Deepak Srivastava, MD

Our laboratory focuses on understanding the causes of heart disease and on using knowledge of cardiac developmental pathways to devise novel therapeutic approaches for human cardiac disorders. Specifically, we study the molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. We focus on transcriptional and post-transcriptional steps, including those involving microRNAs. We have leveraged this knowledge to reprogram fibroblasts directly into cardiomyocyte-like cells for regenerative purposes. We also seek to identify the causes of human cardiovascular disease by applying modern genetic technologies for the study of complex traits such as congenital heart disease. By using a spectrum of approaches including mouse and human genetics, molecular and developmental biology, and biochemistry we hope to develop a broad understanding of the biology underlying cardiogenesis and cardiovascular disorders.
Education
Residency, - School of Medicine, University of California, San Francisco

  1. Arun Padmanabhan, T. Yvanka de Soysa, Angelo Pelonero, Valerie Sapp, Parisha P. Shah, Qiaohong Wang, Li Li, Clara Youngna Lee, Nandhini Sadagopan, Tomohiro Nishino, Lin Ye, Rachel Yang, Ashley Karnay, Andrey Poleshko, Nikhita Bolar, Ricardo Linares-Saldana, Sanjeev S. Ranade, Michael Alexanian, Sarah U. Morton, Mohit Jain, Saptarsi M. Haldar, Deepak Srivastava, Rajan Jain. A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation. Nature Cardiovascular Research 2024. PMID:


  2. Zholudeva LV, Fortino T, Agrawal A, Vila OF, Williams M, McDevitt T, Lane MA, Srivastava D. Human spinal interneurons repair the injured spinal cord through synaptic integration. bioRxiv : the preprint server for biology 2024. PMID: 38260390


  3. Tomohiro Nishino, Sanjeev S. Ranade, Angelo Pelonero, Benjamin J. van Soldt, Lin Ye, Michael Alexanian, Frances Koback, Yu Huang, Langley Grace Wallace, Nandhini Sadagopan, Adrienne Lam, Lyandysha V. Zholudeva, Feiya Li, Arun Padmanabhan, Reuben Thomas, Joke G. van Bemmel, Casey A. Gifford, Mauro W. Costa, Deepak Srivastava. Single-cell multimodal analyses reveal epigenomic and transcriptomic basis for birth defects in maternal diabetes. Nature Cardiovascular Research 2023. PMID:


  4. Maven BEJ, Gifford CA, Weilert M, Gonzalez-Teran B, Hüttenhain R, Pelonero A, Ivey KN, Samse-Knapp K, Kwong W, Gordon D, McGregor M, Nishino T, Okorie E, Rossman S, Costa MW, Krogan NJ, Zeitlinger J, Srivastava D. The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5. Stem cell reports 2023. PMID: 37863045


  5. Zhou H, Yang J, Srinath C, Zeng A, Wu I, Leon EC, Qureshi TN, Reid CA, Nettesheim ER, Xu E, Duclos Z, Mohamed TMA, Farshidfar F, Fejes A, Liu J, Jones S, Feathers C, Chung TW, Jing F, Prince WS, Lin J, Yu P, Srivastava D, Hoey T, Ivey KN, Lombardi LM. Improved Cardiac Function in Postischemic Rats Using an Optimized Cardiac Reprogramming Cocktail Delivered in a Single Novel Adeno-Associated Virus. Circulation 2023. PMID: 37602409


  6. Young Jang M, Patel PN, Pereira AC, Willcox JAL, Haghighi A, Tai AC, Ito K, Morton SU, Gorham JM, McKean DM, DePalma SR, Bernstein D, Brueckner M, Chung WK, Giardini A, Goldmuntz E, Kaltman JR, Kim R, Newburger JW, Shen Y, Srivastava D, Tristani-Firouzi M, Gelb BD, Porter GA, Seidman CE, Seidman JG. Contribution of Previously Unrecognized RNA Splice-Altering Variants to Congenital Heart Disease. Circulation. Genomic and precision medicine 2023. PMID: 37165897


  7. Krup AL, Winchester SAB, Ranade SS, Agrawal A, Devine WP, Sinha T, Choudhary K, Dominguez MH, Thomas R, Black BL, Srivastava D, Bruneau BG. A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors. Development (Cambridge, England) 2023. PMID: 36994838


  8. Yu M, Aguirre M, Jia M, Gjoni K, Cordova-Palomera A, Munger C, Amgalan D, Rosa Ma X, Pereira A, Tcheandjieu C, Seidman C, Seidman J, Tristani-Firouzi M, Chung W, Goldmuntz E, Srivastava D, Loos RJF, Chami N, Cordell H, Dre?en M, Mueller-Myhsok B, Lahm H, Krane M, Pollard KS, Engreitz JM, Gagliano Taliun SA, Gelb BD, Priest JR. Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes. Circulation. Genomic and precision medicine 2023. PMID: 37026454


  9. Bock-Marquette I, Maar K, Maar S, Lippai B, Faskerti G, Gallyas F, Olson EN, Srivastava D. Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies. International immunopharmacology 2023. PMID: 36709593


  10. Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Lee CY, Sadagopan N, Huang Y, Pelonero A, Auclair K, Zhu A, Gonzalez Teran B, Flanigan W, Kim CK, Lumbao-Conradson K, Costa M, Jain R, Charo I, Haldar SM, Pollard KS, Vagnozzi RJ, McKinsey TA, Przytycki PF, Srivastava D. Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis. bioRxiv : the preprint server for biology 2023. PMID: 36711864


  11. Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS. Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor. Science translational medicine 2022. PMID: 36103516


  12. Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van Bemmel JG, Hüttenhain R, Vedantham V, Conklin BR, Black BL, Bruneau BG, Steinmetz L, Krogan NJ, Pollard KS, Srivastava D. Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors. Circulation 2022. PMID: 35938400


  13. Srivastava D. Cellular cross-talk in heart repair. Science (New York, N.Y.) 2022. PMID: 35709257


  14. Little M, Morrison SJ, Rossant J, Srivastava D, Daley GQ. Anniversary reflections: ISSCR presidents on 20 years of progress. 2022. PMID: 35659873


  15. Willcox JAL, Geiger JT, Morton SU, McKean D, Quiat D, Gorham JM, Tai AC, DePalma S, Bernstein D, Brueckner M, Chung WK, Giardini A, Goldmuntz E, Kaltman JR, Kim R, Newburger JW, Shen Y, Srivastava D, Tristani-Firouzi M, Gelb B, Porter GA, Seidman JG, Seidman CE. Neither cardiac mitochondrial DNA variation nor copy number contribute to congenital heart disease risk. 2022. PMID: 35397206


