Jeffrey Fineman, MD

Dr. Jeffrey Fineman is a pediatric critical care specialist who serves as chief of the pediatric critical care division. He is an associate investigator in the UCSF Cardiovascular Research Institute. His research has focused on diseases related to pulmonary circulation and has led to new therapies for pulmonary hypertension, including a drug called inhaled nitric oxide that was approved by the Food and Drug Administration. His laboratory, funded by the National Institutes of Health, investigates disease processes in the body involved in pulmonary hypertension.

Fineman earned his medical degree at New York University Grossman School of Medicine and completed a residency in pediatrics at NYU Langone Health's Bellevue Hospital Center, serving as chief resident. He completed a fellowship in pediatric critical care medicine at UCSF before joining the staff.
Education
2021 - Diversity, Equity, Inclusion Champion Training, UCSF
06/1990 - Pediatric Critical Care Fellowship, UCSF
06/1988 - Pediatric Chief Resident, NYU/Bellevue
06/1987 - Pediatric Residency, NYU/Bellevue
MD, 06/1984 - Medicine, New York University School of Medicine
Websites

  1. Tsoi SM, Cheung S, Valdovinos RA, Amin E, Nawaytou H, Colglazier E, Parker C, Edwell A, Kim S, Fineman JR. Juvenile Systemic Sclerosis Presenting With Severe Pulmonary Vascular Disease: ECMO Stabilization During Aggressive Therapy Resulting in a Favorable Outcome. Pulmonary circulation 2025. PMID: 40463491


  2. Boehme JT, Datar SA, Sun X, Gong W, Lu Q, Soto J, Smith MA, Garcia-Flores AE, Raff GW, Wang T, Maltepe E, Black SM, Fineman JR. Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation. Scientific Reports 2025. PMID: 40348934


  3. Liang Y, Ornatowski W, Lu Q, Sun X, Yegambaram M, Feng A, Dong Y, Aggarwal S, Unwalla HJ, Fineman JR, Black SM, Wang T. Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling. International journal of molecular sciences 2025. PMID: 39941119


  4. Sun X, Yegambaram M, Lu Q, Garcia Flores AE, Pokharel MD, Soto J, Aggarwal S, Wang T, Fineman JR, Black SM. Mitochondrial fission produces a Warburg effect via the oxidative inhibition of prolyl hydroxylase domain-2. Redox biology 2025. PMID: 39978304


  5. Smith MA, Fineman JR. New Insights Into Pediatric Pulmonary Hypertension From Bogota: Is Younger Always Better? Pulmonary circulation 2025. PMID: 39777300


  6. Campos O, Garcia De Herreros A, Sánchez A, Fineman JR, Pawlak G. A Multi-Chamber Pulsating-Flow Device with Optimized Spatial Shear Stress and Pressure for Endothelial-Cell Testing. Journal of biomechanical engineering 2024. PMID: 39382480


  7. Smith MA, Chiacchia S, Boehme J, Datar SA, Morell E, Keller RL, Romer A, Colglazier E, Parker C, Becerra J, Fineman JR. MicroRNA Profiling to Inform Disease Classification, Severity, and Treatment Response in Pediatric Pulmonary Hypertension. American journal of physiology. Heart and circulatory physiology 2024. PMID: 39589759


  8. Sun H, Stockbridge N, Ivy DD, Clark J, Bates A, Handler SS, Krishnan US, Mullen MP, Yung D, Hopper RK, Varghese NP, Avitabile CM, Fineman J, Austin ED, Freire G. Actigraphy Study Endpoints to Reduce Sample Size and Facilitate Drug Development for Pediatric Pulmonary Arterial Hypertension. The Journal of pediatrics 2024. PMID: 39489285


  9. Acosta MF, Encinas-Basurto D, Abrahamson MD, Eedara BB, Hayes D, Fineman JR, Black SM, Mansour HM. Innovative Dual Combination Cospray-Dried Rock Inhibitor/l-Carnitine Inhalable Dry Powder Aerosols. ACS bio & med chem Au 2024. PMID: 39712207


  10. Mike JK, White Y, Ha J, Iranmahboub A, Hawkins C, Hutchings RS, Vento C, Manzoor H, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E. Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia. Stroke 2024. PMID: 39429154


  11. Ruiz VH, Encinas-Basurto D, Ortega-Alarcon N, Eedara BB, Fineman JR, Black SM, Mansour HM. Inhalable Advanced Co-Spray Dried Microparticles/Nanoparticles of a Novel RhoA/Rho Kinase Inhibitor with Lung Surfactant Biomimetic Phospholipids for Targeted Lung Delivery. ACS pharmacology & translational science 2024. PMID: 39416970


  12. Sun X, Moreno Caceres S, Yegambaram M, Lu Q, Pokharel MD, Boehme JT, Datar SA, Aggarwal S, Wang T, Fineman JR, Black SM. The mitochondrial redistribution of ENOS is regulated by AKT1 and dimer status. Nitric oxide : biology and chemistry 2024. PMID: 39332480


  13. Encinas-Basurto D, Acosta MF, Eedara BB, Fineman JR, Black SM, Mansour HM. Design and comprehensive characterization of dry powder inhalation aerosols of simvastatin DPPC/DPPG lung surfactant-mimic nanoparticles/microparticles for pulmonary nanomedicine. RSC advances 2024. PMID: 39285876


  14. Agarwal S, Fineman J, Cornfield DN, Alvira CM, Zamanian RT, Goss K, Yuan K, Bonnet S, Boucherat O, Pullamsetti S, Alcázar MA, Goncharova E, Kudryashova TV, Nicolls MR, de Jesús Pérez V. VIEWING PULMONARY HYPERTENSION THROUGH A PEDIATRIC LENS. The European respiratory journal 2024. PMID: 38575157


  15. Tsoi SM, Steurer M, Nawaytou H, Cheung S, Keller RL, Fineman JR. Defining the Typical Course of Persistent Pulmonary Hypertension of the Newborn: When to Think Beyond Reversible Causes. The Journal of pediatrics 2024. PMID: 38823627


  16. Tsoi SM, Steurer M, Maltepe E, Fineman JR. Pre-eclampsia and barker's hypothesis: are we beginning to see the trees within the forest? Pediatric research 2024. PMID: 38822134


  17. Smith MA, Cheng G, Phelan R, Brazauskas R, Strom J, Ahn KW, Hamilton BK, Peterson A, Savani B, Schoemans H, Schoettler ML, Sorror M, Keller RL, Higham CS, Dvorak CC, Fineman JR, Zinter MS. Pulmonary hypertension in the intensive care unit after pediatric allogeneic hematopoietic stem cell transplant: incidence, risk factors, and outcomes. Frontiers in oncology 2024. PMID: 38868534


  18. Nawaytou H, Lakkaraju R, Stevens L, Reddy VM, Swami N, Keller RL, Teitel DF, Fineman JR. Management of pulmonary vascular disease associated with congenital left-to-right shunts: A single-center experience. The Journal of thoracic and cardiovascular surgery 2024. PMID: 38763305


  19. Pokharel MD, Fu P, Garcia-Flores A, Yegambaram M, Lu Q, Sun X, Unwalla H, Aggarwal S, Fineman JR, Wang T, Black SM. Inflammatory lung injury is associated with endothelial cell mitochondrial fission and requires the nitration of RhoA and cytoskeletal remodeling. Free radical biology & medicine 2024. PMID: 38734269


  20. Maltepe E, Smith M, Boehme J, Datar SA, Hutchings RS, Vento CA, Manzoor H, Loucks A, Winger JA, Fineman JR. OMX: A Novel Oxygen Delivery Biotherapeutic Improves Outcomes in an Ovine Model of Controlled Hemorrhagic Shock. Shock (Augusta, Ga.) 2024. PMID: 38662597


  21. Morell E, Colglazier E, Becerra J, Stevens L, Steurer MA, Sharma A, Nguyen H, Kathiriya IS, Weston S, Teitel D, Keller R, Amin EK, Nawaytou H, Fineman JR. A single institution anesthetic experience with catheterization of pediatric pulmonary hypertension patients. Pulmonary circulation 2024. PMID: 38618291


