus J, Bednarski JJ, Yu LC, Chellapandian D, Aquino VM, Knutsen A, Chong H, Chopek A, Gillio AP, Joshi A, Rangarajan H, Moore TB, Andolina JR, DeSantes KB, Vander Lugt M, Prockop SE, Shyr DC, Sullivan KE, Parikh S, Weinacht KG, Torgerson TR, Marsh R, Dvorak CC, Chan AY, Haddad E, Heimall JR, Pulsipher MA, Leiding JW, Kohn DB, Puck JM, Notarangelo LD, Rawlings DJ, Cowan MJ, Petrovic A, Pai SY, Burroughs LM. Hematopoietic cell transplantation for Wiskott-Aldrich syndrome: a PIDTC report. Blood advances 2026. PMID: 41346295


  2. Zhou Q, Bagaric I, Komma F, Prakash C, Abolhassani H, Chavoshzadeh Z, Tsao L, Vatovec T, Soudée C, Rosain J, Minter DJ, Lu C, Al-Sukaiti N, Wu B, Sun J, Zhang Q, Casanova JL, Pan-Hammarström Q, Chan AY, Al-Farsi T, Wang X, Bustamante J, Bohlen J. Complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease. Journal of Human Immunity 2026. PMID: 41623352


  3. Chandrakasan S, Westbrook A, Griffith LM, Hagin D, Iyengar S, Mangurian C, Scalchunes C, Sullivan KE, Zablocki A, Bakshi N, Sinha C, Burroughs LM, Chan AY, Dvorak CC, Haddad E, Heimall J, Kohn DB, Leiding JW, Notarangelo LD, Pai SY, Puck JM, Pulsipher MA, Marsh RA, Torgerson T, Cowan MJ, Ochs HD, Parikh S. Clinical spectrum of Wiskott-Aldrich syndrome carriers: Self-reported survey of 193 carriers. Clinical immunology (Orlando, Fla.) 2025. PMID: 41419161


  4. Jacovas VC, Zelnick M, McNulty S, Ross JE, Khurana N, Pan X, Nieto A, Martin S, McLean B, Elnagheeb MA, Cowan MJ, Puck JM, Hershfield MS, Verbsky J, Walter J, Allenspach EJ, Chan AY, van Oers NSC, Ghosh R, Piazza M, Yuan B, Notarangelo LD, Johnson BA, Chinn IK, Severe Combined Immunodeficiency Variant Curation Expert Panel. The ClinGen Severe Combined Immunodeficiency Disease Variant Curation Expert Panel: Specifications for classification of variants in ADA, DCLRE1C, IL2RG, IL7R, JAK3, RAG1, and RAG2. Genetics in medicine : official journal of the American College of Medical Genetics 2025. PMID: 41104538


  5. Buddingh EP, Slatter M, Becerra JCA, Garcia LA, von Asmuth E, Baris S, de la Calle-Martín O, Chan AY, Chan SB, Chandrakasan S, Chellapandian D, Dara J, Farmand S, Fasth A, Satter LF, Formankova R, Grunebaum E, Keogh SJ, Kiykim A, Kühl JS, Laberko A, Leahy TR, Lindemans C, Martinez C, Martínez-Martínez L, Mitchell WG, Morris E, Oved JH, Polacik M, Rivière JG, Roifman CM, Kilic SS, Sedlacek P, Shah AJ, Vong L, Lankester AC, Albert MH, Neven B, Torgerson T, Leiding J, Schuetz C. Improved outcome of HSCT in STAT1 gain-of-function disease following JAK inhibition bridging. Journal of Human Immunity 2025. PMID: 41142635


  6. Bauman BM, Stinson JR, Kallarakal MA, Huang LH, Frank AM, Sukumar G, Saucier N, Dalgard CL, Chan AY, Milner JD, Cooper MA, Snow AL. Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells. The Journal of experimental medicine 2025. PMID: 40111223


  7. Dong P, Cai Z, Li B, Zhu Y, Chan AKY, Chiang MWL, Au CH, Sung WK, Cheung TT, Lo CM, Man K, Lee NP. HFE promotes mitotic cell division through recruitment of cytokinetic abscission machinery in hepatocellular carcinoma. Oncogene 2022. PMID: 35882980


  8. Warshauer JT, Belk JA, Chan AY, Wang J, Gupta AR, Shi Q, Skartsis N, Peng Y, Phipps JD, Acenas D, Smith JA, Tamaki SJ, Tang Q, Gardner JM, Satpathy AT, Anderson MS. A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance. The Journal of experimental medicine 2021. PMID: 34115115


  9. Eriksson D, Bacchetta R, Gunnarsson HI, Chan A, Barzaghi F, Ehl S, Hallgren Å, van Gool F, Sardh F, Lundqvist C, Laakso SM, Rönnblom A, Ekwall O, Mäkitie O, Bensing S, Husebye ES, Anderson M, Kämpe O, Landegren N. The autoimmune targets in IPEX are dominated by gut epithelial proteins. The Journal of allergy and clinical immunology 2019. PMID: 31027649


  10. Simeonov DR, Brandt AJ, Chan AY, Cortez JT, Li Z, Woo JM, Lee Y, Carvalho CMB, Indart AC, Roth TL, Zou J, May AP, Lupski JR, Anderson MS, Buaas FW, Rokhsar DS, Marson A. A large CRISPR-induced bystander mutation causes immune dysregulation. Communications biology 2019. PMID: 30793048


