Julie Saba, MD, PhD

physician-scientist
(she/her/hers)

Sphingosine-1-phosphate (S1P) is a bioactive lipid that plays important roles in development, vascular biology, immune cell trafficking, carcinogenesis and other physiological processes. S1P mediates its actions primarily by signaling through a family of G protein-coupled receptors. Our research group is investigating the role of S1P metabolism and signaling in development and disease using cellular and animal models, translational approaches and metabolomics profiling. Our recent findings demonstrate that defects in S1P metabolism underlie a novel childhood syndrome called sphingosine phosphate lyase insufficiency syndrome (SPLIS), which is characterized by defects of kidney, adrenal gland, neurological system, skin and immune system. We are now developing several therapeutic approaches to the treatment of SPLIS including gene therapy and cofactor supplementation.
Education
10/2020 - Diversity, Equity, and Inclusion Champion Training, University of California
Ph.D., 05/1996 - Biochemistry/Cell Biology, Duke University
Pediatric Fellowship, 07/1993 - Hematology/Oncology, Duke University Medical Center
Residency, 07/1989 - Pediatrics, Duke University Medical Center
M.A., 05/1986 - Creative Writing, Johns Hopkins University
M.D., 05/1985 - Medicine, University of Maryland School of Medicine
B.S., 05/1981 - Natural Sciences, Johns Hopkins University
Honors and Awards
  • Eli Lilly Genetic Medicine Grand Challenge Winner, Eli Lilly / Nucleate, 2023
  • Nucleate Pillar Venture Prize, Pillar VC / Nucleate, 2023
  • Director, Swim Across America National Laboratory, Children's Hospital and Research Center Oakland, 2015
  • John and Edna Beck Chair in Pediatric Cancer Research, Children's Hospital and Research Center Oakland, 2012
  • American Society of Clinical Investigation member, ASCI, 2006

  1. Gharagozlou S, Wright NM, Murguila-Favela L, Eshleman J, Midgley J, Saygili S, Mathew G, Lesmana H, Makkoukdji N, Gans M, Saba JD. Sphingosine phosphate lyase insufficiency syndrome as a primary immunodeficiency state. Advances in biological regulation 2024. PMID: 39454238


  2. Keller N, Midgley J, Khalid E, Lesmana H, Mathew G, Mincham C, Teig N, Khan Z, Khosla I, Mehr S, Guran T, Buder K, Xu H, Alhasan K, Buyukyilmaz G, Weaver N, Saba JD. Factors influencing survival in sphingosine phosphate lyase insufficiency syndrome: a retrospective cross-sectional natural history study of 76 patients. Orphanet journal of rare diseases 2024. PMID: 39334450


  3. Arcuschin CD, Kahrizi K, Sayaman RW, DiBenedetto C, Shen Y, Salaberry PJ, Zakroui O, Schwarzer C, Scapozza A, Betancur P, Saba JD, Coppé JP, Barcellos-Hoff MH, Kappes D, van 't Veer L, Schor IE, Muñoz DP. Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4 + cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype. bioRxiv : the preprint server for biology 2024. PMID: 39386673


  4. C. Costantini, E. Camaioni, G. Pampalone, M. Dindo, M. Pariano, C. Stincardini, R. Galarini, F. Paoletti, R. Ronchetti, S. Giovagnoli, J. Saba, L. Romani, B. Cellini. 109 Chemical development of dual species–host and Aspergillus fumigatus–sphingosine-1-phosphate lyase inhibitors as therapeutic strategy in cystic fibrosis. Journal of Cystic Fibrosis 2024. PMID:


  5. Carniglia L, Turati J, Saba J, López Couselo F, Romero AC, Caruso C, Durand D, Lasaga M. Melanocortin-receptor 4 activation modulates proliferation and differentiation of rat postnatal hippocampal neural precursor cells. Neuropharmacology 2024. PMID: 38960135


  6. Tang Y, Majewska M, Leß B, Mehmeti I, Wollnitzke P, Semleit N, Levkau B, Saba JD, van Echten-Deckert G, Gurgul-Convey E. The fate of intracellular S1P regulates lipid droplet turnover and lipotoxicity in pancreatic beta-cells. Journal of lipid research 2024. PMID: 38950680


