Jane Symington, MD, PhD

Dr. Jane Symington is a pediatric physician scientist investigating the pathogenesis of Coccidioides, the fungus that causes Coccidioidomycosis, more commonly known as Valley Fever. Her current work focuses on dissecting the interactions between Coccidioides and innate immune cells to identify and target pathways important for fungal virulence or protective host responses.
Education
2022 - Pediatric Infectious Diseases Fellowship, University of California San Francisco
2019 - Pediatric Residency, University of California San Francisco
MD, PhD, 2016 - Molecular Microbiology and Microbial Pathogenesis, Washington University in St. Louis
BS, 2007 - Biology, Yale University

  1. Cohen A, Jeng EE, Voorhies M, Symington J, Ali N, Rodriguez RA, Bassik MC, Sil A. Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages. Volume 18 of Issue 9. PLoS pathogens 2022. PMID: 36174103


  2. Wang C, Bauckman KA, Ross ASB, Symington JW, Ligon MM, Scholtes G, Kumar A, Chang HW, Twentyman J, Fashemi BE, Xavier RJ, Mysorekar IU. A non-canonical autophagy-dependent role of the ATG16L1T300A variant in urothelial vesicular trafficking and uropathogenic Escherichia coli persistence. Volume 15 of Issue 3. Autophagy 2018. PMID: 30335568


  3. Symington JW, Wang C, Twentyman J, Owusu-Boaitey N, Schwendener R, Núñez G, Schilling JD, Mysorekar IU. ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1β-dependent manner. Volume 8 of Issue 6. Mucosal immunology 2015. PMID: 25669147


  4. Wang C, Symington JW, Ma E, Cao B, Mysorekar IU. Estrogenic modulation of uropathogenic Escherichia coli infection pathogenesis in a murine menopause model. Volume 81 of Issue 3. Infection and immunity 2012. PMID: 23264047


  5. Wang C, Symington JW, Mysorekar IU. ATG16L1 and pathogenesis of urinary tract infections. Volume 8 of Issue 11. Autophagy 2012. PMID: 22874553


  6. Wang C, Mendonsa GR, Symington JW, Zhang Q, Cadwell K, Virgin HW, Mysorekar IU. Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo. Volume 109 of Issue 27. Proceedings of the National Academy of Sciences of the United States of America 2012. PMID: 22715292