Mark Walters, MD

The over-arching goal of my research career has been to develop and expand curative therapies for hemoglobin disorders in particular and non-malignant hematopoietic disorders more broadly. I have focused on genome editing approaches most recently, which rely upon modification of autologous hematopoietic cells to elicit a curative effect. In collaboration with colleagues at UC Berkeley, BCHO and UCLA, we are pursuing genomic editing of the sickle mutation in hematopoietic stem cells using the CRSPR/Cas9 ribonucleoprotein system. I have a long track record of experience in cellular therapies for pediatric acquired and hereditary conditions and in bone marrow transplantation.
Education
2019 - Diversity, Equity, and Inclusion Champion Training, University of California
06/1991 - Pediatric Hem/Onc/BMT fellowship, Fred Hutch/Univ of Washington
06/1988 - Pediatric Residency, University of Washington
M.D., 06/1985 - Medicine, University of California, San Diego
A.B., 06/1981 - Genetics, University of California, Berkeley
Websites

  1. Eapen M, Kou J, Andreansky M, Bhatia M, Brochstein J, Chaudhury S, Haight AE, Haines H, Jacobsohn D, Jaroscak J, Kasow KA, Krishnamurti L, Levine JE, Leung K, Margolis D, Yu LC, Horowitz MM, Kamani N, Walters MC, Shenoy S. Long-term outcomes after unrelated donor transplantation for severe sickle cell disease on the BMT CTN 0601 trial. American journal of hematology 2024. PMID: 38343182


  2. Corbacioglu S, Frangoul H, Locatelli F, Hobbs W, Walters M. Defining curative endpoints for transfusion-dependent β-thalassemia in the era of gene therapy and gene editing. American journal of hematology 2023. PMID: 38100154


  3. Locatelli F, Corbacioglu S, Hobbs W, Frangoul H, Walters MC. Defining curative endpoints for sickle cell disease in the era of gene therapy and gene editing. American journal of hematology 2023. PMID: 38010293


  4. Olson TS, Walters MC. Allogeneic haematopoietic stem-cell transplantation versus gene therapy for haemoglobinopathies. The Lancet. Haematology 2023. PMID: 37793770


  5. Hall AG, Winestone LE, Sullivan EM, Wu Q, Lamble AJ, Walters MC, Aguayo-Hiraldo P, Conde LB, Coker TR, Dornsife D, Keating AK, Merino DM, Ramsey B, Park JR, Agrawal AK. Access to CAR T-cell Clinical Trials in Underrepresented Populations: a Multicenter Cohort Study of Pediatric and Young Adult ALL Patients. Transplantation and cellular therapy 2023. PMID: 36966871


  6. Lin C, Schwarzbach A, Sanz J, Montesinos P, Stiff P, Parikh S, Brunstein C, Cutler C, Lindemans CA, Hanna R, Koh LP, Jagasia MH, Valcarcel D, Maziarz RT, Keating AK, Hwang WYK, Rezvani AR, Karras NA, Fernandes JF, Rocha V, Badell I, Ram R, Schiller GJ, Volodin L, Walters MC, Hamerschlak N, Cilloni D, Frankfurt O, McGuirk JP, Kurtzberg J, Sanz G, Simantov R, Horwitz ME. Multicenter Long-Term Follow-Up of Allogeneic Hematopoietic Cell Transplantation with Omidubicel: A Pooled Analysis of Five Prospective Clinical Trials. Transplantation and cellular therapy 2023. PMID: 36775201


  7. Eapen M, Brazauskas R, Williams DA, Walters MC, St Martin A, Jacobs BL, Antin JH, Bona K, Chaudhury S, Coleman-Cowger VH, DiFronzo NL, Esrick EB, Field JJ, Fitzhugh CD, Kanter J, Kapoor N, Kohn DB, Krishnamurti L, London WB, Pulsipher MA, Talib S, Thompson AA, Waller EK, Wun T, Horowitz MM. Secondary Neoplasms After Hematopoietic Cell Transplant for Sickle Cell Disease. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2023. PMID: 36623245


  8. Lawal RA, Walters MC, Fitzhugh CD. Allogeneic Transplant and Gene Therapy: Evolving Toward a Cure. Hematology/oncology clinics of North America 2022. PMID: 36400545


  9. Krishnamurti L, Neuberg D, Sullivan KM, Smith S, Eapen M, Walters MC. Enrollment Lessons from a Biological Assignment Study of Marrow Transplantation versus Standard Care for Adolescents and Young Adults with Sickle Cell Disease: Considerations for Future Gene and Cellular Therapy Trials. Transplantation and cellular therapy 2022. PMID: 36270432


  10. Kanter J, Thompson AA, Pierciey FJ, Hsieh M, Uchida N, Leboulch P, Schmidt M, Bonner M, Guo R, Miller A, Ribeil JA, Davidson D, Asmal M, Walters MC, Tisdale JF. Lovo-cel gene therapy for sickle cell disease: Treatment process evolution and outcomes in the initial groups of the HGB-206 study. American journal of hematology 2022. PMID: 36161320