  16. Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, McGregor M, Gifford CA, Seidman JG, Seidman CE, Gelb BD, Colombo G, Conklin BR, Black BL, Bruneau BG, Krogan NJ, Pollard KS, Srivastava D. Transcription factor protein interactomes reveal genetic determinants in heart disease. 2022. PMID: 35182466


  17. Abouleisa RRE, Salama ABM, Ou Q, Tang XL, Solanki M, Guo Y, Nong Y, McNally L, Lorkiewicz PK, Kassem KM, Ahern BM, Choudhary K, Thomas R, Huang Y, Juhardeen HR, Siddique A, Ifthikar Z, Hammad SK, El-Baz AS, Ivey KN, Conklin DJ, Satin J, Hill BG, Srivastava D, Bolli R, Mohamed TMA. Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure. 2022. PMID: 35061545


  18. Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R. Publisher Correction: BRD4 orchestrates genome folding to promote neural crest differentiation. 2021. PMID: 34725478


  19. Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R. BRD4 orchestrates genome folding to promote neural crest differentiation. 2021. PMID: 34611363


  20. Srivastava D. Modeling Human Cardiac Chambers with Organoids. The New England journal of medicine 2021. PMID: 34437788


  21. He BJ, Merriman AF, Cakulev I, Stambler BS, Srivastava D, Scheinman MM. Ebstein's Anomaly: Review of Arrhythmia Types and Morphogenesis of the Anomaly. JACC. Clinical electrophysiology 2021. PMID: 34454887


  22. Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, Andreoletti G, Jain R, McKinsey TA, Rosenfeld MG, Gifford CA, Pollard KS, Haldar SM, Srivastava D. A transcriptional switch governs fibroblast activation in heart disease. Nature 2021. PMID: 34163071


  23. Morton SU, Shimamura A, Newburger PE, Opotowsky AR, Quiat D, Pereira AC, Jin SC, Gurvitz M, Brueckner M, Chung WK, Shen Y, Bernstein D, Gelb BD, Giardini A, Goldmuntz E, Kim RW, Lifton RP, Porter GA, Srivastava D, Tristani-Firouzi M, Newburger JW, Seidman JG, Seidman CE. Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease. 2021. PMID: 33084842


  24. Srivastava D, McDevitt TC. Mouse gastruloids take heart. Nature reviews. Cardiology 2021. PMID: 33414560


  25. Mummery C, Little M, Lin H, Clark A, Zaret K, ISSCR Board 2020–2021 , Srivastava D, Fuchs E, Watt F, Temple S. Mentorship in Science: Response to AlShebli et al., Nature Communications 2020. Stem cell reports 2021. PMID: 33440177


  26. Theodoris CV, Zhou P, Liu L, Zhang Y, Nishino T, Huang Y, Kostina A, Ranade SS, Gifford CA, Uspenskiy V, Malashicheva A, Ding S, Srivastava D. Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease. Science (New York, N.Y.) 2020. PMID: 33303684


  27. Padmanabhan A, Alexanian M, Linares-Saldana R, González-Terán B, Andreoletti G, Huang Y, Connolly AJ, Kim W, Hsu A, Duan Q, Winchester SAB, Felix F, Perez-Bermejo JA, Wang Q, Li L, Shah PP, Haldar SM, Jain R, Srivastava D. BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes. Circulation 2020. PMID: 33094644


  28. Sharma A, Wasson LK, Willcox JA, Morton SU, Gorham JM, DeLaughter DM, Neyazi M, Schmid M, Agarwal R, Jang MY, Toepfer CN, Ward T, Kim Y, Pereira AC, DePalma SR, Tai A, Kim S, Conner D, Bernstein D, Gelb BD, Chung WK, Goldmuntz E, Porter G, Tristani-Firouzi M, Srivastava D, Seidman JG, Seidman CE, Pediatric Cardiac Genomics Consortium. GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm. eLife 2020. PMID: 33054971


  29. Boskovski MT, Homsy J, Nathan M, Sleeper LA, Morton S, Manheimer KB, Tai A, Gorham J, Lewis M, Swartz M, Alfieris GM, Bacha EA, Karimi M, Meyer D, Nguyen K, Bernstein D, Romano-Adesman A, Porter GA, Goldmuntz E, Chung WK, Srivastava D, Kaltman JR, Tristani-Firouzi M, Lifton R, Roberts AE, Gaynor JW, Gelb BD, Kim R, Seidman JG, Brueckner M, Mayer JE, Newburger JW, Seidman CE. De Novo Damaging Variants, Clinical Phenotypes, and Post-Operative Outcomes in Congenital Heart Disease. Circulation. Genomic and precision medicine 2020. PMID: 32812804


  30. Richter F, Morton SU, Kim SW, Kitaygorodsky A, Wasson LK, Chen KM, Zhou J, Qi H, Patel N, DePalma SR, Parfenov M, Homsy J, Gorham JM, Manheimer KB, Velinder M, Farrell A, Marth G, Schadt EE, Kaltman JR, Newburger JW, Giardini A, Goldmuntz E, Brueckner M, Kim R, Porter GA, Bernstein D, Chung WK, Srivastava D, Tristani-Firouzi M, Troyanskaya OG, Dickel DE, Shen Y, Seidman JG, Seidman CE, Gelb BD. Genomic analyses implicate noncoding de novo variants in congenital heart disease. Nature genetics 2020. PMID: 32601476


  31. Srivastava D. Creating Opportunities to Advance Stem Cell Science: 2019-2020 Year in Review. Stem cell reports 2020. PMID: 32521249


  32. Hsieh A, Morton SU, Willcox JAL, Gorham JM, Tai AC, Qi H, DePalma S, McKean D, Griffin E, Manheimer KB, Bernstein D, Kim RW, Newburger JW, Porter GA, Srivastava D, Tristani-Firouzi M, Brueckner M, Lifton RP, Goldmuntz E, Gelb BD, Chung WK, Seidman CE, Seidman JG, Shen Y. EM-mosaic detects mosaic point mutations that contribute to congenital heart disease. Genome medicine 2020. PMID: 32349777


  33. Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MPY, Haldar SM, Lin CY, McKinsey TA. Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation. Circulation research 2019. PMID: 31409188


  34. de Soysa TY, Ranade SS, Okawa S, Ravichandran S, Huang Y, Salunga HT, Schricker A, Del Sol A, Gifford CA, Srivastava D. Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects. Nature 2019. PMID: 31341279


  35. Stone NR, Gifford CA, Thomas R, Pratt KJB, Samse-Knapp K, Mohamed TMA, Radzinsky EM, Schricker A, Ye L, Yu P, van Bemmel JG, Ivey KN, Pollard KS, Srivastava D. Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming. Cell stem cell 2019. PMID: 31271750


  36. Gifford CA, Ranade SS, Samarakoon R, Salunga HT, de Soysa TY, Huang Y, Zhou P, Elfenbein A, Wyman SK, Bui YK, Cordes Metzler KR, Ursell P, Ivey KN, Srivastava D. Oligogenic inheritance of a human heart disease involving a genetic modifier. Science (New York, N.Y.) 2019. PMID: 31147515


  37. Samal E, Evangelista M, Galang G, Srivastava D, Zhao Y, Vedantham V. Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System. Frontiers in physiology 2019. PMID: 30936836


  38. Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell 2018. PMID: 30053424


  39. Manheimer KB, Patel N, Richter F, Gorham J, Tai AC, Homsy J, Boskovski MT, Parfenov M, Goldmuntz E, Chung WK, Brueckner M, Tristani-Firouzi M, Srivastava D, Seidman JG, Seidman CE, Gelb BD, Sharp AJ. Robust identification of deletions in exome and genome sequence data based on clustering of Mendelian errors. Human mutation 2018. PMID: 29527824


  40. Mohamed TMA, Ang YS, Radzinsky E, Zhou P, Huang Y, Elfenbein A, Foley A, Magnitsky S, Srivastava D. Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration. Cell 2018. PMID: 29502971


  41. Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, Mital S, Russell MW, Gaynor JW, Deanfield J, Giardini A, Porter GA, Srivastava D, Lo CW, Shen Y, Watkins WS, Yandell M, Yost HJ, Tristani-Firouzi M, Newburger JW, Roberts AE, Kim R, Zhao H, Kaltman JR, Goldmuntz E, Chung WK, Seidman JG, Gelb BD, Seidman CE, Lifton RP, Brueckner M. Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands. Nature genetics 2017. PMID: 28991257


  42. Judge LM, Perez-Bermejo JA, Truong A, Ribeiro AJ, Yoo JC, Jensen CL, Mandegar MA, Huebsch N, Kaake RM, So PL, Srivastava D, Pruitt BL, Krogan NJ, Conklin BR. A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress. JCI insight 2017. PMID: 28724793


  43. Duan Q, McMahon S, Anand P, Shah H, Thomas S, Salunga HT, Huang Y, Zhang R, Sahadevan A, Lemieux ME, Brown JD, Srivastava D, Bradner JE, McKinsey TA, Haldar SM. BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure. Science translational medicine 2017. PMID: 28515341


  44. Ribeiro AJS, Schwab O, Mandegar MA, Ang YS, Conklin BR, Srivastava D, Pruitt BL. Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes. Circulation research 2017. PMID: 28400398


  45. Theodoris CV, Mourkioti F, Huang Y, Ranade SS, Liu L, Blau HM, Srivastava D. Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency. The Journal of clinical investigation 2017. PMID: 28346225


  46. Jun-yi Zhu, Amy Heidersbach, Irfan S. Kathiriya, Bayardo I. Garay, Kathryn N. Ivey, Deepak Srivastava, Zhe Han, Isabelle N. King. The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1. Journal of cell science 2017. PMID:


  47. Zhu JY, Heidersbach A, Kathiriya IS, Garay BI, Ivey KN, Srivastava D, Han Z, King IN. The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1. Development (Cambridge, England) 2017. PMID: 28246214


  48. Ang YS, Rivas RN, Ribeiro AJS, Srivas R, Rivera J, Stone NR, Pratt K, Mohamed TMA, Fu JD, Spencer CI, Tippens ND, Li M, Narasimha A, Radzinsky E, Moon-Grady AJ, Yu H, Pruitt BL, Snyder MP, Srivastava D. Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis. Cell 2016. PMID: 27984724


  49. Mohamed TM, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang YS, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D. Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming. Circulation 2016. PMID: 27834668


  50. Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nature medicine 2016. PMID: 27618650


  51. Srivastava D, DeWitt N. In Vivo Cellular Reprogramming: The Next Generation. Cell 2016. PMID: 27610565


  52. Barruet E, Morales BM, Lwin W, White MP, Theodoris CV, Kim H, Urrutia A, Wong SA, Srivastava D, Hsiao EC. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling. Stem cell research & therapy 2016. PMID: 27530160


  53. Sia J, Yu P, Srivastava D, Li S. Effect of biophysical cues on reprogramming to cardiomyocytes. Biomaterials 2016. PMID: 27376554


  54. Deepak Srivastava, Joseph T. C. Shieh. Molecular Regulation of Cardiogenesis. Epstein\u0027s Inborn Errors of Development 2016. PMID:


  55. Haldar SM, Srivastava D. Sarcomeres and Cardiac Growth: Tension in the Relationship. Trends in molecular medicine 2016. PMID: 27237981


  56. Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H, Ma T, Xu T, Shi G, Srivastava D, Ding S. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science (New York, N.Y.) 2016. PMID: 27127239


  57. Huebsch N, Loskill P, Deveshwar N, Spencer CI, Judge LM, Mandegar MA, Fox CB, Mohamed TM, Ma Z, Mathur A, Sheehan AM, Truong A, Saxton M, Yoo J, Srivastava D, Desai TA, So PL, Healy KE, Conklin BR. Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses. Scientific Reports 2016. PMID: 27095412


  58. Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S. Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts. Cell stem cell 2016. PMID: 26942852


  59. Alexandre J. Ribeiro, Yen-Sin Ang, Robin E. Wilson, Renee N. Rivas, Deepak Srivastava, Beth L. Pruitt. A Tuned Tension Regulates the Contractility of Cardiomyocytes Differentiated from Induced Pluripotent Stem Cells. Biophysical journal 2016. PMID:


  60. Kime C, Mandegar MA, Srivastava D, Yamanaka S, Conklin BR, Rand TA. Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells. Current protocols in human genetics 2016. PMID: 26724721


  61. Gifford CA, Srivastava D. Heart disease modelling adds a Notch to its belt. Nature cell biology 2016. PMID: 26693916


  62. Deepak Srivastava. Reprogramming Approaches to Cardiovascular Disease: From Developmental Biology to Regenerative Medicine. Etiology and Morphogenesis of Congenital Heart Disease 2016. PMID:


  63. Srivastava D, Yu P. Recent advances in direct cardiac reprogramming. Current opinion in genetics & development 2015. PMID: 26454285


  64. Kime C, Rand TA, Ivey KN, Srivastava D, Yamanaka S, Tomoda K. Practical Integration-Free Episomal Methods for Generating Human Induced Pluripotent Stem Cells. Current protocols in human genetics 2015. PMID: 26439714


  65. Ribeiro AJ, Ang YS, Fu JD, Rivas RN, Mohamed TM, Higgs GC, Srivastava D, Pruitt BL. Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness. Proceedings of the National Academy of Sciences of the United States of America 2015. PMID: 26417073


  66. Ivey KN, Srivastava D. microRNAs as Developmental Regulators. Cold Spring Harbor perspectives in biology 2015. PMID: 26134312


  67. White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, Meng X, Robbins RC, Ivey KN, Srivastava D. NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium. Journal of molecular and cellular cardiology 2015. PMID: 25871831


  68. Rasmussen TL, Ma Y, Park CY, Harriss J, Pierce SA, Dekker JD, Valenzuela N, Srivastava D, Schwartz RJ, Stewart MD, Tucker HO. Smyd1 facilitates heart development by antagonizing oxidative and ER stress responses. PloS one 2015. PMID: 25803368


  69. Theodoris CV, Li M, White MP, Liu L, He D, Pollard KS, Bruneau BG, Srivastava D. Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency. Cell 2015. PMID: 25768904


  70. Yadav AK, Sharma R, Kandasamy D, Bhalla AS, Gamanagatti S, Srivastava DN, Upadhyay AD, Garg PK. Perfusion CT: can it predict the development of pancreatic necrosis in early stage of severe acute pancreatitis? Abdominal imaging 2015. PMID: 25173791


  71. Vedantham V, Galang G, Evangelista M, Deo RC, Srivastava D. RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells. Circulation research 2015. PMID: 25623957


  72. Fu JD, Srivastava D. Direct reprogramming of fibroblasts into cardiomyocytes for cardiac regenerative medicine. Circulation journal : official journal of the Japanese Circulation Society 2015. PMID: 25744738


  73. Ang YS, Srivastava D. Oxygen: double-edged sword in cardiac function and repair. Circulation research 2014. PMID: 25342770


  74. Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H. Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia. Human molecular genetics 2014. PMID: 25209980


  75. Hua LL, Vedantham V, Barnes RM, Hu J, Robinson AS, Bressan M, Srivastava D, Black BL. Specification of the mouse cardiac conduction system in the absence of Endothelin signaling. Developmental biology 2014. PMID: 25050930


  76. Hu H, Roach JC, Coon H, Guthery SL, Voelkerding KV, Margraf RL, Durtschi JD, Tavtigian SV, Shankaracharya , Wu W, Scheet P, Wang S, Xing J, Glusman G, Hubley R, Li H, Garg V, Moore B, Hood L, Galas DJ, Srivastava D, Reese MG, Jorde LB, Yandell M, Huff CD. A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data. Nature biotechnology 2014. PMID: 24837662


  77. King IN, Yartseva V, Salas D, Kumar A, Heidersbach A, Ando DM, Stallings NR, Elliott JL, Srivastava D, Ivey KN. The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex. The Journal of biological chemistry 2014. PMID: 24719334


  78. Wang H, Cao N, Spencer CI, Nie B, Ma T, Xu T, Zhang Y, Wang X, Srivastava D, Ding S. Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4. Cell reports 2014. PMID: 24561253


  79. Bruneau BG, Srivastava D. Congenital heart disease: entering a new era of human genetics. Circulation research 2014. PMID: 24526674


  80. Heidersbach A, Saxby C, Carver-Moore K, Huang Y, Ang YS, de Jong PJ, Ivey KN, Srivastava D. microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart. eLife 2013. PMID: 24252873


  81. Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, Narita M, Srivastava D, Yamanaka S. The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes. Cell stem cell 2013. PMID: 24239284


  82. Qian L, Srivastava D. Direct cardiac reprogramming: from developmental biology to cardiac regeneration. Circulation research 2013. PMID: 24030021


  83. Srivastava D, Berry EC. Cardiac reprogramming: from mouse toward man. Current opinion in genetics & development 2013. PMID: 23993230


  84. Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D. Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem cell reports 2013. PMID: 24319660


  85. Cheng P, Andersen P, Hassel D, Kaynak BL, Limphong P, Juergensen L, Kwon C, Srivastava D. Fibronectin mediates mesendodermal cell fate decisions. Development (Cambridge, England) 2013. PMID: 23715551


  86. Qian L, Berry EC, Fu JD, Ieda M, Srivastava D. Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro. Nature protocols 2013. PMID: 23722259


  87. Srivastava D, Heidersbach AJ. Small solutions to big problems: microRNAs for cardiac regeneration. Circulation research 2013. PMID: 23704215


  88. Spindler MJ, Burmeister BT, Huang Y, Hsiao EC, Salomonis N, Scott MJ, Srivastava D, Carnegie GK, Conklin BR. AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to ß-adrenergic-induced cardiac hypertrophy. PloS one 2013. PMID: 23658642


  89. Srivastava D, Cordes Metzler KR. Fending for a Braveheart. The EMBO journal 2013. PMID: 23524853


  90. Limphong P, Zhang H, Christians E, Liu Q, Riedel M, Ivey K, Cheng P, Mitzelfelt K, Taylor G, Winge D, Srivastava D, Benjamin I. Modeling human protein aggregation cardiomyopathy using murine induced pluripotent stem cells. Stem cells translational medicine 2013. PMID: 23430692


  91. White MP, Rufaihah AJ, Liu L, Ghebremariam YT, Ivey KN, Cooke JP, Srivastava D. Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells. Stem cells (Dayton, Ohio) 2013. PMID: 23079999


  92. Ivey KN
    Srivastava D. Tam PPL, Nelson WJ, Rossant J, Eds. Mammalian Development: Networks, Switches, and Morphogenetic Processes MicroRNAs as developmental regulators 2013. PMID:


  93. Plath K, Srivastava D, Alvarez-Buylla A, Tanaka EM, Kriegstein AR. Stem cells in the land of the rising sun: ISSCR 2012. Cell stem cell 2012. PMID: 23122288


  94. Vedantham V, Evangelista M, Huang Y, Srivastava D. Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning. Developmental biology 2012. PMID: 23085412


  95. Farina NH, Hausburg M, Betta ND, Pulliam C, Srivastava D, Cornelison D, Olwin BB. A role for RNA post-transcriptional regulation in satellite cell activation. Skeletal muscle 2012. PMID: 23046558


  96. Srivastava D, Ieda M, Fu J, Qian L. Cardiac repair with thymosin ß4 and cardiac reprogramming factors. Annals of the New York Academy of Sciences 2012. PMID: 23050819


  97. Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, Ding H, Wylie JN, Pico AR, Capra JA, Erwin G, Kattman SJ, Keller GM, Srivastava D, Levine SS, Pollard KS, Holloway AK, Boyer LA, Bruneau BG. Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell 2012. PMID: 22981692


  98. Hassel D, Cheng P, White MP, Ivey KN, Kroll J, Augustin HG, Katus HA, Stainier DY, Srivastava D. MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling. Circulation research 2012. PMID: 22955733


