Matthew Kan, MD, PhD

Matthew Kan, MD, PhD is a physician-scientist and Assistant Professor of pediatrics at University of California, San Francisco (UCSF) developing therapeutic genome editing for inborn errors of immunity (IEI). He is a pre-clinical lead for the Danaher-Innovative Genomics Institute Beacon for CRISPR Cures, developing a CRISPR-based genome editing therapy for patients with Artemis-deficient SCID, and pre-clinical lead on IEI diseases for the Chan Zuckerburg Initiative Center for Pediatric Cures. He received his undergraduate degree from Harvard University, MD and PhD in immunology from Duke University, and completed pediatrics residency and fellowship in allergy and immunology at UCSF. Dr. Kan trained in the labs of Drs. Dale Umetsu, Michael Gunn, Carol Colton, Atul Butte, Jennifer Puck, and Jennifer Doudna. He is a former fellow of the Pediatric Scientist Development Program, nationally selected by the Association of Medical School Pediatric Department Chairs.
Education
2023 - Allergy and Immunology Fellowship, UCSF
2021 - Pediatrics Residency, UCSF
Ph.D., 2016 - Department of Immunology, Duke University
M.D., 2016 - School of Medicine, Duke University
B.A., 2007 - Biology, Harvard University
Honors and Awards
  • Pediatric Scientist Development Program Fellowship, Association of Medical School Pediatric Department Chairs, 2021-2023

  1. Adler BA, Trinidad MI, Bellieny-Rabelo D, Zhang E, Karp HM, Skopintsev P, Thornton BW, Weissman RF, Yoon PH, Chen L, Hessler T, Eggers AR, Colognori D, Boger R, Doherty EE, Tsuchida CA, Tran RV, Hofman L, Shi H, Wasko KM, Zhou Z, Xia C, Al-Shimary MJ, Patel JR, Thomas VCJX, Pattali R, Kan MJ, Vardapetyan A, Yang A, Lahiri A, Maxwell MF, Murdock AG, Ramit GC, Henderson HR, Calvert RW, Bamert RS, Knott GJ, Lapinaite A, Pausch P, Cofsky JC, Sontheimer EJ, Wiedenheft B, Fineran PC, Brouns SJJ, Sashital DG, Thomas BC, Brown CT, Goltsman DSA, Barrangou R, Siksnys V, Banfield JF, Savage DF, Doudna JA. CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes. Volume 52 of Issue D1. Nucleic acids research 2024. PMID: 37889041


  2. Kan MJ, Doudna JA. Treatment of Genetic Diseases With CRISPR Genome Editing. Volume 328 of Issue 10. JAMA 2022. PMID: 36098733


  3. Kan MJ, Grant LMC, Muña MA, Greenhow TL. Fever Without a Source in an Infant Due to Severe Acute Respiratory Syndrome Coronavirus-2. Volume 10 of Issue 1. Journal of the Pediatric Infectious Diseases Society 2021. PMID: 32318729


  4. Yu YA, Malakhau Y, Yu CA, Phelan SJ, Cumming RI, Kan MJ, Mao L, Rajagopal S, Piantadosi CA, Gunn MD. Nonclassical Monocytes Sense Hypoxia, Regulate Pulmonary Vascular Remodeling, and Promote Pulmonary Hypertension. Volume 204 of Issue 6. Journal of immunology (Baltimore, Md. : 1950) 2020. PMID: 31996456


  5. Paik H, Kan MJ, Rappoport N, Hadley D, Sirota M, Chen B, Manber U, Cho SB, Butte AJ. Tracing diagnosis trajectories over millions of patients reveal an unexpected risk in schizophrenia. Volume 6 of Issue 1. Scientific data 2019. PMID: 31615985


  6. Rivera PD, Hanamsagar R, Kan MJ, Tran PK, Stewart D, Jo YC, Gunn M, Bilbo SD. Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors. Volume 76. Brain, behavior, and immunity 2018. PMID: 30447281


