Sanjeev Datar, MD, PhD

Education
2019 - Diversity, Equity, and Inclusion Champion Training, University of California
Fellowship, Pediatric Critical Care Medicine, 2008 - School of Medicine, University of California, San Francisco
Residency, Pediatrics, 2004 - School of Medicine, University of California, San Francisco
M.D., 2001 - School of Medicine, University of Washington
Ph.D., 2000 - Molecular and Cellular Biology, University of Washington/Fred Hutchinson Cancer Research Center
B.S., 1991 - Molecular Biophysics & Biochemistry, Yale University
Honors and Awards
  • RAP Pilot Grant for Established Investigators, UCSF, 2022
  • Pediatric Heart Center Catalyst Award, UCSF Benioff Children's Hospitals, 2022
  • RAP Pilot Grant for Junior Investigators, UCSF, 2014
  • Elected as Member of the Society for Pediatric Research, Council of the Society for Pediatric Research, 2013
  • Ida M. Cannon Award: The Dorothy Bradley Award for Integrity, The Pediatric Social Work Department, UCSF Benioff Children's Hospital, 2013
  • WSA Beginning Grant-in-Aid Award, American Heart Association, 2012
  • Excellence in Teaching Award, The Haile T. Debas Academy of Medical Educators, 2012
  • Charlotte Coleman Frey Pediatric Intensive Care Fellowship Award, Children's Hospital & Research Center Oakland, 2007
  • ACE Partnership Award, Science and Health Education Partnership, 2003
  • ARCS Foundation Fellow, Achievement Rewards for College Scientists (ARCS), 1998
  • Fred Hutchinson Scholarship Award for Outstanding Scholarship in the Field of Cancer Research, Fred Hutchinson Cancer Research Center, 1995
  • MSTP Fellow, University of Washington, 1992-2000
Websites

  1. Sun X, Moreno Caceres S, Yegambaram M, Lu Q, Pokharel MD, Boehme JT, Datar SA, Aggarwal S, Wang T, Fineman JR, Black SM. The mitochondrial redistribution of ENOS is regulated by AKT1 and dimer status. Nitric oxide : biology and chemistry 2024. PMID: 39332480


  2. Maltepe E, Smith M, Boehme J, Datar SA, Hutchings RS, Vento CA, Manzoor H, Loucks A, Winger JA, Fineman JR. OMX: A Novel Oxygen Delivery Biotherapeutic Improves Outcomes in an Ovine Model of Controlled Hemorrhagic Shock. Shock (Augusta, Ga.) 2024. PMID: 38662597


  3. Youssef Ahmed, Stephen Bennett, Jason Boehme, David Teitel, Jeffrey Fineman, Sanjeev Datar. 1180: PULMONARY PULSE WAVE ANALYSIS: A NOVEL MODEL TO IDENTIFY VASCULAR INJURY IN PULMONARY HYPERTENSION. Critical care medicine 2023. PMID:


  4. Boehme JT, Sun X, Lu Q, Barton J, Wu X, Gong W, Raff GW, Datar SA, Wang T, Fineman JR, Black SM. Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation. Nitric oxide : biology and chemistry 2023. PMID: 38061411


  5. Soares JHN, Raff GW, Fineman JR, Datar SA. Respiratory mechanics and gas exchange in an ovine model of congenital heart disease with increased pulmonary blood flow and pressure. Frontiers in physiology 2023. PMID: 37362431


  6. Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA. HIF-1a promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow. Scientific Reports 2021. PMID: 33446832


  7. Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR. Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease. Pulmonary circulation 2020. PMID: 32489641


  8. Antoni Garcia-Herreros, Rebecca J. Kameny, Terry Zhu, Jason Boehme, Gary Raff, Juan C. Lasheras, Stephen M. Black, Emin Maltepe, Sanjeev A. Datar, Jeffrey R. Fineman. Mechanical Forces Alter Endothelin-1 Signaling: Comparative Ovine Models of Congenital Heart Disease. Biophysical journal 2020. PMID:


  9. Rebecca Johnson Kameny, Sanjeev A. Datar, Jason Boehme, Jeffrey R. Fineman. The Adaptive Right Ventricle in Eisenmenger Syndrome: Potential Therapeutic Targets for Pulmonary Hypertension?. 2020. PMID:


  10. Johnson Kameny R, Datar SA, Boehme JB, Morris C, Zhu T, Goudy BD, Johnson EG, Galambos C, Raff GW, Sun X, Wang T, Chiacchia SR, Lu Q, Black SM, Maltepe E, Fineman JR. Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling. American journal of respiratory cell and molecular biology 2019. PMID: 30620615


  11. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS biology 2019. PMID: 30677022


  12. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS biology 2018. PMID: 30335746


  13. Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR. Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease. American journal of physiology. Heart and circulatory physiology 2018. PMID: 29906222


  14. Burke E, Datar SA. Lymphatic dysfunction in critical illness. 2018. PMID: 29538048


  15. Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA. KLF2-mediated disruption of PPAR-? signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. American journal of physiology. Heart and circulatory physiology 2018. PMID: 29631374


  16. Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman JR. Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2017. PMID: 28723882


  17. Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E. Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. American journal of physiology. Heart and circulatory physiology 2016. PMID: 27591215


  18. Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR. Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. American journal of physiology. Heart and circulatory physiology 2016. PMID: 27199125


  19. Kameny RJ, He Y, Morris C, Sun C, Johengen M, Gong W, Raff GW, Datar SA, Oishi PE, Fineman JR. Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype. American journal of physiology. Heart and circulatory physiology 2015. PMID: 25934095


  20. Jun Maki, Rebecca Johnson, Sanjeev Datar, Wenhui Gong, Michael Johengen, Christine Sun, Peter Oishi, Jeffrey Fineman. 162. Critical care medicine 2014. PMID:


  21. Rebecca Kameny, Catherine Morris, Youping He, Christine Sun, Jun Maki, Sanjeev Datar, Peter Oishi, Jeffrey Fineman. 220. Critical care medicine 2014. PMID:


  22. Gross CM, Aggarwal S, Kumar S, Tian J, Kasa A, Bogatcheva N, Datar SA, Verin AD, Fineman JR, Black SM. Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress. Journal of cellular physiology 2014. PMID: 24677020


  23. Johnson RC, Datar SA, Oishi PE, Bennett S, Maki J, Sun C, Johengen M, He Y, Raff GW, Redington AN, Fineman JR. Adaptive right ventricular performance in response to acutely increased afterload in a lamb model of congenital heart disease: evidence for enhanced Anrep effect. American journal of physiology. Heart and circulatory physiology 2014. PMID: 24561861


  24. Datar SA, Oishi PE, Gong W, Bennett SH, Sun CE, Johengen M, Maki J, Johnson RC, Raff GW, Fineman JR. Altered reactivity and nitric oxide signaling in the isolated thoracic duct from an ovine model of congenital heart disease with increased pulmonary blood flow. American journal of physiology. Heart and circulatory physiology 2014. PMID: 24531811


  25. Peter Oishi, Sanjeev A. Datar, Jeffrey R. Fineman. Pulmonary Hypertension. Pediatric Critical Care Medicine 2014. PMID:


  26. Radman M, Keller RL, Oishi P, Datar SA, Wellnitz K, Azakie A, Hanley F, Char D, Hsu JH, Amrinovin R, Adatia I, Fineman JR. Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan). The Journal of thoracic and cardiovascular surgery 2013. PMID: 24079880


  27. Sharma S, Aramburo A, Rafikov R, Sun X, Kumar S, Oishi PE, Datar SA, Raff G, Xoinis K, Kalkan G, Fratz S, Fineman JR, Black SM. L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow. Pediatric research 2013. PMID: 23628882


  28. Radman M, Mack R, Barnoya J, Castañeda A, Rosales M, Azakie A, Mehta N, Keller R, Datar S, Oishi P, Fineman J. The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR). The Journal of thoracic and cardiovascular surgery 2013. PMID: 23583172


  29. Kumar S, Oishi PE, Rafikov R, Aggarwal S, Hou Y, Datar SA, Sharma S, Azakie A, Fineman JR, Black SM. Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow. Journal of cellular biochemistry 2013. PMID: 22961736


  30. Sharma S, Barton J, Rafikov R, Aggarwal S, Kuo HC, Oishi PE, Datar SA, Fineman JR, Black SM. Chronic inhibition of PPAR-? signaling induces endothelial dysfunction in the juvenile lamb. Pulmonary pharmacology & therapeutics 2012. PMID: 23257346


  31. Oishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman JR. Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow. Pediatric research 2012. PMID: 23128423


  32. Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman JR. Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis. Pediatric cardiology 2012. PMID: 22961274


  33. Sharma S, Sun X, Rafikov R, Kumar S, Hou Y, Oishi PE, Datar SA, Raff G, Fineman JR, Black SM. PPAR-? regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow. PloS one 2012. PMID: 22962578


  34. Amirnovin R, Keller RL, Herrera C, Hsu JH, Datar S, Karl TR, Adatia I, Oishi P, Fineman JR. B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion. The Journal of thoracic and cardiovascular surgery 2012. PMID: 22914252


  35. Radman MR, Goldhoff P, Jones KD, Azakie A, Datar S, Adatia I, Oishi PE, Fineman JR. Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease? Pediatric cardiology 2012. PMID: 22614905


  36. Peter E. Oishi, Aida Field-Ridley, Sanjeev A. Datar, Jeffrey R. Fineman. B-Type Natriuretic Peptide (BNP) in Neonates, Infants and Children Undergoing Cardiac Surgery. Front Lines of Thoracic Surgery 2012. PMID:


  37. Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman JR. Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow. American journal of physiology. Lung cellular and molecular physiology 2011. PMID: 22207591


  38. Aggarwal S, Gross CM, Kumar S, Datar S, Oishi P, Kalkan G, Schreiber C, Fratz S, Fineman JR, Black SM. Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. Journal of cellular physiology 2011. PMID: 21351102


  39. Oishi P, Datar SA, Fineman JR. Advances in the management of pediatric pulmonary hypertension. Respiratory care 2011. PMID: 21944683


  40. Oishi P, Datar SA, Fineman JR. Pediatric pulmonary arterial hypertension: current and emerging therapeutic options. Expert opinion on pharmacotherapy 2011. PMID: 21609302


  41. Tian J, Fratz S, Hou Y, Lu Q, Görlach A, Hess J, Schreiber C, Datar SA, Oishi P, Nechtman J, Podolsky R, She JX, Fineman JR, Black SM. Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease. Physiological genomics 2010. PMID: 20978110


  42. Hsu JH, Oishi P, Wiseman DA, Hou Y, Chikovani O, Datar S, Sajti E, Johengen MJ, Harmon C, Black SM, Fineman JR. Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide. American journal of physiology. Lung cellular and molecular physiology 2010. PMID: 20363848


  43. Sharma S, Kumar S, Sud N, Wiseman DA, Tian J, Rehmani I, Datar S, Oishi P, Fratz S, Venema RC, Fineman JR, Black SM. Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow. Vascular pharmacology 2009. PMID: 19818875


  44. Roblee P. Allen, Gary Raff, Sanjeev Datar, Anita Moon, Jay M. Milstein, Stephen H. Bennett, Stephen M. Black, Jeffery R. Fineman, Marlowe W. Eldridge. A CAUSAL DESIGN TRAJECTORY LINKS DIVERSE FORMS OF PULMONARY HYPERTENSION: EVIDENCE OF A FETAL PHENOTYPE OF ARTERIAL REMODELING UNDER THE PRINCIPLE OF MINIMUM WORK. 2009. PMID:


  45. Oishi PE, Wiseman DA, Sharma S, Kumar S, Hou Y, Datar SA, Azakie A, Johengen MJ, Harmon C, Fratz S, Fineman JR, Black SM. Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress. American journal of physiology. Lung cellular and molecular physiology 2008. PMID: 18757524


  46. Datar SA, Galloni M, de la Cruz A, Marti M, Edgar BA, Frei C. Mammalian cyclin D1/Cdk4 complexes induce cell growth in Drosophila. 2006. PMID: 16582602


  47. Meyer CA, Jacobs HW, Datar SA, Du W, Edgar BA, Lehner CF. Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. 2000. PMID: 10970847


  48. Datar SA, Jacobs HW, de la Cruz AF, Lehner CF, Edgar BA. The Drosophila cyclin D-Cdk4 complex promotes cellular growth. 2000. PMID: 10970848


  49. Edgar BA, Datar SA. Zygotic degradation of two maternal Cdc25 mRNAs terminates Drosophila's early cell cycle program. 1996. PMID: 8756353