  22. Avitabile CM, Krishnan US, Yung D, Handler SS, Varghese N, Bates A, Fineman J, Sullivan R, Friere G, Austin E, Mullen MP, Pereira C, Christensen EJ, Yenokyan G, Collaco JM, Abman SH, Romer L, Dunbar Ivy D, Rosenzweig EB. Actigraphy methodology in the Kids Mod PAH trial: Physical activity as a functional endpoint in pediatric clinical trials. Pulmonary circulation 2024. PMID: 38464344


  23. Pokharel MD, Garcia-Flores A, Marciano D, Franco MC, Fineman JR, Aggarwal S, Wang T, Black SM. Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics. Redox biology 2024. PMID: 38295575


  24. Yegambaram M, Sun X, Flores AG, Lu Q, Soto J, Richards J, Aggarwal S, Wang T, Gu H, Fineman JR, Black SM. Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells. International journal of molecular sciences 2023. PMID: 38139362


  25. Boehme JT, Sun X, Lu Q, Barton J, Wu X, Gong W, Raff GW, Datar SA, Wang T, Fineman JR, Black SM. Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation. Nitric oxide : biology and chemistry 2023. PMID: 38061411


  26. Yegambaram M, Sun X, Lu Q, Jin Y, Ornatowski W, Soto J, Aggarwal S, Wang T, Tieu K, Gu H, Fineman JR, Black SM. Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III. Free radical biology & medicine 2023. PMID: 37979892


  27. Tsoi SM, Nawaytou H, Almeneisi H, Steurer M, Zhao Y, Fineman JR, Keller RL. Prostaglandin-E1 infusion in persistent pulmonary hypertension of the newborn. Pediatric pulmonology 2023. PMID: 37975485


  28. Collaco JM, Abman SH, Austin ED, Avitabile CM, Bates A, Fineman JR, Freire GA, Handler SS, Ivy DD, Krishnan US, Mullen MP, Varghese NP, Yung D, Nies MK, Everett AD, Zimmerman KO, Simmons W, Chakraborty H, Yenokyan G, Newell-Sturdivant A, Christensen E, Eyzaguirre LM, Hanley DF, Rosenzweig EB, Romer LH. Kids Mod PAH trial: A multicenter trial comparing mono- versus duo-therapy for initial treatment of pediatric pulmonary hypertension. Pulmonary circulation 2023. PMID: 37915400


  29. Mike JK, White Y, Hutchings RS, Vento C, Ha J, Iranmahboub A, Manzoor H, Gunewardena A, Cheah C, Wang A, Goudy BD, Lakshminrusimha S, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E. Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy. Children (Basel, Switzerland) 2023. PMID: 38002819


  30. Mike JK, White Y, Hutchings RS, Vento C, Ha J, Manzoor H, Lee D, Losser C, Arellano K, Vanhatalo O, Seifert E, Gunewardena A, Wen B, Wang L, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Wu YW, Fineman JR, Ferriero DM, Maltepe E. Perinatal Azithromycin Provides Limited Neuroprotection in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy. Stroke 2023. PMID: 37846563


  31. Colglazier E, Ng AJ, Parker C, Woolsey D, Holmes R, Dsouza A, Becerra J, Stevens L, Nawaytou H, Keller RL, Fineman JR. Safety and tolerability of continuous inhaled iloprost in critically ill pediatric pulmonary hypertension patients: A retrospective case series. Pulmonary circulation 2023. PMID: 37731624


  32. Yegambaram M, Kumar S, Wu X, Lu Q, Sun X, Garcia Flores A, Meadows ML, Barman S, Fulton D, Wang T, Fineman JR, Black SM. Endothelin-1 acutely increases nitric oxide production via the calcineurin mediated dephosphorylation of Caveolin-1. Nitric oxide : biology and chemistry 2023. PMID: 37659679


  33. Mahendra M, Chu P, Amin EK, Nawaytou H, Duncan JR, Fineman JR, Smith-Bindman R. Associated radiation exposure from medical imaging and excess lifetime risk of developing cancer in pediatric patients with pulmonary hypertension. Pulmonary circulation 2023. PMID: 37614831


  34. Avitabile CM, Yung D, Handler S, Hopper RK, Fineman J, Freire G, Varghese N, Mullen MP, Krishnan US, Austin E, Silveira L, Ivy DD. Measurement of Physical Activity by Actigraphy in Infants and Young Children with Pulmonary Arterial Hypertension. The Journal of pediatrics 2023. PMID: 37517653


  35. Pokharel MD, Marciano DP, Fu P, Franco MC, Unwalla H, Tieu K, Fineman JR, Wang T, Black SM. Metabolic reprogramming, oxidative stress, and pulmonary hypertension. Redox biology 2023. PMID: 37392518


  36. Soares JHN, Raff GW, Fineman JR, Datar SA. Respiratory mechanics and gas exchange in an ovine model of congenital heart disease with increased pulmonary blood flow and pressure. Frontiers in physiology 2023. PMID: 37362431


  37. Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou EA, Auer N, Mitra A, Guardado ES, Swaminathan G, Condon DF, Yu J, McCarra M, Juul NH, Mallory A, Guzman-Hernandez RA, Yuan K, Rojas V, Crossno JT, Yung LM, Yu PB, Spencer T, Winn RA, Frump A, Karoor V, Lahm T, Hedlin H, Fineman JR, Lafyatis R, Knutsen CNF, Alvira CM, Cornfield DN, de Jesus Perez VA. WNT7A deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension. The European respiratory journal 2023. PMID: 37024132


  38. Lu Q, Sun X, Yegambran M, Ornatowski W, Wu X, Wang H, Garcia-Flores A, Da Silva V, Zemskov E, Tang H, Fineman J, Tieu K, Wang T, Black S. Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission. The Journal of biological chemistry 2023. PMID: 36841483


  39. Colglazier E, Stevens L, Parker C, Nawaytou HM, Amin EK, Becerra J, Steurer M, Fineman JR. Hemodynamic assessment of transitioning from parenteral prostacyclin to selexipag in pediatric pulmonary hypertension. Pulmonary circulation 2022. PMID: 36514390


  40. Kornblith AE, Singh C, Devlin G, Addo N, Streck CJ, Holmes JF, Kuppermann N, Grupp-Phelan J, Fineman J, Butte AJ, Yu B. Predictability and stability testing to assess clinical decision instrument performance for children after blunt torso trauma. PLOS Digital Health 2022. PMID: 36812570


  41. Farrell R, Colglazier E, Parker C, Stevens L, Austin ED, Fineman JR. Caveolin-1 associated with severe (pediatric-onset) presentation of pulmonary arterial hypertension. Pulmonary circulation 2022. PMID: 35864912


  42. Tsoi SM, Jones K, Colglazier E, Parker C, Nawaytou H, Teitel D, Fineman JR, Keller RL. Persistence of persistent pulmonary hypertension of the newborn: A case of de novo TBX4 variant. Pulmonary circulation 2022. PMID: 35874850


  43. Rosenzweig EB, Bates A, Mullen MP, Abman SH, Austin ED, Everett A, Fineman J, Feinstein J, Hopper RK, Kinsella JP, Krishnan US, Lu M, Mandl KD, Raj JU, Varghese N, Yung D, Handler SS, Sleeper LA, Pediatric Pulmonary Hypertension Network. Cardiac Catheterization and Hemodynamics in a Multicenter Cohort of Children with Pulmonary Hypertension. 2022. PMID: 35049414


  44. Jenkins KJ, Fineman JR. Progress in Pulmonary Vein Stenosis: Lessons from Success in Treating Pulmonary Arterial Hypertension. Children (Basel, Switzerland) 2022. PMID: 35740736


  45. Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JV, Long-Boyle J, Chen P, Wu YW, Fineman JR, Ferriero DM, Maltepe E. Defining longer term outcomes in an ovine model of moderate perinatal hypoxia-ischemia. 2022. PMID: 35588703


  46. Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. 2022. PMID: 35575096


  47. Handler SS, Varghese NP, Rosenzweig EB, Yung D, Krishnan U, Whalen E, Bates A, Avitabile CM, Jackson EO, Hirsch R, Fineman J, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet). Building a dedicated pediatric pulmonary hypertension program: A consensus statement from the pediatric pulmonary hypertension network. 2022. PMID: 35506071


