Brian Feldman, MD, PhD

Brian Feldman, MD, PhD
Walter L. Miller Distinguished Professor
University of California, San Francisco
Department of Pediatrics
Division of Pediatric Endocrinology



A major focus of the Feldman Laboratory is to elucidate previously unrecognized paracrine and endocrine signaling pathways that regulate stem cell fate and differentiation decisions. We are particularly interested in identifying novel pathways that modulate body composition and metabolism. We apply molecular, cellular and in vivo approaches to define these physiological signals as well as examine how perturbations in these pathways can lead to diseases such as diabetes.
Education
- Pediatrics, Harvard University
MD, PhD, - Medicine, Stanford University
- Pediatric Endocrinology, UCSF
Honors and Awards
  • Walter L. Miller Distinguished Professorship, University of California, San Francisco, 2018
  • Elected Member, ASCI, The American Society for Clinical Investigation, 2017
  • Basic Science Research Award of Excellence, Stanford University, 2016
  • Early Investigator Award, Endocrine Society, 2013
  • Bechtel Endowed Faculty Scholar, Stanford University, 2012
  • NIH Director's New Innovator Award, NIH, 2010
  • Young Investigator Award, Society for Pediatric Research, 2008

  1. Li L, Feldman BJ. White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models. The Journal of clinical investigation 2024. PMID: 38949025


  2. Rodrigues AJ, Chernikova SB, Wang Y, Trinh TTH, Solow-Cordero DE, Alexandrova L, Casey KM, Alli E, Aggarwal A, Quill T, Koegel AK, Feldman BJ, Ford JM, Hayden-Gephart M. Repurposing mebendazole against triple-negative breast cancer CNS metastasis. Journal of neuro-oncology 2024. PMID: 38563850


  3. Rodrigues A, Chernikova SB, Wang Y, Trinh TTH, Solow-Cordero DE, Alexandrova L, Casey KM, Alli E, Aggarwal A, Quill T, Koegel A, Feldman BJ, Ford JM, Hayden-Gephart M. Repurposing mebendazole against triple-negative breast cancer leptomeningeal disease. Research square 2024. PMID: 38405839


  4. Babel NK, Feldman BJ. Glucocorticoid Signaling and the Impact of High-Fat Diet on Adipogenesis in Vivo. Steroids 2023. PMID: 37944652


  5. Li L, Gunewardena AM, Nyima T, Feldman BJ. Quantification of cell energetics in human subcutaneous adipose progenitor cells after target gene knockdown. STAR protocols 2023. PMID: 37742183


  6. Chen M, Kim S, Li L, Chattopadhyay S, Rando TA, Feldman BJ. Identification of an adipose tissue-resident pro-preadipocyte population. Cell reports 2023. PMID: 37119138


  7. Cheung SY, Sayeed M, Nakuluri K, Li L, Feldman BJ. MYH9 facilitates autoregulation of adipose tissue depot development. JCI insight 2021. PMID: 33986190


  8. Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Blecha JE, VanBrocklin HF, Seo Y, Sayeed M, Feldman BJ, Aggarwal R, Behr SC, Shao H, Wilson DM, Villanueva-Meyer JE, Gestwicki JE, Evans MJ. A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography. ACS chemical biology 2020. PMID: 32255605


  9. Carter KL, Treurnicht A, Davis KL, Kumar RB, Feldman BJ. A novel platform for isotype-specific testing of autoantibodies. PloS one 2019. PMID: 30730939


  10. Jung Y, Feldman BJ. A context-specific circadian clock in adipocyte precursor cells modulates adipogenesis. Adipocyte 2018. PMID: 30153756


  11. Aggarwal A, Costa MJ, Rivero-Gutiérrez B, Ji L, Morgan SL, Feldman BJ. The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15. Cell reports 2017. PMID: 29186676


  12. Du H, Shih CH, Wosczyna MN, Mueller AA, Cho J, Aggarwal A, Rando TA, Feldman BJ. Macrophage-released ADAMTS1 promotes muscle stem cell activation. Nature communications 2017. PMID: 28939843


