Arun Rangaswami, MD

I am one of the senior solid tumor faculty at UCSF, having joined the institution in 2019. My scholarly and clinical practice have focused on the treatment of pediatric liver cancers and rare cancers. I was the US National PI for the International Hepatoblastoma therapeutic trials, SIOPEL 4 and SIOPEL 6.I am currently the senior sub-PI for the Hepatocellular Carcinoma treatment arm of the Pediatric Hepatic tumors International Therapeutic Trial (PHITT). I am also the Co-chair of the Children's Hepatic tumors International Collaboration (CHIC), the largest extant database for pediatric rare tumors.
I facilitate an International Hepatobiliary Multicenter Tumor Board, where we consider therapeutic strategies for children with relapsed and refractory liver cancers from around the world, with expert participants from North America, Europe, and Asia.
Education
N/A, 09/1996 - Fellowship, Pediatric Hematology-Oncology, Stanford University
N/A, 07/1993 - Internship & Residency, Pediatrics, St.Louis Children's Hospital
MD, 05/1990 - Medicine, Washington University, St.Louis
BSc,B.BME, 05/1986 - Biology, Biomedical Engineering, Johns Hopkins University

  1. Hiyama E, Hishiki T, Yoshimura K, Krailo M, Maibach R, Haeberle B, Rangaswami A, Lopez-Terrada D, Malogolowkin MH, Ansari M, Alaggio R, O'Neill AF, Trobaugh-Lotrario AD, Watanabe K, Schmid I, Ranganathan S, Tanaka Y, Inoue T, Piao J, Lin J, Czauderna P, Meyers RL, Aronson DC. Upfront or delayed surgery in resectable hepatoblastoma: analysis from the children's hepatic tumors international collaboration database. EClinicalMedicine 2024. PMID: 39309724


  2. Bell A, Rangaswami A, Murphy P, Meng M, Raphael R, Wu N, Goldsby R. Subsequent Renal Cancer Among Childhood Cancer Survivors: Analysis of Surveillance, Epidemiology, and End Results. Journal of pediatric hematology/oncology 2024. PMID: 38934569


  3. Cho SJ, Ranganathan S, Alaggio R, Maibach R, Tanaka Y, Inoue T, Leuschner I, de Krijger R, Vokuhl C, Krailo M, Malogolowkin M, Meyers R, Czauderna P, Hiyama E, Ansari M, Morland B, Trobaugh-Lotrario A, O'Neill AF, Rangaswami A, Häberle B, López-Terrada D. Consensus classification of pediatric hepatocellular tumors: A report from the Children's Hepatic tumors International Collaboration (CHIC). Pediatric blood & cancer 2023. PMID: 37384428


  4. Trobaugh-Lotrario AD, Maibach R, Aronson DC, Rangaswami A, H?berle B, O'Neill AF, Schmid I, Ansari M, Hishiki T, Ranganathan S, Alaggio R, de Krijger RR, Tanaka Y, Cho SJ, Vokuhl C, Maxwell R, Krailo M, Hiyama E, Czauderna P, Finegold M, Feusner JH, Malogolowkin MH, Meyers RL, Lopez-Terrada D. Outcomes of Patients Treated for Hepatoblastoma with Low Alpha-Fetoprotein and/or Small Cell Undifferentiated Histology: A Report from the Children's Hepatic Tumors International Collaboration (CHIC). Cancers 2023. PMID: 36672416


  5. Nelson AT, Harris AK, Watson D, Miniati D, Finch M, Kamihara J, Mitchell SG, Wilson DB, Gettinger K, Rangaswami AA, Campos JM, Lederman S, Feltis BA, Vasta LM, Harney LA, Stewart DR, Dehner LP, Messinger YH, Hill DA, Schultz KAP. Type I and Ir pleuropulmonary blastoma (PPB): A report from the International PPB/DICER1 Registry. Cancer 2022. PMID: 36541021


  6. Schultz KAP, Harris AK, Nelson AT, Watson D, Lucas JT, Miniati D, Stewart DR, Hagedorn KN, Mize W, Kamihara J, Mitchell SG, Wilson DB, Gettinger K, Rangaswami AA, Harney LA, Rodriguez Galindo C, Bisogno G, Dehner LP, Hill DA, Messinger YH. Outcomes for Children With Type II and Type III Pleuropulmonary Blastoma Following Chemotherapy: A Report From the International PPB/DICER1 Registry. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2022. PMID: 36137255


  7. Song H, Bucher S, Rosenberg K, Tsui M, Burhan D, Hoffman D, Cho SJ, Rangaswami A, Breese M, Leung S, Ventura MVP, Sweet-Cordero EA, Huang FW, Nijagal A, Wang B. Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids. Nature communications 2022. PMID: 36008377


  8. Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Panah MJN, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH. Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults. 2022. PMID: 35577029


