Daniel Le Grange, PhD

Statement of Research

Daniel Le Grange, Ph.D., is Benioff UCSF Professor in Children's Health, and Eating Disorders Director, Department of Psychiatry, at the University of California, San Francisco. He also is Emeritus Professor of Psychiatry and Behavioral Neuroscience at The University of Chicago Medicine. He received his doctorate at the Institute of Psychiatry, University of London, and trained in family-based treatment (FBT) for adolescent anorexia nervosa (AN) at the Maudsley Hospital in London. It was here that he partnered with the team that developed and pioneered FBT for adolescent AN, now regarded as the first-line outpatient therapy for medically stable patients. In London, he conducted the first randomized controlled study (RCT) that compared two forms of FBT for adolescent AN (Int J Eat Disord, 1992), and collaborated on a 5-year follow-up of the seminal Maudsley treatment study for AN (Arch Gen Psychiatry, 1997), as well as the second comparison of two forms of FBT, one a novel variation better suited for families with high levels of expressed emotion (J Child Psychol Psychiatry, 2000). He introduced FBT to his colleagues in the United States during a postdoctoral fellowship at Stanford University School of Medicine (1994-1995). After completing this fellowship, he was research assistant professor at the State University of New York at Stony Brook before joining The University of Chicago as assistant professor in July 1998. He was promoted to Professor with tenure on 1 January 2009. His primary research and clinical interests are treatment studies for pediatric eating disorders and he has devoted his career to the development and dissemination of psychosocial treatments for this patient population. Dr. Le Grange has considerable expertise in multi-center RCTs, and for the past 15 years, the National Institute for Mental Health (NIMH) has supported his research program. He has contributed to over 400 journal articles, books, book chapters and abstracts.

In collaboration with a colleague at Stanford University, Dr. Le Grange developed a clinician’s guide for adolescent AN: Treatment manual for anorexia nervosa: A family-based approach (Guilford Press, 2nd Ed, 2013). This manual represents the only evidence-based treatment for this patient population, and is now utilized extensively at a global level, including the United States, Canada, Australia, New Zealand, and elsewhere. In a recently completed multi-center RCT (Chicago and Stanford), funded by the NIMH, Dr. Le Grange and colleagues compared FBT-AN with an individual adolescent-focused therapy (AFT). This is the first well-powered treatment trial of FBT for adolescents with AN. Full remission rates between therapies did not differ statistically at end-of-treatment (EOT), but at 6-month follow-up and 12-month follow-up, FBT was statistically superior to AFT. Rates of partial remission were also greater in FBT than AFT at post-treatment, but did not differ at follow-up. Treatment effects on age and gender adjusted BMI percentile were greater in FBT than AFT at EOT, but not at follow-up. Acute treatment effects on the cognitive and behavioural features of AN were greater in FBT than AFT, but not at follow-up (Arch Gen Psychiatry, 2010). Predictor and moderator analyses showed that patients with more severe eating disorder psychopathology have better outcomes in a behaviourally target family treatment (FBT) than an individually focused approach (AFT) (Beh Res Therapy, 2012.). Currently, Dr. Le Grange is principal investigator (P.I.) on a 3-year NIMH-funded treatment development study of adaptive FBT for adolescent AN non-responders. Dr. Le Grange is also site-P.I. on a 5-year multi-center NIMH-funded study to test a fidelity measure for FBT and develop a specific training model for the dissemination of FBT. In addition, he is P.I. on a 2-year NEDA-funded study to develop a telemedicine model of FBT for families not able to reach a specialist service at an urban center.

Dr. Le Grange’s early work on adolescent AN was expanded for adolescents with bulimia nervosa (BN) leading to the first comparative study of adolescents with eating disorders, addressing the fluidity of eating disorder diagnoses in this age group (Arch Ped Adol Med, 2004). At the same time, and as part of a Career Development Award (K23) from the NIMH (2001-2006), Dr. Le Grange published the first treatment manual for adolescents with BN, entitled Treating bulimia in adolescents: A family-based approach (Guilford Press, 2007), and evaluated the relative efficacy of two kinds of psychological treatments for adolescent BN, i.e., family-based treatment (FBT-BN) versus individual supportive psychotherapy (SPT). This RCT was the first for adolescent BN to be conducted in the US and findings showed that FBT is more efficacious than SPT for this patient population (Arch Gen Psychiatry, 2007). Predictor and moderator analyses demonstrated that that lower eating concerns are the best predictor of remission, and that FBT might be most effective for cases with low levels of eating disorder psychopathology (J Am Acad Child Adol Psychiatry, 2008). Currently, Dr. Le Grange is P.I. on the second RCT for adolescent BN in the United States. This 5-year NIMH-funded RCT investigates the relative efficacy of three psychosocial treatments for adolescents with BN; FBT-BN, cognitive-behavioral therapy, and supportive psychotherapy.