  99. Srivastava DP, Jones KA, Woolfrey KM, Burgdorf J, Russell TA, Kalmbach A, Lee H, Yang C, Bradberry MM, Wokosin D, Moskal JR, Casanova MF, Waters J, Penzes P. Social, communication, and cortical structural impairments in Epac2-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012. PMID: 22915127


  100. Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S. Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells. Cell stem cell 2012. PMID: 22770243


  101. Srivastava D, Ieda M. Critical factors for cardiac reprogramming. Circulation research 2012. PMID: 22723217


  102. Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature 2012. PMID: 22522929


  103. Misra C, Sachan N, McNally CR, Koenig SN, Nichols HA, Guggilam A, Lucchesi PA, Pu WT, Srivastava D, Garg V. Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS genetics 2012. PMID: 22589735


  104. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. A resource for the conditional ablation of microRNAs in the mouse. Cell reports 2012. PMID: 22570807


  105. Deepak Srivastava. microRNA regulation of cardiac cell fate, morphogenesis and function. The FASEB Journal 2012. PMID:


  106. Kathiresan S, Srivastava D. Genetics of human cardiovascular disease. Cell 2012. PMID: 22424232


  107. Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H. Tbx1 regulates oral epithelial adhesion and palatal development. Human molecular genetics 2012. PMID: 22371266


  108. Bernstein HS, Srivastava D. Stem cell therapy for cardiac disease. Pediatric research 2012. PMID: 22430385


  109. Baldwin HS
    Srivastava D. Allen HD, Driscoll DJ, Shaddy RE, Feltes TF, Eds. Moss and Adams' Heart Disease in Infants, Children and Adolescents Molecular determinants of cardiac development and disease 2012. PMID:


  110. Roach JC, Glusman G, Hubley R, Montsaroff SZ, Holloway AK, Mauldin DE, Srivastava D, Garg V, Pollard KS, Galas DJ, Hood L, Smit AF. Chromosomal haplotypes by genetic phasing of human families. American journal of human genetics 2011. PMID: 21855840


  111. Kwon C, Cheng P, King IN, Andersen P, Shenje L, Nigam V, Srivastava D. Notch post-translationally regulates ß-catenin protein in stem and progenitor cells. Nature cell biology 2011. PMID: 21841793


  112. AlRais F, Feldstein VA, Srivastava D, Gosnell K, Moon-Grady AJ. Monochorionic twins discordant for congenital heart disease: a referral center's experience and possible pathophysiologic mechanisms. Prenatal diagnosis 2011. PMID: 21744365


  113. Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. The Journal of cell biology 2011. PMID: 21690310


  114. Shieh JT, Huang Y, Gilmore J, Srivastava D. Elevated miR-499 levels blunt the cardiac stress response. PloS one 2011. PMID: 21573063


  115. King IN, Qian L, Liang J, Huang Y, Shieh JT, Kwon C, Srivastava D. A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity. Developmental cell 2011. PMID: 21497762


  116. Fish JE, Wythe JD, Xiao T, Bruneau BG, Stainier DY, Srivastava D, Woo S. A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development (Cambridge, England) 2011. PMID: 21385766


  117. Qian L, Van Laake LW, Huang Y, Liu S, Wendland MF, Srivastava D. miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes. The Journal of experimental medicine 2011. PMID: 21383058


  118. Li Q, Kannan A, DeMayo FJ, Lydon JP, Cooke PS, Yamagishi H, Srivastava D, Bagchi MK, Bagchi IC. The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2. Science (New York, N.Y.) 2011. PMID: 21330545


  119. Yu S, Crawford D, Tsuchihashi T, Behrens TW, Srivastava D. The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. Developmental dynamics : an official publication of the American Association of Anatomists 2011. PMID: 21246655


  120. Srivastava D. <i>Rudplph's Pediatrics</i> (Rudolph C, Rudolph A, Lister G, First L, Gershon A, Eds) Control of embryologic cardiac development 2011. PMID:


  121. Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D. Hand2 function in second heart field progenitors is essential for cardiogenesis. Developmental biology 2010. PMID: 21185281


  122. Sheehy NT, Cordes KR, White MP, Ivey KN, Srivastava D. The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch. Development (Cambridge, England) 2010. PMID: 21098571


  123. Park CY, Pierce SA, von Drehle M, Ivey KN, Morgan JA, Blau HM, Srivastava D. skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration. Proceedings of the National Academy of Sciences of the United States of America 2010. PMID: 21071677


  124. Maitra M, Koenig SN, Srivastava D, Garg V. Identification of GATA6 sequence variants in patients with congenital heart defects. Pediatric research 2010. PMID: 20581743


  125. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 2010. PMID: 20691899


  126. Stephanie Woo, Jason E. Fish, Joshua D. Wythe, Benoit B. Bruneau, Didier Y. Stainier, Deepak Srivastava. A novel Slit–Robo–miR-218 signaling axis regulates VEGF-mediated heart tube formation in zebrafish. Developmental biology 2010. PMID:


  127. Ivey KN, Srivastava D. MicroRNAs as regulators of differentiation and cell fate decisions. Cell stem cell 2010. PMID: 20621048


  128. Nigam V, Sievers HH, Jensen BC, Sier HA, Simpson PC, Srivastava D, Mohamed SA. Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves. The Journal of heart valve disease 2010. PMID: 20845893


  129. van Laake LW, Qian L, Cheng P, Huang Y, Hsiao EC, Conklin BR, Srivastava D. Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance. Circulation research 2010. PMID: 20558827


  130. Jason E. Fish, Matthew S. Yan, Charles C. Matouk, Rosanne St. Bernard, J. J. David Ho, Anna Gavryushova, Deepak Srivastava, Philip A. Marsden. Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. Journal of Biological Chemistry 2010. PMID:


  131. Shrivastava S, Srivastava D, Olson EN, DiMaio JM, Bock-Marquette I. Thymosin beta4 and cardiac repair. Annals of the New York Academy of Sciences 2010. PMID: 20536454


  132. Qian L, Srivastava D. Monkeying around with cardiac progenitors: hope for the future. The Journal of clinical investigation 2010. PMID: 20335651


  133. Cordes KR, Srivastava D, Ivey KN. MicroRNAs in cardiac development. Pediatric cardiology 2010. PMID: 20140609


  134. SA Mohamed, V Nigam, B Jensen, H Sier, P Simpson, D Srivastava, HH Sievers. Micrornas in bicuspid aortic valve: a comparison between stenosis and insufficiency aortic valve. The Thoracic and cardiovascular surgeon 2010. PMID:


  135. Cordes KR, Srivastava D. <i>Heart Development and Regeneration</i> (Rosenthal N, Harvey R, Eds) MicroRNA regulation of cardiac development and disease 2010. PMID:


  136. Bruneau BG, Burn J, Srivastava D. <i>Paediatric Cardiology</i> (Anderson RH, Baker EJ, Penny D, Redington AN, Rigby ML, Wernovsky G, Eds) The Aetiology of Congenital Cardiac Disease 2010. PMID:


  137. Benoit G. Bruneau, John Burn, Deepak Srivastava. CHAPTER 9 Aetiology of Congenital Cardiac Disease. Paediatric Cardiology 2010. PMID:


  138. Kimberly R. Cordes, Deepak Srivastava. Chapter 10.3 MicroRNA Regulation of Cardiac Development and Disease. Heart Development and Regeneration 2010. PMID:


  139. Deepak Srivastava, Chulan Kwon. Chapter 309 Signaling Pathways Involved in Cardiogenesis. Handbook of Cell Signaling 2010. PMID:


  140. Fish JE, Yan MS, Matouk CC, St Bernard R, Ho JJ, Ho JJ, Gavryushova A, Srivastava D, Marsden PA. Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. The Journal of biological chemistry 2009. PMID: 19880524


  141. Nigam V, Srivastava D. Notch1 represses osteogenic pathways in aortic valve cells. Journal of molecular and cellular cardiology 2009. PMID: 19695258


  142. Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D. A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nature cell biology 2009. PMID: 19620969


  143. Shieh JT, Srivastava D. Heart malformation: what are the chances it could happen again? Circulation 2009. PMID: 19597046


  144. Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature 2009. PMID: 19578358


  145. Bock-Marquette I, Shrivastava S, Pipes GC, Thatcher JE, Blystone A, Shelton JM, Galindo CL, Melegh B, Srivastava D, Olson EN, DiMaio JM. Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo. Journal of molecular and cellular cardiology 2009. PMID: 19358334


  146. Cordes KR, Srivastava D. MicroRNA regulation of cardiovascular development. Circulation research 2009. PMID: 19325160


  147. Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL. Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell stem cell 2009. PMID: 19265656


  148. Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Developmental cell 2009. PMID: 19217425


  149. Fish JE, Srivastava D. MicroRNAs: opening a new vein in angiogenesis research. Science signaling 2009. PMID: 19126861


  150. Srivastava D, Kwon C. <i>Handbook of Cell Signaling</i> (Bradshaw RA, Dennis EA, Eds) Signaling pathways involved in cardiogenesis 2009. PMID:


  151. Kwon C, Cordes KR, Srivastava D. Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis. Cell cycle (Georgetown, Tex.) 2008. PMID: 19066459


  152. Maitra M, Schluterman MK, Nichols HA, Richardson JA, Lo CW, Srivastava D, Garg V. Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Developmental biology 2008. PMID: 19084512


  153. Niu Z, Iyer D, Conway SJ, Martin JF, Ivey K, Srivastava D, Nordheim A, Schwartz RJ. Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 19004760


  154. Morton SU, Scherz PJ, Cordes KR, Ivey KN, Stainier DY, Srivastava D. microRNA-138 modulates cardiac patterning during embryonic development. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 19004786


  155. Ransom JF, King IN, Garg V, Srivastava D. A rare human sequence variant reveals myocardin autoinhibition. The Journal of biological chemistry 2008. PMID: 18852265


  156. Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D. miR-126 regulates angiogenic signaling and vascular integrity. Developmental cell 2008. PMID: 18694566


  157. Ivey KN, Sutcliffe D, Richardson J, Clyman RI, Garcia JA, Srivastava D. Transcriptional regulation during development of the ductus arteriosus. Circulation research 2008. PMID: 18635823


  158. Saxena A, Fish JE, White MD, Yu S, Smyth JW, Shaw RM, DiMaio JM, Srivastava D. Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation 2008. PMID: 18427137


  159. Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell stem cell 2008. PMID: 18371447


  160. Nigam V, Srivastava D. <i>Inborn Errors of Development</i> (Epstein CJ, Ed) Molecular regulation of cardiogenesis 2008. PMID:


  161. Gong B, Sun J, Vargas G, Chang Q, Xu Y, Srivastava D, Boor PJ. Nonlinear imaging study of extracellular matrix in chemical-induced, developmental dissecting aortic aneurysm: evidence for defective collagen type III. Birth defects research. Part A, Clinical and molecular teratology 2008. PMID: 18044709


  162. Jia H, King IN, Chopra SS, Wan H, Ni TT, Jiang C, Guan X, Wells S, Srivastava D, Zhong TP. Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5. Proceedings of the National Academy of Sciences of the United States of America 2007. PMID: 17715064


  163. Srivastava D, Saxena A, Michael Dimaio J, Bock-Marquette I. Thymosin beta4 is cardioprotective after myocardial infarction. Annals of the New York Academy of Sciences 2007. PMID: 17600280


  164. Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT. Spectrum of heart disease associated with murine and human GATA4 mutation. Journal of molecular and cellular cardiology 2007. PMID: 17643447


  165. Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proceedings of the National Academy of Sciences of the United States of America 2007. PMID: 17576928


  166. Pierpont ME, Basson CT, Benson DW, Gelb BD, Giglia TM, Goldmuntz E, McGee G, Sable CA, Srivastava D, Webb CL, American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease i. Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation 2007. PMID: 17519398


  167. Xin M, Small EM, van Rooij E, Qi X, Richardson JA, Srivastava D, Nakagawa O, Olson EN. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proceedings of the National Academy of Sciences of the United States of America 2007. PMID: 17468400


  168. Schluterman MK, Krysiak AE, Kathiriya IS, Abate N, Chandalia M, Srivastava D, Garg V. Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease. American journal of medical genetics. Part A 2007. PMID: 17352393


  169. Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 2007. PMID: 17397913


  170. Zhao Y, Srivastava D. A developmental view of microRNA function. Trends in biochemical sciences 2007. PMID: 17350266


  171. Samal E, Srivastava D. <i>Advances in Developmental Biology</i> (Bodmer R, Ed) Role of microRNAs in Cardiovascular Biology 2007. PMID:


  172. Eva Samal, Deepak Srivastava. Role of microRNAs in Cardiovascular Biology. Cardiovascular Development 2007. PMID:


  173. Ransom J, Srivastava D. The genetics of cardiac birth defects. Seminars in cell & developmental biology 2006. PMID: 17240175


  174. Deepak Srivastava, Kathryn N. Ivey. Erratum: Potential of stem-cell-based therapies for heart disease. Nature 2006. PMID:


  175. Ivey KN, Srivastava D. The paradoxical patent ductus arteriosus. The Journal of clinical investigation 2006. PMID: 17080192


