Laurence Cheng, MD, PhD

The long-term goal of my laboratory's research is to enhance understanding of human allergic disease through a combination of basic investigation in animal models coupled with translational approaches in patients with allergic diseases, including food allergy, atopic dermatitis, and asthma. Approaches in model systems include the use of genetically modified reporter/deleter mice coupled with cellular and imaging approaches, including intravital imaging.
Education
Clinical Fellowship, 2009 - Allergy and Immunology, University of California, San Francisco and Stanford University
Residency, 2006 - Pediatrics, University of California, San Francisco
M.D., 2004 - School of Medicine, University of Washington
Ph.D., 2002 - Immunology, University of Washington
Websites

  1. Bissonnette R, DuBois J, Facheris P, Del Duca E, Kim M, Correa Da Rosa J, Trujillo DL, Bose S, Pagan AD, Wustrow D, Brockstedt DG, Wong B, Kassner PD, Jankicevic J, Ho W, Cheng LE, Guttman-Yassky E. Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study. Volume 79 of Issue 4. Allergy 2023. PMID: 37984453


  2. Abuqayyas L, Cheng LE, Teixeira Dos Santos M, Sullivan BA, Ruiz-Santiago N, Wang H, Zhou Y, Chindalore V, Cohen S, Kivitz AJ, Posch MG, Parnes JR. Safety and Biological Activity of Rozibafusp alfa, a Bispecific Inhibitor of Inducible Costimulator Ligand and B Cell Activating Factor, in Patients With Rheumatoid Arthritis: Results of a Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multiple A Volume 4 of Issue 10. ACR Open Rheumatology 2022. PMID: 35899378


  3. Kroenke MA, Barger TE, Hu J, Miller MJ, Kalenian K, He L, Hsu H, Bartley Y, Chow VF, Teixeira Dos Santos MC, Sullivan BA, Cheng LE, Parnes JR, Padaki R, Kuhns S, Mytych DT. Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target. Volume 12. Frontiers in immunology 2021. PMID: 34970265


  4. L. Abuqayyas, L. Cheng, D. Mitragotri, S. Smith, M. Teixeira Dos Santos, Y. Zhou, V. Chindalore, S. Cohen, A. Kivitz, M. Posch, B. Sullivan, J. Parnes. FRI0084 SAFETY, PHARMACOKINETICS, PHARMACODYNAMICS, IMMUNOGENICITY, AND PRELIMINARY EFFICACY OF ROZIBAFUSP ALFA IN SUBJECTS WITH RHEUMATOID ARTHRITIS: INTERIM ANALYSIS OF A PHASE 1B RANDOMIZED, PLACEBO-CONTROLLED, MULTIPLE ASCENDING DOSE CLINICAL TRIAL. Annals of the rheumatic diseases 2020. PMID:


  5. L.E. Cheng, M. Kankam, N. Siebers, R. Stoltz, L. Abuqayyas, B. Ertik, B.A. Sullivan, L. Zhou, D. Mitragotri, J.R. Parnes. AB0521 Safety, pharmacokinetics, and pharmacodynamics of single doses of a bispecific icosl and baff inhibitor, amg 570, in healthy subjects. Annals of the rheumatic diseases 2018. PMID:


  6. Cheng LE, Amoura Z, Cheah B, Hiepe F, Sullivan BA, Zhou L, Arnold GE, Tsuji WH, Merrill JT, Chung JB. Brief Report: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis. Volume 70 of Issue 7. Arthritis & rheumatology (Hoboken, N.J.) 2018. PMID: 29513931


  7. LE Cheng, Z Amoura, B Cheah, F Hiepe, BA Sullivan, L Zhou, GE Arnold, WH Tsuji, JT Merrill, JB Chung. OP0234 Clinical and biologic effects of icosl blockade by amg 557 in subjects with lupus arthritis. Annals of the rheumatic diseases 2017. PMID:


  8. Ahmed A, Reith W, Puck JM, Cheng LE. Novel Mutation in the Class II Transactivator Associated with Immunodeficiency and Autoimmunity. Journal of clinical immunology 2015. PMID: 26271388


  9. Laurence E. Cheng, Brandon M. Sullivan, Lizett E. Retana, Christopher D.C. Allen, Hong-Erh Liang, Richard M. Locksley. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. The Journal of cell biology 2015. PMID:


  10. Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF. Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. Volume 10 of Issue 3. PloS one 2015. PMID: 25789765


  11. Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. Volume 212 of Issue 4. The Journal of experimental medicine 2015. PMID: 25779634


  12. Cheng LE, Cabana MD. Dishing it out to allergies. Volume 135 of Issue 3. Pediatrics 2015. PMID: 25713279


  13. Cheng LE, Locksley RM. Allergic inflammation--innately homeostatic. Volume 7 of Issue 3. Cold Spring Harbor perspectives in biology 2014. PMID: 25414367


  14. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Volume 502 of Issue 7470. Nature 2013. PMID: 24037376


  15. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. Volume 210 of Issue 3. The Journal of experimental medicine 2013. PMID: 23420878


  16. Alice Chan, Morton Cowan, Jennifer M. Puck, Laurence E. Cheng. TREC Newborn Screening Can Identify Patients with Leaky SCID and May Improve Outcome. Journal of Allergy and Clinical Immunology 2013. PMID:


  17. Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Volume 38 of Issue 1. Immunity 2013. PMID: 23290520


  18. Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. Genetic analysis of basophil function in vivo. Volume 12 of Issue 6. Nature immunology 2011. PMID: 21552267


  19. Cheng LE, Wang ZE, Locksley RM. Murine B cells regulate serum IgE levels in a CD23-dependent manner. Volume 185 of Issue 9. Journal of immunology (Baltimore, Md. : 1950) 2010. PMID: 20870945


  20. Cheng LE, Kanwar B, Tcheurekdjian H, Grenert JP, Muskat M, Heyman MB, McCune JM, Wara DW. Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome. Clinical immunology (Orlando, Fla.) 2009. PMID: 19375390


  21. Cheng LE, Greenberg PD. Selective delivery of augmented IL-2 receptor signals to responding CD8+ T cells increases the size of the acute antiviral response and of the resulting memory T cell pool. Volume 169 of Issue 9. Journal of immunology (Baltimore, Md. : 1950) 2002. PMID: 12391213


  22. Blattman JN, Cheng LE, Greenberg PD. CD8(+) T cell responses: it's all downhill after their prime. Volume 3 of Issue 7. Nature immunology 2002. PMID: 12087413


  23. Ohlén C, Kalos M, Cheng LE, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES, Greenberg PD. CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function. Volume 195 of Issue 11. The Journal of experimental medicine 2002. PMID: 12045239


  24. Cheng LE, Ohlén C, Nelson BH, Greenberg PD. Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death. Volume 99 of Issue 5. Proceedings of the National Academy of Sciences of the United States of America 2002. PMID: 11867736


  25. Cheng LE, Chan FK, Cado D, Winoto A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. Volume 16 of Issue 8. The EMBO journal 1997. PMID: 9155013


  26. Woronicz JD, Lina A, Calnan BJ, Szychowski S, Cheng L, Winoto A. Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis. Volume 15 of Issue 11. Molecular and cellular biology 1995. PMID: 7565789


  27. Chan FK, Zhang J, Cheng L, Shapiro DN, Winoto A. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Volume 15 of Issue 5. Molecular and cellular biology 1995. PMID: 7739548