  11. Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature 2018. PMID: 29899441


  12. Tsui JL, Estrada OA, Deng Z, Wang KM, Law CS, Elicker BM, Jones KD, Dell SD, Gudmundsson G, Hansdottir S, Helfgott SM, Volpi S, Gattorno M, Waterfield MR, Chan AY, Chung SA, Ley B, Shum AK. Analysis of pulmonary features and treatment approaches in the COPA syndrome. ERJ open research 2018. PMID: 29977900


  13. Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature 2017. PMID: 28854172


  14. Li D, Streeten EA, Chan A, Lwin W, Tian L, Pellegrino da Silva R, Kim CE, Anderson MS, Hakonarson H, Levine MA. Exome Sequencing Reveals Mutations in AIRE as a Cause of Isolated Hypoparathyroidism. The Journal of clinical endocrinology and metabolism 2017. PMID: 28323927


  15. Stray-Pedersen A, Sorte HS, Samarakoon P, Gambin T, Chinn IK, Coban Akdemir ZH, Erichsen HC, Forbes LR, Gu S, Yuan B, Jhangiani SN, Muzny DM, Rødningen OK, Sheng Y, Nicholas SK, Noroski LM, Seeborg FO, Davis CM, Canter DL, Mace EM, Vece TJ, Allen CE, Abhyankar HA, Boone PM, Beck CR, Wiszniewski W, Fevang B, Aukrust P, Tjønnfjord GE, Gedde-Dahl T, Hjorth-Hansen H, Dybedal I, Nordøy I, Jørgensen SF, Abrahamsen TG, Øverland T, Bechensteen AG, Skogen V, Osnes LTN, Kulseth MA, Prescott TE, Rustad CF, Heimdal KR, Belmont JW, Rider NL, Chinen J, Cao TN, Smith EA, Caldirola MS, Bezrodnik L, Lugo Reyes SO, Espinosa Rosales FJ, Guerrero-Cursaru ND, Pedroza LA, Poli CM, Franco JL, Trujillo Vargas CM, Aldave Becerra JC, Wright N, Issekutz TB, Issekutz AC, Abbott J, Caldwell JW, Bayer DK, Chan AY, Aiuti A, Cancrini C, Holmberg E, West C, Burstedt M, Karaca E, Yesil G, Artac H, Bayram Y, Atik MM, Eldomery MK, Ehlayel MS, Jolles S, Flatø B, Bertuch AA, Hanson IC, Zhang VW, Wong LJ, Hu J, Walkiewicz M, Yang Y, Eng CM, Boerwinkle E, Gibbs RA, Shearer WT, Lyle R, Orange JS, Lupski JR. Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders. The Journal of allergy and clinical immunology 2016. PMID: 27577878


  16. Mohan DM, Kumar P, Mahmood F, Wong KF, Agrawal A, Elgendi M, Shukla R, Ang N, Ching A, Dauwels J, Chan AH. Effect of Subliminal Lexical Priming on the Subjective Perception of Images: A Machine Learning Approach. PloS one 2016. PMID: 26866807


  17. Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM. A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70. The Journal of experimental medicine 2016. PMID: 26783323


  18. Chan AY, Anderson MS. Central tolerance to self revealed by the autoimmune regulator. Annals of the New York Academy of Sciences 2015. PMID: 26579596


  19. Wong EB, Soni C, Chan AY, Domeier PP, Shwetank , Abraham T, Limaye N, Khan TN, Elias MJ, Chodisetti SB, Wakeland EK, Rahman ZS. B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance. Journal of immunology (Baltimore, Md. : 1950) 2015. PMID: 25801429


  20. Punwani D, Wang H, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM. Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation. Journal of clinical immunology 2015. PMID: 25627829


  21. Fong CC, Shi YF, Yu WK, Wei F, van de Merwe JP, Chan AK, Ye R, Au DW, Wu RS, Yang MS. iTRAQ-based proteomic profiling of the marine medaka (Oryzias melastigma) gonad exposed to BDE-47. Marine pollution bulletin 2014. PMID: 24854047


  22. Shin PK, Gopalakrishnan S, Chan AK, Qian PY, Wu RS. Interactive effects of hypoxia and PBDE on larval settlement of a marine benthic polychaete. Marine pollution bulletin 2014. PMID: 24835374


  23. Chan AY, Milojevic D. Treatment of juvenile idiopathic arthritis. Pediatric annals 2012. PMID: 23814934


  24. Chan A, Scalchunes C, Boyle M, Puck JM. Early vs. delayed diagnosis of severe combined immunodeficiency: a family perspective survey. Clinical immunology (Orlando, Fla.) 2010. PMID: 21035402


  25. Jennings P, Chan A, Schwartzberg P, Wakeland EK, Yuan D. Antigen-specific responses and ANA production in B6.Sle1b mice: a role for SAP. Journal of autoimmunity 2008. PMID: 18845419


  26. Chan AY, Westcott JM, Mooney JM, Wakeland EK, Schatzle JD. The role of SAP and the SLAM family in autoimmunity. Current opinion in immunology 2006. PMID: 17011767


  27. Wandstrat AE, Nguyen C, Limaye N, Chan AY, Subramanian S, Tian XH, Yim YS, Pertsemlidis A, Garner HR, Morel L, Wakeland EK. Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity 2004. PMID: 15589166