Joseph Sullivan, MD

  1. Sullivan J, Wirrell E, Knupp KG, Chen D, Flamini R, Zafar M, Ventola P, Avendaño J, Wang F, Parkerson KA, Ticho B. Adaptive functioning and neurodevelopment in patients with Dravet syndrome: 12-month interim analysis of the BUTTERFLY observational study. Epilepsy & behavior : E&B 2024. PMID: 38219604


  2. Kim Bishop, Peter Isquith, Kelly Knupp, Joseph Sullivan, Rima Nabbout, Antonio Gil-Nagel, Ingrid Scheffer, Stéphane Auvin, J Helen Cross, Renzo Guerrini, Robert Roth, Gerard Gioia, Amélie Lothe, Shikha Polega. Fenfluramine Treatment Is Associated With Improvement in Everyday Executive Function in Adults With Lennox-Gastaut Syndrome: Post-Hoc Analysis of Dose Effects From a Phase 3 Trial Rationale (P11-1.001). Neurology 2023. PMID:


  3. Kelly G. Knupp, Ingrid E. Scheffer, Berten Ceulemans, Joseph Sullivan, Katherine C. Nickels, Lieven Lagae, Renzo Guerrini, Sameer M. Zuberi, Rima Nabbout, Kate Riney, Shikha Polega, Amélie Lothe, Ronald Davis, Antonio Gil-Nagel. Impact of Fenfluramine on Drop Seizure Frequency in Adults or Dose-Capped Patients With Lennox-Gastaut Syndrome: Comparative Analysis of Clinical Trial Data (S44.002). Neurology 2023. PMID:


  4. Sullivan J, Wirrell E, Knupp KG, Chen D, Zafar M, Flamini R, Stutely J, Brathwaite C, Ventola P, Avenda?o J, Parkerson KA, Wyant N, Ticho B. Interim results of adaptive functioning and neurodevelopment in BUTTERFLY - An observational study of children and adolescents with Dravet syndrome. Epilepsy & behavior : E&B 2022. PMID: 36332561


  5. Sullivan JE. Genetic Testing in Patients With Epilepsy May Impact Treatments and Improve Outcomes. JAMA neurology 2022. PMID: 36315117


  6. Joseph Sullivan, Elaine C Wirrell. Dravet Syndrome as an Example of Precision Medicine in Epilepsy. Epilepsy currents 2022. PMID:


  7. Knupp KG, Scheffer IE, Ceulemans B, Sullivan JE, Nickels KC, Lagae L, Guerrini R, Zuberi SM, Nabbout R, Riney K, Shore S, Agarwal A, Lock M, Farfel GM, Galer BS, Gammaitoni AR, Davis R, Gil-Nagel A. Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial. 2022. PMID: 35499850


  8. Kim Bishop, Peter Isquith, Gerard Giola, Kelly Knupp, Joseph Sullivan, Rima Nabbout, Gail Farfel, Bradley Galer, Arnold Gammaitoni. Fenfluramine Improves Everyday Executive Functioning in Patients With Lennox-Gastaut Syndrome: Analysis of Phase 3 Data (P12-8.004). Neurology 2022. PMID:


  9. Kelly Knupp, Ingrid Scheffer, Berten Ceulemans, Joseph Sullivan, Katherine Nickels, Lieven Lagae, Renzo Guerrini, Sameer M. Zuberi, Rima Nabbout, Kate Riney, Svetlana Shore, Anupam Agarwal, Michael Lock, Gail Farfel, Bradley Galer, Arnold Gammaitoni, Ronald Davis, Antonio Gil-Nagel. Interim Analysis of Long-Term Safety and Efficacy of FINTEPLA (fenfluramine) in Patients with Lennox-Gastaut Syndrome (S13.010). Neurology 2022. PMID:


  10. K. I. Bishop, P. K. Isquith, G. A. Gioia, K. G. Knupp, I. E. Scheffer, J. Sullivan, R. Nabbout, G. Farfel, B. S. Galer, S. Shore, J. Grünert, A. R. Gammaitoni. Fenfluramine Treatment Improves Everyday Executive Functioning in Patients with Lennox-Gastaut Syndrome: Analysis from a Phase 3 Clinical Trial. 2021. PMID:


  11. T. Polster, A. Gammaitoni, J. Sullivan, S. Perry, E. Wirrell, G. Farfel, B. Galer, R. Nabbout. What Magnitude of Reduction Is a “Clinically Meaningful” Change in Seizure Frequency? Analysis of Long-Term Fenfluramine Phase 3 Dravet Syndrome Data. 2021. PMID:


  12. Chiang S, Moss R, Meskis MA, Vogel-Farley V, Sullivan JE, Patel AD, Rao VR. Impact of intellectual and developmental disability on quality-of-life priorities in adults with epilepsy. Epilepsy & behavior : E&B 2021. PMID: 34509036


  13. Danielle M. Andrade, Anne T. Berg, Veronica Hood, Kelly G. Knupp, Sookyong Koh, Linda Laux, Mary Anne Meskis, Ian Miller, M. Scott Perry, Ingrid E. Scheffer, Joseph Sullivan, Nicole Villas, Elaine Wirrell. Dravet syndrome: a quick transition guide for the adult neurologist. Epilepsy research 2021. PMID:


  14. Sullivan J, Simmons R. Fenfluramine for treatment-resistant epilepsy in Dravet syndrome and other genetically mediated epilepsies. Drugs of today (Barcelona, Spain : 1998) 2021. PMID: 34268532


  15. Sullivan J, Helen Cross J. Raising the bar: Fenfluramine sets new treatment standards for Dravet syndrome. Epilepsy & behavior : E&B 2021. PMID: 34058492


  16. J. Sullivan, D. Dlugos, R. Nabbout, D. Haney, G. Morrison, G.M. Farfel, B.S. Galer, A. Gammaitoni. PIH4 NUMBER NEEDED TO TREAT (NNT) WITH FENFLURAMINE TO ACHIEVE A CLINICALLY MEANINGFUL REDUCTION IN CONVULSIVE SEIZURE FREQUENCY IN PATIENTS WITH DRAVET SYNDROME: HEALTH ECONOMIC IMPLICATIONS. Value in Health 2020. PMID:


  17. Joseph Sullivan, Stéphane Auvin, Milka Pringsheim, Kelly Knupp, Elaine Wirrell, Gail Farfel, Bradley Galer, Glenn Morrison, Michael Lock, Arnold Gammaitoni, Elizabeth Thiele. Long-Term (2-Year) Safety and Efficacy of Adjunctive ZX008 (Fenfluramine Hydrochloride Oral Solution) for Dravet Syndrome: Interim Results of an Ongoing Open-Label Extension Study (4684). Neurology 2020. PMID:


  18. Arnold Gammaitoni, Joseph Sullivan, Dennis Dlugos, Gail M. Farfel, Bradley S. Galer, Glenn Morrison, Douglas Haney, Rima Nabbout. Quantifying “Clinically Meaningful Changes” in Seizure Frequency - Data from Three Phase 3 Studies of ZX008 (Fenfluramine Hydrochloride Oral Solution) in Dravet Syndrome: Do Expectations and Views Change Over Time? (2247). Neurology 2020. PMID:


  19. Gonzalez-Giraldo E, Sullivan JE. Advances in the Treatment of Drug-Resistant Pediatric Epilepsy. Seminars in neurology 2020. PMID: 32185791


  20. Berg AT, Wusthoff C, Shellhaas RA, Loddenkemper T, Grinspan ZM, Saneto RP, Knupp KG, Patel A, Sullivan JE, Kossoff EH, Chu CJ, Massey S, Valencia I, Keator C, Wirrell EC, Coryell J, Millichap JJ, Gaillard WD. Immediate outcomes in early life epilepsy: A contemporary account. Epilepsy & behavior : E&B 2019. PMID: 31181428


  21. Vlaskamp DRM, Bassett AS, Sullivan JE, Robblee J, Sadleir LG, Scheffer IE, Andrade DM. Schizophrenia is a later-onset feature of PCDH19 Girls Clustering Epilepsy. Epilepsia 2019. PMID: 30828795


  22. Ziobro J, Eschbach K, Sullivan JE, Knupp KG. Current Treatment Strategies and Future Treatment Options for Dravet Syndrome. Current treatment options in neurology 2018. PMID: 30315507


  23. Coryell J, Gaillard WD, Shellhaas RA, Grinspan ZM, Wirrell EC, Knupp KG, Wusthoff CJ, Keator C, Sullivan JE, Loddenkemper T, Patel A, Chu CJ, Massey S, Novotny EJ, Saneto RP, Berg AT. Neuroimaging of Early Life Epilepsy. Pediatrics 2018. PMID: 30089657


  24. Grinspan ZM, Shellhaas RA, Coryell J, Sullivan JE, Wirrell EC, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ, Millichap J, Berg AT. Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy. JAMA pediatrics 2018. PMID: 29435578


  25. Singhal NS, Numis AL, Lee MB, Chang EF, Sullivan JE, Auguste KI, Rao VR. Responsive neurostimulation for treatment of pediatric drug-resistant epilepsy. Epilepsy & behavior case reports 2018. PMID: 30013930


