Jeff Fineman, MD
Education
2021 - Diversity, Equity, Inclusion Champion Training, UCSF
06/1990 - Pediatric Critical Care Fellowship, UCSF
06/1988 - Pediatric Chief Resident, NYU/Bellevue
06/1987 - Pediatric Residency, NYU/Bellevue
MD, 06/1984 - Medicine, New York University School of Medicine
Websites
Publications
- Caveolin-1 associated with severe (pediatric-onset) presentation of pulmonary arterial hypertension.
- Cardiac Catheterization and Hemodynamics in a Multicenter Cohort of Children with Pulmonary Hypertension.
- Progress in Pulmonary Vein Stenosis: Lessons from Success in Treating Pulmonary Arterial Hypertension.
- Defining longer term outcomes in an ovine model of moderate perinatal hypoxia-ischemia.
- Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.
- Building a dedicated pediatric pulmonary hypertension program: A consensus statement from the pediatric pulmonary hypertension network.
- Genetics dictating therapeutic decisions in pediatric pulmonary hypertension? A case report suggesting we are getting closer.
- Characterisation of Pediatric Pulmonary Hypertensive Vascular Disease from the PPHNet Registry.
- Advanced Microparticulate/Nanoparticulate Respirable Dry Powders of a Selective RhoA/Rho Kinase (Rock) Inhibitor for Targeted Pulmonary Inhalation Aerosol Delivery.
- Insights into the impact of sections and departments on your career: The APS-SPR Virtual Chat Series.
- Biallelic variants of ATP13A3 cause dose-dependent childhood-onset pulmonary arterial hypertension characterised by extreme morbidity and mortality.
- Mortality from Pulmonary Hypertension in the Pediatric Cardiac Intensive Care Unit.
- Safety and Tolerability of a Rapid Transition From Intravenous Treprostinil to Oral Selexipag in Three Adolescent Patients With Pulmonary Arterial Hypertension.
- Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant.
- Pulmonary Arteriovenous Malformations and the Hepatic "Black Box": Are We Emerging From the Darkness?
- Practice patterns of pulmonary hypertension secondary to left heart disease among pediatric pulmonary hypertension providers.
- Comparison of l-Carnitine and l-Carnitine HCL salt for targeted lung treatment of pulmonary hypertension (PH) as inhalation aerosols: Design, comprehensive characterization, in vitro 2D/3D cell cultures, and in vivo MCT-Rat model of PH.
- HIF-1a promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow.
- Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in viv
- Arginine recycling in endothelial cells is regulated BY HSP90 and the ubiquitin proteasome system.
- Novel Documentation of Onset and Rapid Advancement of Pulmonary Arterial Hypertension without Symptoms in BMPR2 Mutation Carriers: Cautionary Tales?
- Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers.
- Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics.
- Complex interplay between autophagy and oxidative stress in the development of pulmonary disease.
- Pharmacokinetics of Oral Treprostinil in Children With Pulmonary Arterial Hypertension.
- The many faces and outcomes of pulmonary vein stenosis in early childhood.
- Equipoise and Acumen in Pediatric Acute Respiratory Distress Syndrome Research.
- TGF-ß1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis.
- Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease.
- Extracorporeal Membrane Oxygenation in Pediatric Pulmonary Hypertension.
- Clinical Utility of Echocardiography in Former Preterm Infants with Bronchopulmonary Dysplasia.
- Outcomes of pulmonary vascular disease in infants conceived with non-IVF fertility treatment and assisted reproductive technologies at 1 year of age.
- Oral treprostinil in transition or as add-on therapy in pediatric pulmonary arterial hypertension.
- EXPRESS: Acute Vasoreactivity Testing in Pediatric Idiopathic Pulmonary Arterial Hypertension: an international Survey on Current Practice.
- Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling.
- Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury.
- Mortality in infants with bronchopulmonary dysplasia: Data from cardiac catheterization.
- Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease.
- Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.
- Two patients with FOXF1 mutations with alveolar capillary dysplasia with misalignment of pulmonary veins and other malformations: Two different presentations and outcomes.
- Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic.
- Intensive Care Mortality Prognostic Model for Pediatric Pulmonary Hypertension.
- Enhancing the Development and Retention of Physician-Scientists in Academic Pediatrics: Strategies for Success.
- Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease.
- KLF2-mediated disruption of PPAR-? signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.
- The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension.
- Safety, efficacy and Management of subcutaneous treprostinil infusions in the treatment of severe pediatric pulmonary hypertension.
- Multicenter mortality and morbidity associated with pulmonary hypertension in the pediatric intensive care unit.
- Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects.
- Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale.
- Pushing the envelope: a treat and repair strategy for patients with advanced pulmonary hypertension associated with congenital heart disease.
- Evaluation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia.
- Pulmonary vein stenosis of ex-premature infants with pulmonary hypertension and bronchopulmonary dysplasia, epidemiology, and survival from a multicenter cohort.
- The Prescient Prognosticator? Hepatoma-derived Growth Factor in Pulmonary Hypertension.
- Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation.
- Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial.
- Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells.
- Pulmonary Hypertension.
- Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow.
- Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung.
- Change in Pediatric Functional Classification During Treatment and Morbidity and Mortality in Children with Pulmonary Hypertension.
- Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.
- Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension.
- Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society.
- Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.
- Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells.
- Short-Term Treprostinil Use in Infants with Congenital Diaphragmatic Hernia following Repair.
- Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype.
- Longitudinal development of obesity in the post-Fontan population.
- Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.
- B-type natriuretic peptide: prognostic marker in congenital diaphragmatic hernia.
- Are preoperative B-type natriuretic peptide levels associated with outcome after pulmonary artery banding and the double switch operation in patients with congenitally corrected transposition of the great arteries: a pilot study.
- Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.
- Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase.
- Adaptive right ventricular performance in response to acutely increased afterload in a lamb model of congenital heart disease: evidence for enhanced Anrep effect.
- Altered reactivity and nitric oxide signaling in the isolated thoracic duct from an ovine model of congenital heart disease with increased pulmonary blood flow.
- Nitration of tyrosine 247 inhibits protein kinase G-1a activity by attenuating cyclic guanosine monophosphate binding.
- Endothelin-1 stimulates catalase activity through the PKCd-mediated phosphorylation of serine 167.
- Antenatal maternally-administered phosphodiesterase type 5 inhibitors normalize eNOS expression in the fetal lamb model of congenital diaphragmatic hernia.
- Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan).
- Reactive oxygen species in pulmonary vascular remodeling.
- Reply to the editor.
- L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow.
- The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR).
- Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.
- Differential responses of the right ventricle to abnormal loading conditions in vivo: possible pathophysiologic mechanisms.
- Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow.
- Chronic inhibition of PPAR-? signaling induces endothelial dysfunction in the juvenile lamb.
- Implications of the U.S. Food and Drug Administration warning against the use of sildenafil for the treatment of pediatric pulmonary hypertension.
- Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow.
- Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis.
- PPAR-? regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow.
- B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion.
- Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease?
- Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
- Racial disparities in congenital heart disease: beyond red and blue.
- Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow.
- Usefulness of B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease.
- Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration.
- Advances in the management of pediatric pulmonary hypertension.
- Pediatric pulmonary arterial hypertension: current and emerging therapeutic options.
- Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease.
- Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease.
- Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb.
- Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha: a positive-feedback loop promoting pulmonary vascular remodeling.
- Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity.
- Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide.
- Perinatal changes in superoxide generation in the ovine lung: Alterations associated with increased pulmonary blood flow.
- Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site disruption.
- Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury.
- Usefulness of various plasma biomarkers for diagnosis of heart failure in children with single ventricle physiology.
- Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension.
- Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow.
- Peripheral arterial function in infants and young children with one-ventricle physiology and hypoxemia.
- Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress.
- Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection.
- Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension.
- Alterations in cGMP, soluble guanylate cyclase, phosphodiesterase 5, and B-type natriuretic peptide induced by chronic increased pulmonary blood flow in lambs.
- B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery.
- B-type natriuretic peptide levels predict outcome after neonatal cardiac surgery.
- Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90.
- Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow.
- The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow.
- Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension.
- Pediatric pulmonary hypertension: Roles of endothelin-1 and nitric oxide.
- Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy.
- Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo.
- Nesiritide acutely increases pulmonary and systemic levels of nitric oxide in patients with pulmonary hypertension.
- Oxidative and nitrosative stress in pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide.
- BNP for pediatrics--not quite ready for primetime.
- Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase.
- Sp3 inhibits Sp1-mediated activation of the cardiac troponin T promoter and is downregulated during pathological cardiac hypertrophy in vivo.
- Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker.
- Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs.
- Inhaled nitric oxide induced NOS inhibition and rebound pulmonary hypertension: a role for superoxide and peroxynitrite in the intact lamb.
- Divergent transcriptional enhancer factor-1 regulates the cardiac troponin T promoter.
- Endothelin-1 in congenital heart disease.
- Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes.
- Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension.
- Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension.
- Chronic endothelin A receptor blockade in lambs with increased pulmonary blood flow and pressure.
