Brian Feldman, MD, PhD

Brian Feldman, MD, PhD
Walter L. Miller Distinguished Professor
University of California, San Francisco
Department of Pediatrics
Division of Pediatric Endocrinology



A major focus of the Feldman Laboratory is to elucidate previously unrecognized paracrine and endocrine signaling pathways that regulate stem cell fate and differentiation decisions. We are particularly interested in identifying novel pathways that modulate body composition and metabolism. We apply molecular, cellular and in vivo approaches to define these physiological signals as well as examine how perturbations in these pathways can lead to diseases such as diabetes.
Education
- Pediatrics, Harvard University
MD, PhD, - Medicine, Stanford University
- Pediatric Endocrinology, UCSF
Honors and Awards
  • Walter L. Miller Distinguished Professorship, University of California, San Francisco, 2018
  • Elected Member, ASCI, The American Society for Clinical Investigation, 2017
  • Basic Science Research Award of Excellence, Stanford University, 2016
  • Early Investigator Award, Endocrine Society, 2013
  • Bechtel Endowed Faculty Scholar, Stanford University, 2012
  • NIH Director's New Innovator Award, NIH, 2010
  • Young Investigator Award, Society for Pediatric Research, 2008
  1. Rodrigues A, Chernikova SB, Wang Y, Trinh TTH, Solow-Cordero DE, Alexandrova L, Casey KM, Alli E, Aggarwal A, Quill T, Koegel A, Feldman BJ, Ford JM, Hayden-Gephart M. Repurposing mebendazole against triple-negative breast cancer leptomeningeal disease. Research square 2024. PMID: 38405839




  2. Chen M, Kim S, Li L, Chattopadhyay S, Rando TA, Feldman BJ. Identification of an adipose tissue-resident pro-preadipocyte population. Cell reports 2023. PMID: 37119138


  3. Cheung SY, Sayeed M, Nakuluri K, Li L, Feldman BJ. MYH9 facilitates autoregulation of adipose tissue depot development. JCI insight 2021. PMID: 33986190


  4. Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Blecha JE, VanBrocklin HF, Seo Y, Sayeed M, Feldman BJ, Aggarwal R, Behr SC, Shao H, Wilson DM, Villanueva-Meyer JE, Gestwicki JE, Evans MJ. A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography. ACS chemical biology 2020. PMID: 32255605


  5. Carter KL, Treurnicht A, Davis KL, Kumar RB, Feldman BJ. A novel platform for isotype-specific testing of autoantibodies. PloS one 2019. PMID: 30730939



  6. Aggarwal A, Costa MJ, Rivero-Gutiérrez B, Ji L, Morgan SL, Feldman BJ. The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15. Cell reports 2017. PMID: 29186676


  7. Du H, Shih CH, Wosczyna MN, Mueller AA, Cho J, Aggarwal A, Rando TA, Feldman BJ. Macrophage-released ADAMTS1 promotes muscle stem cell activation. Nature communications 2017. PMID: 28939843


  8. Wong JC, Feldman BJ. Adamts1 responds to systemic cues and gates adipogenesis. Adipocyte 2017. PMID: 28700319



  9. Chen PI, Cao A, Miyagawa K, Tojais NF, Hennigs JK, Li CG, Sweeney NM, Inglis AS, Wang L, Li D, Ye M, Feldman BJ, Rabinovitch M. Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension. JCI insight 2017. PMID: 28138562


  10. Wong JC, Krueger KC, Costa MJ, Aggarwal A, Du H, McLaughlin TL, Feldman BJ. A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo. Science signaling 2016. PMID: 27811141


  11. Williams JD, Aggarwal A, Swami S, Krishnan AV, Ji L, Albertelli MA, Feldman BJ. Tumor Autonomous Effects of Vitamin D Deficiency Promote Breast Cancer Metastasis. Endocrinology 2016. PMID: 26934299


  12. Swami S, Krishnan AV, Williams J, Aggarwal A, Albertelli MA, Horst RL, Feldman BJ, Feldman D. Vitamin D mitigates the adverse effects of obesity on breast cancer in mice. Endocrine-related cancer 2016. PMID: 26817629



  13. Banerjee RR, Marina N, Katznelson L, Feldman BJ. Mifepristone Treatment of Cushing's Syndrome in a Pediatric Patient. Pediatrics 2015. PMID: 26459648


  14. Jeong Y, Swami S, Krishnan AV, Williams JD, Martin S, Horst RL, Albertelli MA, Feldman BJ, Feldman D, Diehn M. Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D. Molecular cancer therapeutics 2015. PMID: 25934710


  15. Diebold I, Hennigs JK, Miyagawa K, Li CG, Nickel NP, Kaschwich M, Cao A, Wang L, Reddy S, Chen PI, Nakahira K, Alcazar MA, Hopper RK, Ji L, Feldman BJ, Rabinovitch M. BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension. Cell metabolism 2015. PMID: 25863249


  16. Ota A, Kovary KM, Wu OH, Ahrends R, Shen WJ, Costa MJ, Feldman BJ, Kraemer FB, Teruel MN. Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice. Journal of lipid research 2015. PMID: 25840986


  17. Chao CS, McKnight KD, Cox KL, Chang AL, Kim SK, Feldman BJ. Novel GATA6 mutations in patients with pancreatic agenesis and congenital heart malformations. PloS one 2015. PMID: 25706805




  18. Zhang B, Kumar RB, Dai H, Feldman BJ. A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes. Nature medicine 2014. PMID: 25038825


  19. Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nature reviews. Cancer 2014. PMID: 24705652






  20. Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, Ptacek LJ, Yamamoto KR, Feldman BJ. Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate. The Journal of biological chemistry 2011. PMID: 21228270







  21. Bremer AA, Feldman BJ, Iezza G, Clark OH, Rosenthal SM. Report of a hürthle cell neoplasm in a peripubertal girl. Thyroid : official journal of the American Thyroid Association 2007. PMID: 17316121


  22. Fortescue EB, Shin AY, Greenes DS, Mannix RC, Agarwal S, Feldman BJ, Shah MI, Rifai N, Landzberg MJ, Newburger JW, Almond CS. Cardiac troponin increases among runners in the Boston Marathon. Annals of emergency medicine 2006. PMID: 17145114





  23. Huang EA, Feldman BJ, Schwartz ID, Geller DH, Rosenthal SM, Gitelman SE. Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children. The Journal of pediatrics 2006. PMID: 16423613


  24. Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL, Gitelman SE. Nephrogenic syndrome of inappropriate antidiuresis. The New England journal of medicine 2005. PMID: 15872203






  25. LeBrun DP, Matthews BP, Feldman BJ, Cleary ML. The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains. Oncogene 1997. PMID: 9366523