  26. Berg AT, Chakravorty S, Koh S, Grinspan ZM, Shellhaas RA, Saneto RP, Wirrell EC, Coryell J, Chu CJ, Mytinger JR, Gaillard WD, Valencia I, Knupp KG, Loddenkemper T, Sullivan JE, Poduri A, Millichap JJ, Keator C, Wusthoff C, Ryan N, Dobyns WB, Hegde M. Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms. PloS one 2018. PMID: 29518120


  27. Myers CT, Stong N, Mountier EI, Helbig KL, Freytag S, Sullivan JE, Ben Zeev B, Nissenkorn A, Tzadok M, Heimer G, Shinde DN, Rezazadeh A, Regan BM, Oliver KL, Ernst ME, Lippa NC, Mulhern MS, Ren Z, Poduri A, Andrade DM, Bird LM, Bahlo M, Berkovic SF, Lowenstein DH, Scheffer IE, Sadleir LG, Goldstein DB, Mefford HC, Heinzen EL. De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures. American journal of human genetics 2017. PMID: 28942967


  28. Berg AT, Coryell J, Saneto RP, Grinspan ZM, Alexander JJ, Kekis M, Sullivan JE, Wirrell EC, Shellhaas RA, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Dobyns WB, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ, Koh S. Early-Life Epilepsies and the Emerging Role of Genetic Testing. JAMA pediatrics 2017. PMID: 28759667


  29. Shellhaas RA, Berg AT, Grinspan ZM, Wusthoff CJ, Millichap JJ, Loddenkemper T, Coryell J, Saneto RP, Chu CJ, Joshi SM, Sullivan JE, Knupp KG, Kossoff EH, Keator C, Wirrell EC, Mytinger JR, Valencia I, Massey S, Gaillard WD. Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus. Pediatric neurology 2017. PMID: 28807611


  30. Nilika Shah Singhal, Chellamani Harini, Joseph Sullivan. 68 Epileptic Spasms and Myoclonic Seizures. Swaiman\u0027s Pediatric Neurology 2017. PMID:


  31. Rothman SM, Glass HC, Chang T, Sullivan JE, Bonifacio SL, Shellhaas RA. Risk factors for EEG seizures in neonates treated with hypothermia: a multicenter cohort study. Neurology 2014. PMID: 25367061


  32. Englot DJ, Han SJ, Rolston JD, Ivan ME, Kuperman RA, Chang EF, Gupta N, Sullivan JE, Auguste KI. Epilepsy surgery failure in children: a quantitative and qualitative analysis. Journal of neurosurgery. Pediatrics 2014. PMID: 25127098


  33. Singhal NS, Sullivan JE. Continuous Spike-Wave during Slow Wave Sleep and Related Conditions. ISRN neurology 2014. PMID: 24634784


  34. Numis AL, Angriman M, Sullivan JE, Lewis AJ, Striano P, Nabbout R, Cilio MR. KCNQ2 encephalopathy: delineation of the electroclinical phenotype and treatment response. Neurology 2013. PMID: 24371303


  35. Englot DJ, Rutkowski MJ, Ivan ME, Sun PP, Kuperman RA, Chang EF, Gupta N, Sullivan JE, Auguste KI. Effects of temporal lobectomy on consciousness-impairing and consciousness-sparing seizures in children. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2013. PMID: 23723065


  36. Tsuchida TN, Wusthoff CJ, Shellhaas RA, Abend NS, Hahn CD, Sullivan JE, Nguyen S, Weinstein S, Scher MS, Riviello JJ, Clancy RR, American Clinical Neurophysiology Society Critical Care Monitoring Committee. American clinical neurophysiology society standardized EEG terminology and categorization for the description of continuous EEG monitoring in neonates: report of the American Clinical Neurophysiology Society critical care monitoring committee. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2013. PMID: 23545767


  37. Ortiz-González XR, Poduri A, Roberts CM, Sullivan JE, Marsh ED, Porter BE. Focal cortical dysplasia is more common in boys than in girls. Epilepsy & behavior : E&B 2013. PMID: 23416281


  38. Kendall Nash, Joseph Sullivan. Chapter 56 Myoclonic Seizures and Infantile Spasms. Swaiman\u0027s Pediatric Neurology 2012. PMID:


  39. Glass HC, Hong KJ, Rogers EE, Jeremy RJ, Bonifacio SL, Sullivan JE, Barkovich AJ, Ferriero DM. Risk factors for epilepsy in children with neonatal encephalopathy. Pediatric research 2011. PMID: 21796017


