Shylaja Srinivasan, MD, MAS

I am a clinican-scientist and Assistant Professor of Pediatrics in the Division of Pediatric Endocrinology at UCSF. My clinical and scientific focus is on prediabetes and type 2 diabetes in youth. Specifically, I use pharmacologic and genetic approaches to evaluate pathophysiology and therapeutic strategies for youth with prediabetes and type 2 diabetes. I lead the type 2 diabetes program at the UCSF Madison Clinic for Pediatric Diabetes. I am also an Associate Program Director for the fellowship training program.
Education
MAS, 2022 - Clinical Research, University of California
2021 - Diversity, Equity, and Inclusion Champion Training, University of California
Pediatric endocrinology fellowship training, 2016 - , Massachusetts General Hospital, Boston, MA
Pediatric residency training, 2013 - , Tufts Medical Center, Boston, MA
Pediatric residency training, 2012 - , SUNY Downstate Medical Center, Brooklyn, NY
MBBS, 2008 - , Pondicherry Institute of Medical Sciences, Pondicherry, India
Honors and Awards
  • Young Investigator Award, Pediatric Endocrine Society, 2024
  • Clinical Scholar Award, Pediatric Endocrine Society, 2018-2019
  • Clinical Scholar Award, Pediatric Endocrine Society, 2016-2017

  1. Kwak SH, Srinivasan S, Chen L, Todd J, Mercader JM, Jensen ET, Divers J, Mottl AK, Pihoker C, Gandica RG, Laffel LM, Isganaitis E, Haymond MW, Levitsky LL, Pollin TI, Florez JC, Flannick J, Progress in Diabetes Genetics in Youth (ProDiGY) consortium. Genetic architecture and biology of youth-onset type 2 diabetes. Nature metabolism 2024. PMID: 38278947


  2. Pham DT, Westerman KE, Pan C, Chen L, Srinivasan S, Isganaitis E, Vajravelu ME, Bacha F, Chernausek S, Gubitosi-Klug R, Divers J, Pihoker C, Marcovina SM, Manning AK, Chen H. Re-analysis and meta-analysis of summary statistics from gene-environment interaction studies. Bioinformatics (Oxford, England) 2023. PMID: 38039147


  3. Srinivasan S, Wu P, Mercader JM, Udler MS, Porneala BC, Bartz TM, Floyd JS, Sitlani C, Guo X, Haessler J, Kooperberg C, Liu J, Ahmad S, van Duijn C, Liu CT, Goodarzi MO, Florez JC, Meigs JB, Rotter JI, Rich SS, Dupuis J, Leong A. A Type 1 Diabetes Polygenic Score Is Not Associated With Prevalent Type 2 Diabetes in Large Population Studies. Journal of the Endocrine Society 2023. PMID: 37841955


  4. Misra S, Ke C, Srinivasan S, Goyal A, Nyriyenda MJ, Florez JC, Khunti K, Magliano DJ, Luk A. Current insights and emerging trends in early-onset type 2 diabetes. The lancet. Diabetes & endocrinology 2023. PMID: 37708901


  5. Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, Xiao S, Williams LK, Franks PW, Hanson RL, Kahn SE, Knowler WC, Pollin TI, Florez JC, Diabetes Prevention Program Research Group. Identification of Genetic Variation Influencing Metformin Response in a Multi-Ancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP). Diabetes 2022. PMID: 36525397


  6. Tester JM, Xiao L, Chau CA, Tinajero-Deck L, Srinivasan S, Rosas LG. Greater Improvement in Obesity Among Children With Prediabetes in a Clinical Weight Management Program. Childhood obesity (Print) 2023. PMID: 37347933


  7. SHYLAJA SRINIVASAN, LING CHEN, MEGAN M. KELSEY, JENNIFER TODD, SILVA A. ARSLANIAN, NANCY T. CHANG, LORI M. LAFFEL, LYNNE L. LEVITSKY, JENNIFER E. SPRAGUE, TONI I. POLLIN, ALISA MANNING, JOSE C. FLOREZ. 1091-P: Genetic Ancestry Influences Metformin Treatment Response in Youth with Type 2 Diabetes. Diabetes 2023. PMID:


  8. Srinivasan S, Chen L, Udler M, Todd J, Kelsey MM, Haymond MW, Arslanian S, Zeitler P, Gubitosi-Klug R, Nadeau KJ, Kutney K, White NH, Li JH, Perry JA, Kaur V, Brenner L, Mercader JM, Dawed A, Pearson ER, Yee SW, Giacomini KM, Pollin T, Florez JC. Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes. Pediatric diabetes 2023. PMID: 38590442


  9. Kwak SH, Srinivasan S, Chen L, Todd J, Mercader J, Jensen E, Divers J, Mottl A, Pihoker C, Gandica R, Laffel L, Isganaitis E, Haymond M, Levitsky L, Pollin T, Florez J, Flannick J. Insights from rare variants into the genetic architecture and biology of youth-onset type 2 diabetes. Research square 2023. PMID: 37292813


  10. Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbinski L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL, Marchetti P, Marselli L, Chen L, Srinivasan S, Todd J, Flannick J, Gubitosi-Klug R, Levitsky L, Shah R, Kelsey M, Burke B, Dabelea DM, Divers J, Marcovina S, Stalbow L, Loos RJF, Darst BF, Kooperberg C, Raffield LM, Haiman C, Sun Q, McCormick JB, Fisher-Hoch SP, Ordoñez ML, Meigs J, Baier LJ, González-Villalpando C, González-Villalpando ME, Orozco L, García-García L, Moreno-Estrada A, Mexican Biobank, Aguilar-Salinas CA, Tusié T, Dupuis J, Ng MCY, Manning A, Highland HM, Cnop M, Hanson R, Below J, Florez JC, Leong A, Mercader JM. The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes. Diabetologia 2023. PMID: 37148359


  11. Chesser H, Srinivasan S, Puckett C, Gitelman SE, Wong JC. Real-Time Continuous Glucose Monitoring in Adolescents and Young Adults With Type 2 Diabetes Can Improve Quality of Life. Journal of diabetes science and technology 2022. PMID: 36416098


  12. Magge SN, Wolf RM, Pyle L, Brown EA, Benavides VC, Bianco ME, Chao LC, Cymbaluk A, Gumus Balikcioglu P, Halpin K, Hsia DS, Huerta-Saenz L, Kim JJ, Kumar S, Levitt Katz LE, Marks BE, Neyman A, O'Sullivan KL, Sasidharan Pillai S, Shah AS, Shoemaker AH, Siddiqui JAW, Srinivasan S, Thomas IH, Tryggestad JB, Yousif MF, Kelsey MM, COVID-19 and Type 2 Diabetes Consortium. The COVID-19 pandemic is associated with a substantial rise in frequency and severity of presentation of youth-onset type 2 diabetes. The Journal of pediatrics 2022. PMID: 35985535


  13. Schulmeister C, Lee J, Perwad F, Long R, Srinivasan S. Rickets in a child with prolonged acquired hypothyroidism secondary to Hashimoto's thyroiditis. Endocrinology, diabetes & metabolism case reports 2022. PMID: 35979838


  14. Srinivasan S, Todd J. The genetics of type 2 diabetes in youth: Where we are and the road ahead. 2022. PMID: 35660490


  15. Santoro N, Chen L, Todd J, Divers J, Shah AS, Gidding SS, Burke B, Haymond M, Lange L, Marcovina S, Flannick J, Caprio S, Florez JC, Srinivasan S. Genome-wide Association Study of Lipid Traits in Youth With Type 2 Diabetes. Journal of the Endocrine Society 2021. PMID: 34568709


  16. Todd JN, Kleinberger JW, Zhang H, Srinivasan S, Tollefsen SE, Levitsky LL, Levitt Katz LE, Tryggestad JB, Bacha F, Imperatore G, Lawrence JM, Pihoker C, Divers J, Flannick J, Dabelea D, Florez JC, Pollin TI. Monogenic Diabetes in Youth With Presumed Type 2 Diabetes: Results From the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration. Diabetes care 2021. PMID: 34362814


  17. Srinivasan S, Ekhlaspour L, Cengiz E. Adjunctive Therapies to Optimize Closed-loop Glucose Control. Journal of diabetes science and technology 2021. PMID: 34315267


  18. SOO HEON KWAK, SHYLAJA SRINIVASAN, LING CHEN, JENNIFER TODD, ELIZABETH T. JENSEN, JASMIN DIVERS, AMY K. MOTTL, CATHERINE PIHOKER, RACHELLE GANDICA, LORI M. LAFFEL, ELVIRA M. ISGANAITIS, MOREY W. HAYMOND, LYNNE L. LEVITSKY, TONI I. POLLIN, JOSE C. FLOREZ, JASON FLANNICK. 23-OR: ADA Presidents’ Select Abstract: Genetic Architecture and Novel Genes Implicated in Youth-Onset Type 2 Diabetes. Diabetes 2021. PMID:


  19. LIANA K. BILLINGS, KATHLEEN A. JABLONSKI, PAUL W. FRANKS, RONALD B. GOLDBERG, MARIE-FRANCE HIVERT, STEVEN E. KAHN, WILLIAM C. KNOWLER, CHRISTINE LEE, JORDI MERINO, SRIDHARAN RAGHAVAN, SHYLAJA SRINIVASAN, JIANFENG XU, JOSE C. FLOREZ, MIRIAM UDLER. 249-OR: Type 2 Diabetes (T2D) Genetic Clusters for Association with Glycemic Responses to Intervention for Diabetes Prevention. Diabetes 2021. PMID:


  20. JOSEPHINE H. LI, JAMES A. PERRY, KATHLEEN A. JABLONSKI, LING CHEN, SHYLAJA SRINIVASAN, JENNIFER N. TODD, MAEGAN HARDEN, JOSEP M. MERCADER, PAUL W. FRANKS, ROBERT L. HANSON, STEVEN E. KAHN, WILLIAM C. KNOWLER, TONI I. POLLIN, JOSE C. FLOREZ, DPP RESEARCH GROUP. 28-OR: Identification of Ancestry-Specific Alleles in a Genome-Wide Association Study (GWAS) for Metformin (MET) Response in the Diabetes Prevention Program (DPP). Diabetes 2021. PMID:


  21. HANNAH CHESSER, SHYLAJA SRINIVASAN, JENISE C. WONG. 900-P: Continuous Glucose Monitoring in Youth with Type 2 Diabetes: A Pilot and Feasibility Study. Diabetes 2021. PMID:


  22. Srinivasan S, Chen L, Todd J, Divers J, Gidding S, Chernausek S, Gubitosi-Klug RA, Kelsey MM, Shah R, Black MH, Wagenknecht LE, Manning A, Flannick J, Imperatore G, Mercader JM, Dabelea D, Florez JC, ProDiGY Consortium. The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium. Diabetes 2021. PMID: 33479058


  23. Hannah Chesser, Shylaja Srinivasan. Overview and Initial Management of Type 2 Diabetes in Youth. 2020. PMID:


  24. Srinivasan S, Jablonski KA, Knowler WC, Dagogo-Jack S, E Kahn S, Boyko EJ, Bray GA, Horton ES, Hivert MF, Goldberg R, Chen L, Mercader J, Harden M, Florez JC, Diabetes Prevention Program Research Group. A Polygenic Lipodystrophy Genetic Risk Score Characterizes Risk Independent of BMI in the Diabetes Prevention Program. 2019. PMID: 31428720


  25. LING CHEN, SHYLAJA SRINIVASAN, NICOLA SANTORO, JENNIFER TODD, JASMIN DIVERS, AMY SANGHAVI SHAH, SAMUEL GIDDING, BRIAN K. BURKE, MOREY W. HAYMOND, LESLIE LANGE, SANTICA M. MARCOVINA, ALAN CHAIT, JASON FLANNICK, SONIA CAPRIO, JOSE C. FLOREZ. 177-OR: Genome-Wide Association Study of Lipid Traits in Youth with Type 2 Diabetes: The ProDiGY (Progress in Diabetes Genetics in Youth) Consortium. 2019. PMID:


  26. Armaiti Mody, Janet Lee, Jessica Tenney, Shylaja Srinivasan. MON-268 A Rare Case of Primary Hypoaldosteronism in a Newborn. 2019. PMID:


  27. SHYLAJA SRINIVASAN, AARON LEONG, MIRIAM UDLER, BIANCA C. PORNEALA, JAMES B. MEIGS, STEPHEN S. RICH, JOSEE DUPUIS. A Comprehensive Type 1 Diabetes Genetic Risk Score Is Associated with Type 2 Diabetes in the Framingham Heart Study. 2018. PMID:


  28. Todd JN, Srinivasan S, Pollin TI. Advances in the Genetics of Youth-Onset Type 2 Diabetes. 2018. PMID: 29931398


  29. Srinivasan S, Yee SW, Giacomini KM. Pharmacogenetics of Antidiabetic Drugs. 2018. PMID: 29801583


  30. JENNIFER TODD, JEFFREY W. KLEINBERGER, SHYLAJA SRINIVASAN, SHERIDA E. TOLLEFSEN, LYNNE L. LEVITSKY, LORRAINE E.L. KATZ, JEANIE B. TRYGGESTAD, FIDA BACHA, GIUSEPPINA IMPERATORE, JEAN M. LAWRENCE, CATHERINE PIHOKER, JASMIN DIVERS, JASON FLANNICK, DANA DABELEA, JOSE C. FLOREZ, TONI I. POLLIN. Monogenic Diabetes in the Progress for Diabetes Genetics in Youth (ProDiGY) Collaboration. 2018. PMID:


  31. SHYLAJA SRINIVASAN, JENNIFER TODD, LING CHEN, JASMIN DIVERS, SAM GIDDING, STEVEN CHERNAUSEK, ROSE GUBITOSI-KLUG, MEGAN M. KELSEY, RACHANA SHAH, MARY HELEN BLACK, LYNNE E. WAGENKNECHT, JOSE M. MERCADER, ALISA MANNING, JASON FLANNICK, DANA DABELEA, JOSE C. FLOREZ. The First Genome-Wide Association Study (GWAS) for Type 2 Diabetes in Youth from the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration. 2018. PMID:


  32. Srinivasan S, Kaur V, Chamarthi B, Littleton KR, Chen L, Manning AK, Merino J, Thomas MK, Hudson M, Goldfine A, Florez JC. TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH). 2018. PMID: 29326107


  33. Srinivasan S., Yee SW., Giacomini K. In Advances in Pharmacology, Elsevier 2018. PMID:


  34. Srinivasan S., Levitsky L. Radovick and Misra’s Pediatric Endocrinology: A Practical Clinical Guide, Springer International 2018. PMID:


  35. Shylaja Srinivasan, Lynne L. Levitsky. Type 2 Diabetes Mellitus in Youth. 2018. PMID:


  36. Srinivasan S, O'Rourke J, Bersche Golas S, Neumeyer A, Misra M. Calcium and Vitamin D Supplement Prescribing Practices among Providers Caring for Children with Autism Spectrum Disorders: Are We Addressing Bone Health? 2016. PMID: 27042348


  37. Srinivasan S, Florez JC. Therapeutic Challenges in Diabetes Prevention: We Have Not Found the "Exercise Pill". 2015. PMID: 25974616


  38. Shylaja Srinivasan, Madhusmita Misra. Hyperthyroidism in Children. 2015. PMID:


  39. Srinivasan S, Misra M. Hyperthyroidism in children. 2015. PMID: 26034254


  40. Kaplowitz P, Srinivasan S, He J, McCarter R, Hayeri MR, Sze R. Comparison of bone age readings by pediatric endocrinologists and pediatric radiologists using two bone age atlases. 2010. PMID: 21161206