Joseph Sullivan, MD

  1. Rejena Ameen, Elaine Wirrell, Joseph Sullivan, Travis Zuroske, Devon Grochowski, Shalini Gupta, Rebecca Zhang-Roper, Amélie Lothe, Wesley Kerr. A Retrospective Claims Study Evaluating Mortality in Patients With Lennox-Gastaut or Dravet Syndromes in the United States (P8-11.004). Neurology 2025. PMID:


  2. Rima Nabbout, Joseph Sullivan, Stéphane Auvin, Berten Ceulemans, J Helen Cross, Orrin Devinsky, Antonio Gil-Nagel, Renzo Guerrini, Kelly Knupp, M Scott Perry, Rocio Sanchez-Carpintero, Ingrid Scheffer, Nicola Specchio, Adam Strzelczyk, James Wheless, Elaine Wirrell, Diego Morita, Mélanie Langlois, Patrick Healy, Amélie Lothe, Lieven Lagae. A Stratified Analysis of Efficacy and Safety of Fenfluramine in Patients With Dravet Syndrome (P8-9.014). Neurology 2025. PMID:


  3. Rima Nabbout, Kelly Knupp, Lieven Lagae, J Helen Cross, Joseph Sullivan, Antonio Gil-Nagel, Renzo Guerrini, Adam Strzelczyk, Mélanie Langlois, Patrick Healy, Amélie Lothe, Ingrid Scheffer. Impact of Fenfluramine on Convulsive Seizure Frequency in Dose-Capped Patients With Dravet Syndrome (P8-9.015). Neurology 2025. PMID:


  4. Samden Lhatoo, Wesley Kerr, Elaine Wirrell, Elizabeth Donner, Joseph Sullivan, Renzo Guerrini, Ingrid Scheffer, Sylvain Rheims, J Helen Cross, Lieven Lagae, Philippe Ryvlin, Antonio Gil-Nagel, Jeffrey Noebels, Jenna Roberts, Amélie Lothe, Milena Tryfon, Michael Rañopa, Orrin Devinsky. Real-World Use of Fenfluramine for Dravet Syndrome: a Retrospective Cohort Study Using a National Pharmacy Database (P12-9.002). Neurology 2025. PMID:


  5. Kelly Knupp, Ingrid Scheffer, Berten Ceulemans, Joseph Sullivan, Katherine Nickels, Lieven Lagae, Renzo Guerrini, Sameer Zuberi, Rima Nabbout, Kate Riney, Michael Lock, David Dai, Ronald Davis, Diego Morita, Amélie Lothe, Mélanie Langlois, Rebecca Zhang-Roper, Timothy Minh, Antonio Gil-Nagel. Safety and Effectiveness of Fenfluramine for the Treatment of Seizures in Lennox-Gastaut Syndrome: Results From the Final Analysis of an Open-Label Extension Study (P8-9.002). Neurology 2025. PMID:


  6. Rejena Ameen, Joseph Sullivan, Elaine Wirrell, Amelia Boehme, Rebecca Zhang-Roper, Patrick Healy, Amélie Lothe, Wesley Kerr. Understanding the Incidence, Prevalence, Characteristics, and Healthcare Resource Utilization for Patients With Dravet and Lennox-Gastaut Syndromes (P8-11.003). Neurology 2025. PMID:


  7. Mahmood N, Gonzalez-Giraldo E, Sullivan JE. Pulseless Electrical Activity Arrest Presenting as Tonic Arm Stiffening and a Flat Electroencephalogram. The Neurohospitalist 2024. PMID: 39308465


  8. Sullivan J, Wirrell E, Knupp KG, Chen D, Flamini R, Zafar M, Ventola P, Avendaño J, Wang F, Parkerson KA, Ticho B. Adaptive functioning and neurodevelopment in patients with Dravet syndrome: 12-month interim analysis of the BUTTERFLY observational study. Epilepsy & behavior : E&B 2024. PMID: 38219604


  9. Kim Bishop, Peter Isquith, Kelly Knupp, Joseph Sullivan, Rima Nabbout, Antonio Gil-Nagel, Ingrid Scheffer, Stéphane Auvin, J Helen Cross, Renzo Guerrini, Robert Roth, Gerard Gioia, Amélie Lothe, Shikha Polega. Fenfluramine Treatment Is Associated With Improvement in Everyday Executive Function in Adults With Lennox-Gastaut Syndrome: Post-Hoc Analysis of Dose Effects From a Phase 3 Trial Rationale (P11-1.001). Neurology 2023. PMID:


  10. Kelly G. Knupp, Ingrid E. Scheffer, Berten Ceulemans, Joseph Sullivan, Katherine C. Nickels, Lieven Lagae, Renzo Guerrini, Sameer M. Zuberi, Rima Nabbout, Kate Riney, Shikha Polega, Amélie Lothe, Ronald Davis, Antonio Gil-Nagel. Impact of Fenfluramine on Drop Seizure Frequency in Adults or Dose-Capped Patients With Lennox-Gastaut Syndrome: Comparative Analysis of Clinical Trial Data (S44.002). Neurology 2023. PMID:


  11. Lai GY, Phelps RRL, Singhal NS, Sullivan JE, Numis AL, Auguste KI. The "Canopy Approach": Case Series Using Immersive Virtual Reality for Bottom-Up Target-Based Preoperative Planning in Pediatric Neurosurgery. Neurosurgery practice 2023. PMID: 39958370


  12. Sullivan JE. Genetic Testing in Patients With Epilepsy May Impact Treatments and Improve Outcomes. JAMA neurology 2022. PMID: 36315117


  13. Sullivan J, Wirrell E, Knupp KG, Chen D, Zafar M, Flamini R, Stutely J, Brathwaite C, Ventola P, Avenda?o J, Parkerson KA, Wyant N, Ticho B. Interim results of adaptive functioning and neurodevelopment in BUTTERFLY - An observational study of children and adolescents with Dravet syndrome. Epilepsy & behavior : E&B 2022. PMID: 36332561


  14. Joseph Sullivan, Elaine C Wirrell. Dravet Syndrome as an Example of Precision Medicine in Epilepsy. Epilepsy currents 2022. PMID:


  15. Knupp KG, Scheffer IE, Ceulemans B, Sullivan JE, Nickels KC, Lagae L, Guerrini R, Zuberi SM, Nabbout R, Riney K, Shore S, Agarwal A, Lock M, Farfel GM, Galer BS, Gammaitoni AR, Davis R, Gil-Nagel A. Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial. 2022. PMID: 35499850


  16. Kim Bishop, Peter Isquith, Gerard Giola, Kelly Knupp, Joseph Sullivan, Rima Nabbout, Gail Farfel, Bradley Galer, Arnold Gammaitoni. Fenfluramine Improves Everyday Executive Functioning in Patients With Lennox-Gastaut Syndrome: Analysis of Phase 3 Data (P12-8.004). Neurology 2022. PMID:


  17. Kelly Knupp, Ingrid Scheffer, Berten Ceulemans, Joseph Sullivan, Katherine Nickels, Lieven Lagae, Renzo Guerrini, Sameer M. Zuberi, Rima Nabbout, Kate Riney, Svetlana Shore, Anupam Agarwal, Michael Lock, Gail Farfel, Bradley Galer, Arnold Gammaitoni, Ronald Davis, Antonio Gil-Nagel. Interim Analysis of Long-Term Safety and Efficacy of FINTEPLA (fenfluramine) in Patients with Lennox-Gastaut Syndrome (S13.010). Neurology 2022. PMID:


  18. K. I. Bishop, P. K. Isquith, G. A. Gioia, K. G. Knupp, I. E. Scheffer, J. Sullivan, R. Nabbout, G. Farfel, B. S. Galer, S. Shore, J. Grünert, A. R. Gammaitoni. Fenfluramine Treatment Improves Everyday Executive Functioning in Patients with Lennox-Gastaut Syndrome: Analysis from a Phase 3 Clinical Trial. 2021. PMID:


  19. T. Polster, A. Gammaitoni, J. Sullivan, S. Perry, E. Wirrell, G. Farfel, B. Galer, R. Nabbout. What Magnitude of Reduction Is a “Clinically Meaningful” Change in Seizure Frequency? Analysis of Long-Term Fenfluramine Phase 3 Dravet Syndrome Data. 2021. PMID:


  20. Chiang S, Moss R, Meskis MA, Vogel-Farley V, Sullivan JE, Patel AD, Rao VR. Impact of intellectual and developmental disability on quality-of-life priorities in adults with epilepsy. Epilepsy & behavior : E&B 2021. PMID: 34509036


  21. Danielle M. Andrade, Anne T. Berg, Veronica Hood, Kelly G. Knupp, Sookyong Koh, Linda Laux, Mary Anne Meskis, Ian Miller, M. Scott Perry, Ingrid E. Scheffer, Joseph Sullivan, Nicole Villas, Elaine Wirrell. Dravet syndrome: a quick transition guide for the adult neurologist. Epilepsy research 2021. PMID:


  22. Sullivan J, Simmons R. Fenfluramine for treatment-resistant epilepsy in Dravet syndrome and other genetically mediated epilepsies. Drugs of today (Barcelona, Spain : 1998) 2021. PMID: 34268532