  7. Oskouian B, Lee JY, Asgharzadeh S, Khan R, Zhang M, Weisbrod JR, Choi YJ, Puri L, Aguilar AE, Zhao P, Saba JD. AF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis. Oncogene 2024. PMID: 38413795


  8. Bhattacharyya A, Khan R, Lee JY, Tassew G, Oskouian B, Allende ML, Proia RL, Yin X, Ortega JG, Bhattacharya M, Saba JD. Gene therapy with AAV9-SGPL1 in an animal model of lung fibrosis. The Journal of pathology 2024. PMID: 38332723


  9. Joni C. Sedillo, Chansonette Badduke, Steven J. Schrodi, Vinod Scaria, Onur Emre Onat, Majid Alfadhel, Carole Ober, William Wentworth-Sheilds, Robert D. Steiner, Julie D. Saba. Prevalence estimate of sphingosine phosphate lyase insufficiency syndrome in worldwide and select populations. Genetics in Medicine Open 2024. PMID:


  10. Khan R, Oskouian B, Lee JY, Hodgin JB, Yang Y, Tassew G, Saba JD. AAV-SPL 2.0, a Modified Adeno-Associated Virus Gene Therapy Agent for the Treatment of Sphingosine Phosphate Lyase Insufficiency Syndrome. International journal of molecular sciences 2023. PMID: 37958544


  11. C. Costantini, G. Pampalone, M. Pariano, T. Zelante, L. Macchioni, R. Galarini, E. Camaioni, F. Paoletti, F. Catalano, M. Davidescu, C. Stincardini, M. Bellet, J. Saba, G. Giardina, S. Giovagnoli, B. Cellini, L. Romani. 148 Exploring dual targeting of host and microbial sphingosine-1-phosphate lyase as antimicrobial strategy in cystic fibrosis. Journal of Cystic Fibrosis 2023. PMID:


  12. Pournasiri Z, Madani A, Nazarpack F, Sayer JA, Chavoshzadeh Z, Nili F, Tran P, Saba JD, Jamee M. Sphingosine phosphate lyase insufficiency syndrome: a systematic review. World journal of pediatrics : WJP 2022. PMID: 36371483


  13. Atreya KB, Saba JD. Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency. Frontiers in cellular neuroscience 2022. PMID: 36187293


  14. De la Garza-Rodea AS, Moore SA, Zamora-Pineda J, Hoffman EP, Mistry K, Kumar A, Strober JB, Zhao P, Suh JH, Saba JD. Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice. International journal of molecular sciences 2022. PMID: 35886926


  15. Wolf JJ, Saba JD, Hahm B. Analyzing Opposing Interactions Between Sphingosine 1-Phosphate Lyase and Influenza A Virus. 2022. PMID: 35325556


  16. C. Costantini, M. Pariano, G. Pampalone, T. Zelante, L. Macchioni, R. Galarini, E. Costanzi, M. Bellet, S. Giovagnoli, J. Saba, B. Cellini, L. Romani. 521: Dual targeting of host and fungal sphingosine-1-phosphate lyase as antifungal strategy in cystic fibrosis. Journal of Cystic Fibrosis 2021. PMID:


  17. Spohner AK, Jakobi K, Trautmann S, Thomas D, Schumacher F, Kleuser B, Lütjohann D, El-Hindi K, Grösch S, Pfeilschifter J, Saba JD, Meyer Zu Heringdorf D. Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile. 2021. PMID: 34638955


  18. Saba JD, Keller N, Wang JY, Tang F, Slavin A, Shen Y. Genotype/Phenotype Interactions and First Steps Toward Targeted Therapy for Sphingosine Phosphate Lyase Insufficiency Syndrome. 2021. PMID: 34133011


  19. Zhao P, Tassew GB, Lee JY, Oskouian B, Muñoz DP, Hodgin JB, Watson GL, Tang F, Wang JY, Luo J, Yang Y, King S, Krauss RM, Keller N, Saba JD. Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome. 2021. PMID: 33755599


  20. Martin KW, Weaver N, Alhasan K, Gumus E, Sullivan BR, Zenker M, Hildebrandt F, Saba JD. MRI Spectrum of Brain Involvement in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome. 2020. PMID: 32855188


