Michelle Hsiang, MD, MS

Dr. Michelle Hsiang aims to improve the health of children through clinical care and the study of malaria. She is Associate Professor in the Epidemiology and Biostatistics, Division of Infectious Diseases and Global Epidemiology, with a secondary appointment in the Department of Pediatrics, Division of Pediatric Infectious Diseases, as well as a Chan-Zuckerburg Biohub Investigator. She serves as the Director of Research for the Malaria Elimination Initiative at the Institute for Global Health Sciences.

Her research is in the epidemiology of malaria in low-endemic settings aiming for elimination. She develops and evaluates novel malaria diagnostic, surveillance, and drug and vector control interventions to address the challenge of low-level infections that contribute to persistent transmission and disease. She has worked mainly in sub-Saharan Africa but also works in Latin America and the Asia-Pacific.

She was an inaugural member of the Malaria Elimination Group (MEG) and co-founded the Asia Pacific Malaria Elimination Network (APMEN). She is a WomenLift Leader in Global Health through Stanford and the Bill and Melinda Gates Foundation's program WomenLift Health. She studied Human Biology as an undergraduate at Stanford University and attended medical school at Baylor College of Medicine. She trained in Pediatrics and Pediatric Infectious Diseases at UCSF, and obtained a Masters in Epidemiology at the London School of Hygiene and Tropical Medicine. From 2012-2021, she was Assistant Professor in Pediatrics at UT Southwestern Medical School where she was also a Horchow Family Endowed Scholar in Pediatrics.
Education
MSc, 12/2018 - Epidemiology, London School of Hygiene and Tropical Medicine
Fellow, 06/2012 - Pediatric Infectious Diseases, University of California, San Francisco
Resident, 06/2008 - Pediatrics, University of California, San Francisco
M.D., 05/2005 - Medicine, Baylor College of Medicine
B.A., 06/2000 - Human Biology, Stanford University
Honors and Awards
  • Chan-Zuckerberg Biohub Investigator Award, UCSF, 2021-2026
  • Woman Leader in Global Health, WomenLift Health, Stanford University and Bill and Melinda Gates Foundation, 2020-2021
  • Horchow Family Endowed Scholar in Pediatrics, UT Southwestern, 2014-2021
Websites
  1. Newby G, Cotter C, Roh ME, Harvard K, Bennett A, Hwang J, Chitnis N, Fine S, Stresman G, Chen I, Gosling R, Hsiang MS. Correction: Testing and treatment for malaria elimination: a systematic review. Malaria journal 2024. PMID: 38429746


  2. Gallalee S, Zarlinda I, Silaen MG, Cotter C, Cueto C, Elyazar IRF, Jacobson JO, Gosling R, Hsiang MS, Bennett A, Coutrier FN, Smith JL. Forest-goers as a heterogeneous population at high-risk for malaria: a case-control study in Aceh Province, Indonesia. Malaria journal 2024. PMID: 38291392


  3. Benjamin-Chung J, Li H, Nguyen A, Heitmann GB, Bennett A, Ntuku H, Prach LM, Tambo M, Wu L, Drakeley C, Gosling R, Mumbengegwi D, Kleinschmidt I, Hubbard A, van der Laan M, Hsiang MS. Targeted malaria elimination interventions reduce Plasmodium falciparum infections up to 3 kilometers away. medRxiv : the preprint server for health sciences 2023. PMID: 37790419


  4. Newby G, Cotter C, Roh ME, Harvard K, Bennett A, Hwang J, Chitnis N, Fine S, Stresman G, Chen I, Gosling R, Hsiang MS. Testing and treatment for malaria elimination: a systematic review. Malaria journal 2023. PMID: 37661286


  5. Suwannarong K, Cotter C, Ponlap T, Bubpa N, Thammasutti K, Chaiwan J, Finn TP, Kitchakarn S, Mårtensson A, Baltzell KA, Hsiang MS, Lertpiriyasuwat C, Sudathip P, Bennett A. Assessing the acceptability and feasibility of reactive drug administration for malaria elimination in a Plasmodium vivax predominant setting: a qualitative study in two provinces in Thailand. BMC public health 2023. PMID: 37438774


  6. Marquart L, Webb L, O'Rourke P, Gatton ML, Hsiang MS, Kalnoky M, Jang IK, Ntuku H, Mumbengegwi DR, Domingo GJ, McCarthy JS, Britton S. The in-vivo dynamics of Plasmodium falciparum HRP2: implications for the use of rapid diagnostic tests in malaria elimination. Malaria journal 2022. PMID: 35922803


  7. Lu SN, Ding W, Wang JZ, Yin SQ, Li SG, Zhou XW, Xu QL, Sun XD, Cotter C, Hsiang MS, Tatarsky A, Gosling R, Lv S, Wang DQ. Application of an innovative grid-based surveillance strategy to ensure elimination and prevent reintroduction of malaria in high-risk border communities in China. BMC public health 2022. PMID: 35836156


  8. Ntuku H, Smith-Gueye C, Scott V, Njau J, Whittemore B, Zelman B, Tambo M, Prach LM, Wu L, Schrubbe L, Kang Dufour MS, Mwilima A, Uusiku P, Sturrock H, Bennett A, Smith J, Kleinschmidt I, Mumbengegwi D, Gosling R, Hsiang M. Cost and cost effectiveness of reactive case detection (RACD), reactive focal mass drug administration (rfMDA) and reactive focal vector control (RAVC) to reduce malaria in the low endemic setting of Namibia: an analysis alongside a 2×2 factorial design BMJ open 2022. PMID: 35738650


  9. Llanos-Cuentas A, Manrrique P, Rosas-Aguirre A, Herrera S, Hsiang MS. Tafenoquine for the treatment of Plasmodium vivax malaria. 2022. PMID: 35379070



  10. Huber JH, Hsiang MS, Dlamini N, Murphy M, Vilakati S, Nhlabathi N, Lerch A, Nielsen R, Ntshalintshali N, Greenhouse B, Perkins TA. Inferring person-to-person networks of Plasmodium falciparum transmission: are analyses of routine surveillance data up to the task? 2022. PMID: 35189905


  11. Stubbs LA, Price M, Noland D, Fuchs J, Filkins L, McElvania E, Luu HS, Sebert M, Waters A, Hsiang MS. Transfusion-Transmitted Malaria: Two Pediatric Cases From the United States and Their Relevance in an Increasingly Globalized World. Journal of the Pediatric Infectious Diseases Society 2021. PMID: 34559236


  12. Cao J, Newby G, Cotter C, Hsiang MS, Larson E, Tatarsky A, Gosling RD, Xia Z, Gao Q. Achieving malaria elimination in China. 2021. PMID: 34838192


  13. Krezanoski PJ, Roh ME, Rek J, Nankabirwa JI, Arinaitwe E, Staedke SG, Nayiga S, Hsiang MS, Smith D, Kamya M, Dorsey G. Marked reduction in antibiotic usage following intensive malaria control in a cohort of Ugandan children. 2021. PMID: 34844601


  14. Maxwell D, Sanders KC, Sabot O, Hachem A, Llanos-Cuentas A, Olotu A, Gosling R, Cutrell JB, Hsiang MS. COVID-19 Therapeutics for Low- and Middle-Income Countries: A Review of Candidate Agents with Potential for Near-Term Use and Impact. The American journal of tropical medicine and hygiene 2021. PMID: 34270449


  15. Vilakati S, Mngadi N, Benjamin-Chung J, Dlamini N, Dufour MK, Whittemore B, Bhangu K, Prach LM, Baltzell K, Nhlabathi N, Malambe C, Dlamini B, Helb D, Greenhouse B, Maphalala G, Pindolia D, Kalungero M, Tesfa G, Gosling R, Ntshalintshali N, Kunene S, Hsiang MS. Effectiveness and safety of reactive focal mass drug administration (rfMDA) using dihydroartemisinin-piperaquine to reduce malaria transmission in the very low-endemic setting of Eswatini: a pragmatic cluster randomised controlled trial. BMJ global health 2021. PMID: 34193475