  48. Stevens L, Colglazier E, Parker C, Amin EK, Nawaytou H, Teitel D, Reddy VM, Welch CL, Chung WK, Fineman JR. Genetics dictating therapeutic decisions in pediatric pulmonary hypertension? A case report suggesting we are getting closer. 2022. PMID: 35506084


  49. Abman SH, Mullen MP, Sleeper LA, Austin ED, Rosenzweig EB, Kinsella JP, Ivy D, Hopper RK, Usha Raj J, Fineman J, Keller RL, Bates A, Krishnan US, Avitabile CM, Davidson A, Natter MD, Mandl KD, Pediatric Pulmonary Hypertension Network. Characterisation of Pediatric Pulmonary Hypertensive Vascular Disease from the PPHNet Registry. The European respiratory journal 2021. PMID: 34140292


  50. Muralidharan P, Hayes D, Fineman JR, Black SM, Mansour HM. Advanced Microparticulate/Nanoparticulate Respirable Dry Powders of a Selective RhoA/Rho Kinase (Rock) Inhibitor for Targeted Pulmonary Inhalation Aerosol Delivery. 2021. PMID: 34959469


  51. Davis SD, Fineman JR, St Geme Iii JW. Insights into the impact of sections and departments on your career: The APS-SPR Virtual Chat Series. 2021. PMID: 34824399


  52. Machado R, Welch CL, Haimel M, Bleda M, Colglazier E, Coulson JD, Debeljak M, Ekstein J, Fineman JR, Golden WC, Griffin EL, Hadinnapola C, Harris MA, Hirsch Y, Hoover-Fong J, Nogee L, Romer LH, Vesel S, Graf S, Morrell N, Southgate L, Chung W. Biallelic variants of ATP13A3 cause dose-dependent childhood-onset pulmonary arterial hypertension characterised by extreme morbidity and mortality. Journal of medical genetics 2021. PMID: 34493544


  53. Morell E, Gaies M, Fineman JR, Charpie J, Rao R, Sasaki J, Zhang W, Reichle G, Banerjee M, Tabbutt S. Mortality from Pulmonary Hypertension in the Pediatric Cardiac Intensive Care Unit. American journal of respiratory and critical care medicine 2021. PMID: 33798036


  54. Colglazier E, Ng AJ, Parker C, Nawaytou H, Fineman JR. Safety and Tolerability of a Rapid Transition From Intravenous Treprostinil to Oral Selexipag in Three Adolescent Patients With Pulmonary Arterial Hypertension. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 2021. PMID: 34239406


  55. Sonmezoglu S, Fineman JR, Maltepe E, Maharbiz MM. Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant. Nature biotechnology 2021. PMID: 33782610


  56. Rajagopal SK, Fineman JR. Pulmonary Arteriovenous Malformations and the Hepatic "Black Box": Are We Emerging From the Darkness? JACC. Basic to translational science 2021. PMID: 33779631


  57. Nawaytou H, Fineman JR, Moledina S, Ivy D, Abman SH, Cerro MJD. Practice patterns of pulmonary hypertension secondary to left heart disease among pediatric pulmonary hypertension providers. Pulmonary circulation 2021. PMID: 33623667


  58. Acosta MF, Muralidhran P, Abrahamson MD, Grijalva CL, Carver M, Tang H, Klinger C, Fineman JR, Black SM, Mansour HM. Comparison of l-Carnitine and l-Carnitine HCL salt for targeted lung treatment of pulmonary hypertension (PH) as inhalation aerosols: Design, comprehensive characterization, in vitro 2D/3D cell cultures, and in vivo MCT-Rat model of PH. Pulmonary pharmacology & therapeutics 2021. PMID: 33556627


  59. Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA. HIF-1a promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow. Scientific Reports 2021. PMID: 33446832


  60. Acosta MF, Muralidharan P, Grijalva CL, Abrahamson MD, Hayes D, Fineman JR, Black SM, Mansour HM. Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in viv Therapeutic advances in respiratory disease 2021. PMID: 33719747


  61. Wu X, Sun X, Sharma S, Lu Q, Yegambaram M, Hou Y, Wang T, Fineman JR, Black SM. Arginine recycling in endothelial cells is regulated BY HSP90 and the ubiquitin proteasome system. Nitric oxide : biology and chemistry 2020. PMID: 33338599


  62. Amin EK, Austin ED, Parker C, Colglazier E, Nawaytou H, Leary PJ, Hemnes AR, Teitel D, Fineman JR. Novel Documentation of Onset and Rapid Advancement of Pulmonary Arterial Hypertension without Symptoms in BMPR2 Mutation Carriers: Cautionary Tales? American journal of respiratory and critical care medicine 2020. PMID: 32692583


  63. Acosta MF, Abrahamson MD, Encinas-Basurto D, Fineman JR, Black SM, Mansour HM. Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers. The AAPS journal 2020. PMID: 33200330


  64. Lu Q, Zemskov EA, Sun X, Wang H, Yegambaram M, Wu X, Garcia-Flores A, Song S, Tang H, Kangath A, Cabanillas GZ, Yuan JX, Wang T, Fineman JR, Black SM. Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics. Redox biology 2020. PMID: 33221570


  65. Ornatowski W, Lu Q, Yegambaram M, Garcia AE, Zemskov EA, Maltepe E, Fineman JR, Wang T, Black SM. Complex interplay between autophagy and oxidative stress in the development of pulmonary disease. Redox biology 2020. PMID: 32818797


  66. Hopper RK, Ivy DD, Yung D, Mullen MP, Hanna BD, Kirkpatrick E, Hirsch R, Austin ED, Fineman J, Solum D, Deng CQ, Feinstein JA. Pharmacokinetics of Oral Treprostinil in Children With Pulmonary Arterial Hypertension. Journal of cardiovascular pharmacology 2020. PMID: 32398473


  67. Humpl T, Fineman J, Qureshi AM. The many faces and outcomes of pulmonary vein stenosis in early childhood. Pediatric pulmonology 2020. PMID: 32506838


  68. Oishi P, Fineman JR. Equipoise and Acumen in Pediatric Acute Respiratory Distress Syndrome Research. American journal of respiratory and critical care medicine 2020. PMID: 32271615


  69. Sun X, Lu Q, Yegambaram M, Kumar S, Qu N, Srivastava A, Wang T, Fineman JR, Black SM. TGF-ß1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis. Redox biology 2020. PMID: 32554303


  70. Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR. Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease. Pulmonary circulation 2020. PMID: 32489641


  71. Morell E, Rajagopal SK, Oishi P, Thiagarajan RR, Fineman JR, Steurer MA. Extracorporeal Membrane Oxygenation in Pediatric Pulmonary Hypertension. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2020. PMID: 31577693


  72. Nawaytou H, Steurer MA, Zhao Y, Guslits E, Teitel D, Fineman JR, Keller RL. Clinical Utility of Echocardiography in Former Preterm Infants with Bronchopulmonary Dysplasia. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2020. PMID: 31948712


  73. Fineman DC, Baer RJ, Chambers CD, Rajagopal S, Maltepe E, Rinaudo PF, Fineman JR, Jelliffe-Pawlowski LL, Steurer MA. Outcomes of pulmonary vascular disease in infants conceived with non-IVF fertility treatment and assisted reproductive technologies at 1 year of age. Pediatric pulmonology 2019. PMID: 31328432


  74. Ivy DD, Feinstein JA, Yung D, Mullen MP, Kirkpatrick EC, Hirsch R, Austin ED, Fineman J, Truong U, Solum D, Deng CQ, Hopper RK. Oral treprostinil in transition or as add-on therapy in pediatric pulmonary arterial hypertension. Pulmonary circulation 2019. PMID: 31215336


  75. Caicedo L, Hopper RK, Garcia H, Ivy DD, Haag D, Fineman J, Humpi T, Al-Tamimi O, Feinstein J, Berger RM, Berman-Rosenzweig E, Kashour T, Diaz GF, Mendoza A, Bobhate P, Handler S, Lopes AA, Barwad P, Kumar Rahit M, Krishnan U, Adatia ITK, Moledina S, Abman S, Cerro Marin MJD. EXPRESS: Acute Vasoreactivity Testing in Pediatric Idiopathic Pulmonary Arterial Hypertension: an international Survey on Current Practice. Pulmonary circulation 2019. PMID: 31144586


  76. Johnson Kameny R, Datar SA, Boehme JB, Morris C, Zhu T, Goudy BD, Johnson EG, Galambos C, Raff GW, Sun X, Wang T, Chiacchia SR, Lu Q, Black SM, Maltepe E, Fineman JR. Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling. American journal of respiratory cell and molecular biology 2019. PMID: 30620615


  77. Kelly GT, Faraj R, Zhang Y, Maltepe E, Fineman JR, Black SM, Wang T. Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury. Frontiers in physiology 2019. PMID: 31105595


  78. Steurer MA, Nawaytou H, Guslits E, Colglazier E, Teitel D, Fineman JR, Keller RL. Mortality in infants with bronchopulmonary dysplasia: Data from cardiac catheterization. Pediatric pulmonology 2019. PMID: 30938937


  79. Zemskov EA, Lu Q, Ornatowski W, Klinger CN, Desai AA, Maltepe E, Yuan JX, Wang T, Fineman JR, Black SM. Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease. Antioxidants & redox signaling 2019. PMID: 30623676


  80. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS biology 2019. PMID: 30677022


  81. Abu-El-Haija A, Fineman J, Connolly AJ, Murali P, Judge LM, Slavotinek AM. Two patients with FOXF1 mutations with alveolar capillary dysplasia with misalignment of pulmonary veins and other malformations: Two different presentations and outcomes. American journal of medical genetics. Part A 2018. PMID: 30380203


  82. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS biology 2018. PMID: 30335746


  83. Balkin EM, Zinter MS, Rajagopal SK, Keller RL, Fineman JR, Steurer MA. Intensive Care Mortality Prognostic Model for Pediatric Pulmonary Hypertension. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2018. PMID: 29923941


  84. Alvira CM, Steinhorn RH, Balistreri WF, Fineman JR, Oishi PE, Padbury JF, Kinsella JP, Abman SH. Enhancing the Development and Retention of Physician-Scientists in Academic Pediatrics: Strategies for Success. The Journal of pediatrics 2018. PMID: 30055815


  85. Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR. Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease. American journal of physiology. Heart and circulatory physiology 2018. PMID: 29906222


  86. Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA. KLF2-mediated disruption of PPAR-? signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. American journal of physiology. Heart and circulatory physiology 2018. PMID: 29631374


  87. Kinsella JP, Steinhorn RH, Mullen MP, Hopper RK, Keller RL, Ivy DD, Austin ED, Krishnan US, Rosenzweig EB, Fineman JR, Everett AD, Hanna BD, Humpl T, Raj JU, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet). The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension. The Journal of pediatrics 2018. PMID: 29628412


  88. Levy M, Del Cerro MJ, Nadaud S, Vadlamudi K, Colgazier E, Fineman J, Bonnet D, Adatia I. Safety, efficacy and Management of subcutaneous treprostinil infusions in the treatment of severe pediatric pulmonary hypertension. International journal of cardiology 2018. PMID: 29650343


  89. Balkin EM, Steurer MA, Delagnes EA, Zinter MS, Rajagopal S, Keller RL, Fineman JR. Multicenter mortality and morbidity associated with pulmonary hypertension in the pediatric intensive care unit. Pulmonary circulation 2017. PMID: 29251545


  90. Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman JR. Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2017. PMID: 28723882


  91. Zinter MS, Melton A, Sabnis AJ, Dvorak CC, Elicker BM, Nawaytou HM, Kameny RJ, Fineman JR. Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale. Leukemia & lymphoma 2017. PMID: 28958195


  92. Kameny RJ, Colglazier E, Nawaytou H, Moore P, Reddy VM, Teitel D, Fineman JR. Pushing the envelope: a treat and repair strategy for patients with advanced pulmonary hypertension associated with congenital heart disease. Pulmonary circulation 2017. PMID: 28862067


  93. Krishnan U, Feinstein JA, Adatia I, Austin ED, Mullen MP, Hopper RK, Hanna B, Romer L, Keller RL, Fineman J, Steinhorn R, Kinsella JP, Ivy DD, Rosenzweig EB, Raj U, Humpl T, Abman SH, Pediatric Pulmonary Hypertension Network (PPHNet). Evaluation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia. The Journal of pediatrics 2017. PMID: 28645441


  94. Mahgoub L, Kaddoura T, Kameny AR, Lopez Ortego P, Vanderlaan RD, Kakadekar A, Dicke F, Rebeyka I, Calderone CA, Redington A, Del Cerro MJ, Fineman J, Adatia I. Pulmonary vein stenosis of ex-premature infants with pulmonary hypertension and bronchopulmonary dysplasia, epidemiology, and survival from a multicenter cohort. Pediatric pulmonology 2017. PMID: 28152279


  95. Kameny RJ, Fineman JR. The Prescient Prognosticator? Hepatoma-derived Growth Factor in Pulmonary Hypertension. American journal of respiratory and critical care medicine 2016. PMID: 27845583


  96. Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E. Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. American journal of physiology. Heart and circulatory physiology 2016. PMID: 27591215


  97. Steinhorn RH, Fineman J, Kusic-Pajic A, Cornelisse P, Gehin M, Nowbakht P, Pierce CM, Beghetti M, FUTURE-4 study investigators. Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial. The Journal of pediatrics 2016. PMID: 27502103


  98. Sun X, Kellner M, Desai AA, Wang T, Lu Q, Kangath A, Qu N, Klinger C, Fratz S, Yuan JX, Jacobson JR, Garcia JG, Rafikov R, Fineman JR, Black SM. Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells. American journal of respiratory cell and molecular biology 2016. PMID: 26959555


  99. Oishi P, Fineman JR. Pulmonary Hypertension. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2016. PMID: 27490592


  100. Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR. Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. American journal of physiology. Heart and circulatory physiology 2016. PMID: 27199125


  101. Rafikova O, Meadows ML, Kinchen JM, Mohney RP, Maltepe E, Desai AA, Yuan JX, Garcia JG, Fineman JR, Rafikov R, Black SM. Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung. PloS one 2016. PMID: 26937637


  102. Balkin EM, Olson ED, Robertson L, Adatia I, Fineman JR, Keller RL. Change in Pediatric Functional Classification During Treatment and Morbidity and Mortality in Children with Pulmonary Hypertension. Pediatric cardiology 2016. PMID: 26843461


  103. Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML. Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction. Journal of the American Heart Association 2016. PMID: 26738788


  104. Kinsella JP, Steinhorn RH, Krishnan US, Feinstein JA, Adatia I, Austin ED, Rosenzweig EB, Everett AD, Fineman JR, Hanna BD, Hopper RK, Humpl T, Ivy DD, Keller RL, Mullen MP, Raj JU, Wessel DL, Abman SH. Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension. The Journal of pediatrics 2015. PMID: 26703869


  105. Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL, American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitatio. Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. Circulation 2015. PMID: 26534956


  106. Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY. Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. Cell reports 2015. PMID: 26565914


  107. Rafikov R, Sun X, Rafikova O, Louise Meadows M, Desai AA, Khalpey Z, Yuan JX, Fineman JR, Black SM. Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells. Redox biology 2015. PMID: 26298201


  108. Olson E, Lusk LA, Fineman JR, Robertson L, Keller RL. Short-Term Treprostinil Use in Infants with Congenital Diaphragmatic Hernia following Repair. The Journal of pediatrics 2015. PMID: 26143384


  109. Kameny RJ, He Y, Morris C, Sun C, Johengen M, Gong W, Raff GW, Datar SA, Oishi PE, Fineman JR. Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype. American journal of physiology. Heart and circulatory physiology 2015. PMID: 25934095


  110. Wellnitz K, Harris IS, Sapru A, Fineman JR, Radman M. Longitudinal development of obesity in the post-Fontan population. European journal of clinical nutrition 2015. PMID: 25920422


  111. Gross CM, Aggarwal S, Kumar S, Tian J, Kasa A, Bogatcheva N, Datar SA, Verin AD, Fineman JR, Black SM. Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress. Journal of cellular physiology 2014. PMID: 24677020


  112. Steurer MA, Moon-Grady AJ, Fineman JR, Sun CE, Lusk LA, Wai KC, Keller RL. B-type natriuretic peptide: prognostic marker in congenital diaphragmatic hernia. Pediatric research 2014. PMID: 25188741