  21. Zhao P, Liu ID, Hodgin JB, Benke PI, Selva J, Torta F, Wenk MR, Endrizzi JA, West O, Ou W, Tang E, Goh DL, Tay SK, Yap HK, Loh A, Weaver N, Sullivan B, Larson A, Cooper MA, Alhasan K, Alangari AA, Salim S, Gumus E, Chen K, Zenker M, Hildebrandt F, Saba JD. Responsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation. 2020. PMID: 32233035


  22. Zhao P, Aguilar AE, Lee JY, Paul LA, Suh JH, Puri L, Zhang M, Beckstead J, Witkowski A, Ryan RO, Saba JD. Correction to: Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway. 2019. PMID: 31032525


  23. Durand D, Turati J, Rudi MJ, Ramírez D, Saba J, Caruso C, Carniglia L, von Bernhardi R, Lasaga M. Unraveling the β-amyloid clearance by astrocytes: Involvement of metabotropic glutamate receptor 3, sAPPα, and class-A scavenger receptor. 2019. PMID: 31536785


  24. Jennifer J Wolf, Chuan Xia, Madhuvanthi Vijayan, Yuleum Song, Caleb J Studstill, Hanh Ngo, Marc C Johnson, Julie D Saba, Stephen Alexander, Bumsuk Hahm. Sphingosine 1-phosphate lyase promotes the type I interferon-mediated innate immune response to influenza but is subjected to degradation by influenza A virus NS1. The Journal of Immunology 2019. PMID:


  25. Saba JD. Fifty years of lyase and a moment of truth: sphingosine phosphate lyase from discovery to disease. 2019. PMID: 30635364


  26. Choi YJ, Saba JD. Sphingosine phosphate lyase insufficiency syndrome (SPLIS): A novel inborn error of sphingolipid metabolism. 2018. PMID: 30274713


  27. Saba J, Turati J, Ramírez D, Carniglia L, Durand D, Lasaga M, Caruso C. Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection. 2018. PMID: 29851427


  28. Suh JH, Degagné É, Gleghorn EE, Setty M, Rodriguez A, Park KT, Verstraete SG, Heyman MB, Patel AS, Irek M, Gildengorin GL, Hubbard NE, Borowsky AD, Saba JD. Sphingosine-1-Phosphate Signaling and Metabolism Gene Signature in Pediatric Inflammatory Bowel Disease: A Matched-case Control Pilot Study. Inflammatory bowel diseases 2018. PMID: 29788359


  29. Zhao P, Aguilar AE, Lee JY, Paul LA, Suh JH, Puri L, Zhang M, Beckstead J, Witkowski A, Ryan RO, Saba JD. Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway. 2018. PMID: 29335887