  176. Ramana KV, Willis MS, White MD, Horton JW, DiMaio JM, Srivastava D, Bhatnagar A, Srivastava SK. Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation 2006. PMID: 17030682


  177. Srivastava D. Making or breaking the heart: from lineage determination to morphogenesis. Cell 2006. PMID: 16990131


  178. Srivastava D, Yu S. Stretching to meet needs: integrin-linked kinase and the cardiac pump. Genes & development 2006. PMID: 16951248


  179. Srivastava D, Ivey KN. Potential of stem-cell-based therapies for heart disease. Nature 2006. PMID: 16810246


  180. Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L. Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development (Cambridge, England) 2006. PMID: 16672333


  181. King IN, Kathiriya IS, Murakami M, Nakagawa M, Gardner KA, Srivastava D, Nakagawa O. Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa. Biochemical and biophysical research communications 2006. PMID: 16682003


  182. Yamagishi C, Yamagishi H, Maeda J, Tsuchihashi T, Ivey K, Hu T, Srivastava D. Sonic hedgehog is essential for first pharyngeal arch development. Pediatric research 2006. PMID: 16492970


  183. Maeda J, Yamagishi H, McAnally J, Yamagishi C, Srivastava D. Tbx1 is regulated by forkhead proteins in the secondary heart field. Developmental dynamics : an official publication of the American Association of Anatomists 2006. PMID: 16444712


  184. Gong B, Trent MB, Srivastava D, Boor PJ. Chemical-induced, nonlethal, developmental model of dissecting aortic aneurysm. Birth defects research. Part A, Clinical and molecular teratology 2006. PMID: 16397885


  185. Srivastava D. Genetic regulation of cardiogenesis and congenital heart disease. Annual review of pathology 2006. PMID: 18039113


  186. Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG. Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nature genetics 2005. PMID: 16380715


  187. Kwon C, Han Z, Olson EN, Srivastava D. MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proceedings of the National Academy of Sciences of the United States of America 2005. PMID: 16357195


  188. Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui CC, Backx PH, Bruneau BG. The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell 2005. PMID: 16239150


  189. Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Grossfeld PD, Srivastava D. Mutations in NOTCH1 cause aortic valve disease. Nature 2005. PMID: 16025100


  190. Zhao Y, Samal E, Srivastava D. Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 2005. PMID: 15951802


  191. Aiyer AR, Honarpour N, Herz J, Srivastava D. Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype. Developmental biology 2005. PMID: 15649468


  192. Garg V, Srivastava D. <i>Principles of Molecular Cardiology</i> (Runge MS, Patterson C, Eds) Genetic underpinnings of cardiogenesis and congenital heart disease 2005. PMID:


  193. Vidu Garg, Deepak Srivastava. Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease. Principles of Molecular Cardiology 2005. PMID:


  194. McFadden DG, Barbosa AC, Richardson JA, Schneider MD, Srivastava D, Olson EN. The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development (Cambridge, England) 2004. PMID: 15576406


  195. Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 2004. PMID: 15565145


  196. Kathiriya IS, King IN, Murakami M, Nakagawa M, Astle JM, Gardner KA, Gerard RD, Olson EN, Srivastava D, Nakagawa O. Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. The Journal of biological chemistry 2004. PMID: 15485867


  197. Hu T, Yamagishi H, Maeda J, McAnally J, Yamagishi C, Srivastava D. Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development (Cambridge, England) 2004. PMID: 15469978


  198. Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M. Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development. Developmental biology 2004. PMID: 15223333


  199. Srivastava D. Heart disease: an ongoing genetic battle? Nature 2004. PMID: 15215849


  200. Srivastava D, Olson EN. <i>Molecular Basis of Cardiovascular Disease: A Companion to Braunwald's Heart Disease</i> (Chien KR, Ed) Cardiac Development and Congenital Heart Disease 2004. PMID:


  201. Yamagishi H, Srivastava D. Unraveling the genetic and developmental mysteries of 22q11 deletion syndrome. Trends in molecular medicine 2003. PMID: 13129704


  202. Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature 2003. PMID: 12845333


  203. Ivey K, Tyson B, Ukidwe P, McFadden DG, Levi G, Olson EN, Srivastava D, Wilkie TM. Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme. Developmental biology 2003. PMID: 12648486


  204. Yamagishi C, Hierck BP, Gittenberger-De Groot AC, Yamagishi H, Srivastava D. Functional attenuation of UFD1l, a 22q11.2 deletion syndrome candidate gene, leads to cardiac outflow septation defects in chicken embryos. Pediatric research 2003. PMID: 12612215


  205. Yamagishi H, Maeda J, Hu T, McAnally J, Conway SJ, Kume T, Meyers EN, Yamagishi C, Srivastava D. Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Genes & development 2003. PMID: 12533514


  206. Srivastava D. <i>Handbook of Cell Signaling</i> (Bradshaw RA, Dennis EA, Eds) Signaling pathways involved in cardiogenesis 2003. PMID:


  207. Srivastava D. Building a heart: implications for congenital heart disease. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2003. PMID: 12569333


  208. Deepak Srivastava. Chapter 335 Signaling Pathways Involved in Cardiogenesis. Handbook of Cell Signaling 2003. PMID:


  209. Villanueva MP, Aiyer AR, Muller S, Pletcher MT, Liu X, Emanuel B, Srivastava D, Reeves RH. Genetic and comparative mapping of genes dysregulated in mouse hearts lacking the Hand2 transcription factor gene. Genomics 2002. PMID: 12504851


  210. Abe M, Tamamura Y, Yamagishi H, Maeda T, Kato J, Tabata MJ, Srivastava D, Wakisaka S, Kurisu K. Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis. Cell and tissue research 2002. PMID: 12397375


  211. Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nature genetics 2002. PMID: 11923873


  212. Srivastava D. <i>Neonatal Cardiology</i> (Artman M, Mahony L, Teitel DF, Eds) Molecular and morphogenetic cardiac embryology: Implications for congenital heart disease 2002. PMID:


  213. Srivastava D, Gottlieb PD, Olson EN. Molecular mechanisms of ventricular hypoplasia. Cold Spring Harbor symposia on quantitative biology 2002. PMID: 12858532


  214. Yamagishi H, Yamagishi C, Nakagawa O, Harvey RP, Olson EN, Srivastava D. The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation. Developmental biology 2001. PMID: 11784028


  215. Kunte A, Ivey K, Yamagishi C, Garg V, Yamagishi H, Srivastava D. A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L. Mechanisms of development 2001. PMID: 11578863


  216. Natarajan A, Yamagishi H, Ahmad F, Li D, Roberts R, Matsuoka R, Hill S, Srivastava D. Human eHAND, but not dHAND, is down-regulated in cardiomyopathies. Journal of molecular and cellular cardiology 2001. PMID: 11549340