  113. Char DS, Shiboski SC, Hanley FL, Fineman JR. Are preoperative B-type natriuretic peptide levels associated with outcome after pulmonary artery banding and the double switch operation in patients with congenitally corrected transposition of the great arteries: a pilot study. The Journal of thoracic and cardiovascular surgery 2014. PMID: 25135237


  114. Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. The Journal of clinical investigation 2014. PMID: 24960162


  115. Sun X, Kumar S, Sharma S, Aggarwal S, Lu Q, Gross C, Rafikova O, Lee SG, Dasarathy S, Hou Y, Meadows ML, Han W, Su Y, Fineman JR, Black SM. Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase. American journal of respiratory cell and molecular biology 2014. PMID: 24392990


  116. Johnson RC, Datar SA, Oishi PE, Bennett S, Maki J, Sun C, Johengen M, He Y, Raff GW, Redington AN, Fineman JR. Adaptive right ventricular performance in response to acutely increased afterload in a lamb model of congenital heart disease: evidence for enhanced Anrep effect. American journal of physiology. Heart and circulatory physiology 2014. PMID: 24561861


  117. Datar SA, Oishi PE, Gong W, Bennett SH, Sun CE, Johengen M, Maki J, Johnson RC, Raff GW, Fineman JR. Altered reactivity and nitric oxide signaling in the isolated thoracic duct from an ovine model of congenital heart disease with increased pulmonary blood flow. American journal of physiology. Heart and circulatory physiology 2014. PMID: 24531811


  118. Aggarwal S, Gross CM, Rafikov R, Kumar S, Fineman JR, Ludewig B, Jonigk D, Black SM. Nitration of tyrosine 247 inhibits protein kinase G-1a activity by attenuating cyclic guanosine monophosphate binding. The Journal of biological chemistry 2014. PMID: 24469460


  119. Rafikov R, Kumar S, Aggarwal S, Hou Y, Kangath A, Pardo D, Fineman JR, Black SM. Endothelin-1 stimulates catalase activity through the PKCd-mediated phosphorylation of serine 167. Free radical biology & medicine 2013. PMID: 24211614


  120. Shue EH, Schecter SC, Gong W, Etemadi M, Johengen M, Iqbal C, Derderian SC, Oishi P, Fineman JR, Miniati D. Antenatal maternally-administered phosphodiesterase type 5 inhibitors normalize eNOS expression in the fetal lamb model of congenital diaphragmatic hernia. Journal of pediatric surgery 2013. PMID: 24439578


  121. Radman M, Keller RL, Oishi P, Datar SA, Wellnitz K, Azakie A, Hanley F, Char D, Hsu JH, Amrinovin R, Adatia I, Fineman JR. Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan). The Journal of thoracic and cardiovascular surgery 2013. PMID: 24079880


  122. Aggarwal S, Gross CM, Sharma S, Fineman JR, Black SM. Reactive oxygen species in pulmonary vascular remodeling. Comprehensive Physiology 2013. PMID: 23897679


  123. Amirnovin R, Oishi P, Fineman JR, Keller RL. Reply to the editor. The Journal of thoracic and cardiovascular surgery 2013. PMID: 23597627


  124. Sharma S, Aramburo A, Rafikov R, Sun X, Kumar S, Oishi PE, Datar SA, Raff G, Xoinis K, Kalkan G, Fratz S, Fineman JR, Black SM. L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow. Pediatric research 2013. PMID: 23628882


  125. Radman M, Mack R, Barnoya J, Castañeda A, Rosales M, Azakie A, Mehta N, Keller R, Datar S, Oishi P, Fineman J. The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR). The Journal of thoracic and cardiovascular surgery 2013. PMID: 23583172


  126. Sun X, Sharma S, Fratz S, Kumar S, Rafikov R, Aggarwal S, Rafikova O, Lu Q, Burns T, Dasarathy S, Wright J, Schreiber C, Radman M, Fineman JR, Black SM. Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow. Antioxidants & redox signaling 2013. PMID: 23244702


  127. Azakie A, Fineman J, He Y. Differential responses of the right ventricle to abnormal loading conditions in vivo: possible pathophysiologic mechanisms. The Journal of thoracic and cardiovascular surgery 2013. PMID: 23434296


  128. Kumar S, Oishi PE, Rafikov R, Aggarwal S, Hou Y, Datar SA, Sharma S, Azakie A, Fineman JR, Black SM. Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow. Journal of cellular biochemistry 2013. PMID: 22961736


  129. Sharma S, Barton J, Rafikov R, Aggarwal S, Kuo HC, Oishi PE, Datar SA, Fineman JR, Black SM. Chronic inhibition of PPAR-? signaling induces endothelial dysfunction in the juvenile lamb. Pulmonary pharmacology & therapeutics 2012. PMID: 23257346


  130. Abman SH, Kinsella JP, Rosenzweig EB, Krishnan U, Kulik T, Mullen M, Wessel DL, Steinhorn R, Adatia I, Hanna B, Feinstein J, Fineman J, Raj U, Humpl T, Pediatric Pulmonary Hypertension Network (PPHNet). Implications of the U.S. Food and Drug Administration warning against the use of sildenafil for the treatment of pediatric pulmonary hypertension. American journal of respiratory and critical care medicine 2012. PMID: 23220921


  131. Oishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman JR. Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow. Pediatric research 2012. PMID: 23128423


  132. Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman JR. Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis. Pediatric cardiology 2012. PMID: 22961274


  133. Sharma S, Sun X, Rafikov R, Kumar S, Hou Y, Oishi PE, Datar SA, Raff G, Fineman JR, Black SM. PPAR-? regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow. PloS one 2012. PMID: 22962578


  134. Amirnovin R, Keller RL, Herrera C, Hsu JH, Datar S, Karl TR, Adatia I, Oishi P, Fineman JR. B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion. The Journal of thoracic and cardiovascular surgery 2012. PMID: 22914252


  135. Radman MR, Goldhoff P, Jones KD, Azakie A, Datar S, Adatia I, Oishi PE, Fineman JR. Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease? Pediatric cardiology 2012. PMID: 22614905


  136. Sharma S, Sun X, Kumar S, Rafikov R, Aramburo A, Kalkan G, Tian J, Rehmani I, Kallarackal S, Fineman JR, Black SM. Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. Free radical biology & medicine 2012. PMID: 22583703


  137. Soskolne G, Collins JW, Fineman JR, Fuentes-Afflick E. Racial disparities in congenital heart disease: beyond red and blue. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2012. PMID: 22391831


  138. Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman JR. Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow. American journal of physiology. Lung cellular and molecular physiology 2011. PMID: 22207591


  139. Lowenthal A, Camacho BV, Lowenthal S, Natal-Hernandez L, Liszewski W, Hills NK, Fineman JR, Bernstein HS. Usefulness of B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease. The American journal of cardiology 2011. PMID: 22196786


  140. Aggarwal S, Gross CM, Kumar S, Datar S, Oishi P, Kalkan G, Schreiber C, Fratz S, Fineman JR, Black SM. Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. Journal of cellular physiology 2011. PMID: 21351102


  141. Oishi P, Datar SA, Fineman JR. Advances in the management of pediatric pulmonary hypertension. Respiratory care 2011. PMID: 21944683


  142. Oishi P, Datar SA, Fineman JR. Pediatric pulmonary arterial hypertension: current and emerging therapeutic options. Expert opinion on pharmacotherapy 2011. PMID: 21609302


  143. Fratz S, Fineman JR, Görlach A, Sharma S, Oishi P, Schreiber C, Kietzmann T, Adatia I, Hess J, Black SM. Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease. Circulation 2011. PMID: 21357846


  144. Tian J, Fratz S, Hou Y, Lu Q, Görlach A, Hess J, Schreiber C, Datar SA, Oishi P, Nechtman J, Podolsky R, She JX, Fineman JR, Black SM. Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease. Physiological genomics 2010. PMID: 20978110


  145. Aggarwal S, Gross C, Fineman JR, Black SM. Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb. Trends in cardiovascular medicine 2010. PMID: 22293025


  146. Diebold I, Petry A, Djordjevic T, Belaiba RS, Fineman J, Black S, Schreiber C, Fratz S, Hess J, Kietzmann T, Görlach A. Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha: a positive-feedback loop promoting pulmonary vascular remodeling. Antioxidants & redox signaling 2010. PMID: 20001745