  23. Sullivan J, Helen Cross J. Raising the bar: Fenfluramine sets new treatment standards for Dravet syndrome. Epilepsy & behavior : E&B 2021. PMID: 34058492


  24. J. Sullivan, D. Dlugos, R. Nabbout, D. Haney, G. Morrison, G.M. Farfel, B.S. Galer, A. Gammaitoni. PIH4 NUMBER NEEDED TO TREAT (NNT) WITH FENFLURAMINE TO ACHIEVE A CLINICALLY MEANINGFUL REDUCTION IN CONVULSIVE SEIZURE FREQUENCY IN PATIENTS WITH DRAVET SYNDROME: HEALTH ECONOMIC IMPLICATIONS. Value in Health 2020. PMID:


  25. Joseph Sullivan, Stéphane Auvin, Milka Pringsheim, Kelly Knupp, Elaine Wirrell, Gail Farfel, Bradley Galer, Glenn Morrison, Michael Lock, Arnold Gammaitoni, Elizabeth Thiele. Long-Term (2-Year) Safety and Efficacy of Adjunctive ZX008 (Fenfluramine Hydrochloride Oral Solution) for Dravet Syndrome: Interim Results of an Ongoing Open-Label Extension Study (4684). Neurology 2020. PMID:


  26. Arnold Gammaitoni, Joseph Sullivan, Dennis Dlugos, Gail M. Farfel, Bradley S. Galer, Glenn Morrison, Douglas Haney, Rima Nabbout. Quantifying “Clinically Meaningful Changes” in Seizure Frequency - Data from Three Phase 3 Studies of ZX008 (Fenfluramine Hydrochloride Oral Solution) in Dravet Syndrome: Do Expectations and Views Change Over Time? (2247). Neurology 2020. PMID:


  27. Gonzalez-Giraldo E, Sullivan JE. Advances in the Treatment of Drug-Resistant Pediatric Epilepsy. Seminars in neurology 2020. PMID: 32185791


  28. Berg AT, Wusthoff C, Shellhaas RA, Loddenkemper T, Grinspan ZM, Saneto RP, Knupp KG, Patel A, Sullivan JE, Kossoff EH, Chu CJ, Massey S, Valencia I, Keator C, Wirrell EC, Coryell J, Millichap JJ, Gaillard WD. Immediate outcomes in early life epilepsy: A contemporary account. Epilepsy & behavior : E&B 2019. PMID: 31181428


  29. Vlaskamp DRM, Bassett AS, Sullivan JE, Robblee J, Sadleir LG, Scheffer IE, Andrade DM. Schizophrenia is a later-onset feature of PCDH19 Girls Clustering Epilepsy. Epilepsia 2019. PMID: 30828795


  30. Ziobro J, Eschbach K, Sullivan JE, Knupp KG. Current Treatment Strategies and Future Treatment Options for Dravet Syndrome. Current treatment options in neurology 2018. PMID: 30315507


  31. Coryell J, Gaillard WD, Shellhaas RA, Grinspan ZM, Wirrell EC, Knupp KG, Wusthoff CJ, Keator C, Sullivan JE, Loddenkemper T, Patel A, Chu CJ, Massey S, Novotny EJ, Saneto RP, Berg AT. Neuroimaging of Early Life Epilepsy. Pediatrics 2018. PMID: 30089657


  32. Grinspan ZM, Shellhaas RA, Coryell J, Sullivan JE, Wirrell EC, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ, Millichap J, Berg AT. Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy. JAMA pediatrics 2018. PMID: 29435578


  33. Singhal NS, Numis AL, Lee MB, Chang EF, Sullivan JE, Auguste KI, Rao VR. Responsive neurostimulation for treatment of pediatric drug-resistant epilepsy. Epilepsy & behavior case reports 2018. PMID: 30013930


  34. Berg AT, Chakravorty S, Koh S, Grinspan ZM, Shellhaas RA, Saneto RP, Wirrell EC, Coryell J, Chu CJ, Mytinger JR, Gaillard WD, Valencia I, Knupp KG, Loddenkemper T, Sullivan JE, Poduri A, Millichap JJ, Keator C, Wusthoff C, Ryan N, Dobyns WB, Hegde M. Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms. PloS one 2018. PMID: 29518120