  9. Weiel JJ, Forgo B, Sage J, Rangaswami A, Hazard FK. The Use of Fluorescence in situ Hybridization to Confirm PRKACA Gene Rearrangement in Fibrolamellar Hepatocellular Carcinoma: A Validation Study. Annals of clinical and laboratory science 2022. PMID: 35777788


  10. Wu PV, Rangaswami A. Current Approaches in Hepatoblastoma-New Biological Insights to Inform Therapy. 2022. PMID: 35438389


  11. Wintering A, Smith S, Fuh B, Rangaswami A, Dahl G, Chien M, Gruber TA, Dang J, Li LS, Lenzen A, Savelli S, Dvorak CC, Agrawal AK, Stieglitz E. Therapy-related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature. 2021. PMID: 34939322


  12. Shah AT, Azad TD, Breese MR, Chabon JJ, Hamilton EG, Straessler K, Kurtz DM, Leung SG, Spillinger A, Liu HY, Behroozfard IH, Wittber FM, Hazard FK, Cho SJ, Daldrup-Link HE, Vo KT, Rangaswami A, Pribnow A, Spunt SL, Lacayo NJ, Diehn M, Alizadeh AA, Sweet-Cordero EA. A comprehensive circulating tumor DNA assay for detection of translocation and copy number changes in pediatric sarcomas. Molecular cancer therapeutics 2021. PMID: 34353895


  13. Hui C, Shin DH, Wakeling A, Donaldson SS, Hazard FK, Rangaswami A, Hiniker SM. Multimodality treatment including whole pleura radiation therapy for DICER1-associated pediatric pleuropulmonary blastoma. Pediatric blood & cancer 2021. PMID: 33751747


  14. Aronson M, Colas C, Shuen A, Hampel H, Foulkes WD, Baris Feldman H, Goldberg Y, Muleris M, Wolfe Schneider K, McGee RB, Jasperson K, Rangaswami A, Brugieres L, Tabori U. Diagnostic criteria for constitutional mismatch repair deficiency (CMMRD): recommendations from the international consensus working group. Journal of medical genetics 2021. PMID: 33622763


  15. Haeberle B, Rangaswami A, Krailo M, Czauderna P, Hiyama E, Maibach R, Lopez-Terrada D, Aronson DC, Alaggio R, Ansari M, Malogolowkin MH, Perilongo G, O'Neill AF, Trobaugh-Lotrario AD, Watanabe K, Schmid I, von Schweinitz D, Ranganathan S, Yoshimura K, Hishiki T, Tanaka Y, Piao J, Feng Y, Rinaldi E, Saraceno D, Derosa M, Meyers RL. The importance of age as prognostic factor for the outcome of patients with hepatoblastoma: Analysis from the Children's Hepatic tumors International Collaboration (CHIC) database. Pediatric blood & cancer 2020. PMID: 32383794


  16. Lim TR, Rangaswami AA, Dubin AM, Kapphahn KI, Sakarovitch C, Long J, Motonaga KS, Trela T, Ceresnak SR. QTc Prolongation and Risk of Torsades de Pointes in Hospitalized Pediatric Oncology Patients. The Journal of pediatrics 2019. PMID: 31761428


  17. Sanders LM, Rangaswami A, Bjork I, Lam DL, Beale HC, Kephart ET, Durbin A, Learned K, Currie R, Lyle AG, Pfeil J, Shah AT, Lee AG, Leung SG, Behroozfard IH, Breese MR, Peralez J, Hazard FK, Lacayo N, Spunt SL, Haussler D, Salama SR, Sweet-Cordero EA, Vaske OM. Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor. Cold Spring Harbor molecular case studies 2019. PMID: 31645344


  18. Vaske OM, Bjork I, Salama SR, Beale H, Tayi Shah A, Sanders L, Pfeil J, Lam DL, Learned K, Durbin A, Kephart ET, Currie R, Newton Y, Swatloski T, McColl D, Vivian J, Zhu J, Lee AG, Leung SG, Spillinger A, Liu HY, Liang WS, Byron SA, Berens ME, Resnick AC, Lacayo N, Spunt SL, Rangaswami A, Huynh V, Torno L, Plant A, Kirov I, Zabokrtsky KB, Rassekh SR, Deyell RJ, Laskin J, Marra MA, Sender LS, Mueller S, Sweet-Cordero EA, Goldstein TC, Haussler D. Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer. JAMA network open 2019. PMID: 31651965


  19. Chen E, Rangaswami A, Esquivel CO, Concepcion W, Lungren M, Thakor AS, Yoo CH, Donaldson SS, Hiniker SM. Orthotopic Liver Transplantation After Stereotactic Body Radiotherapy for Pediatric Hepatocellular Carcinoma with Central Biliary Obstruction and Nodal Involvement. Cureus 2018. PMID: 30648040


  20. Brock PR, Maibach R, Childs M, Rajput K, Roebuck D, Sullivan MJ, Laithier V, Ronghe M, Dall'Igna P, Hiyama E, Brichard B, Skeen J, Mateos ME, Capra M, Rangaswami AA, Ansari M, Rechnitzer C, Veal GJ, Covezzoli A, Brugières L, Perilongo G, Czauderna P, Morland B, Neuwelt EA. Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss. The New England journal of medicine 2018. PMID: 29924955