  40. Glass HC, Nash KB, Bonifacio SL, Barkovich AJ, Ferriero DM, Sullivan JE, Cilio MR. Seizures and magnetic resonance imaging-detected brain injury in newborns cooled for hypoxic-ischemic encephalopathy. The Journal of pediatrics 2011. PMID: 21839470


  41. Chang EF, Wang DD, Barkovich AJ, Tihan T, Auguste KI, Sullivan JE, Garcia PA, Barbaro NM. Predictors of seizure freedom after surgery for malformations of cortical development. Annals of neurology 2011. PMID: 21761443


  42. Chang EF, Christie C, Sullivan JE, Garcia PA, Tihan T, Gupta N, Berger MS, Barbaro NM. Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patients. Journal of neurosurgery. Pediatrics 2010. PMID: 20043747


  43. Glass HC, Sullivan JE. Neonatal seizures. Current treatment options in neurology 2009. PMID: 19891904


  44. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey R Bayer, Dennis Dlugos, Richard Lin, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni. RETROSPECTIVE ANALYSIS OF THE PROGNOSTIC VALUE OF ELECTROENCEPHALOGRAPHY PATTERNS OBTAINED IN PEDIATRIC IN-HOSPITAL CARDIAC ARREST SURVIVORS OVER THREE YEARS. Pediatric Critical Care Medicine 2007. PMID:


  45. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey R Bayer, Dennis Dlugos, Richard Lin, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni. RETROSPECTIVE ANALYSIS OF THE PROGNOSTIC VALUE OF ELECTROENCEPHALOGRAPHY PATTERNS OBTAINED IN PEDIATRIC IN-HOSPITAL CARDIAC ARREST SURVIVORS OVER THREE YEARS. Pediatric Critical Care Medicine 2007. PMID:


  46. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey R Bayer, Dennis Dlugos, Richard Lin, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni. RETROSPECTIVE ANALYSIS OF THE PROGNOSTIC VALUE OF ELECTROENCEPHALOGRAPHY PATTERNS OBTAINED IN PEDIATRIC IN-HOSPITAL CARDIAC ARREST SURVIVORS OVER THREE YEARS. Pediatric Critical Care Medicine 2007. PMID:


  47. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey R Bayer, Dennis Dlugos, Richard Lin, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni. RETROSPECTIVE ANALYSIS OF THE PROGNOSTIC VALUE OF ELECTROENCEPHALOGRAPHY PATTERNS OBTAINED IN PEDIATRIC IN-HOSPITAL CARDIAC ARREST SURVIVORS OVER THREE YEARS. Pediatric Critical Care Medicine 2007. PMID:


  48. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey R Bayer, Dennis Dlugos, Richard Lin, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni. Retrospective analysis of the prognostic value of electroencephalography patterns obtained in pediatric in-hospital cardiac arrest survivors over three years. Pediatric Critical Care Medicine 2007. PMID:


  49. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey R. Bayer, Dennis Dlugos, Richard Lin, Rebecca Ichord, Mark A. Helfaer, Vinay Nadkarni. Retrospective analysis of the prognostic value of electroencephalography patterns obtained in pediatric in-hospital cardiac arrest survivors during three years*. Pediatric Critical Care Medicine 2006. PMID:


  50. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey Bayer, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni. HYPOCAPNEA IMMEDIATELY AFTER ROSC IS ASSOCIATED WITH GOOD NEUROLOGIC OUTCOME IN PEDIATRIC IN-HOSPITAL CARDIAC ARREST. Pediatric Critical Care Medicine 2006. PMID:


  51. Akira Nishisaki, Carey Roth Bayer, Troy Dominguez, Richard Lin, Mark A Helfaer, Vinay Nadkarni, Joseph E Sullivan, Rebecca Ichord, Bernhard Steger. ELECTROENCEPHALOGRAPHY(EEG) HAS PROGNOSTIC VALUE FOR NEUROLOGIC OUTCOME IN CHILDREN SURVIVING > 24 HOURS AFTER IN-HOSPITAL CARDIAC ARREST(CA). Critical care medicine 2005. PMID:


  52. Akira Nishisaki, Joseph Sullivan, Bernhard Stegher, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni, Naoki Shimizu, Katsuyuki Miyasaka. A TALE OF TWO CITIES: TIMING OF BRAIN IMAGING AND NEUROPHYSIOLOGIC ASSESSMENTS FOLLOWING IN-HOSPITAL PEDIATRIC CARDIAC ARREST. Critical care medicine 2004. PMID:


  53. Sullivan JE, Dlugos DJ. Idiopathic Generalized Epilepsy. Current treatment options in neurology 2004. PMID: 15043806