Cristina Alvira, MD

  1. Ingles JA, Rodriguez Z, Fornes D, Ying L, Han X, Cornfield DN, Alvira CM. Loss of TRPV4 decreases NFκB-mediated myometrial inflammation and prevents preterm labor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025. PMID: 39989412


  2. Ying L, Fornes DD, Dobberfuhl AD, Ansari JR, Alvira CM, Cornfield DN. miR-203 modulates pregnant myometrium contractility via transient receptor potential vanilloid 4 channel expression. Volume 38 of Issue 22. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024. PMID: 39545721


  3. Dammann CE, Alvira CM, Devaskar SU, St Geme JW, Golden WC, Gordon CM, Hoffmann B, Lakshminrusimha S, Leslie LK, Trent M, Winer KK, Fromme HB. Pediatric subspecialty workforce: what is needed to secure its vitality and survival? Pediatric research 2024. PMID: 39455858


  4. Hough RF, Alvira CM, Bastarache JA, Erzurum SC, Kuebler WM, Schmidt EP, Shimoda LA, Abman SH, Alvarez DF, Belvitch P, Bhattacharya J, Birukov KG, Chan SY, Cornfield DN, Dudek SM, Garcia JGN, Harrington EO, Hsia CCW, Islam MN, Jonigk DD, Kalinichenko VV, Kolb TM, Lee JY, Mammoto A, Mehta D, Rounds S, Schupp JC, Shaver CM, Suresh K, Tambe DT, Ventetuolo CE, Yoder MC, Stevens T, Damarla M. Studying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report. Volume 71 of Issue 4. American journal of respiratory cell and molecular biology 2024. PMID: 39189891


  5. Agarwal S, Fineman J, Cornfield DN, Alvira CM, Zamanian RT, Goss K, Yuan K, Bonnet S, Boucherat O, Pullamsetti S, Alcázar MA, Goncharova E, Kudryashova TV, Nicolls MR, de Jesús Pérez V. VIEWING PULMONARY HYPERTENSION THROUGH A PEDIATRIC LENS. The European respiratory journal 2024. PMID: 38575157


  6. Zanini F, Che X, Suresh NE, Knutsen C, Klavina P, Xie Y, Domingo-Gonzalez R, Liu M, Kum A, Jones RC, Quake SR, Alvira CM, Cornfield DN. Hyperoxia prevents the dynamic neonatal increases in lung mesenchymal cell diversity. Volume 14 of Issue 1. Scientific Reports 2024. PMID: 38263350


  7. Wang C, Wang YJ, Ying L, Wong RJ, Quaintance CC, Hong X, Neff N, Wang X, Biggio JR, Mesiano S, Quake SR, Alvira CM, Cornfield DN, Stevenson DK, Shaw GM, Li J. Integrative analysis of noncoding mutations identifies the druggable genome in preterm birth. Volume 10 of Issue 3. Science advances 2024. PMID: 38241369


  8. Hirani DV, Thielen F, Mansouri S, Danopoulos S, Vohlen C, Haznedar-Karakaya P, Mohr J, Wilke R, Selle J, Grosch T, Mizik I, Odenthal M, Alvira CM, Kuiper-Makris C, Pryhuber GS, Pallasch C, van Koningsbruggen-Rietschel S, Al-Alam D, Seeger W, Savai R, Dötsch J, Alejandre Alcazar MA. CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia. Volume 43 of Issue 1. Inflammation and regeneration 2023. PMID: 37876024


  9. Barnes EA, Ito R, Che X, Alvira CM, Cornfield DN. Loss of prolyl hydroxylase 1 and 2 in SM22α-expressing cells prevents Hypoxia-Induced pulmonary hypertension. Volume 325 of Issue 6. American journal of physiology. Lung cellular and molecular physiology 2023. PMID: 37847687


  10. Barnes EA, Knutsen C, Kindt A, Che X, Ying L, Adams E, Gonzalez E, Oak P, Hilgendorff A, Alvira CM, Cornfield DN. Hypoxia-Inducible Factor-1α in SM22α-Expressing Cells Modulates Alveolarization. Volume 69 of Issue 4. American journal of respiratory cell and molecular biology 2023. PMID: 37290124


  11. Rao S, Liu M, Iosef C, Knutsen C, Alvira CM. Endothelial-specific loss of IKKβ disrupts pulmonary endothelial angiogenesis and impairs postnatal lung growth. Volume 325 of Issue 3. American journal of physiology. Lung cellular and molecular physiology 2023. PMID: 37310763