  7. Zalocusky KA, Kan MJ, Hu Z, Dunn P, Thomson E, Wiser J, Bhattacharya S, Butte AJ. The 10,000 Immunomes Project: Building a Resource for Human Immunology. Volume 25 of Issue 7. Cell reports 2018. PMID: 30428364


  8. Zalocusky KA, Kan MJ, Hu Z, Dunn P, Thomson E, Wiser J, Bhattacharya S, Butte AJ. The 10,000 Immunomes Project: Building a Resource for Human Immunology. Volume 25 of Issue 2. Cell reports 2018. PMID: 30304689


  9. Bhattacharya S, Li J, Sockell A, Kan MJ, Bava FA, Chen SC, Ávila-Arcos MC, Ji X, Smith E, Asadi NB, Lachman RS, Lam HYK, Bustamante CD, Butte AJ, Nolan GP. Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia. Volume 28 of Issue 4. Genome research 2018. PMID: 29567674


  10. Matthew J. Kan, Kelly Zalocusky, Zicheng Hu, Patrick Dunn, Elizabeth Thomson, Jeffrey Wiser, Sanchita Bhattacharya, Atul Butte. The 10,000 Immunomes Project: A Resource for Human Immunology. Journal of Allergy and Clinical Immunology 2018. PMID:


  11. Mastria EM, Cai LY, Kan MJ, Li X, Schaal JL, Fiering S, Gunn MD, Dewhirst MW, Nair SK, Chilkoti A. Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity. Volume 269. Journal of controlled release : official journal of the Controlled Release Society 2017. PMID: 29146246


  12. Rudemiller NP, Patel MB, Zhang JD, Jeffs AD, Karlovich NS, Griffiths R, Kan MJ, Buckley AF, Gunn MD, Crowley SD. C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration. Volume 186 of Issue 11. The American journal of pathology 2016. PMID: 27640148


  13. Carol A. Colton, Ram S. Puranam, Michael P. Vitek, Matthew J. Kan. IMMUNE-MEDIATED NUTRIENT DEPRIVATION AND METABOLIC DISRUPTION IN AN ALZHEIMER'S DISEASE MOUSE MODEL. Alzheimer's & Dementia 2016. PMID:


  14. Yu YR, O'Koren EG, Hotten DF, Kan MJ, Kopin D, Nelson ER, Que L, Gunn MD. A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues. Volume 11 of Issue 3. PloS one 2016. PMID: 26938654


  15. DeFalco T, Potter SJ, Williams AV, Waller B, Kan MJ, Capel B. Macrophages Contribute to the Spermatogonial Niche in the Adult Testis. Volume 12 of Issue 7. Cell reports 2015. PMID: 26257171


  16. Kan MJ, Lee JE, Wilson JG, Everhart AL, Brown CM, Hoofnagle AN, Jansen M, Vitek MP, Gunn MD, Colton CA. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. Volume 35 of Issue 15. The Journal of neuroscience : the official journal of the Society for Neuroscience 2015. PMID: 25878270


  17. Keum S, Lee HK, Chu PL, Kan MJ, Huang MN, Gallione CJ, Gunn MD, Lo DC, Marchuk DA. Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke. Volume 9 of Issue 10. PLoS genetics 2013. PMID: 24130503


  18. Cain DW, O'Koren EG, Kan MJ, Womble M, Sempowski GD, Hopper K, Gunn MD, Kelsoe G. Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages. Volume 191 of Issue 9. Journal of immunology (Baltimore, Md. : 1950) 2013. PMID: 24078688


  19. Meyer EH, Wurbel MA, Staton TL, Pichavant M, Kan MJ, Savage PB, DeKruyff RH, Butcher EC, Campbell JJ, Umetsu DT. iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity. Volume 179 of Issue 7. Journal of immunology (Baltimore, Md. : 1950) 2007. PMID: 17878364