  30. Brian R. Dempsey, Anne C. Rintala-Dempsey, Gary S. Shaw, Igor Prudovsky, Thallapuranam Krishnaswamy Suresh Kumar, Rosario Donato, Rosario Donato, Guglielmo Sorci, Ileana Giambanco, Isadora Carolina Betim Pavan, Fernando Riback Silva, Ana Paula Morelli, Fernando Moreira Simabuco, Yuan Xiao Zhu, A. Keith Stewart, Jaime O. Claudio, Constance E. Runyan, H. William Schnaper, Sushant Singh, Sanjaya K. Sahoo, Muthu Periasamy, Erno Zádor, Magdolna Kósa, Chiung-Ya Chen, Yi-Ping Hsueh, Herman E. Popeijus, Alice Guyon, Laurence J. Miller, Sari S. Hannila, Manoj B. Menon, Akio Yamashita, Veerle Janssens, Ralf-Peter Czekay, Tessa M. Simone, Paul J. Higgins, David Della-Morte, Donatella Pastore, Barbara Capuani, Francesca Pacifici, Davide Lauro, Béatrice L. Charreau, Philip D. King, Matthew D. Blunt, Stephen G. Ward, Christophe Erneux, Stéphane Schurmans, Colin G. Rousseaux, Yasuyuki Saito, Yoji Murata, Takenori Kotani, Takashi Matozaki, Pedro Gomes, Xiaogang Chu, Ryan George, Raghavan Raju, Annegret Reinhold, Burkhart L. Schraven, Víctor Sorribas, Ali H. Jalloul, Robert T. Szerencsei, Tatiana P. Rogasevskaia, Paul P. M. Schnetkamp, Sylvia Y. M. Yao, James D. Young, Bruno Gasnier, Ian Forster, Andreas Werner, Laura R. de La Ballina, Tomás de Garay, Chloé C. Féral, Manuel Palacín, Meytal Landau, Mitsunori Fukuda, Jong Ran Lee, Salman Tamaddon-Jahromi, Venkateswarlu Kanamarlapudi, Julia Strebovsky, Jana Zimmer, Alexander H. Dalpke, Barbara Mariniello, Kaitlyn Ryan, Chin Chiang, Gianni Colotti, Andrea Ilari, Koji Shimozaki, Shiro Koizume, Yohei Miyagi, Aleksander Czogalla, Nadine Beckmann, Erich Gulbins, Katrin Anne Becker, Alexander Carpinteiro, Heidi Neubauer, Stuart Pitson, Ashok Kumar, Julie D. Saba, Samar Masoumi-Moghaddam, Afshin Amini, Sausan A. Moharram, Lars Rönnstrand, Julhash U. Kazi, Sausan A. Moharram, Lars Rönnstrand, Julhash U. Kazi, David A. Jans, Gurpreet Kaur, Cecilia Poderoso, Ana F. Castillo, Pablo G. Mele, Paula M. Maloberti, Ernesto J. Podestá, Su Jun Lim, Willis X. Li, Benjamin Skalkoyannis, Venkateswarlu Kanamarlapudi, Marc J. Tetel, Pui Man Rosalind Lai, Pradeep Kurup, Jian Xu, Manavi Chatterjee, Susan Goebel-Goody, Surojit Paul, Paul Lombroso, Wesley H. Brooks, Sreya Mukherjee, Malgorzata Kloc, Jacek Z. Kubiak, Pia Ragno, Jie Zhang, Zhi-wei Ye, Robert R. Bowers, Danyelle M. Townsend, Kenneth D. Tew, Mikko O. Laukkanen, Alessia Parascandolo, Niharika Swain, Rashmi Maruti Hosalkar, Payel Sen, Nilanjana Chatterjee, Blaine Bartholomew, Robert L. Geahlen, Ashley Bernardo, Shreya Prashar, Luke Molinaro, Ram Mishra, Sang-Ho Song, George J. Augustine, Niharika Swain, Rashmi Maruti Hosalkar, Samapika Routray, Valérie Drouet, Suzanne Lesage, Alexis Brice, Arie Horowitz. S100 Calcium Binding Protein A6. 2018. PMID:


  31. Ashok Kumar, Julie D. Saba. Sphingosine-1-Phosphate. 2018. PMID:


  32. Saba JD. The low down on sphingosine-1-phosphate lyase as a regulator of thymic egress. 2017. PMID: 30740601


  33. Kumar A, Zamora-Pineda J, Degagné E, Saba JD. S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling. 2017. PMID: 29333002


  34. Hahn C, Tyka K, Saba JD, Lenzen S, Gurgul-Convey E. Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity. 2017. PMID: 29070677


  35. Suh JH, Makarova AM, Gomez JM, Paul LA, Saba JD. An LC/MS/MS method for quantitation of chemopreventive sphingadienes in food products and biological samples. 2017. PMID: 28772225


  36. Mitroi DN, Karunakaran I, Gräler M, Saba JD, Ehninger D, Ledesma MD, van Echten-Deckert G. SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. 2017. PMID: 28521611


  37. Saba J, Logan AC. Obinutuzumab-induced serum sickness following salvage therapy for chronic lymphocytic leukemia. 2017. PMID: 28588833


  38. Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI, Shril S, Ashraf S, Tan W, Rao J, Airik M, Schapiro D, Braun DA, Sadowski CE, Widmeier E, Jobst-Schwan T, Schmidt JM, Girik V, Capitani G, Suh JH, Lachaussée N, Arrondel C, Patat J, Gribouval O, Furlano M, Boyer O, Schmitt A, Vuiblet V, Hashmi S, Wilcken R, Bernier FP, Innes AM, Parboosingh JS, Lamont RE, Midgley JP, Wright N, Majewski J, Zenker M, Schaefer F, Kuss N, Greil J, Giese T, Schwarz K, Catheline V, Schanze D, Franke I, Sznajer Y, Truant AS, Adams B, Désir J, Biemann R, Pei Y, Ars E, Lloberas N, Madrid A, Dharnidharka VR, Connolly AM, Willing MC, Cooper MA, Lifton RP, Simons M, Riezman H, Antignac C, Saba JD, Hildebrandt F. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. 2017. PMID: 28165339


  39. Carniglia L, Ramírez D, Durand D, Saba J, Turati J, Caruso C, Scimonelli TN, Lasaga M. Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases. 2017. PMID: 28154473


  40. Mitroi DN, Deutschmann AU, Raucamp M, Karunakaran I, Glebov K, Hans M, Walter J, Saba J, Gräler M, Ehninger D, Sopova E, Shupliakov O, Swandulla D, van Echten-Deckert G. Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism. 2016. PMID: 27883090


  41. Zamora-Pineda J, Kumar A, Suh JH, Zhang M, Saba JD. Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress. 2016. PMID: 27810923


  42. Ashok Kumar, Julie D. Saba. Sphingosine-1-Phosphate. 2016. PMID:


  43. Kumar A, Saba JD. Regulation of Immune Cell Migration by Sphingosine-1-Phosphate. 2015. PMID: 30294722


  44. Suh JH, Saba JD. Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fire. 2015. PMID: 27011900


  45. Suh JH, Eltanawy A, Rangan A, Saba JD. A facile stable-isotope dilution method for determination of sphingosine phosphate lyase activity. 2015. PMID: 26408264


  46. Saba JD. A B cell-dependent mechanism restrains T cell transendothelial migration. 2015. PMID: 25951526


  47. Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. 2014. PMID: 25347472


  48. Suh JH, Saba JD. Tracking hippo in the cancer jungle. 2014. PMID: 25036773


  49. Degagné E, Saba JD. S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer. 2014. PMID: 25061328


  50. de la Garza-Rodea AS, Baldwin DM, Oskouian B, Place RF, Bandhuvula P, Kumar A, Saba JD. Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression. 2013. PMID: 24158395


  51. Smith GS, Kumar A, Saba JD. Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway. 2013. PMID: 24619572


  52. Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y. A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. 2012. PMID: 23230267


  53. Newbigging S, Zhang M, Saba JD. Immunohistochemical analysis of sphingosine phosphate lyase expression during murine development. 2012. PMID: 23041657


  54. Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD. Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. 2012. PMID: 22781001


  55. Saba JD, de la Garza-Rodea AS. S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase. 2012. PMID: 22750505


  56. Upadhyaya P, Kumar A, Byun HS, Bittman R, Saba JD, Hecht SS. The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. 2012. PMID: 22727907


  57. Loh KC, Leong WI, Carlson ME, Oskouian B, Kumar A, Fyrst H, Zhang M, Proia RL, Hoffman EP, Saba JD. Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. 2012. PMID: 22606352


  58. Kumar A, Pandurangan AK, Lu F, Fyrst H, Zhang M, Byun HS, Bittman R, Saba JD. Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3β pathway in colon cancer. 2012. PMID: 22581840


  59. Ashok Kumar, Hoe-Sup Byun, Robert Bittman, Julie D. Saba. Corrigendum to “The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner” [Cell. Signal. 23(7) (2011) 1144-1152]. 2012. PMID:


  60. Brian R. Dempsey, Anne C. Rintala-Dempsey, Gary S. Shaw, Yuan Xiao Zhu, A. Keith Stewart, Jaime O. Claudio, Constance E. Runyan, H. William Schnaper, Philip D. King, Matthew D. Blunt, Stephen G. Ward, Annegret Reinhold, Burkhart L. Schraven, Mitsunori Fukuda, Jong Ran Lee, Julia Strebovsky, Alexander H. Dalpke, Barbara Mariniello, Kaitlyn Ryan, Chin Chiang, Ashok Kumar, Julie D. Saba, David A. Jans, Gurpreet Kaur, Marc J. Tetel, Pui Man Rosalind Lai, Pradeep Kurup, Jian Xu, Susan Goebel-Goody, Surojit Paul, Paul Lombroso, Pia Ragno, Robert R. Bowers, Danyelle M. Townsend, Kenneth D. Tew, Payel Sen, Nilanjana Chatterjee, Blaine Bartholomew, Arie Horowitz. S100 Calcium-Binding Protein. 2012. PMID:


  61. Brian R. Dempsey, Anne C. Rintala-Dempsey, Gary S. Shaw, Yuan Xiao Zhu, A. Keith Stewart, Jaime O. Claudio, Constance E. Runyan, H. William Schnaper, Philip D. King, Matthew D. Blunt, Stephen G. Ward, Annegret Reinhold, Burkhart L. Schraven, Mitsunori Fukuda, Jong Ran Lee, Julia Strebovsky, Alexander H. Dalpke, Barbara Mariniello, Kaitlyn Ryan, Chin Chiang, Ashok Kumar, Julie D. Saba, David A. Jans, Gurpreet Kaur, Marc J. Tetel, Pui Man Rosalind Lai, Pradeep Kurup, Jian Xu, Susan Goebel-Goody, Surojit Paul, Paul Lombroso, Pia Ragno, Robert R. Bowers, Danyelle M. Townsend, Kenneth D. Tew, Payel Sen, Nilanjana Chatterjee, Blaine Bartholomew, Arie Horowitz. Sphingosine-1-Phosphate. 2012. PMID:


  62. Aguilar A, Saba JD. Truth and consequences of sphingosine-1-phosphate lyase. 2012. PMID: 21946005


  63. McElwain MA, Ko DC, Gordon MD, Fyrst H, Saba JD, Nusse R. A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. 2011. PMID: 22069480


  64. Loh KC, Baldwin D, Saba JD. Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond. 2011. PMID: 21707493


  65. Alvarez-Rueda N, Desselle A, Cochonneau D, Chaumette T, Clemenceau B, Leprieur S, Bougras G, Supiot S, Mussini JM, Barbet J, Saba J, Paris F, Aubry J, Birklé S. A monoclonal antibody to O-acetyl-GD2 ganglioside and not to GD2 shows potent anti-tumor activity without peripheral nervous system cross-reactivity. 2011. PMID: 21966461


  66. Julie Deane Saba, Ashok Kumar, Babak Oskouian, Henrik Fyrst, Meng Zhang. S1P lyase regulates DNA damage responses in vitro and in vivo. 2011. PMID:


  67. Kumar A, Byun HS, Bittman R, Saba JD. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. 2011. PMID: 21385609


  68. Bandhuvula P, Honbo N, Wang GY, Jin ZQ, Fyrst H, Zhang M, Borowsky AD, Dillard L, Karliner JS, Saba JD. S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. 2011. PMID: 21335477


  69. Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F, Saba JD. S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. 2011. PMID: 21368890


  70. Allende ML, Bektas M, Lee BG, Bonifacino E, Kang J, Tuymetova G, Chen W, Saba JD, Proia RL. Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. 2010. PMID: 21173151


  71. Zhao Y, Gorshkova IA, Berdyshev E, He D, Fu P, Ma W, Su Y, Usatyuk PV, Pendyala S, Oskouian B, Saba JD, Garcia JG, Natarajan V. Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. 2010. PMID: 21148740


  72. Henrik Fyrst, Julie D Saba. Erratum: An update on sphingosine-1-phosphate and other sphingolipid mediators. 2010. PMID:


  73. Fyrst H, Saba JD. An update on sphingosine-1-phosphate and other sphingolipid mediators. 2010. PMID: 20559316


  74. Leong WI, Saba JD. S1P metabolism in cancer and other pathological conditions. 2010. PMID: 20167244


  75. Prasanna PG, Blakely WF, Bertho JM, Chute JP, Cohen EP, Goans RE, Grace MB, Lillis-Hearne PK, Lloyd DC, Lutgens LC, Meineke V, Ossetrova NI, Romanyukha A, Saba JD, Weisdorf DJ, Wojcik A, Yukihara EG, Pellmar TC. Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop. 2010. PMID: 20095857


  76. Bektas M, Allende ML, Lee BG, Chen W, Amar MJ, Remaley AT, Saba JD, Proia RL. Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. 2010. PMID: 20097939


