James Bayrer, MD, PhD

As a pediatric gastroenterologist and physician scientist, I am keenly aware of the challenges faced by our pediatric population. The intestinal epithelium comprises the human body’s greatest environmentally exposed surface and is the largest sensory and endocrine organ. My research utilizes human intestinal organoids and animal models to understand how the intestine senses and responds to both regular and inflammatory stimuli. By investigating the molecular pathways involved, we aim to discover new ways to promote intestinal wound healing and modulate the signals contributing to visceral pain syndromes.
M.D., 2007 - School of Medicine, Case Western Reserve University
Ph.D., 2005 - Pharmacology, Case Western Reserve University
Honors and Awards
  • Best of DDW, ACG-CCFA IBD Circle Spotlight, 2015
  • Poster of Distinction, American Gastroenterological Association, DDW, 2015
  • Poster Award, Kenneth Rainin Foundation Innovations Symposium, 2015
  • Young Faculty Investigator Research Award, NASPGHAN, 2015
  • Poster of Distinction, American Gastroenterological Association, DDW, 2014
  • Teaching and Tomorrow Travel Award, NASPGHAN, 2008
  • Outstanding Poster Presentation Award, Lepow Research Day, CWRU, 2005
  • Sigma Xi Award for Poster Presentation, ShowCase, CWRU, 2004
  • President's Award for Outstanding Poster Presentation, Graduate Student Symposium, CWRU, 2003
  • Honors in Chemistry, Claremont McKenna College, 1998
  • Honors in Literature, Claremont McKenna College, 1998
  • Magna cum Laude, Claremont McKenna College, 1998
  • Top Thesis in the Sciences, Joint Science Program, Claremont McKenna College, 1998
  1. A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance.
  2. SPARC - Mapping Gut-Spinal Cord Connections in Visceral Pain.
  3. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
  4. 948 – Nuclear Receptor Liver Receptor Homolog-1 Promotes Intestinal Notch Signaling and Enteroendocrine Cell Development.
  5. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
  6. Advances in Enteric Neurobiology: The "Brain" in the Gut in Health and Disease.
  7. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
  8. 273 - Nuclear Receptor LRH-1 Mitigates Intestinal Inflammatory Disease by Promoting Stem Cell Survival and Directing Normal Epithelial Composition.
  9. Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.
  10. Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology.
  11. Tu1824 Targeting Intestinal Stem Cells to Promote Healing in Inflammatory Bowel Disease.
  12. Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.
  13. Sa1803 Dissecting the Oncogenic Activity of the Nuclear Receptor LRH-1 in the Colon.
  14. Doublesex and the regulation of sexual dimorphism in Drosophila melanogaster: structure, function, and mutagenesis of a female-specific domain.
  15. Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation.
  16. Expression, crystallization and preliminary X-ray characterization of the Drosophila transcription factor Doublesex.