  217. Garg V, Yamagishi C, Hu T, Kathiriya IS, Yamagishi H, Srivastava D. Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. Developmental biology 2001. PMID: 11412027


  218. Liu ZP, Nakagawa O, Nakagawa M, Yanagisawa H, Passier R, Richardson JA, Srivastava D, Olson EN. CHAMP, a novel cardiac-specific helicase regulated by MEF2C. Developmental biology 2001. PMID: 11397016


  219. Olson EN, Srivastava D. <i>Encyclopedia of Molecular Medicine</i> (Creighton TE and Kazazian HH, Eds) HAND transcription factors 2001. PMID:


  220. Srivastava D, Baldwin HS. <i>Moss and Adams' Heart Disease in Infants, Children, and Adolescents</i> (Allen HD, Gutsgell HP, Clark EB, Driscoll DJ, Eds) Molecular determinants of cardiac development 2001. PMID:


  221. Srivastava D. Genetic assembly of the heart: implications for congenital heart disease. Annual review of physiology 2001. PMID: 11181963


  222. Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proceedings of the National Academy of Sciences of the United States of America 2000. PMID: 11095750


  223. McFadden DG, Charité J, Richardson JA, Srivastava D, Firulli AB, Olson EN. A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development (Cambridge, England) 2000. PMID: 11076755


  224. Fisher SA, Langille BL, Srivastava D. Apoptosis during cardiovascular development. Circulation research 2000. PMID: 11073880


  225. Srivastava D, Olson EN. A genetic blueprint for cardiac development. Nature 2000. PMID: 11001064


  226. Angelo S, Lohr J, Lee KH, Ticho BS, Breitbart RE, Hill S, Yost HJ, Srivastava D. Conservation of sequence and expression of Xenopus and zebrafish dHAND during cardiac, branchial arch and lateral mesoderm development. Mechanisms of development 2000. PMID: 10906469


  227. Srivastava D. Congenital heart defects: trapping the genetic culprits. Circulation research 2000. PMID: 10807859


  228. Fernandez-Teran M, Piedra ME, Kathiriya IS, Srivastava D, Rodriguez-Rey JC, Ros MA. Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway. Development (Cambridge, England) 2000. PMID: 10769237


  229. Yamagishi H, Olson EN, Srivastava D. The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. The Journal of clinical investigation 2000. PMID: 10675351


  230. Yamagishi H, Srivastava D. <i>Etiology and Morphogenesis of Congenital Heart Disease</i> (Clark EB, Nakazawa M, Takao A, Eds) Role of the bHLH transcription factor, dHAND, in cranial/cardiac neural crest development 2000. PMID:


  231. Srivastava D. <i>Etiology and Morphogenesis of Congenital Heart Disease</i> (Takao A, Nakazawa M, Clark EB, Eds) Understanding CHD through dissection of segmental cardiac molecular pathways 2000. PMID:


  232. Srivastava D. DiGeorge syndrome: an enigma in mice and men. Molecular medicine today 2000. PMID: 10637569


  233. Kathiriya IS, Srivastava D. Left-right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease. American journal of medical genetics 2000. PMID: 11376438


  234. Nakagawa O, Nakagawa M, Richardson JA, Olson EN, Srivastava D. HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. Developmental biology 1999. PMID: 10588864


  235. Srivastava D. Developmental and genetic aspects of congenital heart disease. Current opinion in cardiology 1999. PMID: 10358798


  236. Yamagishi H, Garg V, Matsuoka R, Thomas T, Srivastava D. A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects. Science (New York, N.Y.) 1999. PMID: 10024240


  237. Deepak Srivastava. 9 Segmental Regulation of Cardiac Development by the Basic Helix-Loop-Helix Transcription Factors dHAND and eHAND. Heart Development 1999. PMID:


  238. Srivastava D. <i>Heart Development</i> (Rosenthal N and Harvey R, Eds) Segmental regulation of cardiac development by the basic helix-loop-helix transcription factors dHAND and eHAND 1999. PMID:


  239. Srivastava D. HAND proteins: molecular mediators of cardiac development and congenital heart disease. Trends in cardiovascular medicine 1999. PMID: 10189962


  240. Thomas T, Kurihara H, Yamagishi H, Kurihara Y, Yazaki Y, Olson EN, Srivastava D. A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development (Cambridge, England) 1998. PMID: 9671575


  241. Thomas T, Yamagishi H, Overbeek PA, Olson EN, Srivastava D. The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness. Developmental biology 1998. PMID: 9576835


  242. Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nature genetics 1998. PMID: 9500550


  243. Deepak Srivastava. Role of the Transcription Factors dHAND and eHAND in Cardiac Morphogenesis. Pediatric cardiology 1998. PMID:


  244. Srivastava D, Olson EN. Knowing in your heart what's right. Trends in cell biology 1997. PMID: 17709004


  245. Srivastava D. Left, right ... which way to turn? Nature genetics 1997. PMID: 9354777


  246. Srivastava D, Thomas T, Lin Q, Kirby ML, Brown D, Olson EN. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nature genetics 1997. PMID: 9171826


  247. Srivastava D. <i>Genetic Control of Heart Development</i> (Harvey RP, Olson EN, Schulz RA, Altman JS, Eds) The bHLH proteins, dHAND and eHAND in cardiac development 1997. PMID:


  248. Lin Q, Srivastava D, Olson EN. A transcriptional pathway for cardiac development. Cold Spring Harbor symposia on quantitative biology 1997. PMID: 9598375


  249. Srivastava D, Olson EN. Neurotrophin-3 knocks heart off Trk. Nature medicine 1996. PMID: 8837596


  250. Olson EN, Srivastava D. Molecular pathways controlling heart development. Science (New York, N.Y.) 1996. PMID: 8614825


  251. Srivastava D, Cserjesi P, Olson EN. A subclass of bHLH proteins required for cardiac morphogenesis. Science (New York, N.Y.) 1995. PMID: 8533092


  252. Srivastava D, Preminger T, Lock JE, Mandell V, Keane JF, Mayer JE, Kozakewich H, Spevak PJ. Hepatic venous blood and the development of pulmonary arteriovenous malformations in congenital heart disease. Circulation 1995. PMID: 7648668


  253. Srivastava D, Thompson EB. Two glucocorticoid binding sites on the human glucocorticoid receptor. Endocrinology 1990. PMID: 2205477


  254. Thompson EB, Srivastava D, Johnson BH. Interactions of the phenylpyrazolo steroid cortivazol with glucocorticoid receptors in steroid-sensitive and -resistant human leukemic cells. Cancer research 1989. PMID: 2702665