  13. Wong JC, Feldman BJ. Adamts1 responds to systemic cues and gates adipogenesis. Adipocyte 2017. PMID: 28700319


  14. Aggarwal A, Feldman D, Feldman BJ. Identification of tumor-autonomous and indirect effects of vitamin D action that inhibit breast cancer growth and tumor progression. The Journal of steroid biochemistry and molecular biology 2017. PMID: 28710021


  15. Chen PI, Cao A, Miyagawa K, Tojais NF, Hennigs JK, Li CG, Sweeney NM, Inglis AS, Wang L, Li D, Ye M, Feldman BJ, Rabinovitch M. Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension. JCI insight 2017. PMID: 28138562


  16. Wong JC, Krueger KC, Costa MJ, Aggarwal A, Du H, McLaughlin TL, Feldman BJ. A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo. Science signaling 2016. PMID: 27811141


  17. Williams JD, Aggarwal A, Swami S, Krishnan AV, Ji L, Albertelli MA, Feldman BJ. Tumor Autonomous Effects of Vitamin D Deficiency Promote Breast Cancer Metastasis. Endocrinology 2016. PMID: 26934299


  18. Swami S, Krishnan AV, Williams J, Aggarwal A, Albertelli MA, Horst RL, Feldman BJ, Feldman D. Vitamin D mitigates the adverse effects of obesity on breast cancer in mice. Endocrine-related cancer 2016. PMID: 26817629


  19. Ji L, Gupta M, Feldman BJ. Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3. Endocrinology 2015. PMID: 26488808


  20. Banerjee RR, Marina N, Katznelson L, Feldman BJ. Mifepristone Treatment of Cushing's Syndrome in a Pediatric Patient. Pediatrics 2015. PMID: 26459648


  21. Jeong Y, Swami S, Krishnan AV, Williams JD, Martin S, Horst RL, Albertelli MA, Feldman BJ, Feldman D, Diehn M. Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D. Molecular cancer therapeutics 2015. PMID: 25934710


  22. Diebold I, Hennigs JK, Miyagawa K, Li CG, Nickel NP, Kaschwich M, Cao A, Wang L, Reddy S, Chen PI, Nakahira K, Alcazar MA, Hopper RK, Ji L, Feldman BJ, Rabinovitch M. BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension. Cell metabolism 2015. PMID: 25863249


  23. Ota A, Kovary KM, Wu OH, Ahrends R, Shen WJ, Costa MJ, Feldman BJ, Kraemer FB, Teruel MN. Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice. Journal of lipid research 2015. PMID: 25840986


  24. Chao CS, McKnight KD, Cox KL, Chang AL, Kim SK, Feldman BJ. Novel GATA6 mutations in patients with pancreatic agenesis and congenital heart malformations. PloS one 2015. PMID: 25706805


  25. Kumar RB, Gupta M, Feldman BJ. The development of next-generation screening and diagnostic platforms will change diabetes care. Expert review of molecular diagnostics 2015. PMID: 25583407


  26. Krueger KC, Costa MJ, Du H, Feldman BJ. Characterization of Cre recombinase activity for in vivo targeting of adipocyte precursor cells. Stem cell reports 2014. PMID: 25458893


  27. Zhang B, Kumar RB, Dai H, Feldman BJ. A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes. Nature medicine 2014. PMID: 25038825


  28. Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nature reviews. Cancer 2014. PMID: 24705652


  29. Krueger KC, Feldman BJ. Adipose circadian clocks: coordination of metabolic rhythms by clock genes, steroid hormones, and PPARs. Hormone molecular biology and clinical investigation 2013. PMID: 25436716


  30. Malloy PJ, Feldman BJ. Cell-autonomous regulation of brown fat identity gene UCP1 by unliganded vitamin D receptor. Molecular endocrinology (Baltimore, Md.) 2013. PMID: 23906633


  31. Armstrong SP, Seeber RM, Ayoub MA, Feldman BJ, Pfleger KD. Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V). PloS one 2013. PMID: 23762448


  32. Kocan M, Dalrymple MB, Seeber RM, Feldman BJ, Pfleger KD. Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and ß-Arrestins. Frontiers in endocrinology 2011. PMID: 22654789


  33. Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, Ptacek LJ, Yamamoto KR, Feldman BJ. Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate. The Journal of biological chemistry 2011. PMID: 21228270


  34. So AY, Bernal TU, Pillsbury ML, Yamamoto KR, Feldman BJ. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proceedings of the National Academy of Sciences of the United States of America 2009. PMID: 19805059


  35. Feldman BJ. Glucocorticoids influence on mesenchymal stem cells and implications for metabolic disease. Pediatric research 2009. PMID: 19262295


  36. Kocan M, See HB, Sampaio NG, Eidne KA, Feldman BJ, Pfleger KD. Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis. Molecular endocrinology (Baltimore, Md.) 2009. PMID: 19179480


  37. So AY, Cooper SB, Feldman BJ, Manuchehri M, Yamamoto KR. Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 18408151


  38. Feldman BJ. Is your metabolism determined by (cell) fate? Pediatric research 2007. PMID: 17426662


  39. Bremer AA, Feldman BJ, Iezza G, Clark OH, Rosenthal SM. Report of a hürthle cell neoplasm in a peripubertal girl. Thyroid : official journal of the American Thyroid Association 2007. PMID: 17316121


  40. Fortescue EB, Shin AY, Greenes DS, Mannix RC, Agarwal S, Feldman BJ, Shah MI, Rifai N, Landzberg MJ, Newburger JW, Almond CS. Cardiac troponin increases among runners in the Boston Marathon. Annals of emergency medicine 2006. PMID: 17145114


  41. Rosenthal SM, Feldman BJ, Vargas GA, Gitelman SE. Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction. Pediatric endocrinology reviews : PER 2006. PMID: 17261972


  42. Feldman BJ, Streeper RS, Farese RV, Yamamoto KR. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proceedings of the National Academy of Sciences of the United States of America 2006. PMID: 17030820


  43. Gitelman SE, Feldman BJ, Rosenthal SM. Nephrogenic syndrome of inappropriate antidiuresis: a novel disorder in water balance in pediatric patients. The American journal of medicine 2006. PMID: 16843086


  44. Huang EA, Feldman BJ, Schwartz ID, Geller DH, Rosenthal SM, Gitelman SE. Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children. The Journal of pediatrics 2006. PMID: 16423613


  45. Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL, Gitelman SE. Nephrogenic syndrome of inappropriate antidiuresis. The New England journal of medicine 2005. PMID: 15872203


  46. Feldman BJ, Rosenthal D. Carbohydrate-deficient glycoprotein syndrome-associated pericardial effusion treated with corticosteroids and salicylic acid. Pediatric cardiology 2002. PMID: 12170369


  47. Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nature reviews. Cancer 2001. PMID: 11900250


  48. Feldman BJ, Hampton T, Cleary ML. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. Blood 2000. PMID: 10961893


  49. Feldman BJ, Reid TR, Cleary ML. Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice. Oncogene 1997. PMID: 9401000


  50. LeBrun DP, Matthews BP, Feldman BJ, Cleary ML. The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains. Oncogene 1997. PMID: 9366523


  51. Fox ME, Feldman BJ, Chu G. A novel role for DNA photolyase: binding to DNA damaged by drugs is associated with enhanced cytotoxicity in Saccharomyces cerevisiae. Molecular and cellular biology 1994. PMID: 7969145


  52. Goldman R, Raz A. Concanavalin A and the in vitro induction in macrophages of vacuolation and lysosomal enzyme synthesis. Experimental cell research 1975. PMID: 172360


  53. Robertson WG, Peacock M, Marshall RW, Speed R, Nordin BE. Seasonal variations in the composition of urine in relation to calcium stone-formation. Clinical science and molecular medicine 1975. PMID: 1172


  54. Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. 1975. PMID: 10