  77. Oskouian B, Saba JD. Cancer treatment strategies targeting sphingolipid metabolism. 2010. PMID: 20919655


  78. Fyrst H, Oskouian B, Bandhuvula P, Gong Y, Byun HS, Bittman R, Lee AR, Saba JD. Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis. 2009. PMID: 19934323


  79. Serra M, Saba JD. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. 2009. PMID: 19914275


  80. Francis-Goforth KN, Harken AH, Saba JD. Normalization of diabetic wound healing. 2009. PMID: 19703697


  81. Kumar A, Saba JD. Lyase to live by: sphingosine phosphate lyase as a therapeutic target. 2009. PMID: 19534571


  82. Bandhuvula P, Li Z, Bittman R, Saba JD. Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate. 2009. PMID: 19250638


  83. Tauseef M, Kini V, Knezevic N, Brannan M, Ramchandaran R, Fyrst H, Saba J, Vogel SM, Malik AB, Mehta D. Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells. 2008. PMID: 18849324


  84. Fyrst H, Saba JD. Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight. 2008. PMID: 18558101


  85. Fyrst H, Zhang X, Herr DR, Byun HS, Bittman R, Phan VH, Harris GL, Saba JD. Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes. 2007. PMID: 18156591


  86. Bandhuvula P, Fyrst H, Saba JD. A rapid fluorescence assay for sphingosine-1-phosphate lyase enzyme activity. 2007. PMID: 17872591


  87. Phan VH, Herr DR, Panton D, Fyrst H, Saba JD, Harris GL. Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila. 2007. PMID: 17706961


  88. Bandhuvula P, Saba JD. Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren. 2007. PMID: 17416206


  89. Oskouian B, Saba J. Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again. 2007. PMID: 17361098


  90. Zhang K, Pompey JM, Hsu FF, Key P, Bandhuvula P, Saba JD, Turk J, Beverley SM. Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania. 2007. PMID: 17290222


  91. Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. 2006. PMID: 17090686


  92. Kohno M, Momoi M, Oo ML, Paik JH, Lee YM, Venkataraman K, Ai Y, Ristimaki AP, Fyrst H, Sano H, Rosenberg D, Saba JD, Proia RL, Hla T. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. 2006. PMID: 16980623


  93. Julie Deane Saba, Babak Oskouian, Prathap Sooriyakumaran. S1P Lyase Expression Hypersensitizes Cells to DNA Damage and Other Stress Conditions via p53 and p38 Apoptosis Pathways. 2006. PMID:


  94. Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba JD, Tam YY. Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. 2006. PMID: 16508938


  95. Julie D. Saba. Sphingosine-1-Phosphate Lyase. 2006. PMID:


  96. Mark C. Walters, Lynn Quirolo, Sandie Edwards, Joanna Lee, Shanda Robertson, Julie D. Saba, Elizabeth Trachtenberg, Keith C. Quirolo, Bert Lubin. Directed Donor Cord Blood Transplantation for Hematological Disorders. 2005. PMID:


  97. Bandhuvula P, Tam YY, Oskouian B, Saba JD. The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. 2005. PMID: 16118221


  98. Oskouian B, Mendel J, Shocron E, Lee MA, Fyrst H, Saba JD. Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors. 2005. PMID: 15734735


  99. Walters MC, Quirolo L, Trachtenberg ET, Edwards S, Hale L, Lee J, Morton-Wiley J, Quirolo K, Robertson S, Saba J, Lubin B. Sibling donor cord blood transplantation for thalassemia major: Experience of the Sibling Donor Cord Blood Program. 2005. PMID: 16339667


  100. Jiang Q, Wong J, Fyrst H, Saba JD, Ames BN. gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. 2004. PMID: 15596715


  101. Oskouian B, Saba JD. Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate. 2004. PMID: 15271298


  102. Saba JD. Lysophospholipids in development: Miles apart and edging in. 2004. PMID: 15258919


  103. Saba JD, Hla T. Point-counterpoint of sphingosine 1-phosphate metabolism. 2004. PMID: 15059942


  104. Herr DR, Fyrst H, Creason MB, Phan VH, Saba JD, Harris GL. Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function. 2004. PMID: 14722126


  105. Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AH, Saba JD. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. 2003. PMID: 14570870


  106. Fyrst H, Herr DR, Harris GL, Saba JD. Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster. 2003. PMID: 13130120


  107. Herr DR, Fyrst H, Phan V, Heinecke K, Georges R, Harris GL, Saba JD. Sply regulation of sphingolipid signaling molecules is essential for Drosophila development. 2003. PMID: 12702658


  108. Mendel J, Heinecke K, Fyrst H, Saba JD. Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans. 2003. PMID: 12682045


  109. Reed W, Smith R, Dekovic F, Lee JY, Saba JD, Trachtenberg E, Epstein J, Haaz S, Walters MC, Lubin BH. Comprehensive banking of sibling donor cord blood for children with malignant and nonmalignant disease. Blood 2002. PMID: 12393579


  110. Birchwood CJ, Saba JD, Dickson RC, Cunningham KW. Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation. 2001. PMID: 11278643


  111. Kim S, Fyrst H, Saba J. Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae. 2000. PMID: 11102354


  112. J. Zhou, U. Reiss, J. D. Saba. Molecular cloning - and functional characterization of the human sphingosine-1 -phosphate lyase gene. 2000. PMID:


  113. Caligan TB, Peters K, Ou J, Wang E, Saba J, Merrill AH. A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples. 2000. PMID: 10847608


  114. MAO Cungui, Julie D. SABA, Lina M. OBEID. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. 1999. PMID:


  115. Mao C, Saba JD, Obeid LM. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. 1999. PMID: 10477278


  116. Fyrst H, Oskouian B, Kuypers FA, Saba JD. The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase. 1999. PMID: 10231538


  117. Gottlieb D, Heideman W, Saba JD. The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae. 1999. PMID: 10329480


  118. Oskouian B, Saba JD. YAP1 confers resistance to the fatty acid synthase inhibitor cerulenin through the transporter Flr1p in Saccharomyces cerevisiae. 1999. PMID: 10102370


  119. Lanterman MM, Saba JD. Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants. 1998. PMID: 9601083


  120. Marseille E, Kahn JG, Saba J. Cost-effectiveness of antiviral drug therapy to reduce mother-to-child HIV transmission in sub-Saharan Africa. AIDS (London, England) 1998. PMID: 9631148


  121. Zhou J, Saba JD. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. 1998. PMID: 9464245


  122. Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. 1997. PMID: 9334171


  123. Saba JD, Obeid LM, Hannun YA. Ceramide: an intracellular mediator of apoptosis and growth suppression. 1996. PMID: 8650271


  124. Fishbein JD, Dobrowsky RT, Bielawska A, Garrett S, Hannun YA. Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. 1993. PMID: 8387486


  125. Fishbein JD, Bruggers CS, Friedman NJ, Graham ML, Kurtzberg J. A seven-month-old infant with fever and neutrophilic leukocytosis. 1992. PMID: 1578323


  126. Tope WD, Fishbein JD, White PF, Prose NS. Large-cell lymphoma presenting with a distinctive inflammatory dermatosis. 1991. PMID: 1761769


  127. Fishbein JD, Falletta JM. Pelger-Huet anomaly in an infant with multiple congenital anomalies. 1991. PMID: 1951327


  128. Fishbein J. A piece of my mind. The poetry of medicine. 1990. PMID: 2243427


  129. Fishbein JD, Friedman HS, Bennett BB, Falletta JM. Catheter-related sepsis refractory to antibiotics treated successfully with adjunctive urokinase infusion. 1990. PMID: 2235195


  130. Fishbein WN, Davis JI, Winkert JW, Fishbein JD. Indicator enzyme assays. II. Adenylate kinase: application to human muscle biopsies and blood cells. 1980. PMID: 6257235


  131. Saba JD. Journal of Immunological Sciences . PMID:


  132. Suh JH
    Degagné E
    Gleghorn EE
    Setty M
    Rodriguez A
    Park KT
    Verstraete SG
    Heyman MB
    Patel AS
    Irek M
    Gildengorin GL
    Hubbard NE
    Borowsky AD
    Saba JD. Sphingosine-1-phosphate signaling and metabolism gene signature in pediatric inflammatory bowel disease: a matched-case control pilot study . PMID: