Laura Hertel, PhD

We study the tropism and pathogenesis of human cytomegalovirus (CMV).
Our current goals are to understand the mechanisms supporting CMV transmission from host to host and CMV spread within infected individuals. We seek to identify the cell types targeted during initial entry, and the cellular and viral proteins involved in enabling or antagonizing infection.
Education
Postdoctoral Fellow, - Molecular Virology, Stanford University
Research Associate, - Molecular Virology, Stanford University
B.Sc., - Biological Sciences, University of Torino
Ph.D, - Immunology, University of Torino

  1. Ourahmane A, Hertel L, McVoy MA. The RL13 Temperance Factor Represses Replication of the Highly Cell Culture-Adapted Towne Strain of Human Cytomegalovirus. Viruses 2023. PMID: 37113003


  2. He L, Taylor S, Costa C, Görzer I, Kalser J, Fu TM, Freed D, Wang D, Cui X, Hertel L, McVoy MA. Polymorphic Forms of Human Cytomegalovirus Glycoprotein O Protect against Neutralization of Fibroblast Entry by Antibodies Targeting Epitopes Defined by Glycoproteins H and L. Viruses 2022. PMID: 35891489


  3. Aguiar A, Galinato M, Bradley Silva M, Toth B, McVoy MA, Hertel L. Human Cytomegalovirus Replication and Infection-Induced Syncytia Formation in Labial, Foreskin, and Fetal Lung Fibroblasts. 2021. PMID: 34960624


  4. Al Qaffas A, Camiolo S, Vo M, Aguiar A, Ourahmane A, Sorono M, Davison AJ, McVoy MA, Hertel L. Genome sequences of human cytomegalovirus strain TB40/E variants propagated in fibroblasts and epithelial cells. Virology journal 2021. PMID: 34082757


  5. Al Qaffas A, Nichols J, Davison AJ, Ourahmane A, Hertel L, McVoy MA, Camiolo S. LoReTTA, a user-friendly tool for assembling viral genomes from PacBio sequence data. Virus evolution 2021. PMID: 33996146


  6. Vo M, Aguiar A, McVoy MA, Hertel L. Cytomegalovirus Strain TB40/E Restrictions and Adaptations to Growth in ARPE-19 Epithelial Cells. Microorganisms 2020. PMID: 32344555


  7. Al Qaffas A, Camiolo S, Nichols J, Davison AJ, Ourahmane A, Cui X, Schleiss MR, Hertel L, Dittmer DP, McVoy MA. Genome Sequence of Human Cytomegalovirus Ig-KG-H2, a Variant of Strain KG Propagated in the Presence of Neutralizing Antibodies. Microbiology resource announcements 2020. PMID: 32327516


  8. Qi Y, He L, Cui X, Hertel L, Freed DC, Fu TM, Kauvar LM, McVoy MA, Ruan Q. Comparative neutralizing potencies of antibodies suggest conservation as well as mechanistic differences in human cytomegalovirus entry into epithelial and endothelial cells. Virology journal 2020. PMID: 32268919


  9. Galinato M, Shimoda K, Aguiar A, Hennig F, Boffelli D, McVoy MA, Hertel L. Single-Cell Transcriptome Analysis of CD34+ Stem Cell-Derived Myeloid Cells Infected With Human Cytomegalovirus. Frontiers in microbiology 2019. PMID: 30949159


  10. Ourahmane A, Cui X, He L, Catron M, Dittmer DP, Al Qaffasaa A, Schleiss MR, Hertel L, McVoy MA. Inclusion of Antibodies to Cell Culture Media Preserves the Integrity of Genes Encoding RL13 and the Pentameric Complex Components During Fibroblast Passage of Human Cytomegalovirus. Viruses 2019. PMID: 30841507


  11. Coronel R, Jesus DM, Dalle Ore L, Mymryk JS, Hertel L. Activation of Langerhans-Type Dendritic Cells Alters Human Cytomegalovirus Infection and Reactivation in a Stimulus-Dependent Manner. Frontiers in microbiology 2016. PMID: 27683575


  12. Coronel R, Takayama S, Juwono T, Hertel L. Dynamics of Human Cytomegalovirus Infection in CD34+ Hematopoietic Cells and Derived Langerhans-Type Dendritic Cells. Journal of virology 2015. PMID: 25762731


  13. Hertel L. Human cytomegalovirus tropism for mucosal myeloid dendritic cells. Reviews in medical virology 2014. PMID: 24888709


  14. Lauron EJ, Yu D, Fehr AR, Hertel L. Human cytomegalovirus infection of langerhans-type dendritic cells does not require the presence of the gH/gL/UL128-131A complex and is blocked after nuclear deposition of viral genomes in immature cells. Journal of virology 2013. PMID: 24155395


  15. Hertel L. Herpesviruses and intermediate filaments: close encounters with the third type. Viruses 2011. PMID: 21994768


  16. Lee AW, Wang N, Hornell TM, Harding JJ, Deshpande C, Hertel L, Lacaille V, Pashine A, Macaubas C, Mocarski ES, Mellins ED. Human cytomegalovirus decreases constitutive transcription of MHC class II genes in mature Langerhans cells by reducing CIITA transcript levels. Molecular immunology 2011. PMID: 21458073


  17. Miller MS, Furlong WE, Pennell L, Geadah M, Hertel L. RASCAL is a new human cytomegalovirus-encoded protein that localizes to the nuclear lamina and in cytoplasmic vesicles at late times postinfection. Journal of virology 2010. PMID: 20392852


  18. Miller MS, Hertel L. Onset of human cytomegalovirus replication in fibroblasts requires the presence of an intact vimentin cytoskeleton. Journal of virology 2009. PMID: 19403668


  19. Mandic L, Miller MS, Coulter C, Munshaw B, Hertel L. Human cytomegalovirus US9 protein contains an N-terminal signal sequence and a C-terminal mitochondrial localization domain, and does not alter cellular sensitivity to apoptosis. The Journal of general virology 2009. PMID: 19264602


  20. Jagannathan P, Osborne CM, Royce C, Manion MM, Tilton JC, Li L, Fischer S, Hallahan CW, Metcalf JA, McLaughlin M, Pipeling M, McDyer JF, Manley TJ, Meier JL, Altman JD, Hertel L, Davey RT, Connors M, Migueles SA. Comparisons of CD8+ T cells specific for human immunodeficiency virus, hepatitis C virus, and cytomegalovirus reveal differences in frequency, immunodominance, phenotype, and interleukin-2 responsiveness. Journal of virology 2009. PMID: 19129459


  21. Hertel L, Chou S, Mocarski ES. Viral and cell cycle-regulated kinases in cytomegalovirus-induced pseudomitosis and replication. PLoS pathogens 2007. PMID: 17206862


  22. Lee AW, Hertel L, Louie RK, Burster T, Lacaille V, Pashine A, Abate DA, Mocarski ES, Mellins ED. Human cytomegalovirus alters localization of MHC class II and dendrite morphology in mature Langerhans cells. Journal of immunology (Baltimore, Md. : 1950) 2006. PMID: 16951359


  23. Yao W, Hertel L, Wahl LM. Dynamics of recurrent viral infection. Proceedings. Biological sciences 2006. PMID: 16901839


  24. Hertel L, Mocarski ES. Global analysis of host cell gene expression late during cytomegalovirus infection reveals extensive dysregulation of cell cycle gene expression and induction of Pseudomitosis independent of US28 function. Journal of virology 2004. PMID: 15479839


  25. Hertel L, Lacaille VG, Strobl H, Mellins ED, Mocarski ES. Susceptibility of immature and mature Langerhans cell-type dendritic cells to infection and immunomodulation by human cytomegalovirus. Journal of virology 2003. PMID: 12805456


  26. Rolle S, De Andrea M, Gioia D, Lembo D, Hertel L, Landolfo S, Gariglio M. The interferon-inducible 204 gene is transcriptionally activated by mouse cytomegalovirus and is required for its replication. Virology 2001. PMID: 11485393


  27. Hertel L, Rolle S, De Andrea M, Azzimonti B, Osello R, Gribaudo G, Gariglio M, Landolfo S. The retinoblastoma protein is an essential mediator that links the interferon-inducible 204 gene to cell-cycle regulation. Oncogene 2000. PMID: 10951565


  28. Hertel L, De Andrea M, Azzimonti B, Rolle A, Gariglio M, Landolfo S. The interferon-inducible 204 gene, a member of the Ifi 200 family, is not involved in the antiviral state induction by IFN-alpha, but is required by the mouse cytomegalovirus for its replication. Virology 1999. PMID: 10489335


  29. Azzimonti B, Hertel L, Aluffi P, Pia F, Monga G, Zocchi M, Landolfo S, Gariglio M. Demonstration of multiple HPV types in laryngeal premalignant lesions using polymerase chain reaction and immunohistochemistry. Journal of medical virology 1999. PMID: 10440817


  30. Hertel L, De Andrea M, Bellomo G, Santoro P, Landolfo S, Gariglio M. The HMG protein T160 colocalizes with DNA replication foci and is down-regulated during cell differentiation. Experimental cell research 1999. PMID: 10413586


  31. Gribaudo G, Riera L, Hertel L, Landolfo S. In vitro and in vivo expression analysis of the interferon-inducible 203 gene. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999. PMID: 10090398


  32. Lembo D, Gribaudo G, Cavallo R, Riera L, Angeretti A, Hertel L, Landolfo S. Human cytomegalovirus stimulates cellular dihydrofolate reductase activity in quiescent cells. Intervirology 1999. PMID: 10393501


  33. Lembo D, Cavallo R, Cornaglia M, Mondo A, Hertel L, Angeretti A, Landolfo S. Overexpression of cellular dihydrofolate reductase abolishes the anticytomegaloviral activity of methotrexate. Archives of virology 1999. PMID: 10481745


  34. Hertel L, Foresta P, Barbiero G, Ying GG, Bonelli G, Baccino FM, Landolfo S, Gariglio M. Decreased expression of the high-mobility group protein T160 by antisense RNA impairs the growth of mouse fibroblasts. Biochimie 1997. PMID: 9523013


  35. Gariglio M, Ying GG, Hertel L, Gaboli M, Clerc RG, Landolfo S. The high-mobility group protein T160 binds to both linear and cruciform DNA and mediates DNA bending as determined by ring closure. Experimental cell research 1997. PMID: 9367632


  36. Gariglio M, Foresta P, Sacchi C, Lembo M, Hertel L, Landolfo S. Suppression of high mobility group protein T160 expression impairs mouse cytomegalovirus replication. The Journal of general virology 1997. PMID: 9049420


  37. Gandhi V, Mineishi S, Huang P, Yang Y, Chubb S, Chapman AJ, Nowak BJ, Hertel LW, Plunkett W. Difluorodeoxyguanosine: cytotoxicity, metabolism, and actions on DNA synthesis in human leukemia cells. Seminars in oncology 1995. PMID: 7481847


  38. Lembo D, Angeretti A, Benefazio S, Hertel L, Gariglio M, Novelli F, Landolfo S. Constitutive expression of the interferon-inducible protein p202 in NIH 3T3 cells affects cell cycle progression. Journal of biological regulators and homeostatic agents 1995. PMID: 9127631


  39. Scott WA, Mahoney E. Defects of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in Neurospora and their pleiotropic effects. 1976. PMID: 3390


  40. Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. 1975. PMID: 10


  41. HAGELSTAM L. [Review of activities of the Orthopedic Hospital of the Foundation for the care of the Disabled]. 1953. PMID: 13122355