Onur Cil, MD, PhD

Dr. Onur Cil is a pediatric nephrologist and physician-scientist. Cil Lab’s research focus is small molecule drug discovery and drug repurposing for treatment of renal, gastrointestinal and cardiovascular diseases. Ultimate goal of our research is advancing our discoveries to clinical trials and establishing better and safer treatments. Our research is focused on membrane proteins including calcium-sensing receptor (CaSR), SLC26A3 (DRA), SLC26A4 (Pendrin), SLC26A6 (PAT1), CFTR, TMEM16A and urea transporters.
Education
M.D., - Faculty of Medicine, Hacettepe University
Residency, - Pediatrics, Hacettepe University
Ph.D., - Pharmacology, Hacettepe University
Fellowship, - Pediatric nephrology, University of California, San Francisco
Honors and Awards
  • Stephanie Watts Career Development Award, American Heart Association, 2020
Websites
Publications
  1. Small molecule inhibitor of intestinal anion exchanger SLC26A3 for therapy of hyperoxaluria and nephrolithiasis.
  2. Cystinuria: An Overview of Diagnosis and Medical Management.
  3. Lubiprostone is non-selective activator of cAMP-gated ion channels and Clc-2 has a minor role in its prosecretory effect in intestinal epithelial cells.
  4. SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine.
  5. A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats.
  6. Repurposing calcium-sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas.
  7. a-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases.
  8. 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation.
  9. Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A.
  10. Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.
  11. Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea.
  12. SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation.
  13. Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1.
  14. Monogenic Causes of Proteinuria in Children.
  15. Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A).
  16. High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators.
  17. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.
  18. Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.
  19. Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide.
  20. CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation.
  21. A Turkish BCS1L mutation causes GRACILE-like disorder.
  22. MCP1 2518 A/G polymorphism affects progression of childhood focal segmental glomerulosclerosis.
  23. Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats.
  24. Genetic abnormalities and prognosis in patients with congenital and infantile nephrotic syndrome.
  25. Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.
  26. Small-molecule inhibitors of urea transporters.
  27. A novel mutation in protein C gene (PROC) causing severe phenotype in neonatal period.
  28. Protective effect of coenzyme Q10 in paclitaxel-induced peripheral neuropathy in rats.
  29. Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis.
  30. The diuretic effect of urea analog dimethylthiourea in female Wistar rats.
  31. Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical.
  32. Family history of renal disease severity predicts the mutated gene in ADPKD.
  33. Evidence for pathogenicity of atypical splice mutations in autosomal dominant polycystic kidney disease.