  147. Keller RL, Tacy TA, Hendricks-Munoz K, Xu J, Moon-Grady AJ, Neuhaus J, Moore P, Nobuhara KK, Hawgood S, Fineman JR. Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity. American journal of respiratory and critical care medicine 2010. PMID: 20413632


  148. Hsu JH, Oishi P, Wiseman DA, Hou Y, Chikovani O, Datar S, Sajti E, Johengen MJ, Harmon C, Black SM, Fineman JR. Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide. American journal of physiology. Lung cellular and molecular physiology 2010. PMID: 20363848


  149. Sharma S, Kumar S, Wiseman DA, Kallarackal S, Ponnala S, Elgaish M, Tian J, Fineman JR, Black SM. Perinatal changes in superoxide generation in the ovine lung: Alterations associated with increased pulmonary blood flow. Vascular pharmacology 2010. PMID: 20362073


  150. Fonseca FV, Ravi K, Wiseman D, Tummala M, Harmon C, Ryzhov V, Fineman JR, Black SM. Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site disruption. DNA and cell biology 2010. PMID: 20184449


  151. Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H. Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury. Pediatric pulmonology 2009. PMID: 19830720


  152. Shah A, Feraco AM, Harmon C, Tacy T, Fineman JR, Bernstein HS. Usefulness of various plasma biomarkers for diagnosis of heart failure in children with single ventricle physiology. The American journal of cardiology 2009. PMID: 19840577


  153. Tian J, Smith A, Nechtman J, Podolsky R, Aggarwal S, Snead C, Kumar S, Elgaish M, Oishi P, Göerlach A, Fratz S, Hess J, Catravas JD, Verin AD, Fineman JR, She JX, Black SM. Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension. Physiological genomics 2009. PMID: 19825830


  154. Sharma S, Kumar S, Sud N, Wiseman DA, Tian J, Rehmani I, Datar S, Oishi P, Fratz S, Venema RC, Fineman JR, Black SM. Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow. Vascular pharmacology 2009. PMID: 19818875


  155. Natarajan S, Heiss C, Yeghiazarians Y, Fineman JR, Teitel DF, Tacy TA. Peripheral arterial function in infants and young children with one-ventricle physiology and hypoxemia. The American journal of cardiology 2009. PMID: 19268746


  156. Oishi PE, Wiseman DA, Sharma S, Kumar S, Hou Y, Datar SA, Azakie A, Johengen MJ, Harmon C, Fratz S, Fineman JR, Black SM. Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress. American journal of physiology. Lung cellular and molecular physiology 2008. PMID: 18757524


  157. Hsu JH, Oishi PE, Keller RL, Chikovani O, Karl TR, Azakie A, Adatia I, Fineman JR. Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection. The Journal of thoracic and cardiovascular surgery 2008. PMID: 18374751


  158. Sharma S, Sud N, Wiseman DA, Carter AL, Kumar S, Hou Y, Rau T, Wilham J, Harmon C, Oishi P, Fineman JR, Black SM. Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension. American journal of physiology. Lung cellular and molecular physiology 2007. PMID: 18024721


  159. Oishi P, Sharma S, Grobe A, Azakie A, Harmon C, Johengen MJ, Hsu JH, Fratz S, Black SM, Fineman JR. Alterations in cGMP, soluble guanylate cyclase, phosphodiesterase 5, and B-type natriuretic peptide induced by chronic increased pulmonary blood flow in lambs. Pediatric pulmonology 2007. PMID: 17902145


  160. Chikovani O, Hsu JH, Keller R, Karl TR, Azakie A, Adatia I, Oishi P, Fineman JR. B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery. The Journal of thoracic and cardiovascular surgery 2007. PMID: 17976447


  161. Hsu JH, Keller RL, Chikovani O, Cheng H, Hollander SA, Karl TR, Azakie A, Adatia I, Oishi P, Fineman JR. B-type natriuretic peptide levels predict outcome after neonatal cardiac surgery. The Journal of thoracic and cardiovascular surgery 2007. PMID: 17903511


  162. Sud N, Sharma S, Wiseman DA, Harmon C, Kumar S, Venema RC, Fineman JR, Black SM. Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90. American journal of physiology. Lung cellular and molecular physiology 2007. PMID: 17827253


  163. Sharma S, Grobe AC, Wiseman DA, Kumar S, Englaish M, Najwer I, Benavidez E, Oishi P, Azakie A, Fineman JR, Black SM. Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow. American journal of physiology. Lung cellular and molecular physiology 2007. PMID: 17631609


  164. Lakshminrusimha S, Wiseman D, Black SM, Russell JA, Gugino SF, Oishi P, Steinhorn RH, Fineman JR. The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow. American journal of physiology. Heart and circulatory physiology 2007. PMID: 17513498


  165. Wedgwood S, Devol JM, Grobe A, Benavidez E, Azakie A, Fineman JR, Black SM. Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatric research 2007. PMID: 17211137


  166. Black SM, Kumar S, Wiseman D, Ravi K, Wedgwood S, Ryzhov V, Fineman JR. Pediatric pulmonary hypertension: Roles of endothelin-1 and nitric oxide. Clinical hemorheology and microcirculation 2007. PMID: 17641401


  167. Keller RL, Moore P, Teitel D, Hawgood S, McQuitty J, Fineman JR. Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2006. PMID: 17006391


  168. Azakie A, Fineman JR, He Y. Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo. The Journal of thoracic and cardiovascular surgery 2006. PMID: 17140938


  169. Khush KK, De Marco T, Vakharia KT, Harmon C, Fineman JR, Chatterjee K, Michaels AD. Nesiritide acutely increases pulmonary and systemic levels of nitric oxide in patients with pulmonary hypertension. Journal of cardiac failure 2006. PMID: 16952783


  170. Black SM, Fineman JR. Oxidative and nitrosative stress in pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide. Vascular pharmacology 2006. PMID: 17049313


  171. Oishi PE, Fineman JR. BNP for pediatrics--not quite ready for primetime. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2006. PMID: 16829829


  172. Grobe AC, Wells SM, Benavidez E, Oishi P, Azakie A, Fineman JR, Black SM. Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase. American journal of physiology. Lung cellular and molecular physiology 2006. PMID: 16684951


  173. Azakie A, Fineman JR, He Y. Sp3 inhibits Sp1-mediated activation of the cardiac troponin T promoter and is downregulated during pathological cardiac hypertrophy in vivo. American journal of physiology. Heart and circulatory physiology 2006. PMID: 16617124


  174. Shih CY, Sapru A, Oishi P, Azakie A, Karl TR, Harmon C, Asija R, Adatia I, Fineman JR. Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker. The Journal of thoracic and cardiovascular surgery 2006. PMID: 16515916


  175. Oishi P, Azakie A, Harmon C, Fitzgerald RK, Grobe A, Xu J, Hendricks-Munoz K, Black SM, Fineman JR. Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs. American journal of physiology. Heart and circulatory physiology 2005. PMID: 16339822


  176. Oishi P, Grobe A, Benavidez E, Ovadia B, Harmon C, Ross GA, Hendricks-Munoz K, Xu J, Black SM, Fineman JR. Inhaled nitric oxide induced NOS inhibition and rebound pulmonary hypertension: a role for superoxide and peroxynitrite in the intact lamb. American journal of physiology. Lung cellular and molecular physiology 2005. PMID: 16258003


  177. Azakie A, Lamont L, Fineman JR, He Y. Divergent transcriptional enhancer factor-1 regulates the cardiac troponin T promoter. American journal of physiology. Cell physiology 2005. PMID: 16049055


  178. Beghetti M, Black SM, Fineman JR. Endothelin-1 in congenital heart disease. Pediatric research 2005. PMID: 15817494


  179. Lee JW, Gonzalez RF, Chapin CJ, Busch J, Fineman JR, Gutierrez JA. Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes. American journal of physiology. Lung cellular and molecular physiology 2005. PMID: 15640287


  180. Fitzgerald RK, Oishi P, Ovadia B, Ross GA, Reinhartz O, Johengen MJ, Fineman JR. Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2004. PMID: 15530195


  181. Ross GA, Oishi P, Azakie A, Fratz S, Fitzgerald RK, Johengen MJ, Harmon C, Hendricks-Munoz K, Xu J, Black SM, Fineman JR. Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension. American journal of physiology. Lung cellular and molecular physiology 2004. PMID: 15347565


  182. Fratz S, Meyrick B, Ovadia B, Johengen MJ, Reinhartz O, Azakie A, Ross G, Fitzgerald R, Oishi P, Hess J, Black SM, Fineman JR. Chronic endothelin A receptor blockade in lambs with increased pulmonary blood flow and pressure. American journal of physiology. Lung cellular and molecular physiology 2004. PMID: 15155268


  183. Azakie A, Martinez D, Sapru A, Fineman J, Teitel D, Karl TR. Impact of right ventricle to pulmonary artery conduit on outcome of the modified Norwood procedure. The Annals of thoracic surgery 2004. PMID: 15111174


  184. Thelitz S, Bekker JM, Ovadia B, Stuart RB, Johengen MJ, Black SM, Fineman JR. Inhaled nitric oxide decreases pulmonary soluble guanylate cyclase protein levels in 1-month-old lambs. The Journal of thoracic and cardiovascular surgery 2004. PMID: 15115984


  185. Thelitz S, Oishi P, Sanchez LS, Bekker JM, Ovadia B, Johengen MJ, Black SM, Fineman JR. Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2004. PMID: 15115560


  186. Keller RL, Hamrick SE, Kitterman JA, Fineman JR, Hawgood S. Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2004. PMID: 14987351


  187. Lee JW, Ovadia B, Azakie A, Salas S, Goerke J, Fineman JR, Gutierrez JA. Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life. American journal of physiology. Lung cellular and molecular physiology 2004. PMID: 14751849


  188. Oishi P, Fineman JR. Pharmacologic therapy for persistent pulmonary hypertension of the newborn: as "poly" as the disease itself. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2004. PMID: 14709984


  189. Black SM, Mata-Greenwood E, Dettman RW, Ovadia B, Fitzgerald RK, Reinhartz O, Thelitz S, Steinhorn RH, Gerrets R, Hendricks-Munoz K, Ross GA, Bekker JM, Johengen MJ, Fineman JR. Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flow. Circulation 2003. PMID: 12963646


  190. Stuart RB, Ovadia B, Suzara VV, Ross PA, Thelitz S, Fineman JR, Gutierrez JA. Inhaled nitric oxide increases surfactant protein gene expression in the intact lamb. American journal of physiology. Lung cellular and molecular physiology 2003. PMID: 12765879


  191. Mata-Greenwood E, Meyrick B, Steinhorn RH, Fineman JR, Black SM. Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension. American journal of physiology. Lung cellular and molecular physiology 2003. PMID: 12665463


  192. Mata-Greenwood E, Meyrick B, Soifer SJ, Fineman JR, Black SM. Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. American journal of physiology. Lung cellular and molecular physiology 2003. PMID: 12665467


  193. Wedgwood S, Mitchell CJ, Fineman JR, Black SM. Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1. American journal of physiology. Lung cellular and molecular physiology 2003. PMID: 12533439


  194. Ovadia B, Reinhartz O, Fitzgerald R, Bekker JM, Johengen MJ, Azakie A, Thelitz S, Black SM, Fineman JR. Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow. American journal of physiology. Heart and circulatory physiology 2002. PMID: 12399254


  195. Cornfield DN, Resnik ER, Herron JM, Reinhartz O, Fineman JR. Pulmonary vascular K+ channel expression and vasoreactivity in a model of congenital heart disease. American journal of physiology. Lung cellular and molecular physiology 2002. PMID: 12388350


  196. Black SM, Bekker JM, McMullan DM, Parry AJ, Ovadia B, Reinhartz O, Lakshminrushimha S, Mata-Greenwood E, Steinhorn RH, Fineman JR. Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow. Pediatric research 2002. PMID: 12149501


  197. Ovadia B, Bekker JM, Fitzgerald RK, Kon A, Thelitz S, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman JR. Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs. American journal of physiology. Heart and circulatory physiology 2002. PMID: 11834480


  198. Gutierrez JA, Parry AJ, McMullan DM, Chapin CJ, Fineman JR. Decreased surfactant proteins in lambs with pulmonary hypertension secondary to increased blood flow. American journal of physiology. Lung cellular and molecular physiology 2001. PMID: 11597919


  199. Black SM, Sanchez LS, Mata-Greenwood E, Bekker JM, Steinhorn RH, Fineman JR. sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension. American journal of physiology. Lung cellular and molecular physiology 2001. PMID: 11597895


  200. Wedgwood S, McMullan DM, Bekker JM, Fineman JR, Black SM. Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy. Circulation research 2001. PMID: 11509453


  201. McMullan DM, Bekker JM, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman JR. Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1. American journal of physiology. Heart and circulatory physiology 2001. PMID: 11158977


  202. Tworetzky W, Bristow J, Moore P, Brook MM, Segal MR, Brasch RC, Hawgood S, Fineman JR. Inhaled nitric oxide in neonates with persistent pulmonary hypertension. Lancet (London, England) 2001. PMID: 11197402


  203. Steinhorn RH, Russell JA, Lakshminrusimha S, Gugino SF, Black SM, Fineman JR. Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension. American journal of physiology. Heart and circulatory physiology 2001. PMID: 11123246


  204. McMullan DM, Bekker JM, Parry AJ, Johengen MJ, Kon A, Heidersbach RS, Black SM, Fineman JR. Alterations in endogenous nitric oxide production after cardiopulmonary bypass in lambs with normal and increased pulmonary blood flow. Circulation 2000. PMID: 11082382


  205. Flori HR, Johnson LD, Hanley FL, Fineman JR. Transthoracic intracardiac catheters in pediatric patients recovering from congenital heart defect surgery: associated complications and outcomes. Critical care medicine 2000. PMID: 10966285


  206. McElhinney DB, Reddy VM, Parry AJ, Johnson L, Fineman JR, Hanley FL. Management and outcomes of delayed sternal closure after cardiac surgery in neonates and infants. Critical care medicine 2000. PMID: 10809302


  207. Tworetzky W, Moore P, Bekker JM, Bristow J, Black SM, Fineman JR. Pulmonary blood flow alters nitric oxide production in patients undergoing device closure of atrial septal defects. Journal of the American College of Cardiology 2000. PMID: 10676695


  208. Black SM, Bekker JM, Johengen MJ, Parry AJ, Soifer SJ, Fineman JR. Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatric research 2000. PMID: 10625089


  209. Black SM, Heidersbach RS, McMullan DM, Bekker JM, Johengen MJ, Fineman JR. Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension. The American journal of physiology 1999. PMID: 10564139


  210. Steinhorn RH, Fineman JR. The pathophysiology of pulmonary hypertension in congenital heart disease. Artificial organs 1999. PMID: 10564299


  211. Hintz SR, Vincent JA, Pitlick PT, Fineman JR, Steinhorn RH, Kim GE, Benitz WE. Alveolar capillary dysplasia: diagnostic potential for cardiac catheterization. Journal of perinatology : official journal of the California Perinatal Association 1999. PMID: 10685275


  212. Heidersbach RS, Johengen MJ, Bekker JM, Fineman JR. Inhaled nitric oxide, oxygen, and alkalosis: dose-response interactions in a lamb model of pulmonary hypertension. Pediatric pulmonology 1999. PMID: 10406044


  213. Fineman JR, Wong J, Mikhailov T, Vanderford PA, Jerome HE, Soifer SJ. Altered endothelial function in lambs with pulmonary hypertension and acute lung injury. Pediatric pulmonology 1999. PMID: 10213252


  214. Petrossian E, Parry AJ, Reddy VM, Akkersdijk GP, McMullan DM, Thompson L, Hendricks-Munoz KD, Hallak H, Hanley FL, Fineman JR. Endothelin receptor blockade prevents the rise in pulmonary vascular resistance after cardiopulmonary bypass in lambs with increased pulmonary blood flow. The Journal of thoracic and cardiovascular surgery 1999. PMID: 9918974


  215. Reddy VM, McElhinney DB, Rajasinghe HA, Liddicoat JR, Hendricks-Munoz K, Fineman JR, Hanley FL. Role of the endothelium in placental dysfunction after fetal cardiac bypass. The Journal of thoracic and cardiovascular surgery 1999. PMID: 9918976