Dr. Le Grange has an extensive mentorship, collaborative research, and program development record with colleagues in the US, Canada, Europe and Australia. He has mentored many trainees over the years and was site-director for a three-center NIMH T32 training grant (7/09 – 6/19) for postdoctoral research in eating disorders. In Australia, Dr. le Grange is Professorial Fellow in Child and Adolescent Eating Disorders on a Baker Foundation Grant in the Department of Pediatrics at the University of Melbourne. In this role, since 2009, Dr. Le Grange has built a research infrastructure to the existing clinical program in Adolescent Medicine, and now works closely with his colleagues at the Royal Children’s Hospital as he steers a large clinical-research team in a 6-year RCT. This study evaluates two forms of FBT for adolescent AN. In Canada, Dr. Le Grange collaborates with colleagues in Toronto on a treatment development study of a novel family-based intervention for transition age youth with AN. In Sydney, Australia, he was a P.I. on two 3-year National Health and Medical Research Council funded studies (2007-2009), and past recipient of an International Research Fellowship from the University of Sydney (2008). Both these Sydney studies were RCTs evaluating psychosocial treatments for AN. In the first of these collaborations, a multi-center study with Sydney, London and Chicago, Dr. Le Grange directed the independent Data and Coordinating Center at Chicago overseeing the two clinical sites (Sydney and London). The main findings from both these RCTs have now been published (Psychol Med, 2013; Psychol Med, 2014).

His peers have recognized Dr. Le Grange’s research contributions. He was elected Fellow of the Academy for Eating Disorders in 2002, and has held several leadership positions at the Academy. The Academy has honoured him with the 2014 Leadership in Research Award. He is a member of the Eating Disorders Research Society, serves on the professional advisory panels for Maudsley Parents as well as Family Empowered and Supporting Treatment of Eating Disorders, and is a past member of the clinical and scientific advisory council of the National Eating Disorders Association. He is Associate Editor for BMC Psychiatry as well as the Journal of Eating Disorders, and serves on the Editorial Boards for the European Eating Disorders Review and the International Journal of Eating Disorders. Dr. Le Grange has lectured extensively in North America, Europe, South Africa, and Australia, and has presented his work in more than 200 invited plenaries, lectures and workshops. In addition to the clinician manuals for both AN and BN (described above), he has also co-authored a parent handbook to be used in conjunction with the clinician manuals, Help your teenager beat an eating disorder (Guilford Press, 2nd Ed, 2014), a casebook for parents. My kid is back (University of Melbourne Press, 2008), and a handbook for scholars, Eating Disorders in Children and Adolescents (Guilford Press, 2011). These books have become leading translational resources for researchers and clinicians, a well as for sufferers and their families.

A number of key areas require focused attention to advance this body of work: (1) Adaptations to enhance FBT efficacy (2 current studies and 1 NIH grant application under review); (2) Dissemination of evidence-based treatment (2 current studies), (3) Inpatient refeeding protocols and their relationship to outpatient treatment should be better understood (UCSF grant, PI: Andrea Garber, PhD); and (4) Full range of phenotypic expression of eating disorders need to be studied. This is potentially informative of treatment effects as the majority of adolescent patients do not fit DSM diagnostic groupings, and there is considerable overlap and diagnostic crossover in this age group (multi-site study in preparation).

October 2015
Education
Postdoctoral Fellowship, 1995 - Behavioral Medicine, Stanford University
PhD, 1989 - Psychology, University of London
MA, 1983 - Clinical Psychology, University of Johannesburg
Honors and Awards
  • BIH Visiting Professor, Berlin Institute for Health, Stiftung Charitê, Berlin, 2021
  • Leadership in Research, Academy for Eating Disorders, 2014
  • Presidential Chair, UCSF, 2013-2014
  • Fellow, Academy for Eating Disorders, 2002
Websites
Publications
  1. Negative affect and binge eating: Assessing the unique trajectories of negative affect before and after binge-eating episodes across eating disorder diagnostic classifications.
  2. Case Presentations Combining Family-Based Treatment with the Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents for Comorbid Avoidant Restrictive Food Intake Disorder and Autism Spectrum Disorder.
  3. Family-based treatment for adolescent anorexia nervosa: Outcomes of a stepped-care model.
  4. The 'Good European': A tribute to Fernando Fernandez-Aranda editor in chief of the European Eating Disorder review 2011-2021.
  5. Expressed emotion and long-term outcome among adolescents with anorexia nervosa.
  6. Young adult mental health sequelae of eating and body image disturbances in adolescence.
  7. Gender-based clinical differences in evidence-based treatment for adolescent anorexia nervosa: analysis of aggregated randomized controlled trials.
  8. Understanding outcomes in family-based treatment for adolescent anorexia nervosa: a network approach.
  9. An Examination of the Interpersonal Theory of Suicide's Tenets among Women with Bulimic-Spectrum Pathology.
  10. Psychosocial etiology of maladaptive exercise and its role in eating disorders: A systematic review.
  11. Can adolescents with eating disorders be treated in primary care? A retrospective clinical cohort study.
  12. Motivation to recover for adolescent and adult eating disorder patients in residential treatment.
  13. Higher-Calorie Refeeding in Anorexia Nervosa: 1-Year Outcomes From a Randomized Controlled Trial.
  14. Examining the roles of emotion dysregulation and impulsivity in the relationship between psychological trauma and substance abuse among women with bulimic-spectrum pathology.
  15. Editorial: Innovations in Research and Practice of Family Based Treatment for Eating Disorders.
  16. Short-term Outcomes of the Study of Refeeding to Optimize Inpatient Gains for Patients With Anorexia Nervosa: A Multicenter Randomized Clinical Trial.
  17. Posttraumatic stress disorder symptoms and trauma-informed care in higher levels of care for eating disorders.
  18. Enhanced cognitive-behavior therapy and family-based treatment for adolescents with an eating disorder: a non-randomized effectiveness trial.
  19. Identity problems and suicidal ideation severity among women with bulimic-spectrum pathology.
  20. Exploring Differences in the Role of Hospitalization on Weight Gain Based on Treatment Type From Randomized Clinical Trials for Adolescent Anorexia Nervosa.
  21. The open versus blind weight conundrum: A multisite randomized controlled trial across multiple levels of patient care for anorexia nervosa.
  22. Translating evidence-based treatment for digital health delivery: a protocol for family-based treatment for anorexia nervosa using telemedicine.
  23. Practice-Based Evidence and Clinical Guidance to Support Accelerated Re-Nutrition of Patients With Anorexia Nervosa.
  24. COVID Isolation Eating Scale (CIES): Analysis of the impact of confinement in eating disorders and obesity-A collaborative international study.
  25. Psychotropic medication use in treatment-seeking youth with eating disorders.
  26. Pilot assessment of a virtual intensive outpatient program for adults with eating disorders.
  27. Null hypothesis significance tests, a misleading approach to scientific knowledge: Some implications for eating disorders research.
  28. Differences in Affective Dynamics Among Eating Disorder Diagnostic Groups.
  29. COVID-19 and implications for eating disorders.
  30. Attitudes Toward Family-Based Treatment Impact Therapists' Intent to Change Their Therapeutic Practice for Adolescent Anorexia Nervosa.
  31. Impulsivity and anxiety-related dimensions in adults with bulimic-spectrum disorders differentially relate to eating disordered behaviors.
  32. Dopaminergic activity and exercise behavior in anorexia nervosa.
  33. Remission in adolescents with bulimia nervosa: Empirical evaluation of current conceptual models.
  34. Investigating Early Response to Treatment in a Multi-Site Study for Adolescent Bulimia Nervosa.
  35. Confirming the Efficacy of an Adaptive Component to Family-Based Treatment for Adolescent Anorexia Nervosa: Study Protocol for a Randomized Controlled Trial.
  36. Family-based treatment for adolescent anorexia nervosa: What happens to rates of comorbid diagnoses?
  37. Delivery of Family-Based Treatment for Adolescent Anorexia Nervosa in a Public Health Care Setting: Research Versus Non-Research Specialty Care.
  38. Family-Based Treatment for Anorexia Nervosa Symptoms in High-Risk Youth: A Partially-Randomized Preference-Design Study.
  39. A conceptual comparison of family-based treatment and enhanced cognitive behavior therapy in the treatment of adolescents with eating disorders.
  40. Weight Loss and Illness Severity in Adolescents With Atypical Anorexia Nervosa.
  41. A primary care modification of family-based treatment for adolescent restrictive eating disorders.
  42. An ARFID case report combining family-based treatment with the unified protocol for Transdiagnostic treatment of emotional disorders in children.
  43. Attributes of children and adolescents with avoidant/restrictive food intake disorder.
  44. Youth with Avoidant/Restrictive Food Intake Disorder: Examining Differences by Age, Weight Status, and Symptom Duration.
  45. Adapting family-based treatment for paediatric obesity: A randomized controlled pilot trial.
  46. Variability in remission in family therapy for anorexia nervosa.
  47. Update on Treatments for Adolescent Bulimia Nervosa.
  48. Eating disorder symptoms across the weight spectrum in Australian adolescents.
  49. A pilot study of multifamily therapy group for young adults with anorexia nervosa: Reconnecting for recovery.
  50. The impact of urbanization on risk for eating disorders.
  51. Stay the course: practitioner reflections on implementing family-based treatment with adolescents with atypical anorexia.
  52. Family-based Treatment of Eating Disorders: A Narrative Review.
  53. Predictors of early response in conjoint and separated models of family-based treatment for adolescent anorexia nervosa.
  54. Rituals and preoccupations associated with bulimia nervosa in adolescents: Does motivation to change matter?
  55. Identifying and responding to child maltreatment when delivering family-based treatment-A qualitative study.
  56. Reciprocal relations between dietary restraint and negative affect in adolescents receiving treatment for anorexia nervosa.
  57. A test of the DSM-5 severity specifier for bulimia nervosa in adolescents: Can we anticipate clinical treatment outcomes?
  58. Weight gain trajectories during outpatient family-based treatment for adolescents with anorexia nervosa.
  59. Meta-analysis misunderstood: a cautionary tale in interpreting meta-analytic findings.
  60. Family-based treatment: Where are we and where should we be going to improve recovery in child and adolescent eating disorders.
  61. An exploratory study of challenges and successes in implementing adapted family-based treatment in a community setting.
  62. Treatment outcomes for anorexia nervosa: a systematic review and meta-analysis of randomized-controlled trials - CORRIGENDUM.
  63. Tackling mixed messages: Practitioner reflections on working with adolescents with atypical anorexia and their families.
  64. Family-based treatment for transition age youth: the role of expressed emotion and general family functioning.
  65. A Pilot Study of Neural Correlates of Loss of Control Eating in Children With Overweight/Obesity: Probing Intermittent Access to Food as a Means of Eliciting Disinhibited Eating.
  66. Family-Based Treatment for Pediatric Obesity: Case Study of an Adaptation for a Non-Psychiatric Adolescent Population.
  67. The moderating effect of impulsivity on negative affect and body checking.
  68. Treatment outcomes for anorexia nervosa: a systematic review and meta-analysis of randomized controlled trials.
  69. Family-based treatment for transition age youth: parental self-efficacy and caregiver accommodation.
  70. Associations among eating disorder behaviors and eating disorder quality of life in adult women with anorexia nervosa.
  71. Treatment outcome reporting in anorexia nervosa: time for a paradigm shift?
  72. Using bivariate latent basis growth curve analysis to better understand treatment outcome in youth with anorexia nervosa.
  73. "They don't really get heard": A qualitative study of sibling involvement across two forms of family-based treatment for adolescent anorexia nervosa.
  74. Outcome parameters associated with perceived helpfulness of family-based treatment for adolescent eating disorders.
  75. Subtypes of Adaptive and Maladaptive Perfectionism in Anorexia Nervosa: Associations with Eating Disorder and Affective Symptoms.
  76. Comorbid depressive symptoms and self-esteem improve after either cognitive-behavioural therapy or family-based treatment for adolescent bulimia nervosa.
  77. Network analysis of pediatric eating disorder symptoms in a treatment-seeking, transdiagnostic sample.
  78. Bulimia nervosa in adolescents: prevalence and treatment challenges.
  79. Open Trial of Family-Based Treatment of Anorexia Nervosa for Transition Age Youth.
  80. Examining a staging model for anorexia nervosa: empirical exploration of a four stage model of severity.
  81. Parental Expressed Emotion During Two Forms of Family-Based Treatment for Adolescent Anorexia Nervosa.
  82. The Participation of Mothers, Fathers, and Siblings in Family-Based Treatment for Adolescent Anorexia Nervosa.
  83. When illness severity and research dollars do not align: are we overlooking eating disorders?
  84. Attention-Deficit/Hyperactivity Disorder Symptoms Are Associated with Overeating with and without Loss of Control in Youth with Overweight/Obesity.
  85. Symptom trajectories throughout two family therapy treatments for adolescent anorexia nervosa.
  86. Negative affect and binge eating: Reconciling differences between two analytic approaches in ecological momentary assessment research.
  87. Utilizing Telehealth to deliver family-based treatment for adolescent anorexia nervosa.
  88. Is laxative misuse associated with binge eating? Examination of laxative misuse among individuals seeking treatment for eating disorders.
  89. Exploring Types of Family Environments in Youth with Eating Disorders.
  90. The validity of DSM-5 severity specifiers for anorexia nervosa, bulimia nervosa, and binge-eating disorder.
  91. Examining a momentary mediation model of appearance-related stress, anxiety, and eating disorder behaviors in adult anorexia nervosa.
  92. Adaptation and implementation of family-based treatment enhanced with dialectical behavior therapy skills for anorexia nervosa in community-based specialist clinics.
  93. Relationship between desired weight and eating disorder pathology in youth.
  94. Facets of Impulsivity and Compulsivity in Women with Anorexia Nervosa.
  95. Secretive eating among youth with overweight or obesity.
  96. Executive functioning in a racially diverse sample of children who are overweight and at risk for eating disorders.
  97. A comparison of the frequency of familial suicide attempts across eating disorder diagnoses.
  98. A meta-analysis of the relation between therapeutic alliance and treatment outcome in eating disorders.
  99. A case series of family-based treatment for adolescents with atypical anorexia nervosa.
  100. Outcomes of an inpatient refeeding protocol in youth with Anorexia Nervosa and atypical Anorexia Nervosa at Children's Hospitals and Clinics of Minnesota.
  101. Trajectories of higher- and lower-order dimensions of negative and positive affect relative to restrictive eating in anorexia nervosa.
  102. Residents' and Fellows' Knowledge and Attitudes About Eating Disorders at an Academic Medical Center.
  103. The Impact of DSM-5 on Eating Disorder Diagnoses.
  104. Self-Discrepancy and Eating Disorder Symptoms Across Eating Disorder Diagnostic Groups.
  105. Dissecting the Core Fear in Anorexia Nervosa: Can We Optimize Treatment Mechanisms?
  106. Extinction theory & anorexia nervosa: Deepening therapeutic mechanisms.
  107. Self-weighing behavior in individuals with eating disorders.
  108. Psychosocial Well-being of Siblings of Adolescents with Anorexia Nervosa.
  109. The relation of weight suppression and BMIz to bulimic symptoms in youth with bulimia nervosa.
  110. Patterns of expressed emotion in adolescent eating disorders.
  111. Anorexia nervosa in adults: The urgent need for novel outpatient treatments that work.
  112. Randomized Clinical Trial of Parent-Focused Treatment and Family-Based Treatment for Adolescent Anorexia Nervosa.
  113. Self-weighing behavior in individuals with eating disorders.
  114. The effect of low parental warmth and low monitoring on disordered eating in mid-adolescence: Findings from the Australian Temperament Project.
  115. Examining affect and perfectionism in relation to eating disorder symptoms among women with anorexia nervosa.
  116. The role of interpersonal personality traits and reassurance seeking in eating disorder symptoms and depressive symptoms among women with bulimia nervosa.
  117. Predictors of therapeutic alliance in two treatments for adults with severe and enduring anorexia nervosa.
  118. Physical and Psychological Morbidity in Adolescents With Atypical Anorexia Nervosa.
  119. The importance of loss of control while eating in adolescents with purging disorder.
  120. Examining the utility of narrowing anorexia nervosa subtypes for adults.
  121. Does Sex Matter in the Clinical Presentation of Eating Disorders in Youth?
  122. Associations between negative affect and binge/purge behaviors in women with anorexia nervosa: Considering the role of negative urgency.
  123. Elusive Etiology of Anorexia Nervosa: Finding Answers in an Integrative Biopsychosocial Approach.
  124. Media exposure and associated stress contribute to eating pathology in women with Anorexia Nervosa: Daily and momentary associations.
  125. Overvaluation of shape and weight in adolescents with anorexia nervosa: does shape concern or weight concern matter more for treatment outcome?
  126. A systematic review of approaches to refeeding in patients with anorexia nervosa.
  127. Is childhood trauma associated with lifetime suicide attempts in women with bulimia nervosa?
  128. Prevalence of Alcohol and Other Substance Use in Patients with Eating Disorders.
  129. Randomized Clinical Trial of Family-Based Treatment and Cognitive-Behavioral Therapy for Adolescent Bulimia Nervosa.
  130. A perfect storm: examining the synergistic effects of negative and positive emotional instability on promoting weight loss activities in anorexia nervosa.
  131. Depression and Personality Traits Associated With Emotion Dysregulation: Correlates of Suicide Attempts in Women with Bulimia Nervosa.
  132. Restrictive eating in anorexia nervosa: Examining maintenance and consequences in the natural environment.
  133. A naturalistic examination of the temporal patterns of affect and eating disorder behaviors in anorexia nervosa.
  134. Picking and nibbling in children and adolescents with eating disorders.
  135. Anorexia Nervosa, Bulimia Nervosa, and Binge Eating Disorder in Midlife and Beyond.
  136. Can adaptive treatment improve outcomes in family-based therapy for adolescents with anorexia nervosa? Feasibility and treatment effects of a multi-site treatment study.
  137. Expressed Emotion, Family Functioning, and Treatment Outcome for Adolescents with Anorexia Nervosa.
  138. Associations between weight suppression and dimensions of eating disorder psychopathology in a multisite sample.
  139. Telemedicine of family-based treatment for adolescent anorexia nervosa: A protocol of a treatment development study.
  140. Initial test of an emotional avoidance model of restriction in anorexia nervosa using ecological momentary assessment.
  141. Dietary Restriction Behaviors and Binge Eating in Anorexia Nervosa, Bulimia Nervosa and Binge Eating Disorder: Trans-diagnostic Examination of the Restraint Model.
  142. Adapting Family-Based Treatment for Adolescent Anorexia Nervosa Across Higher Levels of Patient Care.
  143. The Integration of Family-Based Treatment and Dialectical Behavior Therapy for Adolescent Bulimia Nervosa: Philosophical and Practical Considerations.
  144. Who's in the Room? A Parent-Focused Family Therapy for Adolescent Anorexia Nervosa.
  145. Nutritional adequacy of dietary intake in women with anorexia nervosa.
  146. Family Profiles of Expressed Emotion in Adolescent Patients With Anorexia Nervosa and Their Parents.
  147. Predictors and moderators of psychological changes during the treatment of adolescent bulimia nervosa.
  148. An exploratory examination of patient and parental self-efficacy as predictors of weight gain in adolescents with anorexia nervosa.
  149. A pilot study examining diagnostic differences among exercise and weight suppression in bulimia nervosa and binge eating disorder.
  150. Family-based treatment with transition age youth with anorexia nervosa: a qualitative summary of application in clinical practice.
  151. Behavioral, emotional, and situational context of purging episodes in anorexia nervosa.
  152. From efficacy to effectiveness: comparing outcomes for youth with anorexia nervosa treated in research trials versus clinical care.
  153. Examining convergence of retrospective and ecological momentary assessment measures of negative affect and eating disorder behaviors.
  154. Relapse from remission at two- to four-year follow-up in two treatments for adolescent anorexia nervosa.
  155. Central coherence in adolescents with bulimia nervosa spectrum eating disorders.
  156. Development and evaluation of a treatment fidelity instrument for family-based treatment of adolescent anorexia nervosa.
  157. Bidirectional associations between binge eating and restriction in anorexia nervosa. An ecological momentary assessment study.
  158. Eating disorder symptoms and quality of life: where should clinicians place their focus in severe and enduring anorexia nervosa?
  159. Developmental antecedents of abnormal eating attitudes and behaviors in adolescence.
  160. A randomized controlled trial of in-patient treatment for anorexia nervosa in medically unstable adolescents.
  161. Suicidal behavior in adolescents and adults with bulimia nervosa.
  162. Family functioning in two treatments for adolescent anorexia nervosa.
  163. A bidirectional examination of expressed emotion among families of adolescents with bulimia nervosa.
  164. Subjective and objective binge eating in relation to eating disorder symptomatology, depressive symptoms, and self-esteem among treatment-seeking adolescents with bulimia nervosa.
  165. Family therapy for adolescent eating disorders: an update.
  166. Eating patterns in youth with restricting and binge eating/purging type anorexia nervosa.
  167. The effect of driven exercise on treatment outcomes for adolescents with anorexia and bulimia nervosa.
  168. Parent-focused treatment for adolescent anorexia nervosa: a study protocol of a randomised controlled trial.
  169. Predictors and moderators of outcome for severe and enduring anorexia nervosa.
  170. Factors associated with substance use in adolescents with eating disorders.
  171. Pre-treatment predictors of attrition in a randomised controlled trial of psychological therapy for severe and enduring anorexia nervosa.
  172. Latent profile analysis of eating episodes in anorexia nervosa.
  173. Is weight gain really a catalyst for broader recovery?: The impact of weight gain on psychological symptoms in the treatment of adolescent anorexia nervosa.
  174. Family meal frequency among children and adolescents with eating disorders.
  175. The role of collegial alliance in family-based treatment of adolescent anorexia nervosa: a pilot study.
  176. Health-related quality of life among adolescents with eating disorders.
  177. Stress and eating disorder behavior in anorexia nervosa as a function of menstrual cycle status.
  178. Assessment of quality of life in people with severe and enduring anorexia nervosa: a comparison of generic and specific instruments.
  179. Early weight gain predicts outcome in two treatments for adolescent anorexia nervosa.
  180. Examining refeeding protocols for adolescents with anorexia nervosa (again): challenges to current practices.
  181. The role of the pediatrician in family-based treatment for adolescent eating disorders: opportunities and challenges.
  182. Implementation of family-based treatment for adolescents with anorexia nervosa.
  183. Do in-vivo behaviors predict early response in family-based treatment for anorexia nervosa?
  184. Therapeutic alliance in two treatments for adults with severe and enduring anorexia nervosa.
  185. Do end of treatment assessments predict outcome at follow-up in eating disorders?
  186. Picking or nibbling: frequency and associated clinical features in bulimia nervosa, anorexia nervosa, and binge eating disorder.
  187. The role of affect in the maintenance of anorexia nervosa: evidence from a naturalistic assessment of momentary behaviors and emotion.
  188. Hard exercise, affect lability, and personality among individuals with bulimia nervosa.
  189. Associations between retrospective versus ecological momentary assessment measures of emotion and eating disorder symptoms in anorexia nervosa.
  190. Restrictive eating behaviors are a nonweight-based marker of severity in anorexia nervosa.
  191. Parent-therapist alliance in Family-Based Treatment for adolescents with anorexia nervosa.
  192. A naturalistic examination of body checking and dietary restriction in women with anorexia nervosa.
  193. Personality-based subtypes of anorexia nervosa: examining validity and utility using baseline clinical variables and ecological momentary assessment.
  194. Eating disorders with and without comorbid depression and anxiety: similarities and differences in a clinical sample of children and adolescents.
  195. Daily patterns of anxiety in anorexia nervosa: associations with eating disorder behaviors in the natural environment.
  196. Treating severe and enduring anorexia nervosa: a randomized controlled trial.
  197. Resumption of menses in anorexia nervosa during a course of family-based treatment.
  198. Are adolescent treatment studies of eating disorders utilizing clinically relevant samples? A comparison of RCT and clinic treatment-seeking youth with eating disorders.
  199. Response patterns on interview and questionnaire versions of the Eating Disorder Examination and their impact on latent structure analyses.
  200. Moderators of post-binge eating negative emotion in eating disorders.
  201. Exercise caution: over-exercise is associated with suicidality among individuals with disordered eating.
  202. Subjective and objective binge eating in relation to eating disorder symptomatology, negative affect, and personality dimensions.
  203. Set-shifting among adolescents with bulimic spectrum eating disorders.
  204. Body-related social comparison and disordered eating among adolescent females with an eating disorder, depressive disorder, and healthy controls.
  205. Momentary emotion surrounding bulimic behaviors in women with bulimia nervosa and borderline personality disorder.
  206. Internet-based chat support groups for parents in family-based treatment for adolescent eating disorders: a pilot study.
  207. An examination of adults on antipsychotic medication at risk for metabolic syndrome: a comparison with obese and eating disorder populations.
  208. Adolescent bulimia nervosa.
  209. DSM-IV-defined anorexia nervosa versus subthreshold anorexia nervosa (EDNOS-AN).
  210. Therapeutic alliance in two treatments for adolescent anorexia nervosa.
  211. Observed connection and individuation: relation to symptoms in families of adolescents with bulimia nervosa.
  212. A review of family-based treatment for adolescents with eating disorders.
  213. The Yale-Brown-Cornell eating disorders scale self-report questionnaire: a new, efficient tool for clinicians and researchers.
  214. Eating disorder not otherwise specified presentation in the US population.
  215. Recruitment and retention in an adolescent anorexia nervosa treatment trial.
  216. Olanzapine, but not fluoxetine, treatment increases survival in activity-based anorexia in mice.
  217. Which dieters are at risk for the onset of binge eating? A prospective study of adolescents and young adults.
  218. The use of multiple methods of compensatory behaviors as an indicator of eating disorder severity in treatment-seeking youth.
  219. Transdiagnostic Theory and Application of Family-Based Treatment for Youth with Eating Disorders.
  220. Calculation of expected body weight in adolescents with eating disorders.
  221. Moderators and mediators of remission in family-based treatment and adolescent focused therapy for anorexia nervosa.
  222. Momentary affect surrounding loss of control and overeating in obese adults with and without binge eating disorder.
  223. Driven exercise among treatment-seeking youth with eating disorders.
  224. The clinician administered staging instrument for anorexia nervosa: development and psychometric properties.
  225. Diagnostic concordance of the interview and questionnaire versions of the eating disorder examination.
  226. Overvaluation of shape and weight among overweight children and adolescents with loss of control eating.
  227. Prevalence and correlates of eating disorders in adolescents. Results from the national comorbidity survey replication adolescent supplement.
  228. The Eating Disorders Examination in adolescent males with anorexia nervosa: how does it compare to adolescent females?
  229. Eating disorder symptomatology in normal-weight vs. obese individuals with binge eating disorder.
  230. Cultural variability in Expressed Emotion among families of adolescents with anorexia nervosa.
  231. Eating disorders in youth: diagnostic variability and predictive validity.
  232. Parental expressed emotion of adolescents with anorexia nervosa: outcome in family-based treatment.
  233. Early response to family-based treatment for adolescent anorexia nervosa.
  234. Randomized clinical trial comparing family-based treatment with adolescent-focused individual therapy for adolescents with anorexia nervosa.
  235. A prevalence study and description of alli use by patients with eating disorders.
  236. Changes in desired body shape after bariatric surgery.
  237. A Case Series of Family-Based Therapy for Weight Restoration in Young Adults with Anorexia Nervosa.
  238. Classification of eating disturbance in children and adolescents: proposed changes for the DSM-V.
  239. Diagnostic classification of eating disorders in children and adolescents: how does DSM-IV-TR compare to empirically-derived categories?
  240. Academy for Eating Disorders position paper: the role of the family in eating disorders.
  241. Caffeine, artificial sweetener, and fluid intake in anorexia nervosa.
  242. An assessment of daily food intake in participants with anorexia nervosa in the natural environment.
  243. Compensatory eating disorder behaviors and gastric bypass surgery outcome.
  244. Affective lability and impulsivity in a clinical sample of women with bulimia nervosa: the role of affect in severely dysregulated behavior.
  245. Are single-parent families different from two-parent families in the treatment of adolescent bulimia nervosa using family-based treatment?
  246. Empirical identification and validation of eating disorder phenotypes in a multisite clinical sample.
  247. Family interventions in adolescent anorexia nervosa.
  248. Family-Based Treatment for Adolescent Eating Disorders: Current Status, New Applications and Future Directions.
  249. Early response to treatment in adolescent bulimia nervosa.
  250. Revisiting differences in individuals with bulimia nervosa with and without a history of anorexia nervosa: Eating pathology, personality, and maltreatment.
  251. Body mass index as a predictor of 1-year outcome in gastric bypass surgery.
  252. Expressed emotion among white and ethnic minority families of adolescents with bulimia nervosa.
  253. How do adolescents with bulimia nervosa rate the acceptability and therapeutic relationship in family-based treatment?
  254. Examining a psychosocial interactive model of binge eating and vomiting in women with bulimia nervosa and subthreshold bulimia nervosa.
  255. Predictors and moderators of outcome in family-based treatment for adolescent bulimia nervosa.
  256. Eating disorder not otherwise specified in adolescents.
  257. Staging anorexia nervosa: conceptualizing illness severity.
  258. Comorbidity and high-risk behaviors in treatment-seeking adolescents with bulimia nervosa.
  259. Classification of child and adolescent eating disturbances. Workgroup for Classification of Eating Disorders in Children and Adolescents (WCEDCA).
  260. Latent profile analysis of a cohort of patients with eating disorders not otherwise specified.
  261. What can dropouts teach us about retention in eating disorder treatment studies?
  262. Why patients seek bariatric surgery: a qualitative and quantitative analysis of patient motivation.
  263. Subtyping adolescents with bulimia nervosa.
  264. A randomized controlled comparison of family-based treatment and supportive psychotherapy for adolescent bulimia nervosa.
  265. Considerations for the use of the Beck Depression Inventory in the assessment of weight-loss surgery seeking patients.
  266. Open trial of family-based treatment for full and partial anorexia nervosa in adolescence: evidence of successful dissemination.
  267. Emotional eating in a morbidly obese bariatric surgery-seeking population.
  268. Depressed mood in class III obesity predicted by weight-related stigma.
  269. Psychometric properties of the eating disorder examination-questionnaire: factor structure and internal consistency.
  270. Family interaction among white and ethnic minority adolescents with bulimia nervosa and their parents.
  271. Early identification and treatment of eating disorders: prodrome to syndrome.
  272. Psychosocial and physical impairment in overweight adolescents at high risk for eating disorders.
  273. Is family therapy useful for treating children with anorexia nervosa? Results of a case series.
  274. Recruitment for an adolescent bulimia nervosa treatment study.
  275. DSM-IV threshold versus subthreshold bulimia nervosa.
  276. Eating attitudes and behaviours in South african adolescents and young adults.
  277. Pre-surgery binge eating status: effect on eating behavior and weight outcome after gastric bypass.
  278. Olanzapine use in adolescent anorexia nervosa.
  279. Impulsivity and compulsivity in bulimia nervosa.
  280. The Maudsley family-based treatment for adolescent anorexia nervosa.
  281. Adolescents with bulimia nervosa and eating disorder not otherwise specified-purging only.
  282. Personality subtyping and bulimia nervosa: psychopathological and genetic correlates.
  283. The dearth of psychological treatment studies for anorexia nervosa.
  284. Eating Disorders Examination versus Eating Disorders Examination-Questionnaire in adolescents with full and partial-syndrome bulimia nervosa and anorexia nervosa.
  285. Family-based treatment of eating disorders.
  286. Manualized family-based treatment for anorexia nervosa: a case series.
  287. The meaning of 'self-starvation' in impoverished black adolescents in South Africa.
  288. Psychosocial outcome of gastric bypass surgery for patients with and without binge eating.
  289. Bulimia nervosa in adolescents: a disorder in evolution?
  290. Report of the National Institutes of Health workshop on overcoming barriers to treatment research in anorexia nervosa.
  291. Binge eating and eating-related cognitions and behavior in ethnically diverse obese women.
  292. Effectiveness of spouse involvement in cognitive behavioral therapy for binge eating disorder.
  293. Family therapy for identical twins with anorexia nervosa.
  294. Characteristics of binge eating among women in the community seeking treatment for binge eating or weight loss.
  295. Family-based therapy for adolescents with bulimia nervosa.
  296. Quality of life after gastric bypass surgery: a cross-sectional study.
  297. Anorexia nervosa with comorbid psychosis and borderline mental retardation: a case report.
  298. The effects of Roux-en-Y gastric bypass surgery on body image.
  299. Quality of life and psychosocial adjustment in patients after Roux-en-Y gastric bypass: a brief report.
  300. Can family-based treatment of anorexia nervosa be manualized?
  301. Family therapy for adolescent anorexia nervosa: the results of a controlled comparison of two family interventions.
  302. Family therapy for adolescent anorexia nervosa.
  303. Eating disturbances in white and minority female dieters.
  304. Eating attitudes and behaviors in 1,435 South African Caucasian and non-Caucasian college students.
  305. Family and individual therapy in anorexia nervosa. A 5-year follow-up.
  306. Eating and general psychopathology in a sample of Caucasian and ethnic minority subjects.
  307. Body size and parenting in eating disorders: a comparative study of the attitudes of mothers towards their children.
  308. Redefining the psychosomatic family: family process of 26 eating disorder families.
  309. Implications of a diagnosis of anorexia nervosa in a ballet school.
  310. Expressed emotion in the investigation of eating disorders: a review.