  16. Roberts KW, Smith Gueye C, Baltzell K, Ntuku H, McCreesh P, Maglior A, Whittemore B, Uusiku P, Mumbengegwi D, Kleinschmidt I, Gosling R, Hsiang MS. Community acceptance of reactive focal mass drug administration and reactive focal vector control using indoor residual spraying, a mixed-methods study in Zambezi region, Namibia. Malaria journal 2021. PMID: 33752673


  17. Hsiang MS, Mumbengegwi D, Chimumbwa J. Mini-outbreak response for malaria using indoor residual spraying. Lancet (London, England) 2021. PMID: 33640045


  18. Wu SL, Mertens AN, Crider YS, Nguyen A, Pokpongkiat NN, Djajadi S, Seth A, Hsiang MS, Colford JM, Reingold A, Arnold BF, Hubbard A, Benjamin-Chung J. Substantial underestimation of SARS-CoV-2 infection in the United States. 2020. PMID: 32908126


  19. Hsiang MS, Ntuku H, Roberts KW, Dufour MK, Whittemore B, Tambo M, McCreesh P, Medzihradsky OF, Prach LM, Siloka G, Siame N, Gueye CS, Schrubbe L, Wu L, Scott V, Tessema S, Greenhouse B, Erlank E, Koekemoer LL, Sturrock HJW, Mwilima A, Katokele S, Uusiku P, Bennett A, Smith JL, Kleinschmidt I, Mumbengegwi D, Gosling R. Effectiveness of reactive focal mass drug administration and reactive focal vector control to reduce malaria transmission in the low malaria-endemic setting of Namibia: a cluster-randomised controlled, open-label, two-by-two factorial design trial. Lancet (London, England) 2020. PMID: 32334702


  20. Hsiang MS, Ntshalintshali N, Kang Dufour MS, Dlamini N, Nhlabathi N, Vilakati S, Malambe C, Zulu Z, Maphalala G, Novotny J, Murphy M, Schwartz A, Sturrock H, Gosling R, Dorsey G, Kunene S, Greenhouse B. Active Case Finding for Malaria: A 3-Year National Evaluation of Optimal Approaches to Detect Infections and Hotspots Through Reactive Case Detection in the Low-transmission Setting of Eswatini. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2020. PMID: 31095677


  21. Baltzell KA, Maglior A, Bangu K, Mngadi N, Prach LM, Whittemore B, Ntshalintshali N, Saini M, Dlamini N, Kunene S, Hsiang MS. "We were afraid of the lion that has roared next to us"; community response to reactive focal mass drug administration for malaria in Eswatini (formerly Swaziland). Malaria journal 2019. PMID: 31307494



  22. Jacobson JO, Smith JL, Cueto C, Chisenga M, Roberts K, Hsiang M, Gosling R, Mumbengegwi D, Bennett A. Assessing malaria risk at night-time venues in a low-transmission setting: a time-location sampling study in Zambezi, Namibia. Malaria journal 2019. PMID: 31118028


  23. Tessema S, Wesolowski A, Chen A, Murphy M, Wilheim J, Mupiri AR, Ruktanonchai NW, Alegana VA, Tatem AJ, Tambo M, Didier B, Cohen JM, Bennett A, Sturrock HJ, Gosling R, Hsiang MS, Smith DL, Mumbengegwi DR, Smith JL, Greenhouse B. Using parasite genetic and human mobility data to infer local and cross-border malaria connectivity in Southern Africa. eLife 2019. PMID: 30938286


  24. McCreesh P, Mumbengegwi D, Roberts K, Tambo M, Smith J, Whittemore B, Kelly G, Moe C, Murphy M, Chisenga M, Greenhouse B, Ntuku H, Kleinschmidt I, Sturrock H, Uusiku P, Gosling R, Bennett A, Hsiang MS. Subpatent malaria in a low transmission African setting: a cross-sectional study using rapid diagnostic testing (RDT) and loop-mediated isothermal amplification (LAMP) from Zambezi region, Namibia. Malaria journal 2018. PMID: 30567537


  25. Coutrier FN, Tirta YK, Cotter C, Zarlinda I, González IJ, Schwartz A, Maneh C, Marfurt J, Murphy M, Herdiana H, Anstey NM, Greenhouse B, Hsiang MS, Noviyanti R. Laboratory challenges of Plasmodium species identification in Aceh Province, Indonesia, a malaria elimination setting with newly discovered P. knowlesi. PLoS neglected tropical diseases 2018. PMID: 30500828


  26. Zelman BW, Baral R, Zarlinda I, Coutrier FN, Sanders KC, Cotter C, Herdiana H, Greenhouse B, Shretta R, Gosling RD, Hsiang MS. Costs and cost-effectiveness of malaria reactive case detection using loop-mediated isothermal amplification compared to microscopy in the low transmission setting of Aceh Province, Indonesia. Malaria journal 2018. PMID: 29859081


  27. Mumbengegwi DR, Sturrock H, Hsiang M, Roberts K, Kleinschmidt I, Nghipumbwa M, Uusiku P, Smith J, Bennet A, Kizito W, Takarinda K, Ade S, Gosling R. Is there a correlation between malaria incidence and IRS coverage in western Zambezi region, Namibia? Public health action 2018. PMID: 29713594


  28. Medzihradsky OF, Kleinschmidt I, Mumbengegwi D, Roberts KW, McCreesh P, Dufour MK, Uusiku P, Katokele S, Bennett A, Smith J, Sturrock H, Prach LM, Ntuku H, Tambo M, Didier B, Greenhouse B, Gani Z, Aerts A, Gosling R, Hsiang MS. Study protocol for a cluster randomised controlled factorial design trial to assess the effectiveness and feasibility of reactive focal mass drug administration and vector control to reduce malaria transmission in the low endemic setting of Namibia. BMJ open 2018. PMID: 29374672


  29. Hsiang MS, Ranadive N, Chitundu S, Ntshalintshali N, Greenhouse B. Reply to Rossi et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017. PMID: 29020318



  30. Dlamini N, Hsiang MS, Ntshalintshali N, Pindolia D, Allen R, Nhlabathi N, Novotny J, Kang Dufour MS, Midekisa A, Gosling R, LeMenach A, Cohen J, Dorsey G, Greenhouse B, Kunene S. Low-Quality Housing Is Associated With Increased Risk of Malaria Infection: A National Population-Based Study From the Low Transmission Setting of Swaziland. Open forum infectious diseases 2017. PMID: 28580365



  31. N. Mkhonta, R. Allen, D. Pindolia, N. Ntshalintshali, J. Novotny, M. Kang Dufour, R. Gosling, A. LeMenach, J. Cohen, A. Midekisa, B. Greenhouse, M.S. Hsiang, S. Kunene. Housing quality as a potential risk factor for locally acquired malaria infection in Swaziland. Annals of global health 2016. PMID:


  32. Reiner RC, Le Menach A, Kunene S, Ntshalintshali N, Hsiang MS, Perkins TA, Greenhouse B, Tatem AJ, Cohen JM, Smith DL. Mapping residual transmission for malaria elimination. eLife 2015. PMID: 26714110




  33. Hsiang MS, Greenhouse B, Rosenthal PJ. Reply to Goyal et al. The Journal of infectious diseases 2014. PMID: 25512627


  34. Sturrock HJ, Cohen JM, Keil P, Tatem AJ, Le Menach A, Ntshalintshali NE, Hsiang MS, Gosling RD. Fine-scale malaria risk mapping from routine aggregated case data. Malaria journal 2014. PMID: 25366929



  35. Liu Y, Hsiang MS, Zhou H, Wang W, Cao Y, Gosling RD, Cao J, Gao Q. Malaria in overseas labourers returning to China: an analysis of imported malaria in Jiangsu Province, 2001-2011. Malaria journal 2014. PMID: 24460982


  36. Stieglitz E, Hsiang MS, Simko JP, Hirose S, Goldsby RE. Pulmonary coccidiomycosis masquerading as refractory metastatic Ewing sarcoma. Journal of pediatric hematology/oncology 2014. PMID: 23588326



  37. Hsiang MS, Hwang J, Tao AR, Liu Y, Bennett A, Shanks GD, Cao J, Kachur SP, Feachem RG, Gosling RD, Gao Q. Mass drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China. Malaria journal 2013. PMID: 24175930


  38. Smith Gueye C, Sanders KC, Galappaththy GN, Rundi C, Tobgay T, Sovannaroth S, Gao Q, Surya A, Thakur GD, Baquilod M, Lee WJ, Bobogare A, Deniyage SL, Satimai W, Taleo G, Hung NM, Cotter C, Hsiang MS, Vestergaard LS, Gosling RD. Active case detection for malaria elimination: a survey among Asia Pacific countries. Malaria journal 2013. PMID: 24103345


  39. Sturrock HJ, Hsiang MS, Cohen JM, Smith DL, Greenhouse B, Bousema T, Gosling RD. Targeting asymptomatic malaria infections: active surveillance in control and elimination. PLoS medicine 2013. PMID: 23853551


  40. Sturrock HJ, Novotny JM, Kunene S, Dlamini S, Zulu Z, Cohen JM, Hsiang MS, Greenhouse B, Gosling RD. Reactive case detection for malaria elimination: real-life experience from an ongoing program in Swaziland. PloS one 2013. PMID: 23700437


  41. Cotter C, Sturrock HJ, Hsiang MS, Liu J, Phillips AA, Hwang J, Gueye CS, Fullman N, Gosling RD, Feachem RG. The changing epidemiology of malaria elimination: new strategies for new challenges. Lancet (London, England) 2013. PMID: 23594387


  42. Baltzell KA, Shakely D, Hsiang M, Kemere J, Ali AS, Björkman A, Mårtensson A, Omar R, Elfving K, Msellem M, Aydin-Schmidt B, Rosenthal PJ, Greenhouse B. Prevalence of PCR detectable malaria infection among febrile patients with a negative Plasmodium falciparum specific rapid diagnostic test in Zanzibar. The American journal of tropical medicine and hygiene 2012. PMID: 23249688


  43. Eziefula AC, Gosling R, Hwang J, Hsiang MS, Bousema T, von Seidlein L, Drakeley C, Primaquine in Africa Discussion Group. Rationale for short course primaquine in Africa to interrupt malaria transmission. Malaria journal 2012. PMID: 23130957



  44. Hsiang MS, Hwang J, Kunene S, Drakeley C, Kandula D, Novotny J, Parizo J, Jensen T, Tong M, Kemere J, Dlamini S, Moonen B, Angov E, Dutta S, Ockenhouse C, Dorsey G, Greenhouse B. Surveillance for malaria elimination in Swaziland: a national cross-sectional study using pooled PCR and serology. PloS one 2012. PMID: 22238621



  45. Andersen F, Douglas NM, Bustos D, Galappaththy G, Qi G, Hsiang MS, Kusriastuti R, Mendis K, Taleo G, Whittaker M, Price RN, von Seidlein L. Trends in malaria research in 11 Asian Pacific countries: an analysis of peer-reviewed publications over two decades. Malaria journal 2011. PMID: 21586174


  46. Sabot O, Cohen JM, Hsiang MS, Kahn JG, Basu S, Tang L, Zheng B, Gao Q, Zou L, Tatarsky A, Aboobakar S, Usas J, Barrett S, Cohen JL, Jamison DT, Feachem RG. Costs and financial feasibility of malaria elimination. Lancet (London, England) 2010. PMID: 21035839




  47. Hsiang MS, Abeyasinghe R, Whittaker M, Feachem RG. Malaria elimination in Asia-Pacific: an under-told story. Lancet (London, England) 2010. PMID: 20452505