- Impact of right ventricle to pulmonary artery conduit on outcome of the modified Norwood procedure.
- Inhaled nitric oxide decreases pulmonary soluble guanylate cyclase protein levels in 1-month-old lambs.
- Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs.
- Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia.
- Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life.
- Pharmacologic therapy for persistent pulmonary hypertension of the newborn: as "poly" as the disease itself.
- Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flow.
- Inhaled nitric oxide increases surfactant protein gene expression in the intact lamb.
- Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension.
- Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension.
- Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1.
- Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow.
- Pulmonary vascular K+ channel expression and vasoreactivity in a model of congenital heart disease.
- Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow.
- Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs.
- Decreased surfactant proteins in lambs with pulmonary hypertension secondary to increased blood flow.
- sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension.
- Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy.
- Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1.
- Inhaled nitric oxide in neonates with persistent pulmonary hypertension.
- Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension.
- Alterations in endogenous nitric oxide production after cardiopulmonary bypass in lambs with normal and increased pulmonary blood flow.
- Transthoracic intracardiac catheters in pediatric patients recovering from congenital heart defect surgery: associated complications and outcomes.
- Management and outcomes of delayed sternal closure after cardiac surgery in neonates and infants.
- Pulmonary blood flow alters nitric oxide production in patients undergoing device closure of atrial septal defects.
- Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension.
- Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension.
- The pathophysiology of pulmonary hypertension in congenital heart disease.
- Alveolar capillary dysplasia: diagnostic potential for cardiac catheterization.
- Inhaled nitric oxide, oxygen, and alkalosis: dose-response interactions in a lamb model of pulmonary hypertension.
- Altered endothelial function in lambs with pulmonary hypertension and acute lung injury.
- Endothelin receptor blockade prevents the rise in pulmonary vascular resistance after cardiopulmonary bypass in lambs with increased pulmonary blood flow.
- Role of the endothelium in placental dysfunction after fetal cardiac bypass.
- Endothelin-receptor blockade does not alter closure of the ductus arteriosus.
- Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension.
- Increased pulmonary blood flow alters the molecular regulation of vascular reactivity in the lamb.
- The effects of inhaled nitric oxide on postoperative pulmonary hypertension in infants and children undergoing surgical repair of congenital heart disease.
- Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation.
- Inhaled nitric oxide enhances oxygenation but not survival in infants with alveolar capillary dysplasia.
- Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group.
- Post-cardiopulmonary bypass pulmonary hypertension in lambs with increased pulmonary blood flow. A role for endothelin 1.
- Hemodynamic effects of epinephrine, bicarbonate and calcium in the early postnatal period in a lamb model of single-ventricle physiology created in utero.
- Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow.
- Exogenous endothelin-1 causes renal vasodilation in the fetal lamb.
- Fetal model of single ventricle physiology: hemodynamic effects of oxygen, nitric oxide, carbon dioxide, and hypoxia in the early postnatal period.
- Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs.
- Invited editorial on "Antenatal betamethasone therapy augments nitric oxide-mediated relaxation of preterm ovine pulmonary veins".
- Endothelin-1 vasoactive responses in lambs with pulmonary hypertension and increased pulmonary blood flow.
- In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs.
- Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn.
- Endothelinb receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension.
- Regulation of pulmonary vascular tone in the perinatal period.
- Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia or oligohydramnios.
- Developmental effects of endothelin-1 on the pulmonary circulation in sheep.
- Use of ATP-MgCl2 in the evaluation and treatment of children with pulmonary hypertension secondary to congenital heart defects.
- Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs.
- The role of endothelin and endothelin receptor subtypes in regulation of fetal pulmonary vascular tone.
- HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs.
- Diethylamine/nitric oxide (NO) adduct, an NO donor, produces potent pulmonary and systemic vasodilation in intact newborn lambs.
- Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb.
- Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs.
- Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb.
- M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs.
- EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs.
- K+ channel pulmonary vasodilation in fetal lambs: role of endothelium-derived nitric oxide.
- EDRF inhibition augments pulmonary hypertension in intact newborn lambs.
- L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs.
- In vivo attenuation of endothelium-dependent pulmonary vasodilation by methylene blue.
- N omega-nitro-L-arginine attenuates endothelium-dependent pulmonary vasodilation in lambs.
- Effects of vasoactive drugs on thromboxane A2 mimetic-induced pulmonary hypertension in newborn lambs.
- The role of pulmonary vascular endothelium in perinatal pulmonary circulatory regulation.
- Selective pulmonary vasodilation with ATP-MgCl2 during pulmonary hypertension in lambs.