  11. Magis W, DeWitt MA, Wyman SK, Vu JT, Heo SJ, Shao SJ, Hennig F, Romero ZG, Campo-Fernandez B, Said S, McNeill MS, Rettig GR, Sun Y, Wang Y, Behlke MA, Kohn DB, Boffelli D, Walters MC, Corn JE, Martin DIK. High-level correction of the sickle mutation is amplified in vivo during erythroid differentiation. Volume 25 of Issue 6. iScience 2022. PMID: 35633935


  12. Kanter J, Walters MC, Krishnamurti L, Mapara MY, Kwiatkowski JL, Rifkin-Zenenberg S, Aygun B, Kasow KA, Pierciey FJ, Bonner M, Miller A, Zhang X, Lynch J, Kim D, Ribeil JA, Asmal M, Goyal S, Thompson AA, Tisdale JF. Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease. Volume 386 of Issue 7. The New England journal of medicine 2021. PMID: 34898139


  13. Locatelli F, Thompson AA, Kwiatkowski JL, Porter JB, Thrasher AJ, Hongeng S, Sauer MG, Thuret I, Lal A, Algeri M, Schneiderman J, Olson TS, Carpenter B, Amrolia PJ, Anurathapan U, Schambach A, Chabannon C, Schmidt M, Labik I, Elliot H, Guo R, Asmal M, Colvin RA, Walters MC. Betibeglogene Autotemcel Gene Therapy for Non-β0/β0 Genotype β-Thalassemia. 2021. PMID: 34891223


  14. Kanter J, Liem RI, Bernaudin F, Bolaños-Meade J, Fitzhugh CD, Hankins JS, Murad MH, Panepinto JA, Rondelli D, Shenoy S, Wagner J, Walters MC, Woolford T, Meerpohl JJ, Tisdale J. American Society of Hematology 2021 guidelines for sickle cell disease: stem cell transplantation. Volume 5 of Issue 18. Blood advances 2021. PMID: 34581773


  15. Heslop HE, Stadtmauer EA, Levine JE, Ballen KK, Chen YB, DeZern AE, Eapen M, Hamadani M, Hamilton BK, Hari P, Jones RJ, Logan BR, Kean LS, Leifer ES, Locke FL, Maziarz RT, Nemecek ER, Pasquini M, Phelan R, Riches ML, Shaw BE, Walters MC, Foley A, Devine SM, Horowitz MM. Blood and Marrow Transplant Clinical Trials Network State of the Science Symposium 2021: Looking Forward as the Network Celebrates its 20th Year. Volume 27 of Issue 11. Transplantation and cellular therapy 2021. PMID: 34461278


  16. Friedman D, Dozor AJ, Milner J, D'Souza M, Talano JA, Moore TB, Shenoy S, Shi Q, Walters MC, Vichinsky E, Parsons SK, Braniecki S, Moorthy CR, Ayello J, Flower A, Morris E, Mahanti H, Fabricatore S, Klejmont L, van de Ven C, Baxter-Lowe LA, Cairo MS. Stable to improved cardiac and pulmonary function in children with high-risk sickle cell disease following haploidentical stem cell transplantation. Volume 56 of Issue 9. Bone marrow transplantation 2021. PMID: 33958740


  17. Walters MC. Induction of Fetal Hemoglobin by Gene Therapy. Volume 384 of Issue 3. The New England journal of medicine 2021. PMID: 33471981


  18. Brazauskas R, Scigliuolo GM, Wang HL, Cappelli B, Ruggeri A, Fitzhugh CD, Hankins JS, Kanter J, Meerpohl JJ, Panepinto JA, Rondelli D, Shenoy S, Walters MC, Wagner JE, Tisdale JF, Gluckman E, Eapen M. Risk score to predict event-free survival after hematopoietic cell transplant for sickle cell disease. Volume 136 of Issue 5. Blood 2020. PMID: 32518950


  19. Walters MC. Sickle marrow: double, double toil and trouble. Volume 135 of Issue 23. Blood 2020. PMID: 32497220


  20. Tisdale JF, Pierciey FJ, Bonner M, Thompson AA, Krishnamurti L, Mapara MY, Kwiatkowski JL, Shestopalov I, Ribeil JA, Huang W, Asmal M, Kanter J, Walters MC. Safety and feasibility of hematopoietic progenitor stem cell collection by mobilization with plerixafor followed by apheresis vs bone marrow harvest in patients with sickle cell disease in the multi-center HGB-206 trial. Volume 95 of Issue 9. American journal of hematology 2020. PMID: 32401372


  21. Hsieh MM, Bonner M, Pierciey FJ, Uchida N, Rottman J, Demopoulos L, Schmidt M, Kanter J, Walters MC, Thompson AA, Asmal M, Tisdale JF. Myelodysplastic syndrome unrelated to lentiviral vector in a patient treated with gene therapy for sickle cell disease. Volume 4 of Issue 9. Blood advances 2020. PMID: 32396618


  22. Farrell AT, Panepinto J, Desai AA, Kassim AA, Lebensburger J, Walters MC, Bauer DE, Blaylark RM, DiMichele DM, Gladwin MT, Green NS, Hassell K, Kato GJ, Klings ES, Kohn DB, Krishnamurti L, Little J, Makani J, Malik P, McGann PT, Minniti C, Morris CR, Odame I, Oneal PA, Setse R, Sharma P, Shenoy S. End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings. Volume 3 of Issue 23. Blood advances 2019. PMID: 31809537


  23. Li C, Mathews V, Kim S, George B, Hebert K, Jiang H, Li C, Zhu Y, Keesler DA, Boelens JJ, Dvorak CC, Agarwal R, Auletta JJ, Goyal RK, Hanna R, Kasow K, Shenoy S, Smith AR, Walters MC, Eapen M. Related and unrelated donor transplantation for ß-thalassemia major: results of an international survey. Blood advances 2019. PMID: 31471325


  24. Eapen M, Brazauskas R, Walters MC, Bernaudin F, Bo-Subait K, Fitzhugh CD, Hankins JS, Kanter J, Meerpohl JJ, Bolaños-Meade J, Panepinto JA, Rondelli D, Shenoy S, Williamson J, Woolford TL, Gluckman E, Wagner JE, Tisdale JF. Effect of donor type and conditioning regimen intensity on allogeneic transplantation outcomes in patients with sickle cell disease: a retrospective multicentre, cohort study. Volume 6 of Issue 11. The Lancet. Haematology 2019. PMID: 31495699


  25. Krishnamurti L, Neuberg DS, Sullivan KM, Kamani NR, Abraham A, Campigotto F, Zhang W, Dahdoul T, De Castro L, Parikh S, Bakshi N, Haight A, Hassell KL, Loving R, Rosenthal J, Smith SL, Smith W, Spearman M, Stevenson K, Wu CJ, Wiedl C, Waller EK, Walters MC. Bone marrow transplantation for adolescents and young adults with sickle cell disease: Results of a prospective multicenter pilot study. Volume 94 of Issue 4. American journal of hematology 2019. PMID: 30637784


  26. Chung JE, Magis W, Vu J, Heo SJ, Wartiovaara K, Walters MC, Kurita R, Nakamura Y, Boffelli D, Martin DIK, Corn JE, DeWitt MA. CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells. Volume 14 of Issue 1. PloS one 2019. PMID: 30645582


  27. Romero Z, DeWitt M, Walters MC. Promise of gene therapy to treat sickle cell disease. Volume 18 of Issue 11. Expert opinion on biological therapy 2018. PMID: 30324810


  28. Hochberg J, Zahler S, Geyer MB, Chen N, Krajewski J, Harrison L, Militano O, Ozkaynak MF, Cheerva AC, Talano J, Moore TB, Gillio AP, Walters MC, Baxter-Lowe LA, Hamby C, Cairo MS. The safety and efficacy of clofarabine in combination with high-dose cytarabine and total body irradiation myeloablative conditioning and allogeneic stem cell transplantation in children, adolescents, and young adults (CAYA) with poor-risk acute leukemia. Volume 54 of Issue 2. Bone marrow transplantation 2018. PMID: 29899571


  29. Jamieson CHM, Millan MT, Creasey AA, Lomax G, Donohoe ME, Walters MC, Abedi M, Bota DA, Zaia JA, Adams JS. CIRM Alpha Stem Cell Clinics: Collaboratively Addressing Regenerative Medicine Challenges. Volume 22 of Issue 6. Cell stem cell 2018. PMID: 29859170


  30. Thompson AA, Walters MC, Kwiatkowski J, Rasko JEJ, Ribeil JA, Hongeng S, Magrin E, Schiller GJ, Payen E, Semeraro M, Moshous D, Lefrere F, Puy H, Bourget P, Magnani A, Caccavelli L, Diana JS, Suarez F, Monpoux F, Brousse V, Poirot C, Brouzes C, Meritet JF, Pondarré C, Beuzard Y, Chrétien S, Lefebvre T, Teachey DT, Anurathapan U, Ho PJ, von Kalle C, Kletzel M, Vichinsky E, Soni S, Veres G, Negre O, Ross RW, Davidson D, Petrusich A, Sandler L, Asmal M, Hermine O, De Montalembert M, Hacein-Bey-Abina S, Blanche S, Leboulch P, Cavazzana M. Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia. Volume 378 of Issue 16. The New England journal of medicine 2018. PMID: 29669226


  31. Shenoy S, Gaziev J, Angelucci E, King A, Bhatia M, Smith A, Bresters D, Haight AE, Duncan CN, de la Fuente J, Dietz AC, Baker KS, Pulsipher MA, Walters MC. Late Effects Screening Guidelines after Hematopoietic Cell Transplantation (HCT) for Hemoglobinopathy: Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric HCT. Volume 24 of Issue 7. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2018. PMID: 29653206


  32. Shenoy S, Walters MC, Ngwube A, Soni S, Jacobsohn D, Chaudhury S, Grimley M, Chan K, Haight A, Kasow KA, Parikh S, Andreansky M, Connelly J, Delgado D, Godder K, Hale G, Nieder M, Pulsipher MA, Trachtenberg F, Neufeld E, Kwiatkowski JL, Thompson AA. Unrelated Donor Transplantation in Children with Thalassemia using Reduced-Intensity Conditioning: The URTH Trial. Volume 24 of Issue 6. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2018. PMID: 29374585


  33. Fitzhugh CD, Walters MC. The case for HLA-identical sibling hematopoietic stem cell transplantation in children with symptomatic sickle cell anemia. Volume 1 of Issue 26. Blood advances 2017. PMID: 29296908


  34. Abraham A, Hsieh M, Eapen M, Fitzhugh C, Carreras J, Keesler D, Guilcher G, Kamani N, Walters MC, Boelens JJ, Tisdale J, Shenoy S, National Institutes of Health, Center for International Blood and Marrow Transplant Research. Relationship between Mixed Donor-Recipient Chimerism and Disease Recurrence after Hematopoietic Cell Transplantation for Sickle Cell Disease. Volume 23 of Issue 12. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017. PMID: 28882446


  35. Arnold SD, Brazauskas R, He N, Li Y, Aplenc R, Jin Z, Hall M, Atsuta Y, Dalal J, Hahn T, Khera N, Bonfim C, Majhail NS, Diaz MA, Freytes CO, Wood WA, Savani BN, Kamble RT, Parsons S, Ahmed I, Sullivan K, Beattie S, Dandoy C, Munker R, Marino S, Bitan M, Abdel-Azim H, Aljurf M, Olsson RF, Joshi S, Buchbinder D, Eckrich MJ, Hashmi S, Lazarus H, Marks DI, Steinberg A, Saad A, Gergis U, Krishnamurti L, Abraham A, Rangarajan HG, Walters M, Lipscomb J, Saber W, Satwani P. Clinical risks and healthcare utilization of hematopoietic cell transplantation for sickle cell disease in the USA using merged databases. Volume 102 of Issue 11. Haematologica 2017. PMID: 28818869


  36. Thakar MS, Bonfim C, Walters MC, Storb R, Pasquini R, Burroughs L, Sandmaier BM, Woolfrey A, Kiem HP. Dose-adapted post-transplant cyclophosphamide for HLA-haploidentical transplantation in Fanconi anemia. Volume 52 of Issue 4. Bone marrow transplantation 2017. PMID: 28067886


  37. Shenoy S, Angelucci E, Arnold SD, Baker KS, Bhatia M, Bresters D, Dietz AC, De La Fuente J, Duncan C, Gaziev J, King AA, Pulsipher MA, Smith AR, Walters MC. Current Results and Future Research Priorities in Late Effects after Hematopoietic Stem Cell Transplantation for Children with Sickle Cell Disease and Thalassemia: A Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium Inte Volume 23 of Issue 4. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017. PMID: 28065838


  38. Gluckman E, Cappelli B, Bernaudin F, Labopin M, Volt F, Carreras J, Pinto Simões B, Ferster A, Dupont S, de la Fuente J, Dalle JH, Zecca M, Walters MC, Krishnamurti L, Bhatia M, Leung K, Yanik G, Kurtzberg J, Dhedin N, Kuentz M, Michel G, Apperley J, Lutz P, Neven B, Bertrand Y, Vannier JP, Ayas M, Cavazzana M, Matthes-Martin S, Rocha V, Elayoubi H, Kenzey C, Bader P, Locatelli F, Ruggeri A, Eapen M, Eurocord, the Pediatric Working Party of the European Society for Blood and Marrow Transplantation,. Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation. Volume 129 of Issue 11. Blood 2016. PMID: 27965196


  39. DeWitt MA, Magis W, Bray NL, Wang T, Berman JR, Urbinati F, Heo SJ, Mitros T, Muñoz DP, Boffelli D, Kohn DB, Walters MC, Carroll D, Martin DI, Corn JE. Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells. Volume 8 of Issue 360. Science translational medicine 2016. PMID: 27733558


  40. Dietz AC, Duncan CN, Alter BP, Bresters D, Cowan MJ, Notarangelo L, Rosenberg PS, Shenoy S, Skinner R, Walters MC, Wagner J, Baker KS, Pulsipher MA. The Second Pediatric Blood and Marrow Transplant Consortium International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: Defining the Unique Late Effects of Children Undergoing Hematopoietic Cell Transplantation f Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2016. PMID: 27737772


  41. Shenoy S, Eapen M, Panepinto JA, Logan BR, Wu J, Abraham A, Brochstein J, Chaudhury S, Godder K, Haight AE, Kasow KA, Leung K, Andreansky M, Bhatia M, Dalal J, Haines H, Jaroscak J, Lazarus HM, Levine JE, Krishnamurti L, Margolis D, Megason GC, Yu LC, Pulsipher MA, Gersten I, DiFronzo N, Horowitz MM, Walters MC, Kamani N. A trial of unrelated donor marrow transplantation for children with severe sickle cell disease. Volume 128 of Issue 21. Blood 2016. PMID: 27625358


  42. Maddala R, Walters M, Brophy PJ, Bennett V, Rao PV. Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics. American journal of physiology. Cell physiology 2015. PMID: 26538089


  43. Walters MC, De Castro LM, Sullivan KM, Krishnamurti L, Kamani N, Bredeson C, Neuberg D, Hassell KL, Farnia S, Campbell A, Petersdorf E. Indications and Results of HLA-Identical Sibling Hematopoietic Cell Transplantation for Sickle Cell Disease. Volume 22 of Issue 2. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2015. PMID: 26500093


  44. Walters MC, MacKenzie TC. A booster shot to cure hemoglobinopathies. Volume 126 of Issue 10. Blood 2015. PMID: 26337353


  45. Walters MC. Update of hematopoietic cell transplantation for sickle cell disease. Volume 22 of Issue 3. Current opinion in hematology 2015. PMID: 25767957


  46. Derderian SC, Jeanty C, Walters MC, Vichinsky E, MacKenzie TC. In utero hematopoietic cell transplantation for hemoglobinopathies. Volume 5. Frontiers in pharmacology 2015. PMID: 25628564


  47. Wagner JE, Eapen M, Carter S, Wang Y, Schultz KR, Wall DA, Bunin N, Delaney C, Haut P, Margolis D, Peres E, Verneris MR, Walters M, Horowitz MM, Kurtzberg J, Blood and Marrow Transplant Clinical Trials Network. One-unit versus two-unit cord-blood transplantation for hematologic cancers. Volume 371 of Issue 18. The New England journal of medicine 2014. PMID: 25354103


  48. Baynam G, Walters M, Claes P, Kung S, LeSouef P, Dawkins H, Bellgard M, Girdea M, Brudno M, Robinson P, Zankl A, Groza T, Gillett D, Goldblatt J. Phenotyping: targeting genotype's rich cousin for diagnosis. Volume 51 of Issue 4. Journal of paediatrics and child health 2014. PMID: 25109851


  49. Soni S, Boulad F, Cowan MJ, Scaradavou A, Dahake J, Edwards S, Walters MC. Combined umbilical cord blood and bone marrow from HLA-identical sibling donors for hematopoietic stem cell transplantation in children with hemoglobinopathies. Pediatric blood & cancer 2014. PMID: 24803091


  50. Karafin MS, Graminske S, Erickson P, Walters MC, Scott EP, Carter S, Padmanabhan A. Evaluation of the Spectra Optia apheresis system for mononuclear cell (MNC) collection in G-CSF mobilized and nonmobilized healthy donors: results of a multicenter study. Volume 29 of Issue 5. Journal of clinical apheresis 2014. PMID: 24677347


  51. Suh JH, Kanathezhath B, Shenvi S, Guo H, Zhou A, Tiwana A, Kuypers F, Ames BN, Walters MC. Thiol/redox metabolomic profiling implicates GSH dysregulation in early experimental graft versus host disease (GVHD). Volume 9 of Issue 2. PloS one 2014. PMID: 24558439


  52. Romero Z, Urbinati F, Geiger S, Cooper AR, Wherley J, Kaufman ML, Hollis RP, de Assin RR, Senadheera S, Sahagian A, Jin X, Gellis A, Wang X, Gjertson D, Deoliveira S, Kempert P, Shupien S, Abdel-Azim H, Walters MC, Meiselman HJ, Wenby RB, Gruber T, Marder V, Coates TD, Kohn DB. β-globin gene transfer to human bone marrow for sickle cell disease. Volume 123 of Issue 8. The Journal of clinical investigation 2013. PMID: 23863630


  53. Locatelli F, Kabbara N, Ruggeri A, Ghavamzadeh A, Roberts I, Li CK, Bernaudin F, Vermylen C, Dalle JH, Stein J, Wynn R, Cordonnier C, Pinto F, Angelucci E, Socié G, Gluckman E, Walters MC, Rocha V, Eurocord and European Blood and Marrow Transplantation (EBMT) group. Outcome of patients with hemoglobinopathies given either cord blood or bone marrow transplantation from an HLA-identical sibling. Volume 122 of Issue 6. Blood 2013. PMID: 23692854


  54. Kamani NR, Walters MC, Carter S, Aquino V, Brochstein JA, Chaudhury S, Eapen M, Freed BM, Grimley M, Levine JE, Logan B, Moore T, Panepinto J, Parikh S, Pulsipher MA, Sande J, Schultz KR, Spellman S, Shenoy S. Unrelated donor cord blood transplantation for children with severe sickle cell disease: results of one cohort from the phase II study from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN). Volume 18 of Issue 8. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012. PMID: 22343376


  55. Tolar J, Mehta PA, Walters MC. Hematopoietic cell transplantation for nonmalignant disorders. Volume 18 of Issue 1 Suppl. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012. PMID: 22226101


  56. Kanathezhath B, Mizokami M, Stanislaus S, Hounshell C, Neumayr L, Guo H, Hearst JE, Walters MC, Kuypers FA. Improved engraftment with minimal graft-versus-host disease after major histocompatibility complex-mismatched cord blood transplantation with photochemically treated donor lymphocytes. Volume 236 of Issue 4. Experimental biology and medicine (Maywood, N.J.) 2011. PMID: 21454375


  57. Ruggeri A, Eapen M, Scaravadou A, Cairo MS, Bhatia M, Kurtzberg J, Wingard JR, Fasth A, Lo Nigro L, Ayas M, Purtill D, Boudjedir K, Chaves W, Walters MC, Wagner J, Gluckman E, Rocha V, Eurocord Registry, Center for International Blood and Marrow Transplant Research, New York Blood Center. Umbilical cord blood transplantation for children with thalassemia and sickle cell disease. Volume 17 of Issue 9. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2011. PMID: 21277376


  58. Kanathezhath B, Walters MC. Umbilical cord blood transplantation for thalassemia major. Volume 24 of Issue 6. Hematology/oncology clinics of North America 2010. PMID: 21075286


  59. Sabloff M, Chandy M, Wang Z, Logan BR, Ghavamzadeh A, Li CK, Irfan SM, Bredeson CN, Cowan MJ, Gale RP, Hale GA, Horan J, Hongeng S, Eapen M, Walters MC. HLA-matched sibling bone marrow transplantation for ß-thalassemia major. Blood 2010. PMID: 21119108


  60. Walters MC. Gene therapy and bone marrow transplantation for thalassemia: changing of the guard? Volume 18 of Issue 9. Molecular therapy : the journal of the American Society of Gene Therapy 2010. PMID: 20808320


  61. Walters MC, Sullivan KM. Stem-cell transplantation for sickle cell disease. Volume 362 of Issue 10. The New England journal of medicine 2010. PMID: 20225347


  62. MacMillan ML, Walters MC, Gluckman E. Transplant outcomes in bone marrow failure syndromes and hemoglobinopathies. Volume 47 of Issue 1. Seminars in hematology 2010. PMID: 20109610


  63. Walters MC, Hardy K, Edwards S, Adamkiewicz T, Barkovich J, Bernaudin F, Buchanan GR, Bunin N, Dickerhoff R, Giller R, Haut PR, Horan J, Hsu LL, Kamani N, Levine JE, Margolis D, Ohene-Frempong K, Patience M, Redding-Lallinger R, Roberts IA, Rogers ZR, Sanders JE, Scott JP, Sullivan KM, Multicenter Study of Bone Marrow Transplantation for Sickle Cell Disease. Pulmonary, gonadal, and central nervous system status after bone marrow transplantation for sickle cell disease. Volume 16 of Issue 2. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009. PMID: 19822218


  64. Walters MC. Translational stability for sickle gene therapy. Volume 16 of Issue 8. Gene therapy 2009. PMID: 19554033


  65. Serikov V, Hounshell C, Larkin S, Green W, Ikeda H, Walters MC, Kuypers FA. Human term placenta as a source of hematopoietic cells. Volume 234 of Issue 7. Experimental biology and medicine (Maywood, N.J.) 2009. PMID: 19429852


  66. Horan JT, Carreras J, Tarima S, Camitta BM, Gale RP, Hale GA, Hinterberger W, Marsh J, Passweg JR, Walters MC, Eapen M. Risk factors affecting outcome of second HLA-matched sibling donor transplantations for graft failure in severe acquired aplastic anemia. Volume 15 of Issue 5. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009. PMID: 19361755


  67. Michlitsch J, Azimi M, Hoppe C, Walters MC, Lubin B, Lorey F, Vichinsky E. Newborn screening for hemoglobinopathies in California. 2009. PMID: 19061217


  68. Michlitsch JG, Walters MC. Recent advances in bone marrow transplantation in hemoglobinopathies. 2008. PMID: 18991653


  69. Jastaniah W, Harmatz P, Pakbaz Z, Fischer R, Vichinsky E, Walters MC. Transfusional iron burden and liver toxicity after bone marrow transplantation for acute myelogenous leukemia and hemoglobinopathies. Pediatric blood & cancer 2008. PMID: 17557314


  70. Bhatia M, Walters MC. Hematopoietic cell transplantation for thalassemia and sickle cell disease: past, present and future. Volume 41 of Issue 2. Bone marrow transplantation 2007. PMID: 18059330


  71. Wu CJ, Gladwin M, Tisdale J, Hsieh M, Law T, Biernacki M, Rogers S, Wang X, Walters M, Zahrieh D, Antin JH, Ritz J, Krishnamurti L. Mixed haematopoietic chimerism for sickle cell disease prevents intravascular haemolysis. Volume 139 of Issue 3. British journal of haematology 2007. PMID: 17910640


  72. Frangoul H, Nemecek ER, Billheimer D, Pulsipher MA, Khan S, Woolfrey A, Manes B, Cole C, Walters MC, Ayas M, Ravindranath Y, Levine JE, Grupp SA. A prospective study of G-CSF primed bone marrow as a stem-cell source for allogeneic bone marrow transplantation in children: a Pediatric Blood and Marrow Transplant Consortium (PBMTC) study. Volume 110 of Issue 13. Blood 2007. PMID: 17827386


  73. Walters MC. Cord blood transplantation for sickle cell anemia: bust or boom? Volume 11 of Issue 6. Pediatric transplantation 2007. PMID: 17663678


  74. Panepinto JA, Walters MC, Carreras J, Marsh J, Bredeson CN, Gale RP, Hale GA, Horan J, Hows JM, Klein JP, Pasquini R, Roberts I, Sullivan K, Eapen M, Ferster A, Non-Malignant Marrow Disorders Working Committee, Center for International Blood and Marrow Transpla. Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research. Volume 137 of Issue 5. British journal of haematology 2007. PMID: 17459050


  75. Eggleston B, Patience M, Edwards S, Adamkiewicz T, Buchanan GR, Davies SC, Dickerhoff R, Donfield S, Feig SA, Giller RH, Haight A, Horan J, Hsu LL, Kamani N, Lane P, Levine JE, Margolis D, Moore TB, Ohene-Frempong K, Redding-Lallinger R, Roberts IA, Rogers ZR, Sanders JE, Scott JP, Sleight B, Thompson AA, Sullivan KM, Walters MC, Multicenter Study of HCT for SCA. Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia. Volume 136 of Issue 4. British journal of haematology 2007. PMID: 17223910


  76. Morris CR, Singer ST, Walters MC. Clinical hemoglobinopathies: iron, lungs and new blood. Volume 13 of Issue 6. Current opinion in hematology 2006. PMID: 17053452


  77. Qureshi N, Lubin B, Walters MC. The prevention and management of stroke in sickle cell anaemia. Volume 6 of Issue 11. Expert opinion on biological therapy 2006. PMID: 17049007


  78. Horan JT, Liesveld JL, Fenton P, Blumberg N, Walters MC. Hematopoietic stem cell transplantation for multiply transfused patients with sickle cell disease and thalassemia after low-dose total body irradiation, fludarabine, and rabbit anti-thymocyte globulin. Volume 35 of Issue 2. Bone marrow transplantation 2005. PMID: 15531901


  79. Qureshi N, Foote D, Walters MC, Singer ST, Quirolo K, Vichinsky EP. Outcomes of preimplantation genetic diagnosis therapy in treatment of beta-thalassemia: A retrospective analysis. Volume 1054. Annals of the New York Academy of Sciences 2005. PMID: 16339706


  80. Walters MC, Quirolo L, Trachtenberg ET, Edwards S, Hale L, Lee J, Morton-Wiley J, Quirolo K, Robertson S, Saba J, Lubin B. Sibling donor cord blood transplantation for thalassemia major: Experience of the Sibling Donor Cord Blood Program. 2005. PMID: 16339667


  81. Walters MC. Stem cell therapy for sickle cell disease: transplantation and gene therapy. Hematology. American Society of Hematology. Education Program 2005. PMID: 16304361


  82. Kuypers FA, Watson G, Sage E, Walters MC, Hamrick J, Hearst JE. Stem cell transplantation with S-59 photochemically treated T-cell add-backs to establish allochimerism in murine thalassemia. Volume 1054. Annals of the New York Academy of Sciences 2005. PMID: 16339668


  83. Butensky E, Pakbaz Z, Foote D, Walters MC, Vichinsky EP, Harmatz P. Treatment of hepatitis C virus infection in thalassemia. Annals of the New York Academy of Sciences 2005. PMID: 16339677


  84. Walters MC. Sickle cell anemia and hematopoietic cell transplantation: When is a pound of cure worth more than an ounce of prevention? Volume 8 Suppl 5. Pediatric transplantation 2004. PMID: 15125704


  85. Atkins RC, Walters MC. Haematopoietic cell transplantation in the treatment of sickle cell disease. Volume 3 of Issue 8. Expert opinion on biological therapy 2003. PMID: 14640947


  86. Iannone R, Casella JF, Fuchs EJ, Chen AR, Jones RJ, Woolfrey A, Amylon M, Sullivan KM, Storb RF, Walters MC. Results of minimally toxic nonmyeloablative transplantation in patients with sickle cell anemia and beta-thalassemia. Volume 9 of Issue 8. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2003. PMID: 12931121


  87. Reed W, Smith R, Dekovic F, Lee JY, Saba JD, Trachtenberg E, Epstein J, Haaz S, Walters MC, Lubin BH. Comprehensive banking of sibling donor cord blood for children with malignant and nonmalignant disease. Blood 2002. PMID: 12393579


  88. Hoppe CC, Walters MC. Bone marrow transplantation in sickle cell anemia. Volume 13 of Issue 2. Current opinion in oncology 2001. PMID: 11224704


  89. Reed W, Walters M, Trachtenberg E, Smith R, Lubin BH. Sibling donor cord blood banking for children with sickle cell disease. Volume 20 of Issue 2. Pediatric pathology & molecular medicine 2001. PMID: 12673840


  90. Walters MC, Patience M, Leisenring W, Rogers ZR, Aquino VM, Buchanan GR, Roberts IA, Yeager AM, Hsu L, Adamkiewicz T, Kurtzberg J, Vichinsky E, Storer B, Storb R, Sullivan KM, Multicenter Investigation of Bone Marrow Transplantation for Sickle Cell Disease. Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia. Volume 7 of Issue 12. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2001. PMID: 11787529


  91. Fixler J, Vichinsky E, Walters MC. Stem cell transplantation for sickle cell disease: can we reduce the toxicity? Volume 20 of Issue 1. Pediatric pathology & molecular medicine 2001. PMID: 12673845


  92. Reed W, Walters M, Lubin BH. Collection of sibling donor cord blood for children with thalassemia. Volume 22 of Issue 6. Journal of pediatric hematology/oncology 2000. PMID: 11132238


  93. Walters MC, Storb R, Patience M, Leisenring W, Taylor T, Sanders JE, Buchanan GE, Rogers ZR, Dinndorf P, Davies SC, Roberts IA, Dickerhoff R, Yeager AM, Hsu L, Kurtzberg J, Ohene-Frempong K, Bunin N, Bernaudin F, Wong WY, Scott JP, Margolis D, Vichinsky E, Wall DA, Wayne AS, Pegelow C, Redding-Lallinger R, Wiley J, Klemperer M, Mentzer WC, Smith FO, Sullivan KM. Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report. Multicenter investigation of bone marrow transplantation for sickle cell disease. Volume 95 of Issue 6. Blood 2000. PMID: 10706855


  94. Sullivan KM, Parkman R, Walters MC. Bone Marrow Transplantation for Non-Malignant Disease. Hematology. American Society of Hematology. Education Program 2000. PMID: 11701549


  95. Walters MC. Bone marrow transplantation for sickle cell disease: where do we go from here? Volume 21 of Issue 6. Journal of pediatric hematology/oncology 1999. PMID: 10598656


  96. Francastel C, Walters MC, Groudine M, Martin DI. A functional enhancer suppresses silencing of a transgene and prevents its localization close to centrometric heterochromatin. Volume 99 of Issue 3. Cell 1999. PMID: 10555142


  97. Walters MC, Fiering S, Bouhassira EE, Scalzo D, Goeke S, Magis W, Garrick D, Whitelaw E, Martin DI. The chicken beta-globin 5'HS4 boundary element blocks enhancer-mediated suppression of silencing. Volume 19 of Issue 5. Molecular and cellular biology 1999. PMID: 10207095


  98. Storb R, Yu C, Deeg HJ, Georges G, Kiem HP, Mcsweeney PA, Nash RA, Sandmaier BM, Sullivan KM, Wagner JL, Walters MC. Current and future preparative regimens for bone marrow transplantation in thalassemia. Volume 850. Annals of the New York Academy of Sciences 1998. PMID: 9668549


  99. Sullivan KM, Anasetti C, Horowitz M, Rowlings PA, Petersdorf EW, Martin PJ, Clift RA, Walters MC, Gooley T, Sierra J, Anderson JE, Bjerke J, Siadak M, Flowers ME, Nash RA, Sanders JE, Appelbaum FR, Storb R, Hansen JA. Unrelated and HLA-nonidentical related donor marrow transplantation for thalassemia and leukemia. A combined report from the Seattle Marrow Transplant Team and the International Bone Marrow Transplant Registry. Volume 850. Annals of the New York Academy of Sciences 1998. PMID: 9668553


  100. Walters MC, Patience M, Leisenring W, Rogers ZR, Dinndorf P, Davies SC, Roberts IA, Yeager A, Kurtzberg J, Bunin N, Scott JP, Wall DA, Wayne AS, Wiley J, Darbyshire PJ, Mentzer WC, Smith FO, Sullivan KM. Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions. Volume 3 of Issue 6. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 1997. PMID: 9502298


  101. Walters MC, Patience M, Leisenring W, Eckman JR, Scott JP, Mentzer WC, Davies SC, Ohene-Frempong K, Bernaudin F, Matthews DC, Storb R, Sullivan KM. Bone marrow transplantation for sickle cell disease. Volume 335 of Issue 6. The New England journal of medicine 1996. PMID: 8663884


  102. Walters MC, Patience M, Leisenring W, Eckman JR, Buchanan GR, Rogers ZR, Olivieri NE, Vichinsky E, Davies SC, Mentzer WC, Powars D, Scott JP, Bernaudin F, Ohene-Frempong K, Darbyshire PJ, Wayne A, Roberts IA, Dinndorf P, Brandalise S, Sanders JE, Matthews DC, Appelbaum FR, Storb R, Sullivan KM. Barriers to bone marrow transplantation for sickle cell anemia. Volume 2 of Issue 2. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 1996. PMID: 9118298


  103. Walters MC, Magis W, Fiering S, Eidemiller J, Scalzo D, Groudine M, Martin DI. Transcriptional enhancers act in cis to suppress position-effect variegation. Volume 10 of Issue 2. Genes & development 1996. PMID: 8566752


  104. Walters MC, Fiering S, Eidemiller J, Magis W, Groudine M, Martin DI. Enhancers increase the probability but not the level of gene expression. Volume 92 of Issue 15. Proceedings of the National Academy of Sciences of the United States of America 1995. PMID: 7624382


  105. Walters MC, Sullivan KM, Bernaudin F, Souillet G, Vannier JP, Johnson FL, Lenarsky C, Powars D, Bunin N, Ohene-Frempong K. Neurologic complications after allogeneic marrow transplantation for sickle cell anemia. Volume 85 of Issue 4. Blood 1995. PMID: 7849310


  106. Walters MC, Sullivan KM, O'Reilly RJ, Boulad F, Brockstein J, Blume K, Amylon M, Johnson FL, Klemperer M, Graham-Pole J. Bone marrow transplantation for thalassemia. The USA experience. Volume 16 of Issue 1. The American journal of pediatric hematology/oncology 1994. PMID: 8311166