  21. Weiss KE, Sze DY, Rangaswami AA, Esquivel CO, Concepcion W, Lebowitz EA, Kothary N, Lungren MP. Transarterial chemoembolization in children to treat unresectable hepatocellular carcinoma. Pediatric transplantation 2018. PMID: 29707868


  22. Cooney T, Wei MC, Rangaswami A, Xu L, Sage J, Hazard FK. CD47 is not Over-Expressed in Fibrolamellar Hepatocellular Carcinoma. Annals of clinical and laboratory science 2017. PMID: 28801364


  23. Meyers RL, Maibach R, Hiyama E, Häberle B, Krailo M, Rangaswami A, Aronson DC, Malogolowkin MH, Perilongo G, von Schweinitz D, Ansari M, Lopez-Terrada D, Tanaka Y, Alaggio R, Leuschner I, Hishiki T, Schmid I, Watanabe K, Yoshimura K, Feng Y, Rinaldi E, Saraceno D, Derosa M, Czauderna P. Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration. The Lancet. Oncology 2016. PMID: 27884679


  24. Hiniker SM, Rangaswami A, Lungren MP, Thakor AS, Concepcion W, Balazy KE, Kovalchuk N, Donaldson SS. Stereotactic body radiotherapy for pediatric hepatocellular carcinoma with central biliary obstruction. Pediatric blood & cancer 2016. PMID: 28436210


  25. Louie CY, Concepcion W, Park JK, Rangaswami A, Finegold MJ, Hazard FK. Hepatoblastoma Arising in a Pigmented ß-catenin-activated Hepatocellular Adenoma: Case Report and Review of the Literature. The American journal of surgical pathology 2016. PMID: 27096257


  26. Czauderna P, Haeberle B, Hiyama E, Rangaswami A, Krailo M, Maibach R, Rinaldi E, Feng Y, Aronson D, Malogolowkin M, Yoshimura K, Leuschner I, Lopez-Terrada D, Hishiki T, Perilongo G, von Schweinitz D, Schmid I, Watanabe K, Derosa M, Meyers R. The Children's Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model. European journal of cancer (Oxford, England : 1990) 2015. PMID: 26655560


  27. Ozawa MG, Cooney T, Rangaswami A, Hazard FK. Synchronous Hepatoblastoma, Neuroblastoma, and Cutaneous Capillary Hemangiomas: A Case Report. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2015. PMID: 26368548


  28. Xu L, Hazard FK, Zmoos AF, Jahchan N, Chaib H, Garfin PM, Rangaswami A, Snyder MP, Sage J. Genomic analysis of fibrolamellar hepatocellular carcinoma. Human molecular genetics 2014. PMID: 25122662


  29. Chamberlain LJ, Pineda N, Winestone L, Saynina O, Rangaswami A, Link M, Wise PH. Increased utilization of pediatric specialty care: a population study of pediatric oncology inpatients in California. Journal of pediatric hematology/oncology 2014. PMID: 24517965


  30. Zsiros J, Brugieres L, Brock P, Roebuck D, Maibach R, Zimmermann A, Childs M, Pariente D, Laithier V, Otte JB, Branchereau S, Aronson D, Rangaswami A, Ronghe M, Casanova M, Sullivan M, Morland B, Czauderna P, Perilongo G, International Childhood Liver Tumours Strategy Group (SIOPEL). Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study. The Lancet. Oncology 2013. PMID: 23831416


  31. Chisholm KM, Hsu CH, Kim MJ, Rangaswami A, Gray Hazard FK. Congenital pancreatoblastoma: report of an atypical case and review of the literature. Journal of pediatric hematology/oncology 2012. PMID: 22278199


  32. Cheung AT, Chan MS, Ramanujam S, Rangaswami A, Curl K, Franklin P, Wun T. Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis: computer-assisted intravital microscopy study. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2004. PMID: 15612454


  33. West DC, Andrada E, Azari R, Rangaswami AA, Kuppermann N. Predictors of bacteremia in febrile children with sickle cell disease. Journal of pediatric hematology/oncology 2002. PMID: 11972096


  34. Wun T, Cordoba M, Rangaswami A, Cheung AW, Paglieroni T. Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease. Clinical and laboratory haematology 2002. PMID: 11985552


  35. Williams SS, French JN, Gilbert M, Rangaswami AA, Walleczek J, Knox SJ. Bcl-2 overexpression results in enhanced capacitative calcium entry and resistance to SKF-96365-induced apoptosis. Cancer research 2000. PMID: 10969777


  36. Wun T, Paglieroni T, Rangaswami A, Franklin PH, Welborn J, Cheung A, Tablin F. Platelet activation in patients with sickle cell disease. British journal of haematology 1998. PMID: 9531343