  216. Fineman JR, Takahashi Y, Roman C, Clyman RI. Endothelin-receptor blockade does not alter closure of the ductus arteriosus. The American journal of physiology 1998. PMID: 9815069


  217. Black SM, Fineman JR, Steinhorn RH, Bristow J, Soifer SJ. Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension. The American journal of physiology 1998. PMID: 9815072


  218. Black S, Fineman J, Johengen M, Bristow J, Soifer S. Increased pulmonary blood flow alters the molecular regulation of vascular reactivity in the lamb. Chest 1998. PMID: 9676621


  219. Russell IA, Zwass MS, Fineman JR, Balea M, Rouine-Rapp K, Brook M, Hanley FL, Silverman NH, Cahalan MK. The effects of inhaled nitric oxide on postoperative pulmonary hypertension in infants and children undergoing surgical repair of congenital heart disease. Anesthesia and analgesia 1998. PMID: 9661544


  220. Steinhorn RH, Morin FC, Fineman JR. Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation. Seminars in perinatology 1997. PMID: 9352612


  221. Steinhorn RH, Cox PN, Fineman JR, Finer NN, Rosenberg EM, Silver MM, Tyebkhan J, Zwass MS, Morin FC. Inhaled nitric oxide enhances oxygenation but not survival in infants with alveolar capillary dysplasia. The Journal of pediatrics 1997. PMID: 9063417


  222. Roberts JD, Fineman JR, Morin FC, Shaul PW, Rimar S, Schreiber MD, Polin RA, Zwass MS, Zayek MM, Gross I, Heymann MA, Zapol WM. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. The New England journal of medicine 1997. PMID: 9032045


  223. Reddy VM, Hendricks-Munoz KD, Rajasinghe HA, Petrossian E, Hanley FL, Fineman JR. Post-cardiopulmonary bypass pulmonary hypertension in lambs with increased pulmonary blood flow. A role for endothelin 1. Circulation 1997. PMID: 9054770


  224. Reddy VM, Liddicoat JR, McElhinney DB, Fineman JR, Klein JR, Chang R, Hanley FL. Hemodynamic effects of epinephrine, bicarbonate and calcium in the early postnatal period in a lamb model of single-ventricle physiology created in utero. Journal of the American College of Cardiology 1996. PMID: 8962579


  225. Reddy VM, Wong J, Liddicoat JR, Johengen M, Chang R, Fineman JR. Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow. The American journal of physiology 1996. PMID: 8770097


  226. Bogaert GA, Kogan BA, Mevorach RA, Wong J, Gluckman GR, Fineman JR, Heymann MA. Exogenous endothelin-1 causes renal vasodilation in the fetal lamb. The Journal of urology 1996. PMID: 8683799


  227. Reddy VM, Liddicoat JR, Fineman JR, McElhinney DB, Klein JR, Hanley FL. Fetal model of single ventricle physiology: hemodynamic effects of oxygen, nitric oxide, carbon dioxide, and hypoxia in the early postnatal period. The Journal of thoracic and cardiovascular surgery 1996. PMID: 8751513


  228. Winters JW, Wong J, Van Dyke D, Johengen M, Heymann MA, Fineman JR. Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. Pediatric research 1996. PMID: 8798262


  229. Fineman JR, Taeusch HW. Invited editorial on "Antenatal betamethasone therapy augments nitric oxide-mediated relaxation of preterm ovine pulmonary veins". Journal of applied physiology (Bethesda, Md. : 1985) 1996. PMID: 8929573


  230. Wong J, Reddy VM, Hendricks-Munoz K, Liddicoat JR, Gerrets R, Fineman JR. Endothelin-1 vasoactive responses in lambs with pulmonary hypertension and increased pulmonary blood flow. The American journal of physiology 1995. PMID: 8594905


  231. Reddy VM, Meyrick B, Wong J, Khoor A, Liddicoat JR, Hanley FL, Fineman JR. In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs. Circulation 1995. PMID: 7634475


  232. Fineman JR, Zwass MS. Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn. Acta paediatrica Japonica : Overseas edition 1995. PMID: 7572140


  233. Wong J, Vanderford PA, Winters J, Soifer SJ, Fineman JR. Endothelinb receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension. Journal of cardiovascular pharmacology 1995. PMID: 7752646


  234. Fineman JR, Soifer SJ, Heymann MA. Regulation of pulmonary vascular tone in the perinatal period. Annual review of physiology 1995. PMID: 7778860


  235. Karamanoukian HL, Glick PL, Zayek M, Steinhorn RH, Zwass MS, Fineman JR, Morin FC. Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia or oligohydramnios. Pediatrics 1994. PMID: 7936901


  236. Wong J, Vanderford PA, Fineman JR, Soifer SJ. Developmental effects of endothelin-1 on the pulmonary circulation in sheep. Pediatric research 1994. PMID: 7808838


  237. Brook MM, Fineman JR, Bolinger AM, Wong AF, Heymann MA, Soifer SJ. Use of ATP-MgCl2 in the evaluation and treatment of children with pulmonary hypertension secondary to congenital heart defects. Circulation 1994. PMID: 8087937


  238. Fineman JR, Wong J, Morin FC, Wild LM, Soifer SJ. Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs. The Journal of clinical investigation 1994. PMID: 8201005


  239. Wong J, Fineman JR, Heymann MA. The role of endothelin and endothelin receptor subtypes in regulation of fetal pulmonary vascular tone. Pediatric research 1994. PMID: 7936815


  240. Crowley MR, Fineman JR, Soifer SJ. HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs. Journal of cardiovascular pharmacology 1994. PMID: 7521465


  241. Vanderford PA, Wong J, Chang R, Keefer LK, Soifer SJ, Fineman JR. Diethylamine/nitric oxide (NO) adduct, an NO donor, produces potent pulmonary and systemic vasodilation in intact newborn lambs. Journal of cardiovascular pharmacology 1994. PMID: 7511722


  242. Wong J, Vanderford PA, Fineman JR, Chang R, Soifer SJ. Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb. The American journal of physiology 1993. PMID: 8238420


  243. Fineman JR, Wong J, Soifer SJ. Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs. Pediatric research 1993. PMID: 8479813


  244. Wong J, Vanderford PA, Winters JW, Chang R, Soifer SJ, Fineman JR. Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb. Journal of cardiovascular pharmacology 1993. PMID: 7509961


  245. Braner DA, Fineman JR, Chang R, Soifer SJ. M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs. The American journal of physiology 1993. PMID: 8381611


  246. Moore P, Velvis H, Fineman JR, Soifer SJ, Heymann MA. EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. Journal of applied physiology (Bethesda, Md. : 1985) 1992. PMID: 1474097


  247. Chang JK, Moore P, Fineman JR, Soifer SJ, Heymann MA. K+ channel pulmonary vasodilation in fetal lambs: role of endothelium-derived nitric oxide. Journal of applied physiology (Bethesda, Md. : 1985) 1992. PMID: 1506367


  248. Fineman JR, Chang R, Soifer SJ. EDRF inhibition augments pulmonary hypertension in intact newborn lambs. The American journal of physiology 1992. PMID: 1590440


  249. Fineman JR, Chang R, Soifer SJ. L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs. The American journal of physiology 1991. PMID: 1659228


  250. Fineman JR, Crowley MR, Heymann MA, Soifer SJ. In vivo attenuation of endothelium-dependent pulmonary vasodilation by methylene blue. Journal of applied physiology (Bethesda, Md. : 1985) 1991. PMID: 1657862


  251. Fineman JR, Heymann MA, Soifer SJ. N omega-nitro-L-arginine attenuates endothelium-dependent pulmonary vasodilation in lambs. The American journal of physiology 1991. PMID: 1849373


  252. Crowley MR, Fineman JR, Soifer SJ. Effects of vasoactive drugs on thromboxane A2 mimetic-induced pulmonary hypertension in newborn lambs. Pediatric research 1991. PMID: 2014153


  253. Fineman JR, Soifer SJ, Heymann MA. The role of pulmonary vascular endothelium in perinatal pulmonary circulatory regulation. Seminars in perinatology 1991. PMID: 2063230


  254. Fineman JR, Crowley MR, Soifer SJ. Selective pulmonary vasodilation with ATP-MgCl2 during pulmonary hypertension in lambs. Journal of applied physiology (Bethesda, Md. : 1985) 1990. PMID: 2272976