  12. Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou EA, Auer N, Mitra A, Guardado ES, Swaminathan G, Condon DF, Yu J, McCarra M, Juul NH, Mallory A, Guzman-Hernandez RA, Yuan K, Rojas V, Crossno JT, Yung LM, Yu PB, Spencer T, Winn RA, Frump A, Karoor V, Lahm T, Hedlin H, Fineman JR, Lafyatis R, Knutsen CNF, Alvira CM, Cornfield DN, de Jesus Perez VA. WNT7A deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension. The European respiratory journal 2023. PMID: 37024132


  13. Zanini F, Che X, Knutsen C, Liu M, Suresh NE, Domingo-Gonzalez R, Dou SH, Zhang D, Pryhuber GS, Jones RC, Quake SR, Cornfield DN, Alvira CM. Developmental diversity and unique sensitivity to injury of lung endothelial subtypes during postnatal growth. Volume 26 of Issue 3. iScience 2023. PMID: 36879800


  14. Ito R, Barnes EA, Che X, Alvira CM, Cornfield DN. SM22α cell-specific HIF stabilization mitigates hyperoxia-induced neonatal lung injury. Volume 323 of Issue 2. American journal of physiology. Lung cellular and molecular physiology 2022. PMID: 35762602


  15. Hirani D, Alvira CM, Danopoulos S, Milla C, Donato M, Tian L, Mohr J, Dinger K, Vohlen C, Selle J, V Koningsbruggen-Rietschel S, Barbarino V, Pallasch C, Rose-John S, Odenthal M, Pryhuber GS, Mansouri S, Savai R, Seeger W, Khatri P, Al Alam D, Dötsch J, Alejandre Alcazar MA. Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia. Volume 59 of Issue 2. The European respiratory journal 2022. PMID: 34446466


  16. Alvira CM. Dynamism of the Human Lung Proteome during Alveolarization: Moving beyond the Transcriptome. Volume 205 of Issue 2. American journal of respiratory and critical care medicine 2022. PMID: 34797738


  17. Liu M, Iosef C, Rao S, Domingo-Gonzalez R, Fu S, Snider P, Conway SJ, Umbach GS, Heilshorn SC, Dewi RE, Dahl MJ, Null DM, Albertine KH, Alvira CM. Transforming Growth Factor-induced Protein Promotes NF-κB-mediated Angiogenesis during Postnatal Lung Development. Volume 64 of Issue 3. American journal of respiratory cell and molecular biology 2021. PMID: 33264084


  18. Zepp JA, Alvira CM. Nanoparticle Delivery of Angiogenic Gene Therapy. Save the Vessels, Save the Lung! Volume 202 of Issue 1. American journal of respiratory and critical care medicine 2020. PMID: 32338996


  19. Domingo-Gonzalez R, Zanini F, Che X, Liu M, Jones RC, Swift MA, Quake SR, Cornfield DN, Alvira CM. Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution. Volume 9. eLife 2020. PMID: 32484158


  20. Duan S, Chan WK, Oman A, Basile DP, Alvira CM, Buxton ILO, Iosef C. NF-κB/NKILA signaling modulates the anti-cancerous effects of EZH2 inhibition. Volume 23 of Issue 9. Journal of cellular and molecular medicine 2019. PMID: 31282094


  21. Alvira CM, Steinhorn RH, Balistreri WF, Fineman JR, Oishi PE, Padbury JF, Kinsella JP, Abman SH. Enhancing the Development and Retention of Physician-Scientists in Academic Pediatrics: Strategies for Success. The Journal of pediatrics 2018. PMID: 30055815


  22. Iosef C, Liu M, Ying L, Rao SP, Concepcion KR, Chan WK, Oman A, Alvira CM. Distinct roles for IκB kinases alpha and beta in regulating pulmonary endothelial angiogenic function during late lung development. Volume 22 of Issue 9. Journal of cellular and molecular medicine 2018. PMID: 29993183


  23. Wang CC, Ying L, Barnes EA, Adams ES, Kim FY, Engel KW, Alvira CM, Cornfield DN. Pulmonary artery smooth muscle cell HIF-1α regulates endothelin expression via microRNA-543. Volume 315 of Issue 3. American journal of physiology. Lung cellular and molecular physiology 2018. PMID: 29745253


  24. Dodson RB, Powers KN, Gien J, Rozance PJ, Seedorf G, Astling D, Jones K, Crombleholme TM, Abman SH, Alvira CM. Intrauterine growth restriction decreases NF-κB signaling in fetal pulmonary artery endothelial cells of fetal sheep. Volume 315 of Issue 3. American journal of physiology. Lung cellular and molecular physiology 2018. PMID: 29722560


  25. Barnes EA, Lee L, Barnes SL, Brenner R, Alvira CM, Cornfield DN. β1-Subunit of the calcium-sensitive potassium channel modulates the pulmonary vascular smooth muscle cell response to hypoxia. Volume 315 of Issue 2. American journal of physiology. Lung cellular and molecular physiology 2018. PMID: 29644895


  26. Ying L, Alvira CM, Cornfield DN. Developmental differences in focal adhesion kinase expression modulate pulmonary endothelial barrier function in response to inflammation. Volume 315 of Issue 1. American journal of physiology. Lung cellular and molecular physiology 2018. PMID: 29597831


  27. Alvira CM, Morty RE. Can We Understand the Pathobiology of Bronchopulmonary Dysplasia? Volume 190. The Journal of pediatrics 2017. PMID: 29144252


  28. Okamura H, Emrich F, Trojan J, Chiu P, Dalal AR, Arakawa M, Sato T, Penov K, Koyano T, Pedroza A, Connolly AJ, Rabinovitch M, Alvira C, Fischbein MP. Long-term miR-29b suppression reduces aneurysm formation in a Marfan mouse model. Volume 5 of Issue 8. Physiological reports 2017. PMID: 28455451


  29. Alvira CM. Aberrant Pulmonary Vascular Growth and Remodeling in Bronchopulmonary Dysplasia. Volume 3. Frontiers in medicine 2016. PMID: 27243014


  30. Ehrhardt H, Pritzke T, Oak P, Kossert M, Biebach L, Förster K, Koschlig M, Alvira CM, Hilgendorff A. Absence of TNF-α enhances inflammatory response in the newborn lung undergoing mechanical ventilation. Volume 310 of Issue 10. American journal of physiology. Lung cellular and molecular physiology 2016. PMID: 27016588


  31. Vattulainen-Collanus S, Akinrinade O, Li M, Koskenvuo M, Li CG, Rao SP, de Jesus Perez V, Yuan K, Sawada H, Koskenvuo JW, Alvira C, Rabinovitch M, Alastalo TP. Loss of PPARγ in endothelial cells leads to impaired angiogenesis. Volume 129 of Issue 4. Journal of cell science 2016. PMID: 26743080


  32. Ying L, Becard M, Lyell D, Han X, Shortliffe L, Husted CI, Alvira CM, Cornfield DN. The transient receptor potential vanilloid 4 channel modulates uterine tone during pregnancy. Volume 7 of Issue 319. Science translational medicine 2015. PMID: 26702092


  33. Hou Y, Liu M, Husted C, Chen C, Thiagarajan K, Johns JL, Rao SP, Alvira CM. Activation of the nuclear factor-κB pathway during postnatal lung inflammation preserves alveolarization by suppressing macrophage inflammatory protein-2. Volume 309 of Issue 6. American journal of physiology. Lung cellular and molecular physiology 2015. PMID: 26163511


  34. Kim FY, Barnes EA, Ying L, Chen C, Lee L, Alvira CM, Cornfield DN. Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia. Volume 308 of Issue 4. American journal of physiology. Lung cellular and molecular physiology 2014. PMID: 25399435


  35. Emrich FC, Okamura H, Dalal AR, Penov K, Merk DR, Raaz U, Hennigs JK, Chin JT, Miller MO, Pedroza AJ, Craig JK, Koyano TK, Blankenberg FG, Connolly AJ, Mohr FW, Alvira CM, Rabinovitch M, Fischbein MP. Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of Marfan syndrome. Volume 35 of Issue 1. Arteriosclerosis, thrombosis, and vascular biology 2014. PMID: 25359856


  36. Ramsi M, Alvira C, Purohit P, Cornfield D. Haemophagocytic lymphohistiocytosis associated with coccidiomycosis. Volume 2014. BMJ case reports 2014. PMID: 25139924


  37. Baker CD, Alvira CM. Disrupted lung development and bronchopulmonary dysplasia: opportunities for lung repair and regeneration. Volume 26 of Issue 3. Current opinion in pediatrics 2014. PMID: 24739494


  38. Alvira CM. Nuclear factor-kappa-B signaling in lung development and disease: one pathway, numerous functions. Volume 100 of Issue 3. Birth defects research. Part A, Clinical and molecular teratology 2014. PMID: 24639404


  39. Hilgendorff A, Reiss I, Ehrhardt H, Eickelberg O, Alvira CM. Chronic lung disease in the preterm infant. Lessons learned from animal models. Volume 50 of Issue 2. American journal of respiratory cell and molecular biology 2014. PMID: 24024524


  40. Kim YM, Barnes EA, Alvira CM, Ying L, Reddy S, Cornfield DN. Hypoxia-inducible factor-1α in pulmonary artery smooth muscle cells lowers vascular tone by decreasing myosin light chain phosphorylation. Volume 112 of Issue 9. Circulation research 2013. PMID: 23513056


  41. Alvira CM, Umesh A, Husted C, Ying L, Hou Y, Lyu SC, Nowak J, Cornfield DN. Voltage-dependent anion channel-2 interaction with nitric oxide synthase enhances pulmonary artery endothelial cell nitric oxide production. Volume 47 of Issue 5. American journal of respiratory cell and molecular biology 2012. PMID: 22842492


  42. Iosef C, Alastalo TP, Hou Y, Chen C, Adams ES, Lyu SC, Cornfield DN, Alvira CM. Inhibiting NF-κB in the developing lung disrupts angiogenesis and alveolarization. Volume 302 of Issue 10. American journal of physiology. Lung cellular and molecular physiology 2012. PMID: 22367785


  43. Ahn YT, Kim YM, Adams E, Lyu SC, Alvira CM, Cornfield DN. Hypoxia-inducible factor-1α regulates KCNMB1 expression in human pulmonary artery smooth muscle cells. Volume 302 of Issue 3. American journal of physiology. Lung cellular and molecular physiology 2011. PMID: 22114151


  44. Merk DR, Chin JT, Dake BA, Maegdefessel L, Miller MO, Kimura N, Tsao PS, Iosef C, Berry GJ, Mohr FW, Spin JM, Alvira CM, Robbins RC, Fischbein MP. miR-29b participates in early aneurysm development in Marfan syndrome. Volume 110 of Issue 2. Circulation research 2011. PMID: 22116819


  45. Kim YM, Haghighat L, Spiekerkoetter E, Sawada H, Alvira CM, Wang L, Acharya S, Rodriguez-Colon G, Orton A, Zhao M, Rabinovitch M. Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions. Volume 179 of Issue 3. The American journal of pathology 2011. PMID: 21763677


  46. Alvira CM, Guignabert C, Kim YM, Chen C, Wang L, Duong TT, Yeung RS, Li DY, Rabinovitch M. Inhibition of transforming growth factor β worsens elastin degradation in a murine model of Kawasaki disease. Volume 178 of Issue 3. The American journal of pathology 2011. PMID: 21356372


  47. Alvira CM, Sukovich DJ, Lyu SC, Cornfield DN. Rho kinase modulates postnatal adaptation of the pulmonary circulation through separate effects on pulmonary artery endothelial and smooth muscle cells. Volume 299 of Issue 6. American journal of physiology. Lung cellular and molecular physiology 2010. PMID: 20709731


  48. Mokres LM, Parai K, Hilgendorff A, Ertsey R, Alvira CM, Rabinovitch M, Bland RD. Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice. Volume 298 of Issue 1. American journal of physiology. Lung cellular and molecular physiology 2009. PMID: 19854954


  49. Guignabert C, Alvira CM, Alastalo TP, Sawada H, Hansmann G, Zhao M, Wang L, El-Bizri N, Rabinovitch M. Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization. Volume 297 of Issue 6. American journal of physiology. Lung cellular and molecular physiology 2009. PMID: 19801450


  50. Ying L, Lau A, Alvira CM, West R, Cann GM, Zhou B, Kinnear C, Jan E, Sarnow P, Van de Rijn M, Rabinovitch M. LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. Volume 122 of Issue Pt 9. Journal of cell science 2009. PMID: 19366727


  51. Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekker JM, Schellong S, Urashima T, Wang L, Morrell NW, Rabinovitch M. An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. Volume 118 of Issue 5. The Journal of clinical investigation 2008. PMID: 18382765


  52. Spiekerkoetter E, Alvira CM, Kim YM, Bruneau A, Pricola KL, Wang L, Ambartsumian N, Rabinovitch M. Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin. Volume 294 of Issue 2. American journal of physiology. Lung cellular and molecular physiology 2007. PMID: 18083765


  53. Bland RD, Ertsey R, Mokres LM, Xu L, Jacobson BE, Jiang S, Alvira CM, Rabinovitch M, Shinwell ES, Dixit A. Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice. Prelude to defective alveolar septation during lung development? Volume 294 of Issue 1. American journal of physiology. Lung cellular and molecular physiology 2007. PMID: 17934062


  54. Alvira CM, Abate A, Yang G, Dennery PA, Rabinovitch M. Nuclear factor-kappaB activation in neonatal mouse lung protects against lipopolysaccharide-induced inflammation. Volume 175 of Issue 8. American journal of respiratory and critical care medicine 2007. PMID: 17255561