  35. Myers CT, Stong N, Mountier EI, Helbig KL, Freytag S, Sullivan JE, Ben Zeev B, Nissenkorn A, Tzadok M, Heimer G, Shinde DN, Rezazadeh A, Regan BM, Oliver KL, Ernst ME, Lippa NC, Mulhern MS, Ren Z, Poduri A, Andrade DM, Bird LM, Bahlo M, Berkovic SF, Lowenstein DH, Scheffer IE, Sadleir LG, Goldstein DB, Mefford HC, Heinzen EL. De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures. American journal of human genetics 2017. PMID: 28942967


  36. Berg AT, Coryell J, Saneto RP, Grinspan ZM, Alexander JJ, Kekis M, Sullivan JE, Wirrell EC, Shellhaas RA, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Dobyns WB, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ, Koh S. Early-Life Epilepsies and the Emerging Role of Genetic Testing. JAMA pediatrics 2017. PMID: 28759667


  37. Shellhaas RA, Berg AT, Grinspan ZM, Wusthoff CJ, Millichap JJ, Loddenkemper T, Coryell J, Saneto RP, Chu CJ, Joshi SM, Sullivan JE, Knupp KG, Kossoff EH, Keator C, Wirrell EC, Mytinger JR, Valencia I, Massey S, Gaillard WD. Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus. Pediatric neurology 2017. PMID: 28807611


  38. Jaakko Lappalainen, Michael Chez, Joseph Sullivan, Jozef Gecz, Nicola Specchio, Albena Patroneva. A multicenter, open-label trial of ganaxolone in children with PCDH19 epilepsy (P5.236). Neurology 2017. PMID:


  39. Nilika Shah Singhal, Chellamani Harini, Joseph Sullivan. 68 Epileptic Spasms and Myoclonic Seizures. Swaiman\u0027s Pediatric Neurology 2017. PMID:


  40. Rothman SM, Glass HC, Chang T, Sullivan JE, Bonifacio SL, Shellhaas RA. Risk factors for EEG seizures in neonates treated with hypothermia: a multicenter cohort study. Neurology 2014. PMID: 25367061


  41. Englot DJ, Han SJ, Rolston JD, Ivan ME, Kuperman RA, Chang EF, Gupta N, Sullivan JE, Auguste KI. Epilepsy surgery failure in children: a quantitative and qualitative analysis. Journal of neurosurgery. Pediatrics 2014. PMID: 25127098


  42. Singhal NS, Sullivan JE. Continuous Spike-Wave during Slow Wave Sleep and Related Conditions. ISRN neurology 2014. PMID: 24634784


  43. Numis AL, Angriman M, Sullivan JE, Lewis AJ, Striano P, Nabbout R, Cilio MR. KCNQ2 encephalopathy: delineation of the electroclinical phenotype and treatment response. Neurology 2013. PMID: 24371303


  44. Englot DJ, Rutkowski MJ, Ivan ME, Sun PP, Kuperman RA, Chang EF, Gupta N, Sullivan JE, Auguste KI. Effects of temporal lobectomy on consciousness-impairing and consciousness-sparing seizures in children. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2013. PMID: 23723065


  45. Tsuchida TN, Wusthoff CJ, Shellhaas RA, Abend NS, Hahn CD, Sullivan JE, Nguyen S, Weinstein S, Scher MS, Riviello JJ, Clancy RR, American Clinical Neurophysiology Society Critical Care Monitoring Committee. American clinical neurophysiology society standardized EEG terminology and categorization for the description of continuous EEG monitoring in neonates: report of the American Clinical Neurophysiology Society critical care monitoring committee. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2013. PMID: 23545767


  46. Ortiz-González XR, Poduri A, Roberts CM, Sullivan JE, Marsh ED, Porter BE. Focal cortical dysplasia is more common in boys than in girls. Epilepsy & behavior : E&B 2013. PMID: 23416281


  47. Kendall Nash, Joseph Sullivan. Chapter 56 Myoclonic Seizures and Infantile Spasms. Swaiman\u0027s Pediatric Neurology 2012. PMID:


  48. Glass HC, Hong KJ, Rogers EE, Jeremy RJ, Bonifacio SL, Sullivan JE, Barkovich AJ, Ferriero DM. Risk factors for epilepsy in children with neonatal encephalopathy. Pediatric research 2011. PMID: 21796017


  49. Glass HC, Nash KB, Bonifacio SL, Barkovich AJ, Ferriero DM, Sullivan JE, Cilio MR. Seizures and magnetic resonance imaging-detected brain injury in newborns cooled for hypoxic-ischemic encephalopathy. The Journal of pediatrics 2011. PMID: 21839470


  50. Chang EF, Wang DD, Barkovich AJ, Tihan T, Auguste KI, Sullivan JE, Garcia PA, Barbaro NM. Predictors of seizure freedom after surgery for malformations of cortical development. Annals of neurology 2011. PMID: 21761443


  51. Chang EF, Christie C, Sullivan JE, Garcia PA, Tihan T, Gupta N, Berger MS, Barbaro NM. Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patients. Journal of neurosurgery. Pediatrics 2010. PMID: 20043747


  52. Glass HC, Sullivan JE. Neonatal seizures. Current treatment options in neurology 2009. PMID: 19891904


  53. Sullivan JE, Corcoran-Donnelly M, Dlugos DJ. Challenges in pediatric video-EEG monitoring. American journal of electroneurodiagnostic technology 2007. PMID: 17679580


  54. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey R Bayer, Dennis Dlugos, Richard Lin, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni. RETROSPECTIVE ANALYSIS OF THE PROGNOSTIC VALUE OF ELECTROENCEPHALOGRAPHY PATTERNS OBTAINED IN PEDIATRIC IN-HOSPITAL CARDIAC ARREST SURVIVORS OVER THREE YEARS. Pediatric Critical Care Medicine 2007. PMID:


  55. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey R Bayer, Dennis Dlugos, Richard Lin, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni. RETROSPECTIVE ANALYSIS OF THE PROGNOSTIC VALUE OF ELECTROENCEPHALOGRAPHY PATTERNS OBTAINED IN PEDIATRIC IN-HOSPITAL CARDIAC ARREST SURVIVORS OVER THREE YEARS. Pediatric Critical Care Medicine 2007. PMID:


  56. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey R Bayer, Dennis Dlugos, Richard Lin, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni. RETROSPECTIVE ANALYSIS OF THE PROGNOSTIC VALUE OF ELECTROENCEPHALOGRAPHY PATTERNS OBTAINED IN PEDIATRIC IN-HOSPITAL CARDIAC ARREST SURVIVORS OVER THREE YEARS. Pediatric Critical Care Medicine 2007. PMID:


  57. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey R Bayer, Dennis Dlugos, Richard Lin, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni. RETROSPECTIVE ANALYSIS OF THE PROGNOSTIC VALUE OF ELECTROENCEPHALOGRAPHY PATTERNS OBTAINED IN PEDIATRIC IN-HOSPITAL CARDIAC ARREST SURVIVORS OVER THREE YEARS. Pediatric Critical Care Medicine 2007. PMID:


  58. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey R Bayer, Dennis Dlugos, Richard Lin, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni. Retrospective analysis of the prognostic value of electroencephalography patterns obtained in pediatric in-hospital cardiac arrest survivors over three years. Pediatric Critical Care Medicine 2007. PMID:


  59. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey R. Bayer, Dennis Dlugos, Richard Lin, Rebecca Ichord, Mark A. Helfaer, Vinay Nadkarni. Retrospective analysis of the prognostic value of electroencephalography patterns obtained in pediatric in-hospital cardiac arrest survivors during three years*. Pediatric Critical Care Medicine 2006. PMID:


  60. Akira Nishisaki, Joseph Sullivan, Bernhard Steger, Carey Bayer, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni. HYPOCAPNEA IMMEDIATELY AFTER ROSC IS ASSOCIATED WITH GOOD NEUROLOGIC OUTCOME IN PEDIATRIC IN-HOSPITAL CARDIAC ARREST. Pediatric Critical Care Medicine 2006. PMID:


  61. Akira Nishisaki, Carey Roth Bayer, Troy Dominguez, Richard Lin, Mark A Helfaer, Vinay Nadkarni, Joseph E Sullivan, Rebecca Ichord, Bernhard Steger. ELECTROENCEPHALOGRAPHY(EEG) HAS PROGNOSTIC VALUE FOR NEUROLOGIC OUTCOME IN CHILDREN SURVIVING > 24 HOURS AFTER IN-HOSPITAL CARDIAC ARREST(CA). Critical care medicine 2005. PMID:


  62. Sullivan JE, Dlugos DJ. Antiepileptic drug monotherapy: pediatric concerns. Seminars in pediatric neurology 2005. PMID: 16114174


  63. Akira Nishisaki, Joseph Sullivan, Bernhard Stegher, Rebecca Ichord, Mark A Helfaer, Vinay Nadkarni, Naoki Shimizu, Katsuyuki Miyasaka. A TALE OF TWO CITIES: TIMING OF BRAIN IMAGING AND NEUROPHYSIOLOGIC ASSESSMENTS FOLLOWING IN-HOSPITAL PEDIATRIC CARDIAC ARREST. Critical care medicine 2004. PMID:


  64. Sullivan JE, Dlugos DJ. Idiopathic Generalized Epilepsy. Current treatment options in neurology 2004. PMID: 15043806