Srinath Sanda, MD

My research focuses on the immunology and genetics of diabetes. I run a research lab that utilizes cell line experiments, analysis of human samples, large data set analysis, and clinical research to develop biomarkers and new paradigms of human disease. My current projects focus on type 1 diabetes and cystic fibrosis related diabetes (CFRD).

In addition, I am a Director of Clinical and Translational Medicine in the Immune Tolerance Network, a large NIH-sponsored clinical trials consortium that conductsl immune modulating trials in type 1 diabetes, allergy, transplantation, and autoimmune diseases (https://www.immunetolerance.org). I design international, multi-center phase 1 and 2 clinical trials in type 1 diabetes and allergic disease utilizing cutting-edge immune modulation therapy. We combine data from the clinical trials data with cutting edge immunophenotyping data to better understand mechanisms of immune tolerance in humans.
Education
06/2007 - Pediatric Endocrinology, UC San Diego
06/2002 - Pediatrics Chief Resident, Cedar-Sinai Medical Center
06/2001 - Internal Medicine/Pediatrics, Cedars-Sinai Medical Center
M.D., 06/1997 - Medicine, UC Davis
Websites

  1. Altman MC, Segnitz RM, Larson D, Jayavelu ND, Smith M, Patel S, Scadding GW, Qin T, Sanda S, Steveling E, Eifan AO, Penagos M, Jacobson MR, Parkin RV, Shamji MH, Togias A, Durham SR. Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy. The Journal of allergy and clinical immunology 2023. PMID: 37460024


  2. Calise J, DeBerg H, Garabatos N, Khosa S, Bajzik V, Calderon LB, Aldridge K, Rosasco M, Ferslew BC, Zhu T, Smulders R, Wheatley LM, Laidlaw TM, Qin T, Chichili GR, Adelman DC, Farrington M, Robinson D, Jeong D, Jones SM, Sanda S, Larson D, Kwok WW, Baloh C, Nepom GT, Wambre E, IMPACT. Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy. The Journal of allergy and clinical immunology 2023. PMID: 37003475


  3. Mustafa Ozcam, Kathryn McCauley, Lisa Wheatley, Carolyn Baloh, Srinath Sanda, Stacie Jones, Susan Lynch. Gut Microbiome Membrane Lipids and Bile Acids Relate to Peanut Oral Immunotherapy Outcomes. Journal of Allergy and Clinical Immunology 2023. PMID:


  4. Kanchan K, Shankar G, Huffaker MF, Bahnson HT, Chinthrajah RS, Sanda S, Manohar M, Ling H, Paschall JE, Toit GD, Ruczinski I, Togias A, Lack G, Nadeau KC, Jones SM, Nepom GT, Mathias RA. HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success. Frontiers in immunology 2022. PMID: 36466872


  5. Corren J, Larson D, Altman MC, Segnitz RM, Avila PC, Greenberger PA, Baroody F, Moss MH, Nelson H, Burbank AJ, Hernandez ML, Peden D, Saini S, Tilles S, Hussain I, Whitehouse D, Qin T, Villarreal M, Sever M, Wheatley LM, Nepom GT, Sanda S, Immune Tolerance Network ITN057AD CATNIP Study Team. Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen: A�randomized controlled trial. The Journal of allergy and clinical immunology 2022. PMID: 36223848


  6. Lambert K, Diggins KE, Jones BE, Hundhausen C, Maerz MD, Hocking AM, Sanda S, Greenbaum CJ, Linsley PS, Cerosaletti K, Buckner JH. IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation. Frontiers in immunology 2022. PMID: 35911690


  7. Lee JY, Fan B, Montenegro G, Long RK, Sanda S, Capodanno G, Schafer AL, Burghardt AJ, Rosenthal SM, Fung EB. Interpretation of Bone Mineral Density Z-Scores by Dual-Energy X-Ray Absorptiometry in Transgender and Gender Diverse Youth Prior to Gender-Affirming Medical Therapy. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 2022. PMID: 35941040


  8. Kanika Kanchan, Gautam Shankar, Michelle Huffaker, Henry Bahnson, R Sharon Chinthrajah, Srinath Sanda, Monali Manohar, George Du Toit, Ingo Ruczinski, Gideon Lack, Kari Nadeau, Stacie Jones, Gerald Nepom, Rasika Mathias. Translating lessons learned on the role of HLA in immunological responses in LEAP to peanut OIT Trials: IMPACT and POISED. Journal of Allergy and Clinical Immunology 2022. PMID:


  9. Jones SM, Kim EH, Nadeau KC, Nowak-Wegrzyn A, Wood RA, Sampson HA, Scurlock AM, Chinthrajah S, Wang J, Pesek RD, Sindher SB, Kulis M, Johnson J, Spain K, Babineau DC, Chin H, Laurienzo-Panza J, Yan R, Larson D, Qin T, Whitehouse D, Sever ML, Sanda S, Plaut M, Wheatley LM, Burks AW, Immune Tolerance Network. Efficacy and safety of oral immunotherapy in children aged 1-3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study. 2022. PMID: 35065784


  10. Greenbaum CJ, Serti E, Lambert K, Weiner LJ, Kanaparthi S, Lord S, Gitelman SE, Wilson DM, Gaglia JL, Griffin KJ, Russell WE, Raskin P, Moran A, Willi SM, Tsalikian E, DiMeglio LA, Herold KC, Moore WV, Goland R, Harris M, Craig ME, Schatz DA, Baidal DA, Rodriguez H, Utzschneider KM, Nel HJ, Soppe CL, Boyle KD, Cerosaletti K, Keyes-Elstein L, Long SA, Thomas R, McNamara JG, Buckner JH, Sanda S, ITN058AI EXTEND Study Team. IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes. 2021. PMID: 34747368


  11. Huffaker MF, Sanda S, Chandran S, Chung SA, St Clair EW, Nepom GT, Smilek DE. Approaches to Establishing Tolerance in Immune Mediated Diseases. Frontiers in immunology 2021. PMID: 34616405


  12. Gitelman SE, Bundy BN, Ferrannini E, Lim N, Blanchfield JL, DiMeglio LA, Felner EI, Gaglia JL, Gottlieb PA, Long SA, Mari A, Mirmira RG, Raskin P, Sanda S, Tsalikian E, Wentworth JM, Willi SM, Krischer JP, Bluestone JA, Gleevec Trial Study Group. Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. The lancet. Diabetes & endocrinology 2021. PMID: 34214479


  13. Alonso GT, Ebekozien O, Gallagher MP, Rompicherla S, Lyons SK, Choudhary A, Majidi S, Pinnaro CT, Balachandar S, Gangat M, Curda Roberts AJ, Marks BE, Creo A, Sanchez J, Seeherunvong T, Jimenez-Vega J, Patel NS, Wood JR, Gabriel L, Sumpter KM, Wilkes M, Rapaport R, Cymbaluk A, Wong JC, Sanda S, Albanese-O'neill A. Diabetic ketoacidosis drives COVID-19 related hospitalizations in children with type 1 diabetes. Journal of diabetes 2021. PMID: 33855813


  14. Shamji MH, Larson D, Eifan A, Scadding GW, Qin T, Lawson K, Sever ML, Macfarlane E, Layhadi JA, Würtzen PA, Parkin RV, Sanda S, Harris KM, Nepom GT, Togias A, Durham SR. Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy. The Journal of allergy and clinical immunology 2021. PMID: 33819508


  15. Ebekozien O, Agarwal S, Noor N, Albanese-O'Neill A, Wong JC, Seeherunvong T, Sanchez J, DeSalvo D, Lyons SK, Majidi S, Wood JR, Acharya R, Aleppo G, Sumpter KM, Cymbaluk A, Shah NA, Van Name M, Cruz-Aviles L, Alonso GT, Gallagher MP, Sanda S, Feuer AJ, Cossen K, Rioles N, Jones NY, Kamboj MK, Hirsch IB. Inequities in Diabetic Ketoacidosis Among Patients With Type 1 Diabetes and COVID-19: Data From 52 US Clinical Centers. The Journal of clinical endocrinology and metabolism 2021. PMID: 33410917


  16. Cortez FJ, Gebhart D, Robinson PV, Seftel D, Pourmandi N, Owyoung J, Bertozzi CR, Wilson DM, Maahs DM, Buckingham BA, Mills JR, Roforth MM, Pittock SJ, McKeon A, Page K, Wolf WA, Sanda S, Speake C, Greenbaum CJ, Tsai CT. Sensitive detection of multiple islet autoantibodies in type 1 diabetes using small sample volumes by agglutination-PCR. PloS one 2020. PMID: 33186361


  17. Larson D, Patel P, Salapatek AM, Couroux P, Whitehouse D, Pina A, Johnson JL, Sever ML, Sanda S, Poyser J, Allio T, Scadding GW, Qin T, Shamji MH, Kwok WW, James EA, French D, Lelic A, Larché M, Altman MC, Togias A, Durham SR. Nasal allergen challenge and environmental exposure chamber challenge: A randomized trial comparing clinical and biological responses to cat allergen. The Journal of allergy and clinical immunology 2020. PMID: 32169380


  18. Jonathan Corren, Lisa Wheatley, Srinath Sanda, David Larson, Tielin Qin, Pedro Avila, Fuad Baroody, Paul Greenberger, Iftikhar Hussain, Mark Moss, Harold Nelson, Sarbjit Saini, Stephen Tilles, Joy Laurienzo, Michelle Sever, Don Whitehouse, Rachel Yan, Gerald Nepom. Effects of Combined Treatment with Cat Allergen Immunotherapy and Tezepelumab on Nasal Allergen Challenge. Journal of Allergy and Clinical Immunology 2020. PMID:


  19. Stacie Jones, Edwin Kim, Kari Nadeau, Anna Nowak-Wegrzyn, Robert Wood, Hugh Sampson, Amy Scurlock, Sharon Chinthrajan, Jacqueline Johnson, Katharine Spain, Joy Laurienzo, David Larson, Marshall Plaut, Tielin Qin, Srinath Sanda, Michelle Sever, Lisa Wheatley, Don Whitehouse, Rachel Yan, A. Wesley Burks. Tolerance Development Following Oral Immunotherapy (OIT) in 1-3 Year Old Children with Peanut Allergy: Findings from the Immune Tolerance Network (ITN) IMPACT TRIAL. Journal of Allergy and Clinical Immunology 2020. PMID:


  20. Norris AW, Ode KL, Merjaneh L, Sanda S, Yi Y, Sun X, Engelhardt JF, Hull RL. Survival in a bad neighborhood: pancreatic islets in cystic fibrosis. The Journal of endocrinology 2019. PMID: 30759072


  21. Nagy N, Sunkari VG, Kaber G, Hasbun S, Lam DN, Speake C, Sanda S, McLaughlin TL, Wight TN, Long SR, Bollyky PL. Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control. Matrix biology : journal of the International Society for Matrix Biology 2018. PMID: 30196101


  22. Hull RL, Gibson RL, McNamara S, Deutsch GH, Fligner CL, Frevert CW, Ramsey BW, Sanda S. Islet Interleukin-1ß Immunoreactivity Is an Early Feature of Cystic Fibrosis That May Contribute to ß-Cell Failure. Diabetes care 2018. PMID: 29437698


  23. Long SA, Thorpe J, Herold KC, Ehlers M, Sanda S, Lim N, Linsley PS, Nepom GT, Harris KM. Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes. Cellular immunology 2017. PMID: 28844471


  24. Sanda S, Type 1 Diabetes TrialNet Study Group. Increasing ICA512 autoantibody titers predict development of abnormal oral glucose tolerance tests. Pediatric diabetes 2017. PMID: 28707353


  25. Spindler MP, Ho AM, Tridgell D, McCulloch-Olson M, Gersuk V, Ni C, Greenbaum C, Sanda S. Acute hyperglycemia impairs IL-6 expression in humans. Immunity, inflammation and disease 2016. PMID: 27042306


  26. Durinovic-Belló I, Gersuk VH, Ni C, Wu R, Thorpe J, Jospe N, Sanda S, Greenbaum CJ, Nepom GT. Avidity-dependent programming of autoreactive T cells in T1D. PloS one 2014. PMID: 24844227


  27. Mauseth R, Hirsch IB, Bollyky J, Kircher R, Matheson D, Sanda S, Greenbaum C. Use of a "fuzzy logic" controller in a closed-loop artificial pancreas. Diabetes technology & therapeutics 2013. PMID: 23829285


  28. Moran A, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Greenbaum CJ, Herold KC, Marks JB, Raskin P, Sanda S, Schatz D, Wherrett DK, Wilson DM, Krischer JP, Skyler JS, Type 1 Diabetes TrialNet Canakinumab Study Group , Pickersgill L, de Koning E, Ziegler AG, Böehm B, Badenhoop K, Schloot N, Bak JF, Pozzilli P, Mauricio D, Donath MY, Castaño L, Wägner A, Lervang HH, Perrild H, Mandrup-Poulsen T, AIDA Study Group. Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials. Lancet (London, England) 2013. PMID: 23562090


  29. Yang J, James EA, Sanda S, Greenbaum C, Kwok WW. CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring. Immunology 2013. PMID: 23228173


  30. Chiu HK, Sanda S, Fechner PY, Pihoker C. Correlation of TSH with the risk of paediatric thyroid carcinoma. Clinical endocrinology 2012. PMID: 22404106


  31. Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, Ahmann A, Rabinovitch A, Aggarwal S, Phippard D, Turka LA, Ehlers MR, Bianchine PJ, Boyle KD, Adah SA, Bluestone JA, Buckner JH, Greenbaum CJ, Diabetes TrialNet and the Immune Tolerance Network. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs ß-cell function. Diabetes 2012. PMID: 22721971


  32. Greenbaum CJ, Schatz DA, Haller MJ, Sanda S. Through the fog: recent clinical trials to preserve ß-cell function in type 1 diabetes. Diabetes 2012. PMID: 22618767


  33. Sanda S, Wei S, Rue T, Shilling H, Greenbaum C. A SNP in G6PC2 predicts insulin secretion in type 1 diabetes. Acta diabetologica 2012. PMID: 22438186


  34. Kanter JE, Kramer F, Barnhart S, Averill MM, Vivekanandan-Giri A, Vickery T, Li LO, Becker L, Yuan W, Chait A, Braun KR, Potter-Perigo S, Sanda S, Wight TN, Pennathur S, Serhan CN, Heinecke JW, Coleman RA, Bornfeldt KE. Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proceedings of the National Academy of Sciences of the United States of America 2012. PMID: 22308341


  35. Hondowicz BD, Schwedhelm KV, Kas A, Tasch MA, Rawlings C, Ramchurren N, McIntosh M, D'Amico LA, Sanda S, Standifer NE, Shendure J, Stone B. Discovery of T cell antigens by high-throughput screening of synthetic minigene libraries. PloS one 2012. PMID: 22253836


  36. Habib T, Funk A, Rieck M, Brahmandam A, Dai X, Panigrahi AK, Luning Prak ET, Meyer-Bahlburg A, Sanda S, Greenbaum C, Rawlings DJ, Buckner JH. Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant. Journal of immunology (Baltimore, Md. : 1950) 2011. PMID: 22105996


  37. Sanda S, Greenbaum CJ. Comment on: Atkinson. It's time to consider changing the rules: the rationale for rethinking control groups in clinical trials aimed at reversing type 1 diabetes. Diabetes 2011;60:361-363. Diabetes 2011. PMID: 21617183


  38. Sanda S, Bollyky J, Standifer N, Nepom G, Hamerman JA, Greenbaum C. Short-term IL-1beta blockade reduces monocyte CD11b integrin expression in an IL-8 dependent fashion in patients with type 1 diabetes. Clinical immunology (Orlando, Fla.) 2010. PMID: 20483667


  39. S. Alice Long, Karen Cerosaletti, Heather Shilling, Paul Bollyky, David Rawlings, Srinath Sanda, Jane Buckner. A T1D-associated Variant of PTPN2 Correlates with Decreased IL-2/IL-15 Responsiveness, Reduced FOXP3 Expression and Altered CD8 T Cell Differentiation. Clinical Immunology 2010. PMID:


  40. Brian Hondowicz, Katharine Schwedhelm, Arnold Kas, Michael Tasch, Nirasha Ramchurren, Nathan Standifer, Srinath Sanda, Crystal Rawlings, Jay Shendure, Brad Stone. High-throughput Screening for CD8+ T Cell Epitopes Targeted in Type 1 Diabetes. Clinical Immunology 2010. PMID:


  41. Srinath Sanda, Jenna Bollyky, Gerald Nepom, Jessica Hamerman, Carla Greenbaum. Reduced CD11b Integrin Expression with Short-term Administration of an IL-1R Antagonist in Type 1 Diabetes Patients. Clinical Immunology 2010. PMID:


  42. Long SA, Cerosaletti K, Bollyky PL, Tatum M, Shilling H, Zhang S, Zhang ZY, Pihoker C, Sanda S, Greenbaum C, Buckner JH. Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes 2009. PMID: 19875613


  43. Sarah Alice Long, Paul Bollyky, Karen Cerosaletti, Heather Shilling, Catherine Pihoker, Srinath Sanda, Carla Greenbaum, Jane Buckner. Diminished IL-2 responsiveness and FOXP3 expression in T1D subjects is revealed by a disease-associated variant of PTPN2 (49.1). The Journal of Immunology 2009. PMID:


  44. Long SA, Walker MR, Rieck M, James E, Kwok WW, Sanda S, Pihoker C, Greenbaum C, Nepom GT, Buckner JH. Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects. European journal of immunology 2009. PMID: 19180473


  45. Ivana Durinovic-Bello, Rebecca Wu, Srinath Sanda, Gerald Nepom. F.69. Selection of Antigen Specific Autoreactive T Cells is Influenced by INS-VNTR Genotype. Clinical Immunology 2009. PMID:


  46. S. Alice Long, Paul Bollyky, Karen Cerosaletti, Heather Shilling, Catherine Pihoker, Srinath Sanda, Carla Greenbaum, Jane Buckner. OR.62. Impaired IL-2 Responsiveness and Treg Persistence in T1D is Revealed by Disease-Associated Variants in PTPN2. Clinical Immunology 2009. PMID:


  47. Srinath Sanda, Jennifer Bollyky, Emily Burwell, Nathan Standifer, Gerald Nepom, Carla Greenbaum. T.128. Short-term Administration of Anakinra does not Appear to Affect Stimulated C-peptide Responses Acutely in Patients with Type 1 Diabetes. Clinical Immunology 2009. PMID:


  48. Schneider A, Rieck M, Sanda S, Pihoker C, Greenbaum C, Buckner JH. The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. Journal of immunology (Baltimore, Md. : 1950) 2008. PMID: 18981158


  49. Bollyky J, Sanda S, Greenbaum CJ. Type 1 diabetes mellitus: primary, secondary, and tertiary prevention. The Mount Sinai journal of medicine, New York 2008. PMID: 18729155


  50. Sanda S, Schlingmann KP, Newfield RS. Autosomal dominant hypoparathyroidism with severe hypomagnesemia and hypocalcemia, successfully treated with recombinant PTH and continuous subcutaneous magnesium infusion. Journal of pediatric endocrinology & metabolism : JPEM 2008. PMID: 18556971


  51. Sanda S, Roep BO, von Herrath M. Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes. Clinical immunology (Orlando, Fla.) 2008. PMID: 18304876


  52. Sanda S, Newfield RS. A child with pericardial effusion and cardiac tamponade due to previously unrecognized hypothyroidism. Journal of the National Medical Association 2007. PMID: 18229779


  53. von Herrath M, Sanda S, Herold K. Type 1 diabetes as a relapsing-remitting disease? Nature reviews. Immunology 2007. PMID: 17982429


  54. Srinath Sanda, Bart Roep, Matthias von Herrath. Reduced Foxp3 and Interleukin 10 Expression During the Partial Remission Phase of Type 1 Diabetes in Children. Clinical Immunology 2007. PMID: